SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO7_B_CHDB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 LEU A  43
PRO A  13
VAL A   7
GLY A   6
MET A 276
 None
 1.33A 2po7B-1ghsA:
0.0		 2po7B-1ghsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		5 LEU A 209
ARG A  59
PRO A 159
VAL A  96
GLY A  95
 None
 1.49A 2po7B-1jfxA:
1.2		 2po7B-1jfxA:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 LEU A  62
PRO A 238
VAL A 277
GLY A 278
TRP A 282
 None
 1.25A 2po7B-1lbqA:
47.9		 2po7B-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1

(Trypanosoma
brucei) 		PF09387
(MRP) 		5 MET B 109
LEU B  88
LEU B 154
VAL B  99
GLY B  98
 None
 1.27A 2po7B-2gidB:
0.0		 2po7B-2gidB:
18.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 LEU A  92
PRO A 266
VAL A 305
GLY A 306
TRP A 310
 CHD  A   1 (-4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
CHD  A   2 (-4.7A)
 1.32A 2po7B-3aqiA:
60.0		 2po7B-3aqiA:
99.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		9 MET A  99
LEU A 101
ARG A 114
LEU A 115
PRO A 266
VAL A 305
GLY A 306
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
None
CHD  A   2 (-4.7A)
 0.45A 2po7B-3aqiA:
60.0		 2po7B-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtx AMINOTRANSFERASE

(Neisseria
meningitidis) 		PF00155
(Aminotran_1_2) 		5 LEU A 220
LEU A 236
PRO A 155
VAL A 192
TRP A 157
 None
 1.29A 2po7B-3jtxA:
0.5		 2po7B-3jtxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 MET A 130
LEU A  75
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 1.00A 2po7B-3ubcA:
1.0		 2po7B-3ubcA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		5 LEU A 478
LEU A 359
PRO A  10
VAL A 419
GLY A 421
 None
 1.22A 2po7B-4zfmA:
0.0		 2po7B-4zfmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxb PROXP-ALA

(Caulobacter
vibrioides) 		PF04073
(tRNA_edit) 		5 LEU A 152
LEU A  58
VAL A  95
GLY A  94
MET A   1
 None
 1.14A 2po7B-5vxbA:
0.0		 2po7B-5vxbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfp UBIQUITIN-LIKE
PROTEIN
SMT3,POLYMERASE
ACIDIC PROTEIN

(Saccharomyces
cerevisiae;
Influenza A
virus) 		no annotation 5 LEU A 500
LEU A 342
VAL A 545
GLY A 546
MET A 548
 None
EZS  A 801 (-4.2A)
None
None
None
 1.33A 2po7B-6cfpA:
undetectable		 2po7B-6cfpA:
undetectable