SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO5_B_CHDB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 LEU 3 165
LEU 3  94
PRO 3 141
GLY 3 192
 None
 0.91A 2po5B-1bev3:
undetectable		 2po5B-1bev3:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		4 ARG A  55
LEU A  58
VAL A   8
GLY A  41
 None
 0.82A 2po5B-1cfzA:
5.4		 2po5B-1cfzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmv HUMAN
CYTOMEGALOVIRUS
PROTEASE

(Human
betaherpesvirus
5) 		PF00716
(Peptidase_S21) 		4 LEU A 131
LEU A 124
VAL A  69
GLY A  70
 None
 0.96A 2po5B-1cmvA:
undetectable		 2po5B-1cmvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		4 MET A  65
LEU A  61
LEU A 280
GLY A 180
 None
None
None
IN0  A 991 (-3.2A)
 0.94A 2po5B-1ezfA:
undetectable		 2po5B-1ezfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2n CAPSID PROTEIN

(Rice yellow
mottle virus) 		PF00729
(Viral_coat) 		4 MET A 226
LEU A 228
ARG A  93
PRO A 200
 None
 0.96A 2po5B-1f2nA:
undetectable		 2po5B-1f2nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 MET A 348
LEU A 543
ARG A 548
GLY A 202
 None
 0.90A 2po5B-1fuiA:
4.9		 2po5B-1fuiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq2 MALIC ENZYME

(Columba livia) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A 251
ARG A 270
LEU A 266
GLY A 282
 None
 0.89A 2po5B-1gq2A:
1.8		 2po5B-1gq2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 MET A 378
LEU A 382
ARG A 434
VAL A 542
 None
 0.95A 2po5B-1h3gA:
undetectable		 2po5B-1h3gA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		4 LEU B 128
LEU B 109
VAL B  17
GLY B  15
 None
 0.97A 2po5B-1hdsB:
undetectable		 2po5B-1hdsB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		4 LEU A 246
PRO A 122
VAL A 129
GLY A 130
 None
 0.88A 2po5B-1j93A:
undetectable		 2po5B-1j93A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 LEU A 209
PRO A 159
VAL A  96
GLY A  95
 None
 0.97A 2po5B-1jfxA:
undetectable		 2po5B-1jfxA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.82A 2po5B-1lnsA:
undetectable		 2po5B-1lnsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvl DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 106
LEU A   8
GLY A 320
MET A 317
 None
 0.93A 2po5B-1lvlA:
undetectable		 2po5B-1lvlA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 LEU C 166
LEU C  95
PRO C 142
GLY C 188
 None
 0.85A 2po5B-1mqtC:
undetectable		 2po5B-1mqtC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		4 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 0.98A 2po5B-1n47A:
undetectable		 2po5B-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
TRANSCRIPTION
INITIATION FACTOR
IIA GAMMA CHAIN

(Homo sapiens;
Homo sapiens) 		PF03153
(TFIIA)
PF02268
(TFIIA_gamma_N)
PF02751
(TFIIA_gamma_C) 		4 MET C 358
LEU C 360
ARG D  82
GLY C 372
 None
 0.92A 2po5B-1nvpC:
undetectable		 2po5B-1nvpC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		4 LEU A 290
LEU A 251
VAL A 240
GLY A 241
 None
 0.82A 2po5B-1ogqA:
undetectable		 2po5B-1ogqA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 MET A 127
LEU A 132
ARG A 169
VAL A 145
 None
 0.85A 2po5B-1oywA:
3.7		 2po5B-1oywA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0z SENSOR KINASE CITA

(Klebsiella
pneumoniae) 		PF17203
(sCache_3_2) 		4 LEU A 132
ARG A  15
VAL A  95
GLY A 108
 MO7  A1630 ( 4.3A)
None
None
None
 0.89A 2po5B-1p0zA:
undetectable		 2po5B-1p0zA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 184
ARG A 118
GLY A  33
MET A  31
 None
None
None
EPU  A 598 (-4.5A)
 0.77A 2po5B-1p31A:
3.3		 2po5B-1p31A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		4 MET A 113
LEU A 140
VAL A  85
GLY A  84
 None
 0.92A 2po5B-1pz3A:
undetectable		 2po5B-1pz3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		4 LEU A 356
ARG A  46
LEU A  43
GLY A  22
 None
 0.93A 2po5B-1r53A:
undetectable		 2po5B-1r53A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujx POLYNUCLEOTIDE
KINASE
3'-PHOSPHATASE

(Mus musculus) 		no annotation 4 LEU A  60
PRO A  26
VAL A  48
GLY A  43
 None
 0.92A 2po5B-1ujxA:
undetectable		 2po5B-1ujxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unn DNA POLYMERASE IV

(Escherichia
coli) 		PF11799
(IMS_C) 		4 LEU C 281
LEU C 312
VAL C 245
GLY C 244
 None
 0.96A 2po5B-1unnC:
undetectable		 2po5B-1unnC:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 123
LEU A 154
VAL A  67
GLY A  66
 None
 0.79A 2po5B-1we5A:
2.2		 2po5B-1we5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wi9 PROTEIN C20ORF116
HOMOLOG

(Mus musculus) 		PF09756
(DDRGK) 		4 MET A 128
LEU A 130
LEU A 142
GLY A 104
 None
 0.89A 2po5B-1wi9A:
undetectable		 2po5B-1wi9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A 267
LEU A 260
VAL A 221
GLY A 220
 None
 0.81A 2po5B-1wwlA:
undetectable		 2po5B-1wwlA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 MET A  78
LEU A  39
LEU A 330
GLY A  70
 None
 0.97A 2po5B-1wzzA:
undetectable		 2po5B-1wzzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		4 LEU A  80
LEU A  20
VAL A  63
GLY A  64
 None
 0.97A 2po5B-1xqaA:
undetectable		 2po5B-1xqaA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		4 LEU A  21
LEU A 226
VAL A  51
GLY A  52
 None
 0.96A 2po5B-1ybdA:
3.1		 2po5B-1ybdA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 248
LEU A 274
VAL A 322
GLY A 323
 None
 0.95A 2po5B-2ag1A:
2.5		 2po5B-2ag1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2a TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF11474
(N-Term_TEN) 		4 LEU A  71
LEU A  30
VAL A 172
GLY A 171
 None
 0.87A 2po5B-2b2aA:
undetectable		 2po5B-2b2aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 231
LEU A 399
PRO A 218
GLY A 248
 None
 0.89A 2po5B-2bvgA:
undetectable		 2po5B-2bvgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfj DIADENOSINETETRAPHOS
PHATASE

(Shigella
flexneri) 		PF00149
(Metallophos) 		4 LEU A  38
PRO A  27
VAL A  59
GLY A  56
 None
 0.93A 2po5B-2dfjA:
undetectable		 2po5B-2dfjA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 LEU A 175
LEU A  85
VAL A  43
GLY A  44
 None
 0.93A 2po5B-2dkdA:
undetectable		 2po5B-2dkdA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A  29
ARG A  18
PRO A 224
GLY A 221
 None
 0.92A 2po5B-2dy3A:
2.1		 2po5B-2dy3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 107
LEU A  12
GLY A 329
MET A 326
 None
 0.95A 2po5B-2eq9A:
undetectable		 2po5B-2eq9A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 LEU A 179
LEU A 114
VAL A 142
GLY A  69
 None
 0.95A 2po5B-2es3A:
undetectable		 2po5B-2es3A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 185
ARG A 119
GLY A  34
MET A  32
 None
 0.80A 2po5B-2f00A:
2.5		 2po5B-2f00A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 LEU A 183
LEU A  23
VAL A  32
GLY A  31
 None
 0.92A 2po5B-2fmtA:
2.5		 2po5B-2fmtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz5 FLAVODOXIN

(Megasphaera
elsdenii) 		PF00258
(Flavodoxin_1) 		4 LEU A  62
LEU A  74
VAL A  83
GLY A  84
 None
 0.87A 2po5B-2fz5A:
3.5		 2po5B-2fz5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 LEU A  89
LEU A 346
VAL A 263
GLY A 361
 None
 0.97A 2po5B-2gsnA:
undetectable		 2po5B-2gsnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzx PUTATIVE TATD
RELATED DNASE

(Staphylococcus
aureus) 		PF01026
(TatD_DNase) 		4 LEU A   2
LEU A 199
PRO A 210
VAL A 179
 None
 0.90A 2po5B-2gzxA:
2.2		 2po5B-2gzxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		4 LEU A 183
ARG A 228
VAL A   4
GLY A   3
 None
 0.76A 2po5B-2hf0A:
undetectable		 2po5B-2hf0A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 MET A 142
LEU A 164
VAL A 347
GLY A 357
 None
 0.89A 2po5B-2hmaA:
undetectable		 2po5B-2hmaA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0u ATP-DEPENDENT RNA
HELICASE DDX48

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 331
ARG A 364
GLY A 309
MET A 311
 None
 0.96A 2po5B-2j0uA:
3.5		 2po5B-2j0uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 LEU A  78
LEU A  28
PRO A 493
VAL A   7
 None
 0.85A 2po5B-2jh9A:
3.0		 2po5B-2jh9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khz C-MYC-RESPONSIVE
PROTEIN RCL

(Rattus
norvegicus) 		PF05014
(Nuc_deoxyrib_tr) 		4 LEU A 143
ARG A 109
VAL A  90
GLY A  16
 None
 0.98A 2po5B-2khzA:
4.0		 2po5B-2khzA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.85A 2po5B-2nztA:
2.2		 2po5B-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6s VARIABLE LYMPHOCYTE
RECEPTOR B

(Eptatretus
burgeri) 		PF11921
(DUF3439)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 LEU A 193
LEU A 152
VAL A 142
GLY A 141
 None
 0.98A 2po5B-2o6sA:
undetectable		 2po5B-2o6sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2op5 HYPOTHETICAL PROTEIN

(uncultured
marine organism) 		no annotation 4 MET A  65
LEU A  13
LEU A  94
VAL A  33
 None
 0.97A 2po5B-2op5A:
undetectable		 2po5B-2op5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		4 LEU A 205
ARG A 144
VAL A  87
GLY A  72
 None
None
None
BB2  A 400 (-4.6A)
 0.87A 2po5B-2os3A:
undetectable		 2po5B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 640
ARG A 514
PRO A 658
GLY A 520
 None
 0.71A 2po5B-2q1fA:
undetectable		 2po5B-2q1fA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A  52
ARG A  41
LEU A  96
GLY A 228
 None
 0.98A 2po5B-2qo3A:
2.9		 2po5B-2qo3A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		4 MET A  91
LEU A 226
VAL A  51
GLY A  52
 None
 0.88A 2po5B-2v4yA:
2.8		 2po5B-2v4yA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 0.89A 2po5B-2w3pA:
2.4		 2po5B-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 MET A 308
LEU A 300
LEU A 319
GLY A 354
 None
 0.91A 2po5B-2wd9A:
undetectable		 2po5B-2wd9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 LEU A  38
LEU A  33
VAL A 163
GLY A 164
 None
 0.81A 2po5B-2xfbA:
undetectable		 2po5B-2xfbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 LEU A 265
PRO A 192
VAL A 188
GLY A 216
 None
 0.91A 2po5B-2yb4A:
undetectable		 2po5B-2yb4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq1 ORF73

(Murid
gammaherpesvirus
4) 		no annotation 4 MET A 146
LEU A 150
LEU A 217
VAL A 245
 None
 0.81A 2po5B-2yq1A:
undetectable		 2po5B-2yq1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 MET A 327
LEU A 269
PRO A 232
GLY A 211
 None
 0.92A 2po5B-2yr5A:
undetectable		 2po5B-2yr5A:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 MET A  99
LEU A 101
ARG A 114
LEU A 115
PRO A 266
VAL A 305
GLY A 306
MET A 308
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
None
 0.53A 2po5B-3aqiA:
60.3		 2po5B-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 MET A  99
LEU A 101
LEU A  89
PRO A 266
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
None
CHD  A   2 ( 4.5A)
 0.88A 2po5B-3aqiA:
60.3		 2po5B-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 168
PRO A 152
VAL A  38
GLY A 157
 None
 0.93A 2po5B-3aupA:
undetectable		 2po5B-3aupA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7h PROPHAGE LP1 PROTEIN
11

(Lactobacillus
plantarum) 		PF01381
(HTH_3) 		4 LEU A  60
ARG A  25
PRO A  48
VAL A  37
 None
 0.91A 2po5B-3b7hA:
undetectable		 2po5B-3b7hA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 LEU A 210
ARG A 217
VAL A 170
GLY A 169
 None
 0.89A 2po5B-3c37A:
undetectable		 2po5B-3c37A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 232
ARG A 294
LEU A 299
PRO A 312
VAL A 309
 None
None
UDP  A 600 ( 4.3A)
None
None
 1.47A 2po5B-3c4qA:
3.4		 2po5B-3c4qA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 133
ARG A 139
LEU A 349
VAL A 309
GLY A 341
 None
 1.37A 2po5B-3c8tA:
undetectable		 2po5B-3c8tA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 362
LEU A 355
VAL A 337
GLY A 336
 None
 0.88A 2po5B-3ddmA:
undetectable		 2po5B-3ddmA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.81A 2po5B-3ecdA:
2.3		 2po5B-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 228
ARG A 156
VAL A 103
GLY A 102
 None
 0.87A 2po5B-3f2aA:
undetectable		 2po5B-3f2aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3geh TRNA MODIFICATION
GTPASE MNME

(Nostoc sp. PCC
7120) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		4 LEU A 371
LEU A 330
VAL A 227
GLY A 228
 None
 0.94A 2po5B-3gehA:
3.0		 2po5B-3gehA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 LEU B 272
PRO B 294
VAL B 228
GLY B 227
 None
 0.83A 2po5B-3hrdB:
undetectable		 2po5B-3hrdB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		4 LEU A 142
LEU A   3
PRO A 299
GLY A 246
 None
 0.95A 2po5B-3igfA:
2.4		 2po5B-3igfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxc REPRESSOR PROTEIN C2

(Salmonella
virus P22) 		PF01381
(HTH_3) 		4 LEU L  64
VAL L  30
GLY L  25
MET L  27
 None
 0.97A 2po5B-3jxcL:
undetectable		 2po5B-3jxcL:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU E 111
LEU E 306
PRO E  88
GLY F  46
 None
 0.88A 2po5B-3kfuE:
undetectable		 2po5B-3kfuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 LEU A 316
ARG A 301
VAL A  39
GLY A  40
 None
None
FAD  A 487 ( 4.6A)
FAD  A 487 (-3.3A)
 0.95A 2po5B-3kveA:
undetectable		 2po5B-3kveA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 LEU A 719
LEU A 804
VAL A 689
MET A 704
 None
ADP  A2101 (-4.4A)
ADP  A2101 (-4.5A)
None
 0.85A 2po5B-3lj0A:
undetectable		 2po5B-3lj0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 LEU B  56
ARG A 146
PRO B 193
GLY B  70
 None
 0.96A 2po5B-3ml0B:
undetectable		 2po5B-3ml0B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  66
LEU A 500
PRO A 400
GLY A 329
 None
 0.97A 2po5B-3nbuA:
4.1		 2po5B-3nbuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nok GLUTAMINYL CYCLASE

(Myxococcus
xanthus) 		PF05096
(Glu_cyclase_2) 		4 LEU A  96
ARG A  66
LEU A  68
GLY A 227
 None
 0.95A 2po5B-3nokA:
undetectable		 2po5B-3nokA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 LEU B 397
ARG B 392
VAL B 344
GLY B 345
 None
F6P  B 980 (-3.8A)
None
None
 0.97A 2po5B-3o8oB:
4.9		 2po5B-3o8oB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A  34
LEU A  60
VAL A  10
GLY A   9
 None
 0.84A 2po5B-3pdkA:
2.0		 2po5B-3pdkA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 LEU A 194
LEU A 144
VAL A  15
GLY A  16
 None
 0.93A 2po5B-3penA:
4.8		 2po5B-3penA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 LEU A 262
LEU A 281
VAL A 339
GLY A 338
 None
 0.91A 2po5B-3q9cA:
3.0		 2po5B-3q9cA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 LEU A 303
LEU A 363
VAL A 316
GLY A 315
 None
 0.97A 2po5B-3qp9A:
3.7		 2po5B-3qp9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 LEU A 366
LEU A 295
VAL A 247
GLY A 248
 None
 0.91A 2po5B-3swgA:
undetectable		 2po5B-3swgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.87A 2po5B-3tcsA:
undetectable		 2po5B-3tcsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 LEU A  44
LEU A 106
VAL A  96
GLY A   6
 None
 0.73A 2po5B-3u02A:
undetectable		 2po5B-3u02A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.82A 2po5B-3u4fA:
undetectable		 2po5B-3u4fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		5 MET A 130
LEU A  75
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
None
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.93A 2po5B-3ubcA:
undetectable		 2po5B-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 LEU A 826
LEU A 785
VAL A 703
GLY A 702
 None
 0.98A 2po5B-3ux8A:
undetectable		 2po5B-3ux8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ARG C 479
LEU C 481
VAL C 505
GLY C 542
 None
 0.84A 2po5B-3v64C:
undetectable		 2po5B-3v64C:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 181
ARG A  73
VAL A 520
GLY A  64
 None
 0.89A 2po5B-3viuA:
undetectable		 2po5B-3viuA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 MET A 180
LEU A 182
PRO A 165
GLY A  43
 None
 0.91A 2po5B-3vlaA:
undetectable		 2po5B-3vlaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 LEU A 308
LEU A 283
PRO A 124
GLY A 159
 None
 0.94A 2po5B-3vocA:
undetectable		 2po5B-3vocA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF00494
(SQS_PSY) 		4 MET A  56
LEU A  52
LEU A 274
GLY A 172
 None
None
None
FPS  A 501 (-3.6A)
 0.74A 2po5B-3wsbA:
undetectable		 2po5B-3wsbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0u UNCHARACTERIZED
PROTEIN

(Vibrio
parahaemolyticus) 		PF03945
(Endotoxin_N) 		4 MET A 409
LEU A 330
VAL A 325
GLY A 326
 None
 0.84A 2po5B-3x0uA:
undetectable		 2po5B-3x0uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		4 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 0.90A 2po5B-4ak5A:
undetectable		 2po5B-4ak5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF12802
(MarR_2) 		4 LEU A  83
ARG A  59
LEU A  97
VAL A 127
 None
 0.82A 2po5B-4b8xA:
undetectable		 2po5B-4b8xA:
18.16