SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO7_B_CHDB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ble FRUCTOSE PERMEASE

(Bacillus
subtilis) 		PF03830
(PTSIIB_sorb) 		5 LEU A  83
LEU A  19
ILE A  90
LEU A 146
PRO A 147
 None
 0.98A 2po7B-1bleA:
0.8		 2po7B-1bleA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		5 SER A 118
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 None
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.07A 2po7B-1c9eA:
34.6		 2po7B-1c9eA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9e PROTOHEME FERROLYASE

(Bacillus
subtilis) 		PF00762
(Ferrochelatase) 		5 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.06A 2po7B-1c9eA:
34.6		 2po7B-1c9eA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6n PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Homo sapiens) 		PF00156
(Pribosyltran) 		5 LEU A 124
LEU A 121
ILE A  61
LEU A 101
VAL A 115
 None
 1.16A 2po7B-1d6nA:
undetectable		 2po7B-1d6nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 LEU A 468
ILE A 477
SER A 423
LEU A 419
VAL A 382
 None
 1.08A 2po7B-1dcqA:
undetectable		 2po7B-1dcqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fta FRUCTOSE-1,6-BISPHOS
PHATASE

(Homo sapiens) 		PF00316
(FBPase) 		5 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.19A 2po7B-1ftaA:
0.4		 2po7B-1ftaA:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 LEU A  62
PHE A  63
ILE A  91
SER A 167
HIS A 235
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 0.50A 2po7B-1lbqA:
47.9		 2po7B-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 MET A  46
LEU A  62
PHE A  63
SER A 167
HIS A 235
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 0.79A 2po7B-1lbqA:
47.9		 2po7B-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 PHE A  63
LEU A  68
SER A 167
HIS A 235
LEU A 237
TRP A 282
 None
 1.33A 2po7B-1lbqA:
47.9		 2po7B-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 SER A 169
HIS A 235
LEU A 237
VAL A 241
TRP A 282
 None
 1.26A 2po7B-1lbqA:
47.9		 2po7B-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.17A 2po7B-1pujA:
2.2		 2po7B-1pujA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		5 MET A 325
PHE A  96
LEU A 187
PRO A 401
VAL A 191
 None
EPB  A 450 ( 3.6A)
None
None
None
 1.24A 2po7B-1q5dA:
undetectable		 2po7B-1q5dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU C 131
LEU C 127
ILE C 173
SER C 114
VAL C 100
 None
None
None
FAD  C4931 (-4.2A)
FAD  C4931 ( 3.7A)
 1.18A 2po7B-1t3qC:
undetectable		 2po7B-1t3qC:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU A 291
PHE A 287
LEU A 292
ILE A 255
LEU A  60
 None
 1.23A 2po7B-1vmaA:
2.8		 2po7B-1vmaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.22A 2po7B-1wa5C:
undetectable		 2po7B-1wa5C:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A  82
LEU A  41
ILE A  91
PRO A  22
VAL A  37
 None
 1.22A 2po7B-1wn1A:
undetectable		 2po7B-1wn1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.03A 2po7B-1yirA:
undetectable		 2po7B-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		5 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.21A 2po7B-2b4wA:
undetectable		 2po7B-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8j FERROCHELATASE 1

(Bacillus
anthracis) 		PF00762
(Ferrochelatase) 		5 SER A 117
HIS A 182
LEU A 184
PRO A 185
TRP A 229
 None
 0.94A 2po7B-2c8jA:
34.1		 2po7B-2c8jA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		5 LEU A 536
LEU A 525
ILE A 593
SER A 482
VAL A 521
 None
 1.18A 2po7B-2ckhA:
undetectable		 2po7B-2ckhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 LEU A 327
LEU A 347
SER A 341
LEU A 379
VAL A 376
 None
 1.27A 2po7B-2fgeA:
undetectable		 2po7B-2fgeA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 LEU A 103
PHE A 124
ILE A 158
LEU A  78
PRO A  81
 None
 1.15A 2po7B-2fi1A:
2.3		 2po7B-2fi1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 450
PHE A 451
LEU A 382
ILE A 372
VAL A 227
 HEM  A 900 (-4.0A)
HEM  A 900 (-4.1A)
HEM  A 900 (-4.0A)
None
None
 1.13A 2po7B-2hi4A:
undetectable		 2po7B-2hi4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.18A 2po7B-2hmiD:
undetectable		 2po7B-2hmiD:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A 103
LEU A 106
ILE A 128
LEU A 171
VAL A   2
 None
 1.18A 2po7B-2hoqA:
3.5		 2po7B-2hoqA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 MET A 928
LEU A 311
LEU A 541
MET A 100
LEU A 603
 None
 1.24A 2po7B-2inyA:
undetectable		 2po7B-2inyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nck NUCLEOSIDE
DIPHOSPHATE KINASE

(Myxococcus
xanthus) 		no annotation 5 MET R  67
LEU R  63
PHE R  59
ILE R 111
LEU R   7
 None
 1.25A 2po7B-2nckR:
undetectable		 2po7B-2nckR:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlx XYLULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 132
ILE A 142
SER A 166
PRO A 152
TRP A  48
 None
 1.27A 2po7B-2nlxA:
undetectable		 2po7B-2nlxA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.23A 2po7B-2nn3C:
3.1		 2po7B-2nn3C:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 LEU A1022
ILE A1057
SER A1013
LEU A1041
VAL A 992
 None
 1.14A 2po7B-2vz9A:
undetectable		 2po7B-2vz9A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 0.87A 2po7B-2w3wA:
undetectable		 2po7B-2w3wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.92A 2po7B-2z63A:
undetectable		 2po7B-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU A  29
PHE A  33
LEU A 101
ILE A  46
LEU A 136
 None
None
HEM  A 201 (-4.1A)
None
None
 1.19A 2po7B-3a0gA:
undetectable		 2po7B-3a0gA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.86A 2po7B-3a8kA:
undetectable		 2po7B-3a8kA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.23A 2po7B-3abbA:
undetectable		 2po7B-3abbA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 MET A 238
LEU A 234
LEU A 280
ILE A 183
VAL A 354
 None
 1.24A 2po7B-3ajbA:
undetectable		 2po7B-3ajbA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		12 MET A  76
LEU A  92
PHE A  93
LEU A  98
MET A  99
ILE A 119
SER A 195
HIS A 263
LEU A 265
PRO A 266
VAL A 269
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
None
None
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 0.57A 2po7B-3aqiA:
60.0		 2po7B-3aqiA:
99.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		5 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.24A 2po7B-3caxA:
undetectable		 2po7B-3caxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fms TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF00392
(GntR)
PF07729
(FCD) 		5 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.19A 2po7B-3fmsA:
undetectable		 2po7B-3fmsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.84A 2po7B-3fxiA:
undetectable		 2po7B-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 285
ILE A 273
LEU A 113
PRO A 153
VAL A 156
 None
 1.23A 2po7B-3gp0A:
undetectable		 2po7B-3gp0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		5 LEU A1300
PHE A1380
LEU A1388
ILE A1285
LEU A1362
 None
 1.25A 2po7B-3jroA:
undetectable		 2po7B-3jroA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		5 MET A 341
LEU A 278
ILE A 261
LEU A 135
VAL A  87
 None
 1.24A 2po7B-3khjA:
undetectable		 2po7B-3khjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		5 LEU A 221
LEU A 226
SER A  27
LEU A  44
VAL A  15
 None
 1.14A 2po7B-3kxwA:
undetectable		 2po7B-3kxwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.11A 2po7B-3m1mA:
undetectable		 2po7B-3m1mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		5 LEU A 133
PHE A 137
LEU A 152
PRO A 151
VAL A  86
 None
 1.07A 2po7B-3n91A:
undetectable		 2po7B-3n91A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 139
LEU A  88
ILE A   3
LEU A  64
VAL A  51
 EDO  A 507 (-4.1A)
None
None
None
None
 1.26A 2po7B-3peiA:
3.4		 2po7B-3peiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 MET A 331
LEU A 305
LEU A 301
LEU A 253
VAL A 293
 None
 1.21A 2po7B-3pt1A:
undetectable		 2po7B-3pt1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		5 LEU A 933
PHE A 929
ILE A 876
SER A 961
LEU A 981
 None
 1.23A 2po7B-3s51A:
undetectable		 2po7B-3s51A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF07729
(FCD) 		5 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.22A 2po7B-3sxmA:
undetectable		 2po7B-3sxmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
 None
 1.16A 2po7B-3v4oA:
2.7		 2po7B-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 LEU H 260
LEU H  54
SER H 117
PRO H  41
TRP H  23
 None
 1.10A 2po7B-3x1lH:
undetectable		 2po7B-3x1lH:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.23A 2po7B-3zyiA:
undetectable		 2po7B-3zyiA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 321
PHE A 325
LEU A 320
LEU A 340
VAL A 336
 None
 1.14A 2po7B-4a27A:
3.6		 2po7B-4a27A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 MET A 432
LEU A 439
LEU A 402
LEU A 383
VAL A 305
 None
 1.19A 2po7B-4fddA:
undetectable		 2po7B-4fddA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.19A 2po7B-4h59A:
undetectable		 2po7B-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
 None
 1.20A 2po7B-4hq1A:
undetectable		 2po7B-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas;
Pseudomonas) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		5 MET A  99
LEU A 163
ILE B 106
SER B 141
VAL A 168
 None
 1.22A 2po7B-4hstA:
undetectable		 2po7B-4hstA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 LEU A 264
LEU A 355
MET A 280
SER A 329
LEU A 385
 None
 1.18A 2po7B-4hucA:
undetectable		 2po7B-4hucA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
 None
 1.15A 2po7B-4i1pA:
undetectable		 2po7B-4i1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 136
LEU A 280
HIS A 178
LEU A 182
VAL A 186
 None
 0.98A 2po7B-4idaA:
undetectable		 2po7B-4idaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 823
PHE A 822
LEU A 819
ILE A 830
LEU A 660
 None
 0.99A 2po7B-4k0eA:
undetectable		 2po7B-4k0eA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 LEU A 410
PHE A 408
ILE A 339
PRO A 196
VAL A 193
 None
None
NDP  A 601 (-4.2A)
None
None
 1.25A 2po7B-4l4xA:
3.0		 2po7B-4l4xA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.21A 2po7B-4lctA:
undetectable		 2po7B-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 176
PHE A 200
LEU A 182
ILE A 192
SER A 136
 None
 1.25A 2po7B-4li2A:
undetectable		 2po7B-4li2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1305
PHE A1342
LEU A1353
LEU A1260
VAL A1331
 None
 1.17A 2po7B-4ll8A:
undetectable		 2po7B-4ll8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.05A 2po7B-4mn8A:
undetectable		 2po7B-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.10A 2po7B-4mnaA:
undetectable		 2po7B-4mnaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1s V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermoplasma
volcanium) 		PF14890
(Intein_splicing) 		5 LEU A  97
LEU A 167
ILE A 137
PRO A  11
VAL A  12
 None
 1.24A 2po7B-4o1sA:
undetectable		 2po7B-4o1sA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 381
PHE A 392
LEU A 385
MET A 387
LEU A 618
 None
 1.10A 2po7B-4pd3A:
2.5		 2po7B-4pd3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 LEU A 264
LEU A 355
MET A 280
SER A 329
LEU A 385
 None
 1.21A 2po7B-4qtfA:
undetectable		 2po7B-4qtfA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 173
PHE A 197
LEU A 179
ILE A 189
SER A 133
 None
 1.22A 2po7B-4qxeA:
undetectable		 2po7B-4qxeA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 183
LEU A 179
ILE A 143
LEU A 195
VAL A 164
 None
 1.01A 2po7B-4tx8A:
undetectable		 2po7B-4tx8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A  77
LEU A 100
ILE A  41
LEU A 110
PRO A 111
 None
 1.25A 2po7B-4u08A:
undetectable		 2po7B-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 169
LEU A 192
ILE A 133
LEU A 202
PRO A 203
 None
 1.21A 2po7B-4u08A:
undetectable		 2po7B-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 215
LEU A 238
ILE A 179
LEU A 248
PRO A 249
 None
 1.20A 2po7B-4u08A:
undetectable		 2po7B-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A  92
LEU A 115
ILE A  78
LEU A 125
PRO A 126
 None
 1.23A 2po7B-4u09A:
undetectable		 2po7B-4u09A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		5 LEU A 223
ILE A 323
PRO A 168
VAL A 171
TRP A 146
 None
 0.99A 2po7B-4y7iA:
undetectable		 2po7B-4y7iA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylg ADP-RIBOSYLATION
FACTOR

(Entamoeba
histolytica) 		PF00025
(Arf) 		5 LEU A 141
LEU A 103
ILE A 132
LEU A  21
VAL A  64
 None
 1.21A 2po7B-4ylgA:
4.0		 2po7B-4ylgA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr5 NEPRILYSIN

(Oryctolagus
cuniculus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 LEU A 314
PHE A 321
LEU A 359
ILE A 219
LEU A 370
 None
 1.25A 2po7B-4zr5A:
undetectable		 2po7B-4zr5A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.17A 2po7B-5ddvA:
2.6		 2po7B-5ddvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dq6 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 3

(Mus musculus) 		PF02338
(OTU) 		5 LEU A 275
LEU A 303
ILE A 210
LEU A 236
PRO A 235
 None
 1.19A 2po7B-5dq6A:
undetectable		 2po7B-5dq6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5for PHOSPHOINOSITIDE
3-KINASE ADAPTER
PROTEIN 1

(Homo sapiens) 		no annotation 5 LEU A  81
LEU A  85
HIS A  42
LEU A  10
VAL A  64
 MLY  A  78 ( 4.3A)
None
None
None
None
 1.20A 2po7B-5forA:
3.5		 2po7B-5forA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzy (R)-2-HALOACID
DEHALOGENASE

(Pseudomonas
putida) 		PF10778
(DehI) 		5 PHE A 295
LEU A 216
MET A 209
ILE A 227
VAL A 177
 None
 1.08A 2po7B-5gzyA:
undetectable		 2po7B-5gzyA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k69 L,D-TRANSPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 LEU A 264
LEU A 355
MET A 280
SER A 329
LEU A 385
 None
 1.19A 2po7B-5k69A:
undetectable		 2po7B-5k69A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		5 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.25A 2po7B-5l3xB:
undetectable		 2po7B-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjr PROTEIN THF1

(Thermosynechococcus
elongatus) 		PF11264
(ThylakoidFormat) 		5 LEU A  40
HIS A 127
LEU A 167
PRO A 168
VAL A 172
 None
 1.26A 2po7B-5mjrA:
undetectable		 2po7B-5mjrA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		5 LEU A  63
ILE A  42
SER A  17
LEU A  29
VAL A  77
 None
FAD  A 401 ( 4.7A)
None
None
None
 1.23A 2po7B-5twbA:
undetectable		 2po7B-5twbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwv L,D-TRANSPEPTIDASE 2

(Mycobacteroides
abscessus) 		no annotation 5 LEU B 261
LEU B 352
MET B 277
SER B 326
LEU B 382
 None
 1.24A 2po7B-5uwvB:
undetectable		 2po7B-5uwvB:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.18A 2po7B-5vl1A:
undetectable		 2po7B-5vl1A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjc KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 341
LEU A 331
ILE A 358
LEU A 260
VAL A 254
 None
 1.08A 2po7B-5wjcA:
undetectable		 2po7B-5wjcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 5 LEU A 200
PHE A 191
LEU A 235
ILE A 162
LEU A 242
 None
 1.21A 2po7B-5xnpA:
undetectable		 2po7B-5xnpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 590
PHE A 591
LEU A 410
PRO A 549
VAL A 398
 None
 1.17A 2po7B-5xxoA:
3.5		 2po7B-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.17A 2po7B-5yxgA:
undetectable		 2po7B-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.21A 2po7B-5z24A:
undetectable		 2po7B-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 193
PHE A 198
LEU A 292
LEU A 413
TRP A 411
 None
 1.26A 2po7B-6aqhA:
undetectable		 2po7B-6aqhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6euv POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		no annotation 5 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.24A 2po7B-6euvA:
undetectable		 2po7B-6euvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 667
LEU A 690
ILE A 629
LEU A 700
PRO A 701
 None
 1.22A 2po7B-6fnwA:
undetectable		 2po7B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.16A 2po7B-6fnwA:
undetectable		 2po7B-6fnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g9o VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.21A 2po7B-6g9oA:
undetectable		 2po7B-6g9oA:
undetectable