SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO5_B_CHDB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		5 LEU A 164
LEU A  85
LEU A 151
PRO A 150
VAL A 121
 None
 1.39A 2po5B-1gz0A:
3.8		 2po5B-1gz0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq7 OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 LEU A 528
LEU A 531
LEU A 569
VAL A 443
VAL A 578
 None
 1.37A 2po5B-1iq7A:
undetectable		 2po5B-1iq7A:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		8 LEU A  62
PHE A  63
SER A 169
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.66A 2po5B-1lbqA:
48.1		 2po5B-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 MET A  46
SER A 169
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 1.13A 2po5B-1lbqA:
48.1		 2po5B-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 PHE A  63
LEU A  68
SER A 169
LEU A 237
VAL A 277
TRP A 282
 None
 1.40A 2po5B-1lbqA:
48.1		 2po5B-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		5 LEU A 204
PHE A 213
LEU A 156
LEU A 110
VAL A 140
 None
 1.37A 2po5B-1p9eA:
undetectable		 2po5B-1p9eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pov POLIOVIRUS NATIVE
EMPTY CAPSID (TYPE
1)

(Enterovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		5 LEU 0 301
PHE 0 226
LEU 0 277
VAL 0 177
VAL 0 196
 None
 1.16A 2po5B-1pov0:
undetectable		 2po5B-1pov0:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 LEU A 149
LEU A 153
LEU A 412
PRO A 413
VAL A 330
 None
 1.28A 2po5B-1sqgA:
2.5		 2po5B-1sqgA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpk DNA POLYMERASE III,
BETA SUBUNIT

(Thermotoga
maritima) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 LEU A 166
PHE A 127
LEU A 134
VAL A 204
VAL A 222
 None
 1.23A 2po5B-1vpkA:
undetectable		 2po5B-1vpkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 LEU A 433
LEU A 404
MET A 405
LEU A 309
VAL A 411
 None
 1.34A 2po5B-1xa6A:
undetectable		 2po5B-1xa6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zag PROTEIN
(ZINC-ALPHA-2-GLYCOP
ROTEIN)

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 LEU A  10
LEU A  33
SER A 177
VAL A  57
TRP A  63
 None
 1.36A 2po5B-1zagA:
undetectable		 2po5B-1zagA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		5 LEU A 102
LEU A 112
SER A 111
PRO A  79
VAL A  72
 None
 1.27A 2po5B-1zkdA:
3.1		 2po5B-1zkdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		5 LEU A 528
LEU A 531
LEU A 569
VAL A 443
VAL A 578
 None
 1.36A 2po5B-2d3iA:
2.6		 2po5B-2d3iA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 1.01A 2po5B-2dc0A:
undetectable		 2po5B-2dc0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dos ATAXIN-3

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A  33
PHE A  28
LEU A  91
VAL A 165
VAL A  86
 None
 1.10A 2po5B-2dosA:
undetectable		 2po5B-2dosA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		5 LEU A 470
PHE A 553
LEU A 568
MET A 564
LEU A 440
 None
 1.34A 2po5B-2f5uA:
undetectable		 2po5B-2f5uA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 LEU A  86
PHE A  83
LEU A 103
SER A  98
VAL A  68
 None
 1.38A 2po5B-2ghbA:
undetectable		 2po5B-2ghbA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 311
LEU A 541
MET A 100
LEU A 603
VAL A  92
 None
 1.23A 2po5B-2inyA:
undetectable		 2po5B-2inyA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la3 UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06042
(NTP_transf_6) 		5 LEU A  51
PHE A 152
LEU A 150
LEU A 140
VAL A 142
 None
 1.26A 2po5B-2la3A:
undetectable		 2po5B-2la3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		5 LEU A 249
SER A 246
LEU A  83
VAL A  82
VAL A 263
 None
 1.26A 2po5B-2nq2A:
undetectable		 2po5B-2nq2A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw9 PUTATIVE FORMATE
DEHYDROGENASE
ACCESSORY PROTEIN

(Desulfotalea
psychrophila) 		PF02634
(FdhD-NarQ) 		5 LEU A 164
PHE A 136
SER A 144
VAL A 153
VAL A 180
 None
 1.24A 2po5B-2pw9A:
undetectable		 2po5B-2pw9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 238
PHE A 234
LEU A 132
VAL A 102
VAL A 254
 None
 1.22A 2po5B-2pwzA:
3.0		 2po5B-2pwzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		5 MET A 146
LEU A  86
SER A 117
LEU A  63
VAL A  69
 None
 1.16A 2po5B-2qjgA:
undetectable		 2po5B-2qjgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		5 LEU A 127
LEU A 361
LEU A  14
VAL A  32
VAL A  28
 None
 1.32A 2po5B-2rfzA:
undetectable		 2po5B-2rfzA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G1960
LEU G1904
SER G1850
PRO G1975
VAL G1842
 None
 1.36A 2po5B-2uv8G:
undetectable		 2po5B-2uv8G:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.34A 2po5B-2x66A:
undetectable		 2po5B-2x66A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 229
PHE A 309
LEU A 151
LEU A 115
VAL A 119
 HEM  A1359 (-4.5A)
HEM  A1359 (-4.7A)
None
None
None
 1.24A 2po5B-2x66A:
undetectable		 2po5B-2x66A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 1.07A 2po5B-2z63A:
undetectable		 2po5B-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		5 MET A 295
LEU A 291
LEU A 209
LEU A 191
VAL A 190
 None
 1.20A 2po5B-3ajbA:
undetectable		 2po5B-3ajbA:
24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		11 MET A  76
LEU A  92
PHE A  93
LEU A  98
MET A  99
SER A 197
LEU A 265
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
CHD  A   1 (-3.0A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.69A 2po5B-3aqiA:
60.3		 2po5B-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 SER A 195
LEU A 265
PRO A 266
VAL A 269
TRP A 310
 None
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 1.17A 2po5B-3aqiA:
60.3		 2po5B-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 LEU A 340
LEU A 279
LEU A 247
VAL A 250
VAL A 386
 HEM  A 450 (-4.9A)
None
None
None
None
 1.22A 2po5B-3bdzA:
undetectable		 2po5B-3bdzA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		5 LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.28A 2po5B-3caxA:
undetectable		 2po5B-3caxA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvv UNCHARACTERIZED
PROTEIN

(Bordetella
pertussis) 		PF12710
(HAD) 		5 MET A  85
LEU A  93
LEU A  16
SER A  20
VAL A 131
 None
 1.20A 2po5B-3fvvA:
3.5		 2po5B-3fvvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.95A 2po5B-3fxiA:
undetectable		 2po5B-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 0.97A 2po5B-3fxiA:
undetectable		 2po5B-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bacteroides
fragilis) 		PF13407
(Peripla_BP_4) 		5 LEU A 275
LEU A 285
SER A 304
LEU A 188
VAL A 258
 None
 1.31A 2po5B-3gbvA:
3.4		 2po5B-3gbvA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gon PHOSPHOMEVALONATE
KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N) 		5 LEU A 179
LEU A  72
LEU A 118
VAL A 114
VAL A 126
 None
 1.30A 2po5B-3gonA:
undetectable		 2po5B-3gonA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 MET A 137
LEU A 133
PHE A 129
LEU A 121
VAL A  74
 None
 1.21A 2po5B-3hbjA:
3.2		 2po5B-3hbjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		5 LEU A 305
LEU A 348
MET A 347
VAL A 341
VAL A 295
 None
 1.34A 2po5B-3ianA:
undetectable		 2po5B-3ianA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.07A 2po5B-3m1mA:
undetectable		 2po5B-3m1mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxq SENSOR PROTEIN

(Vibrio cholerae) 		PF08448
(PAS_4) 		5 LEU A  86
PHE A  55
LEU A  62
VAL A 121
VAL A  31
 None
 1.19A 2po5B-3mxqA:
undetectable		 2po5B-3mxqA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0c THYMIDYLATE SYNTHASE
THYX

(Thermotoga
maritima) 		PF02511
(Thy1) 		5 LEU A 171
PHE A 170
LEU A 167
VAL A  16
VAL A  11
 None
 0.91A 2po5B-3n0cA:
undetectable		 2po5B-3n0cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 LEU A 104
PHE A 193
LEU A 190
LEU A 305
VAL A  68
 None
 1.10A 2po5B-3n28A:
2.3		 2po5B-3n28A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		5 LEU A 133
PHE A 137
LEU A 152
PRO A 151
VAL A  86
 None
 1.03A 2po5B-3n91A:
undetectable		 2po5B-3n91A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 MET A 260
LEU A  96
PHE A 122
LEU A  99
LEU A 207
 None
 1.39A 2po5B-3pkjA:
undetectable		 2po5B-3pkjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		5 LEU A 123
PHE A 206
LEU A  65
SER A  61
VAL A 388
 None
 1.38A 2po5B-3pw3A:
undetectable		 2po5B-3pw3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		5 LEU B 165
LEU B 150
SER B 149
PRO B  89
VAL B  92
 None
 1.34A 2po5B-3q75B:
undetectable		 2po5B-3q75B:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 MET A 308
LEU A 261
LEU A 284
VAL A 275
VAL A  16
 None
 1.14A 2po5B-3sweA:
undetectable		 2po5B-3sweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
VAL A 380
VAL A 458
 None
 1.17A 2po5B-3v4oA:
3.1		 2po5B-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  17
 None
 1.17A 2po5B-3vcyA:
undetectable		 2po5B-3vcyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woh SIAM

(Streptomyces
sp. A7248) 		PF13561
(adh_short_C2) 		5 LEU A 119
PHE A 123
LEU A 166
SER A 145
VAL A 240
 None
 1.24A 2po5B-3wohA:
3.9		 2po5B-3wohA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 MET A 339
LEU A 358
LEU A 284
PRO A 281
VAL A 279
 None
 1.32A 2po5B-3wrtA:
undetectable		 2po5B-3wrtA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LEU A  53
PHE A  54
LEU A 364
VAL A  27
VAL A 436
 None
 1.31A 2po5B-3zvtA:
2.4		 2po5B-3zvtA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 LEU A  96
LEU A  99
LEU A 278
PRO A 279
VAL A 251
 None
 1.32A 2po5B-3zzuA:
3.0		 2po5B-3zzuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		5 LEU A 418
LEU A  70
SER A  74
LEU A 293
VAL A 284
 None
 1.37A 2po5B-4ajtA:
undetectable		 2po5B-4ajtA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 LEU A 319
LEU A 359
LEU A 394
VAL A 397
VAL A 329
 None
 1.34A 2po5B-4hehA:
6.5		 2po5B-4hehA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 180
SER A 155
VAL A 130
VAL A 172
TRP A 150
 None
 1.38A 2po5B-4hq1A:
undetectable		 2po5B-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
VAL A 380
VAL A 458
 None
 1.08A 2po5B-4i1pA:
2.2		 2po5B-4i1pA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.05A 2po5B-4irqA:
2.9		 2po5B-4irqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzt DGTP
PYROPHOSPHOHYDROLASE

(Bacillus
subtilis) 		PF00293
(NUDIX) 		5 MET A 139
LEU A 125
LEU A 148
SER A 147
LEU A  83
 None
 1.28A 2po5B-4jztA:
undetectable		 2po5B-4jztA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzu RNA
PYROPHOSPHOHYDROLASE

(Bacillus
subtilis) 		PF00293
(NUDIX) 		5 MET A 139
LEU A 125
LEU A 148
SER A 147
LEU A  83
 None
 1.24A 2po5B-4jzuA:
undetectable		 2po5B-4jzuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13

(Komagataella
pastoris;
Komagataella
phaffii) 		PF00400
(WD40) 		5 LEU A2035
LEU A1057
SER A1058
LEU A1060
VAL A2281
 None
None
None
None
EDO  A2408 ( 4.1A)
 1.34A 2po5B-4l9oA:
undetectable		 2po5B-4l9oA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		5 LEU A 223
PHE A 192
LEU A 226
LEU A 321
VAL A 331
 None
 1.25A 2po5B-4lctA:
undetectable		 2po5B-4lctA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 LEU A 215
SER A 229
LEU A 153
VAL A 148
VAL A 233
 None
 1.35A 2po5B-4ntdA:
2.3		 2po5B-4ntdA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p17 RABGAP/TBC PROTEIN

(Chlamydomonas
reinhardtii) 		PF00566
(RabGAP-TBC) 		5 MET A 157
LEU A 175
LEU A 232
SER A 234
VAL A 147
 None
 1.35A 2po5B-4p17A:
undetectable		 2po5B-4p17A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 381
PHE A 392
LEU A 385
MET A 387
LEU A 618
 None
 1.13A 2po5B-4pd3A:
2.7		 2po5B-4pd3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A2961
LEU A2715
LEU A2972
VAL A2800
VAL A2841
 None
 1.30A 2po5B-4qyrA:
undetectable		 2po5B-4qyrA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 LEU A 359
PHE A 309
LEU A 396
VAL A 367
VAL A 420
 None
None
EDO  A 706 (-4.1A)
None
None
 1.28A 2po5B-4wd1A:
4.2		 2po5B-4wd1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 LEU M 484
PHE M 534
LEU M 539
LEU M 263
VAL M 262
 None
 1.29A 2po5B-4wj3M:
undetectable		 2po5B-4wj3M:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 388
LEU A 379
PRO A 401
VAL A 381
VAL A 141
 None
 1.25A 2po5B-4wpzA:
undetectable		 2po5B-4wpzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq2 CALE6

(Micromonospora
echinospora) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  57
LEU A 244
PRO A 178
VAL A 179
VAL A 211
 None
 1.25A 2po5B-4xq2A:
2.8		 2po5B-4xq2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A1067
PHE A1066
LEU A1063
LEU A1166
VAL A1034
 None
 1.32A 2po5B-4zdnA:
3.4		 2po5B-4zdnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		5 LEU A 144
LEU A 183
PRO A 276
VAL A 277
VAL A  38
 None
 1.30A 2po5B-4zrqA:
undetectable		 2po5B-4zrqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 385
PHE E 382
LEU E 419
SER E 446
LEU E 426
 None
 1.26A 2po5B-4zxbE:
undetectable		 2po5B-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdh MAJOR ACID
PHOSPHATASE

(Legionella
pneumophila) 		PF00328
(His_Phos_2) 		5 LEU A 343
LEU A 262
LEU A 277
VAL A 275
VAL A 305
 None
 1.34A 2po5B-5cdhA:
undetectable		 2po5B-5cdhA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.19A 2po5B-5ddvA:
undetectable		 2po5B-5ddvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e24 SUPPRESSOR OF
HAIRLESS PROTEIN

(Drosophila
melanogaster) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU E 336
PHE E 362
LEU E 333
VAL E 279
VAL E 261
 None
 1.37A 2po5B-5e24E:
undetectable		 2po5B-5e24E:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS

(Mus musculus) 		PF09270
(BTD)
PF09271
(LAG1-DNAbind) 		5 LEU C 288
PHE C 314
LEU C 285
VAL C 231
VAL C 213
 None
 1.36A 2po5B-5eg6C:
undetectable		 2po5B-5eg6C:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.18A 2po5B-5fqlA:
undetectable		 2po5B-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 MET A 478
LEU A 424
LEU A 421
PRO A 394
VAL A 409
 None
 1.39A 2po5B-5gk9A:
undetectable		 2po5B-5gk9A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.23A 2po5B-5gslA:
undetectable		 2po5B-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 385
PHE E 382
LEU E 419
SER E 446
LEU E 426
 None
 1.23A 2po5B-5kqvE:
undetectable		 2po5B-5kqvE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR A
NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens;
Homo sapiens) 		no annotation
PF04858
(TH1) 		5 LEU B 239
LEU A  61
LEU A  75
PRO A 101
VAL A  68
 None
 1.26A 2po5B-5l3xB:
undetectable		 2po5B-5l3xB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 128
PHE A 119
LEU A 143
LEU A 162
VAL A 135
 None
 1.22A 2po5B-5lfnA:
undetectable		 2po5B-5lfnA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		5 LEU N 163
SER N 210
LEU N 190
VAL N 228
VAL N 197
 None
 1.04A 2po5B-5mpdN:
undetectable		 2po5B-5mpdN:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA

(Chaetomium
thermophilum) 		PF01602
(Adaptin_N) 		5 LEU A 123
PHE A 122
LEU A 108
SER A 138
VAL A 100
 None
 1.32A 2po5B-5mu7A:
undetectable		 2po5B-5mu7A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 31

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF05669
(Med31) 		5 MET X  89
LEU X  85
LEU X  58
PRO U  16
VAL U  20
 None
 1.31A 2po5B-5svaX:
undetectable		 2po5B-5svaX:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		5 LEU A1236
LEU A1199
SER A1091
LEU A1115
VAL A1117
 None
 1.25A 2po5B-5t3eA:
undetectable		 2po5B-5t3eA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  16
 None
 1.22A 2po5B-5u4hA:
undetectable		 2po5B-5u4hA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 LEU A  96
LEU A  99
LEU A 278
PRO A 279
VAL A 251
 None
 1.35A 2po5B-5vh6A:
3.4		 2po5B-5vh6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.16A 2po5B-5vl1A:
undetectable		 2po5B-5vl1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A1369
PHE A1287
SER A1253
LEU A1228
VAL A1218
 None
None
ATP  A1502 (-3.5A)
None
None
 0.96A 2po5B-5w81A:
undetectable		 2po5B-5w81A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 MET A 231
LEU A 206
LEU A 202
LEU A 242
VAL A 187
 None
 1.33A 2po5B-5wveA:
2.8		 2po5B-5wveA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 5 MET A 285
LEU A 252
LEU A 190
PRO A 167
VAL A 165
 None
 1.33A 2po5B-5x7nA:
3.3		 2po5B-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 PHE C3967
LEU C3970
MET C3971
LEU C3900
VAL C3937
 None
 1.20A 2po5B-5y3rC:
undetectable		 2po5B-5y3rC:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.26A 2po5B-5yxgA:
undetectable		 2po5B-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.32A 2po5B-5z24A:
undetectable		 2po5B-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 193
PHE A 198
LEU A 292
LEU A 413
TRP A 411
 None
 1.26A 2po5B-6aqhA:
undetectable		 2po5B-6aqhA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 5 LEU A 104
PHE A 108
LEU A   7
VAL A   4
VAL A 168
 None
 1.32A 2po5B-6dxpA:
2.5		 2po5B-6dxpA:
undetectable