SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO5_B_CHDB503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		3 LEU A 305
PRO A 304
LEU A 308
 None
 0.61A 2po5B-1bg6A:
2.6		 2po5B-1bg6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bix AP ENDONUCLEASE 1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 LEU A 104
PRO A 105
LEU A 108
 None
 0.63A 2po5B-1bixA:
undetectable		 2po5B-1bixA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		3 LEU A 203
PRO A 202
LEU A 206
 None
 0.55A 2po5B-1bxkA:
2.4		 2po5B-1bxkA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		3 LEU A 410
PRO A 411
LEU A 112
 None
 0.52A 2po5B-1c7tA:
undetectable		 2po5B-1c7tA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 LEU A 106
PRO A 107
LEU A 110
 NAD  A 500 (-3.9A)
NAD  A 500 (-4.5A)
None
 0.57A 2po5B-1evjA:
3.1		 2po5B-1evjA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h29 HIGH-MOLECULAR-WEIGH
T CYTOCHROME C

(Desulfovibrio
vulgaris) 		PF02085
(Cytochrom_CIII) 		3 LEU A 276
PRO A 277
LEU A 399
 None
HEC  A1112 (-3.7A)
None
 0.60A 2po5B-1h29A:
undetectable		 2po5B-1h29A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hss 0.19 ALPHA-AMYLASE
INHIBITOR

(Triticum
aestivum) 		PF00234
(Tryp_alpha_amyl) 		3 LEU A  23
PRO A  22
LEU A  26
 None
 0.61A 2po5B-1hssA:
undetectable		 2po5B-1hssA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		3 LEU A 403
PRO A 402
LEU A 406
 None
 0.57A 2po5B-1i5aA:
undetectable		 2po5B-1i5aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 LEU A 713
PRO A 714
LEU A 699
 None
 0.55A 2po5B-1iv8A:
undetectable		 2po5B-1iv8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9o ALASERPIN

(Manduca sexta) 		PF00079
(Serpin) 		3 LEU I  54
PRO I  53
LEU I  57
 None
 0.47A 2po5B-1k9oI:
undetectable		 2po5B-1k9oI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klq MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2A

(Homo sapiens) 		PF02301
(HORMA) 		3 LEU A 144
PRO A 145
LEU A 147
 None
 0.59A 2po5B-1klqA:
undetectable		 2po5B-1klqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kps RAN-GTPASE
ACTIVATING PROTEIN 1

(Mus musculus) 		PF07834
(RanGAP1_C) 		3 LEU B 541
PRO B 540
LEU B 544
 None
 0.52A 2po5B-1kpsB:
undetectable		 2po5B-1kpsB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 LEU A 137
PRO A 138
LEU A 143
 None
 0.62A 2po5B-1kvkA:
undetectable		 2po5B-1kvkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 LEU A 279
PRO A 280
LEU A 305
 None
 0.60A 2po5B-1l5aA:
undetectable		 2po5B-1l5aA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		3 LEU A 226
PRO A 227
LEU A 230
 None
None
MLY  A 231 ( 4.0A)
 0.51A 2po5B-1llnA:
undetectable		 2po5B-1llnA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk2 SMAD 3

(Homo sapiens) 		PF03166
(MH2) 		3 LEU A 403
PRO A 402
LEU A 406
 None
 0.51A 2po5B-1mk2A:
undetectable		 2po5B-1mk2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A  16
PRO A  15
LEU A  19
 None
 0.53A 2po5B-1mldA:
3.3		 2po5B-1mldA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		3 LEU A  41
PRO A  40
LEU A  44
 None
 0.62A 2po5B-1mp3A:
2.6		 2po5B-1mp3A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n97 CYP175A1

(Thermus
thermophilus) 		PF00067
(p450) 		3 LEU A  21
PRO A  20
LEU A  24
 None
 0.53A 2po5B-1n97A:
undetectable		 2po5B-1n97A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 LEU A 294
PRO A 293
LEU A 316
 None
 0.50A 2po5B-1odoA:
undetectable		 2po5B-1odoA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 3 LEU A  81
PRO A  80
LEU A  84
 None
 0.53A 2po5B-1onsA:
undetectable		 2po5B-1onsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 513
PRO A 438
LEU A 522
 None
 0.00A 2po5B-1q5aA:
undetectable		 2po5B-1q5aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 513
PRO A 520
LEU A 522
 None
 0.00A 2po5B-1q5aA:
undetectable		 2po5B-1q5aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU A 425
PRO A 426
LEU A 302
 None
 0.62A 2po5B-1qasA:
3.8		 2po5B-1qasA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyi HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF13242
(Hydrolase_like) 		3 LEU A 134
PRO A 133
LEU A 137
 None
 0.60A 2po5B-1qyiA:
2.2		 2po5B-1qyiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		3 LEU A  28
PRO A  27
LEU A  31
 None
 0.56A 2po5B-1rfvA:
2.2		 2po5B-1rfvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008

(Archaeoglobus
fulgidus) 		PF01978
(TrmB) 		3 LEU A   5
PRO A   4
LEU A   8
 None
 0.63A 2po5B-1sfxA:
undetectable		 2po5B-1sfxA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2C
1

(Homo sapiens) 		PF02170
(PAZ) 		3 LEU A 323
PRO A 324
LEU A 339
 None
 0.36A 2po5B-1si2A:
undetectable		 2po5B-1si2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL

(Citrullus
lanatus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A  60
PRO A  59
LEU A  63
 None
 0.59A 2po5B-1smkA:
2.3		 2po5B-1smkA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sou 5,10-METHENYLTETRAHY
DROFOLATE SYNTHETASE

(Aquifex
aeolicus) 		PF01812
(5-FTHF_cyc-lig) 		3 LEU A 160
PRO A 161
LEU A 129
 None
 0.47A 2po5B-1souA:
undetectable		 2po5B-1souA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sw6 REGULATORY PROTEIN
SWI6

(Saccharomyces
cerevisiae) 		PF00023
(Ank)
PF13857
(Ank_5) 		3 LEU A 322
PRO A 321
LEU A 325
 None
 0.61A 2po5B-1sw6A:
undetectable		 2po5B-1sw6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LEU A 549
PRO A 548
LEU A 552
 None
 0.52A 2po5B-1taqA:
2.8		 2po5B-1taqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		3 LEU A  78
PRO A  77
LEU A  83
 None
 0.57A 2po5B-1tv8A:
undetectable		 2po5B-1tv8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us7 HSP90 CO-CHAPERONE
CDC37

(Homo sapiens) 		PF08564
(CDC37_C)
PF08565
(CDC37_M) 		3 LEU B 301
PRO B 302
LEU B 305
 None
 0.58A 2po5B-1us7B:
undetectable		 2po5B-1us7B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		3 LEU A 135
PRO A 134
LEU A 138
 None
 0.59A 2po5B-1vlpA:
undetectable		 2po5B-1vlpA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 LEU B 388
PRO B 387
LEU B 391
 None
 0.60A 2po5B-1wa5B:
undetectable		 2po5B-1wa5B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wju NEDD8 ULTIMATE
BUSTER-1

(Homo sapiens) 		no annotation 3 LEU A  22
PRO A  23
LEU A  26
 None
 0.61A 2po5B-1wjuA:
undetectable		 2po5B-1wjuA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm9 GTP CYCLOHYDROLASE I

(Thermus
thermophilus) 		PF01227
(GTP_cyclohydroI) 		3 LEU A 113
PRO A 114
LEU A 178
 None
 0.61A 2po5B-1wm9A:
undetectable		 2po5B-1wm9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqj INSULIN-LIKE GROWTH
FACTOR BINDING
PROTEIN 4

(Homo sapiens) 		PF00219
(IGFBP) 		3 LEU B  69
PRO B  68
LEU B  72
 None
 0.61A 2po5B-1wqjB:
undetectable		 2po5B-1wqjB:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvc GLUCOSE-1-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Salmonella
enterica) 		PF00483
(NTP_transferase) 		3 LEU A 214
PRO A 213
LEU A 217
 None
 0.58A 2po5B-1wvcA:
2.3		 2po5B-1wvcA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0a MALATE/L-LACTATE
DEHYDROGENASE FAMILY
PROTEIN

(Thermus
thermophilus) 		PF02615
(Ldh_2) 		3 LEU A 302
PRO A 303
LEU A 169
 None
 0.63A 2po5B-1x0aA:
undetectable		 2po5B-1x0aA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x51 A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF14815
(NUDIX_4) 		3 LEU A  80
PRO A  81
LEU A  70
 None
 0.62A 2po5B-1x51A:
undetectable		 2po5B-1x51A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		3 LEU A 266
PRO A 265
LEU A 269
 None
 0.54A 2po5B-1xdnA:
undetectable		 2po5B-1xdnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1s HYPOTHETICAL PROTEIN
PA3332

(Pseudomonas
aeruginosa) 		PF12680
(SnoaL_2) 		3 LEU A 122
PRO A 121
LEU A 125
 None
 0.57A 2po5B-1z1sA:
undetectable		 2po5B-1z1sA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgh METHIONYL-TRNA
FORMYLTRANSFERASE

(Ruminiclostridium
thermocellum) 		PF00551
(Formyl_trans_N) 		3 LEU A  87
PRO A  86
LEU A  90
 None
 0.55A 2po5B-1zghA:
3.3		 2po5B-1zghA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 239
PRO A 238
LEU A 242
 None
 0.53A 2po5B-1zltA:
undetectable		 2po5B-1zltA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		3 LEU A 116
PRO A 117
LEU A  57
 None
 0.48A 2po5B-2a33A:
3.3		 2po5B-2a33A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 3 LEU A 212
PRO A 213
LEU A  92
 None
 0.54A 2po5B-2b2nA:
undetectable		 2po5B-2b2nA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5i CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 LEU C  35
PRO C  36
LEU C 110
 None
 0.53A 2po5B-2b5iC:
undetectable		 2po5B-2b5iC:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		3 LEU A 430
PRO A 429
LEU A 433
 None
 0.55A 2po5B-2braA:
undetectable		 2po5B-2braA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 LEU A 266
PRO A 265
LEU A 269
 None
 0.54A 2po5B-2cukA:
2.3		 2po5B-2cukA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		3 LEU A 269
PRO A 270
LEU A 282
 None
 0.63A 2po5B-2d6fA:
5.5		 2po5B-2d6fA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		3 LEU A 488
PRO A 489
LEU A 510
 None
 0.54A 2po5B-2dh3A:
undetectable		 2po5B-2dh3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		3 LEU A 140
PRO A 139
LEU A 143
 None
 0.63A 2po5B-2ef4A:
2.5		 2po5B-2ef4A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erj CYTOKINE RECEPTOR
COMMON GAMMA CHAIN

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		3 LEU C  35
PRO C  36
LEU C 110
 None
 0.44A 2po5B-2erjC:
undetectable		 2po5B-2erjC:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyn ALPHA-ACTININ 1

(Homo sapiens) 		PF00307
(CH) 		3 LEU A 202
PRO A 201
LEU A 205
 None
 0.54A 2po5B-2eynA:
undetectable		 2po5B-2eynA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		3 LEU A 212
PRO A 213
LEU A  92
 None
 0.58A 2po5B-2eyqA:
3.5		 2po5B-2eyqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		3 LEU A  40
PRO A  39
LEU A  43
 MLY  A   3 ( 4.6A)
None
None
 0.51A 2po5B-2ftzA:
undetectable		 2po5B-2ftzA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2d ATP:COBALAMIN
ADENOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01923
(Cob_adeno_trans) 		3 LEU A 125
PRO A 124
LEU A 128
 None
 0.63A 2po5B-2g2dA:
undetectable		 2po5B-2g2dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		3 LEU A 377
PRO A 376
LEU A 380
 None
 0.56A 2po5B-2gqwA:
undetectable		 2po5B-2gqwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2m COMM
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF17221
(COMMD1_N) 		3 LEU A  12
PRO A  11
LEU A  15
 None
 0.61A 2po5B-2h2mA:
undetectable		 2po5B-2h2mA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 LEU A 126
PRO A 125
LEU A 129
 None
 0.60A 2po5B-2ip4A:
2.3		 2po5B-2ip4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		3 LEU A 227
PRO A 228
LEU A 132
 None
 0.59A 2po5B-2ix2A:
undetectable		 2po5B-2ix2A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		3 LEU A  73
PRO A  72
LEU A  76
 None
 0.60A 2po5B-2jf4A:
undetectable		 2po5B-2jf4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jq6 EH DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF12763
(EF-hand_4) 		3 LEU A 122
PRO A 123
LEU A  92
 None
 0.59A 2po5B-2jq6A:
undetectable		 2po5B-2jq6A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ket CATHELICIDIN-6

(Bos taurus) 		no annotation 3 LEU A  23
PRO A  22
LEU A  26
 NH2  A  27 ( 4.9A)
None
NH2  A  27 (-3.9A)
 0.63A 2po5B-2ketA:
undetectable		 2po5B-2ketA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 LEU A 549
PRO A 548
LEU A 552
 None
 0.52A 2po5B-2ktqA:
undetectable		 2po5B-2ktqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4d SCO1/SENC FAMILY
PROTEIN/CYTOCHROME C

(Pseudomonas
putida) 		PF00034
(Cytochrom_C) 		3 LEU A  59
PRO A  58
LEU A  62
 None
 0.53A 2po5B-2l4dA:
undetectable		 2po5B-2l4dA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf3 EFFECTOR PROTEIN
HOPAB3

(Pseudomonas
syringae group
genomosp. 3) 		PF16847
(AvrPtoB_bdg) 		3 LEU A 372
PRO A 371
LEU A 375
 None
 0.62A 2po5B-2lf3A:
undetectable		 2po5B-2lf3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msv MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		no annotation 3 LEU A  42
PRO A  41
LEU A  45
 None
 0.61A 2po5B-2msvA:
undetectable		 2po5B-2msvA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyg YOKD PROTEIN

(Bacillus
subtilis) 		PF02522
(Antibiotic_NAT) 		3 LEU A 161
PRO A 160
LEU A 164
 None
 0.55A 2po5B-2nygA:
undetectable		 2po5B-2nygA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 161
PRO A 162
LEU A 172
 None
 0.49A 2po5B-2ppgA:
2.5		 2po5B-2ppgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A 222
PRO A 221
LEU A 225
 None
 0.57A 2po5B-2ptzA:
undetectable		 2po5B-2ptzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4d LYSINE
DECARBOXYLASE-LIKE
PROTEIN AT5G11950

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		3 LEU A 112
PRO A 113
LEU A  53
 None
 0.41A 2po5B-2q4dA:
3.3		 2po5B-2q4dA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjn RESPONSE REGULATOR
RECEIVER:METAL-DEPEN
DENT
PHOSPHOHYDROLASE, HD
SUBDOMAIN

(Neptuniibacter
caesariensis) 		PF00072
(Response_reg) 		3 LEU A  41
PRO A  40
LEU A  44
 None
 0.62A 2po5B-2rjnA:
5.2		 2po5B-2rjnA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		3 LEU C 154
PRO C 153
LEU C 157
 None
 0.60A 2po5B-2vpwC:
undetectable		 2po5B-2vpwC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 LEU A 374
PRO A 375
LEU A   9
 None
 0.62A 2po5B-2xdqA:
5.8		 2po5B-2xdqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		3 LEU A  69
PRO A  70
LEU A  75
 None
 0.60A 2po5B-2yysA:
3.1		 2po5B-2yysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		3 LEU A 188
PRO A 187
LEU A 191
 None
 0.50A 2po5B-2z0jA:
2.9		 2po5B-2z0jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		3 LEU A 156
PRO A 155
LEU A 159
 None
 0.52A 2po5B-2z3tA:
undetectable		 2po5B-2z3tA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		3 LEU A 640
PRO A 639
LEU A 643
 None
 0.58A 2po5B-2z6hA:
undetectable		 2po5B-2z6hA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LEU X 448
PRO X 449
LEU X 318
 None
 0.61A 2po5B-2zkmX:
3.6		 2po5B-2zkmX:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A 106
PRO A 107
LEU A   2
 None
 0.61A 2po5B-2zr2A:
undetectable		 2po5B-2zr2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 LEU A 722
PRO A 723
LEU A 727
 None
 0.56A 2po5B-2zzgA:
undetectable		 2po5B-2zzgA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aam ENDONUCLEASE IV

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		3 LEU A 185
PRO A 184
LEU A 188
 None
 0.61A 2po5B-3aamA:
2.1		 2po5B-3aamA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajf NON-STRUCTURAL
PROTEIN 3

(Rice hoja
blanca
tenuivirus) 		PF05310
(Tenui_NS3) 		3 LEU A  97
PRO A  96
LEU A 100
 None
 0.62A 2po5B-3ajfA:
undetectable		 2po5B-3ajfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		3 LEU A1423
PRO A1424
LEU A1430
 None
 0.58A 2po5B-3al2A:
2.6		 2po5B-3al2A:
25.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 LEU A 101
PRO A 102
LEU A 107
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
 0.25A 2po5B-3aqiA:
37.1		 2po5B-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1

(Homo sapiens) 		PF13324
(GCIP) 		3 LEU A  18
PRO A  17
LEU A  21
 None
 0.63A 2po5B-3ay5A:
undetectable		 2po5B-3ay5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bd9 HEPARAN SULFATE
GLUCOSAMINE
3-O-SULFOTRANSFERASE
5

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 LEU A 263
PRO A 262
LEU A 266
 None
 0.57A 2po5B-3bd9A:
3.4		 2po5B-3bd9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be5 PUTATIVE IRON
COMPOUND-BINDING
PROTEIN OF ABC
TRANSPORTER FAMILY

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		3 LEU A  53
PRO A  52
LEU A  56
 None
 0.60A 2po5B-3be5A:
2.2		 2po5B-3be5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF13407
(Peripla_BP_4) 		3 LEU A 280
PRO A 279
LEU A 283
 None
 0.63A 2po5B-3bilA:
5.3		 2po5B-3bilA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		3 LEU A 327
PRO A 326
LEU A 330
 None
 0.53A 2po5B-3bl9A:
undetectable		 2po5B-3bl9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		3 LEU A 245
PRO A 244
LEU A 248
 None
 0.59A 2po5B-3c02A:
undetectable		 2po5B-3c02A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		3 LEU A 118
PRO A 117
LEU A 125
 None
 0.60A 2po5B-3do5A:
3.0		 2po5B-3do5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzm HYPOTHETICAL
CONSERVED PROTEIN

(Thermus
thermophilus) 		no annotation 3 LEU A  31
PRO A  32
LEU A  33
 None
 0.61A 2po5B-3dzmA:
undetectable		 2po5B-3dzmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		3 LEU A  28
PRO A  27
LEU A  31
 None
 0.61A 2po5B-3fhxA:
3.4		 2po5B-3fhxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 LEU A 533
PRO A 534
LEU A 537
 None
 0.63A 2po5B-3gbdA:
undetectable		 2po5B-3gbdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LEU A 179
PRO A 178
LEU A 182
 NAD  A 500 (-4.1A)
NAD  A 500 (-3.4A)
None
 0.59A 2po5B-3gfbA:
3.3		 2po5B-3gfbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 LEU A  15
PRO A  16
LEU A  17
 None
 0.63A 2po5B-3girA:
undetectable		 2po5B-3girA:
23.73