SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO5_A_CHDA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		4 LEU 3 165
LEU 3  94
PRO 3 141
GLY 3 192
 None
 0.97A 2po5A-1bev3:
undetectable		 2po5A-1bev3:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2n CAPSID PROTEIN

(Rice yellow
mottle virus) 		PF00729
(Viral_coat) 		4 MET A 226
LEU A 228
ARG A  93
PRO A 200
 None
 0.88A 2po5A-1f2nA:
undetectable		 2po5A-1f2nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 LEU A 398
PRO A 209
VAL A 290
GLY A 291
 None
 0.85A 2po5A-1lnsA:
1.8		 2po5A-1lnsA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 LEU C 166
LEU C  95
PRO C 142
GLY C 188
 None
 0.91A 2po5A-1mqtC:
undetectable		 2po5A-1mqtC:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n47 ISOLECTIN B4

(Vicia villosa) 		PF00139
(Lectin_legB) 		4 MET A  75
LEU A 105
PRO A  42
GLY A 212
 None
None
None
TNR  A1401 ( 3.7A)
 0.99A 2po5A-1n47A:
undetectable		 2po5A-1n47A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		4 MET A 127
LEU A 132
ARG A 169
VAL A 145
 None
 0.77A 2po5A-1oywA:
3.6		 2po5A-1oywA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0z SENSOR KINASE CITA

(Klebsiella
pneumoniae) 		PF17203
(sCache_3_2) 		4 LEU A 132
ARG A  15
VAL A  95
GLY A 108
 MO7  A1630 ( 4.3A)
None
None
None
 0.97A 2po5A-1p0zA:
undetectable		 2po5A-1p0zA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 184
ARG A 118
GLY A  33
MET A  31
 None
None
None
EPU  A 598 (-4.5A)
 0.75A 2po5A-1p31A:
2.7		 2po5A-1p31A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unn DNA POLYMERASE IV

(Escherichia
coli) 		PF11799
(IMS_C) 		4 LEU C 281
LEU C 312
VAL C 245
GLY C 244
 None
 0.90A 2po5A-1unnC:
undetectable		 2po5A-1unnC:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 123
LEU A 154
VAL A  67
GLY A  66
 None
 0.70A 2po5A-1we5A:
undetectable		 2po5A-1we5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuu GALACTOKINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 LEU A 206
ARG A 166
PRO A  54
GLY A 193
 None
 0.97A 2po5A-1wuuA:
undetectable		 2po5A-1wuuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwl MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Mus musculus) 		no annotation 4 LEU A 267
LEU A 260
VAL A 221
GLY A 220
 None
 0.78A 2po5A-1wwlA:
undetectable		 2po5A-1wwlA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 MET A  78
LEU A  39
LEU A 330
GLY A  70
 None
 0.93A 2po5A-1wzzA:
undetectable		 2po5A-1wzzA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2a TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF11474
(N-Term_TEN) 		4 LEU A  71
LEU A  30
VAL A 172
GLY A 171
 None
 0.84A 2po5A-2b2aA:
undetectable		 2po5A-2b2aA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A 231
LEU A 399
PRO A 218
GLY A 248
 None
 0.91A 2po5A-2bvgA:
undetectable		 2po5A-2bvgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A  29
ARG A  18
PRO A 224
GLY A 221
 None
 0.84A 2po5A-2dy3A:
undetectable		 2po5A-2dy3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f00 UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 185
ARG A 119
GLY A  34
MET A  32
 None
 0.77A 2po5A-2f00A:
3.3		 2po5A-2f00A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz5 FLAVODOXIN

(Megasphaera
elsdenii) 		PF00258
(Flavodoxin_1) 		4 LEU A  62
LEU A  74
VAL A  83
GLY A  84
 None
 0.90A 2po5A-2fz5A:
2.9		 2po5A-2fz5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gid MITOCHONDRIAL
RNA-BINDING PROTEIN
1

(Trypanosoma
brucei) 		PF09387
(MRP) 		4 LEU B  88
LEU B 154
VAL B  99
GLY B  98
 None
 0.94A 2po5A-2gidB:
undetectable		 2po5A-2gidB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 207
LEU A  26
VAL A 172
GLY A 173
 None
 0.96A 2po5A-2hivA:
undetectable		 2po5A-2hivA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjg GTP-BINDING PROTEIN
ENGA

(Bacillus
subtilis) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 LEU A  55
ARG A  22
LEU A 152
GLY A  15
 None
None
None
GDP  A 800 (-3.1A)
 1.01A 2po5A-2hjgA:
4.8		 2po5A-2hjgA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		4 LEU A 297
LEU A 264
PRO A 231
GLY A 117
 None
 1.01A 2po5A-2horA:
undetectable		 2po5A-2horA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 MET A 153
LEU A 157
VAL A  75
GLY A  96
 None
 0.96A 2po5A-2hxoA:
undetectable		 2po5A-2hxoA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 LEU A  78
LEU A  28
PRO A 493
VAL A   7
 None
 0.89A 2po5A-2jh9A:
2.6		 2po5A-2jh9A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lb5 SENSOR HISTIDINE
KINASE

(Synechococcus
sp.
JA-2-3B'a(2-13)) 		PF01590
(GAF) 		4 LEU A 181
LEU A 166
PRO A 173
GLY A  47
 None
 0.98A 2po5A-2lb5A:
undetectable		 2po5A-2lb5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		4 LEU A 219
ARG A 194
LEU A 182
GLY A  14
 None
None
None
ASL  A  11 ( 4.2A)
 0.88A 2po5A-2no5A:
2.8		 2po5A-2no5A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 LEU A 427
VAL A 412
GLY A 411
MET A 214
 None
 0.85A 2po5A-2nztA:
2.2		 2po5A-2nztA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 LEU A 367
VAL A 191
GLY A 192
MET A 194
 None
 0.98A 2po5A-2o1xA:
5.1		 2po5A-2o1xA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 640
ARG A 514
PRO A 658
GLY A 520
 None
 0.68A 2po5A-2q1fA:
undetectable		 2po5A-2q1fA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vla RESTRICTION
ENDONUCLEASE R.BPUJI

(Bacillus
pumilus) 		PF11564
(BpuJI_N) 		4 LEU A 232
LEU A 214
PRO A 177
VAL A 164
 None
 0.98A 2po5A-2vlaA:
undetectable		 2po5A-2vlaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		4 ARG A 311
LEU A 307
PRO A 243
GLY A 248
 None
 0.83A 2po5A-2w3pA:
undetectable		 2po5A-2w3pA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 LEU A  38
LEU A  33
VAL A 163
GLY A 164
 None
 0.98A 2po5A-2xfbA:
undetectable		 2po5A-2xfbA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 424
LEU A 232
PRO A 440
GLY A 349
 None
 0.94A 2po5A-2y8nA:
undetectable		 2po5A-2y8nA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq1 ORF73

(Murid
gammaherpesvirus
4) 		no annotation 4 MET A 146
LEU A 150
LEU A 217
VAL A 245
 None
 0.88A 2po5A-2yq1A:
undetectable		 2po5A-2yq1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 MET A 327
LEU A 269
PRO A 232
GLY A 211
 None
 0.88A 2po5A-2yr5A:
undetectable		 2po5A-2yr5A:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		8 MET A  99
LEU A 101
ARG A 114
LEU A 115
PRO A 266
VAL A 305
GLY A 306
MET A 308
 CHD  A   2 (-4.0A)
CHD  A   3 ( 4.9A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.8A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
CHD  A   2 ( 3.8A)
None
 0.51A 2po5A-3aqiA:
60.6		 2po5A-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aup BASIC 7S GLOBULIN

(Glycine max) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 LEU A 168
PRO A 152
VAL A  38
GLY A 157
 None
 0.92A 2po5A-3aupA:
undetectable		 2po5A-3aupA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		4 LEU A 263
LEU A 230
PRO A 197
GLY A  85
 None
 1.01A 2po5A-3bwnA:
undetectable		 2po5A-3bwnA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 LEU A 210
ARG A 217
VAL A 170
GLY A 169
 None
 0.85A 2po5A-3c37A:
undetectable		 2po5A-3c37A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.79A 2po5A-3ecdA:
undetectable		 2po5A-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 228
ARG A 156
VAL A 103
GLY A 102
 None
 0.89A 2po5A-3f2aA:
undetectable		 2po5A-3f2aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF02738
(Ald_Xan_dh_C2) 		4 LEU B 272
PRO B 294
VAL B 228
GLY B 227
 None
 0.87A 2po5A-3hrdB:
undetectable		 2po5A-3hrdB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU E 111
LEU E 306
PRO E  88
GLY F  46
 None
 0.86A 2po5A-3kfuE:
undetectable		 2po5A-3kfuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kve L-AMINO ACID OXIDASE

(Vipera
ammodytes) 		PF01593
(Amino_oxidase) 		4 LEU A 316
ARG A 301
VAL A  39
GLY A  40
 None
None
FAD  A 487 ( 4.6A)
FAD  A 487 (-3.3A)
 0.85A 2po5A-3kveA:
undetectable		 2po5A-3kveA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF06957
(COPI_C) 		4 LEU A1038
LEU A1022
VAL A 933
GLY A 932
 None
 0.96A 2po5A-3mv3A:
undetectable		 2po5A-3mv3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 LEU A  58
ARG A  51
LEU A 288
GLY A  19
 None
None
None
CA  A 364 (-4.1A)
 1.01A 2po5A-3mx9A:
undetectable		 2po5A-3mx9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		4 LEU A  66
LEU A 500
PRO A 400
GLY A 329
 None
 0.96A 2po5A-3nbuA:
2.2		 2po5A-3nbuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 LEU A 303
LEU A 363
VAL A 316
GLY A 315
 None
 0.92A 2po5A-3qp9A:
3.1		 2po5A-3qp9A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 LEU A 366
LEU A 295
VAL A 247
GLY A 248
 None
 0.84A 2po5A-3swgA:
undetectable		 2po5A-3swgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.82A 2po5A-3tcsA:
undetectable		 2po5A-3tcsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u02 PUTATIVE
TRANSCRIPTION-ASSOCI
ATED PROTEIN TFIIS

(Pyrococcus
furiosus) 		PF08489
(DUF1743) 		4 LEU A  44
LEU A 106
VAL A  96
GLY A   6
 None
 0.87A 2po5A-3u02A:
undetectable		 2po5A-3u02A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		4 LEU A  77
LEU A  86
VAL A  39
GLY A  38
 None
 1.01A 2po5A-3u37A:
3.3		 2po5A-3u37A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  63
LEU A   3
VAL A  17
GLY A  29
 None
 0.79A 2po5A-3u4fA:
undetectable		 2po5A-3u4fA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubc HEMOGLOBIN-LIKE
FLAVOPROTEIN

(Methylacidiphilum
infernorum) 		PF00042
(Globin) 		4 MET A 130
LEU A  54
VAL A  95
GLY A  96
 HEM  A 201 ( 3.7A)
OXY  A 202 ( 4.3A)
HEM  A 201 (-4.1A)
None
 0.62A 2po5A-3ubcA:
undetectable		 2po5A-3ubcA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ARG C 479
LEU C 481
VAL C 505
GLY C 542
 None
 0.89A 2po5A-3v64C:
undetectable		 2po5A-3v64C:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		4 MET A  54
LEU A 306
LEU A 175
GLY A 315
 None
 0.98A 2po5A-3vvjA:
undetectable		 2po5A-3vvjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 189
LEU A 219
VAL A 160
GLY A 152
 None
 0.96A 2po5A-4a3rA:
undetectable		 2po5A-4a3rA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak5 ANHYDRO-ALPHA-L-GALA
CTOSIDASE

(Bacteroides
plebeius) 		PF04616
(Glyco_hydro_43) 		4 ARG A 383
LEU A  76
PRO A 166
VAL A 103
 None
 1.00A 2po5A-4ak5A:
undetectable		 2po5A-4ak5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 106
LEU A 150
VAL A 171
GLY A 167
 None
 0.94A 2po5A-4bhtA:
2.8		 2po5A-4bhtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 LEU A 692
LEU A 685
PRO A 438
GLY A 717
 None
 0.81A 2po5A-4d72A:
undetectable		 2po5A-4d72A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 4 LEU A  74
ARG A  67
GLY A 323
MET A 320
 None
 1.00A 2po5A-4g4iA:
undetectable		 2po5A-4g4iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j35 PHOSPHOTRIESTERASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF02126
(PTE) 		4 LEU A 247
LEU A 218
PRO A  20
GLY A 203
 None
 0.84A 2po5A-4j35A:
undetectable		 2po5A-4j35A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5u VARIABLE LYMPHOCYTE
RECEPTOR

(Petromyzon
marinus) 		no annotation 4 LEU B  97
LEU B  59
VAL B  49
GLY B  48
 None
 0.93A 2po5A-4k5uB:
undetectable		 2po5A-4k5uB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2f ADENYLATE CYCLASE

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc) 		4 LEU A 396
VAL A 345
GLY A 346
MET A 377
 None
None
None
EDO  A 510 ( 4.7A)
 0.99A 2po5A-4p2fA:
undetectable		 2po5A-4p2fA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql9 ALKYLHYDROPEROXIDE
REDUCTASE SUBUNIT C

(Escherichia
coli) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 LEU A 149
PRO A 127
VAL A  66
GLY A  65
 None
 0.94A 2po5A-4ql9A:
2.3		 2po5A-4ql9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzu ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 LEU A 202
PRO A  45
VAL A  59
GLY A  58
 None
 1.00A 2po5A-4uzuA:
undetectable		 2po5A-4uzuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 164
LEU A 160
VAL A 216
GLY A 192
 None
 0.97A 2po5A-4xybA:
4.5		 2po5A-4xybA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any E1

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 LEU A  38
LEU A  33
VAL A 163
GLY A 164
 None
 0.93A 2po5A-5anyA:
undetectable		 2po5A-5anyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 4 LEU B 280
VAL B 268
GLY B 288
MET B 290
 None
 0.90A 2po5A-5b5uB:
undetectable		 2po5A-5b5uB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 LEU A 137
ARG A 115
PRO A  45
GLY A  68
 None
None
MPD  A 302 ( 4.8A)
None
 0.81A 2po5A-5b7zA:
undetectable		 2po5A-5b7zA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		4 LEU A 260
LEU A 315
VAL A 205
GLY A 204
 None
 0.96A 2po5A-5btbA:
undetectable		 2po5A-5btbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz3 NA(+)/H(+)
ANTIPORTER

(Thermus
thermophilus) 		PF00999
(Na_H_Exchanger) 		4 LEU A 365
PRO A  44
VAL A  40
GLY A  39
 None
 0.79A 2po5A-5bz3A:
undetectable		 2po5A-5bz3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d19 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 LEU A 199
LEU A  98
VAL A 175
GLY A 174
 None
 0.93A 2po5A-5d19A:
undetectable		 2po5A-5d19A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 LEU A 507
LEU A 477
VAL A 521
GLY A 520
 None
 1.02A 2po5A-5d39A:
undetectable		 2po5A-5d39A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7t MINOR STRUCTURAL
PROTEIN 5

(Lactococcus
phage Tuc2009) 		no annotation 4 MET B  58
LEU B  69
VAL B 177
GLY B  54
 None
 0.82A 2po5A-5e7tB:
undetectable		 2po5A-5e7tB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A

(Homo sapiens) 		PF06105
(Aph-1) 		4 LEU C  35
LEU C  43
VAL C 131
GLY C 130
 None
 1.01A 2po5A-5fn4C:
undetectable		 2po5A-5fn4C:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hlb PENICILLIN-BINDING
PROTEIN 1B

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF14814
(UB2H) 		4 LEU A 394
LEU A 342
VAL A 401
GLY A 400
 None
 0.93A 2po5A-5hlbA:
undetectable		 2po5A-5hlbA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		4 LEU A 172
LEU A  66
PRO A 163
GLY A 196
 None
 0.92A 2po5A-5i3aA:
undetectable		 2po5A-5i3aA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 LEU A 467
PRO A 506
VAL A 426
GLY A 425
 None
 0.99A 2po5A-5im3A:
undetectable		 2po5A-5im3A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 193
LEU A 223
VAL A 164
GLY A 156
 None
 0.98A 2po5A-5j04A:
undetectable		 2po5A-5j04A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 LEU A 201
LEU A 244
VAL A 212
GLY A 211
 None
 0.99A 2po5A-5ko3A:
undetectable		 2po5A-5ko3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2x DNA-DIRECTED
PRIMASE/POLYMERASE
PROTEIN

(Homo sapiens) 		no annotation 4 LEU A 134
LEU A 142
VAL A 185
GLY A 186
 None
 1.00A 2po5A-5l2xA:
undetectable		 2po5A-5l2xA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		4 LEU A 365
VAL A 297
GLY A 298
MET A 300
 None
 0.89A 2po5A-5lxgA:
undetectable		 2po5A-5lxgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 LEU A 337
LEU A 221
PRO A 328
GLY A 361
 None
 0.92A 2po5A-5m8tA:
undetectable		 2po5A-5m8tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 LEU A  71
VAL A  89
GLY A  43
MET A  45
 None
 1.02A 2po5A-5ocsA:
undetectable		 2po5A-5ocsA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 LEU A 281
VAL A 269
GLY A 289
MET A 291
 None
 0.89A 2po5A-5ot0A:
4.9		 2po5A-5ot0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov6 PORPHOBILINOGEN
DEAMINASE

(Bacillus
megaterium) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 LEU A  87
ARG A 228
VAL A 195
GLY A 196
 None
 0.82A 2po5A-5ov6A:
undetectable		 2po5A-5ov6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		4 MET B 118
LEU B  96
ARG B  35
LEU B  42
 None
 1.02A 2po5A-5to3B:
undetectable		 2po5A-5to3B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4v RHO
GTPASE-ACTIVATING
PROTEIN 5

(Homo sapiens) 		no annotation 4 LEU A 610
LEU A 632
VAL A 753
GLY A 752
 None
 0.95A 2po5A-5u4vA:
3.4		 2po5A-5u4vA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9l PARALOG OF
ACCUMULATION AND
REPLICATION OF
CHLOROPLASTS 6
(PARC6)

(Arabidopsis
thaliana) 		no annotation 4 LEU A 708
LEU A 721
VAL A 643
GLY A 644
 None
 0.68A 2po5A-5u9lA:
undetectable		 2po5A-5u9lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 ARG A 274
LEU A 244
VAL A 262
GLY A 263
 None
 0.97A 2po5A-5utiA:
undetectable		 2po5A-5utiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve2 ENOYL-COA HYDRATASE

(Pseudoalteromonas
atlantica) 		PF00378
(ECH_1) 		4 ARG A 161
LEU A 163
VAL A 148
GLY A 149
 ARG  A 161 ( 0.6A)
LEU  A 163 ( 0.5A)
VAL  A 148 ( 0.6A)
GLY  A 149 ( 0.0A)
 0.90A 2po5A-5ve2A:
undetectable		 2po5A-5ve2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		no annotation 4 LEU M  38
LEU M  33
VAL M 163
GLY M 164
 None
 0.90A 2po5A-5vu2M:
undetectable		 2po5A-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxb PROXP-ALA

(Caulobacter
vibrioides) 		PF04073
(tRNA_edit) 		4 LEU A 152
VAL A  95
GLY A  94
MET A   1
 None
 0.99A 2po5A-5vxbA:
undetectable		 2po5A-5vxbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7y LIPOCALIN-CAN F 6
ALLERGEN

(Canis lupus) 		no annotation 4 MET A  59
LEU A  72
LEU A 119
GLY A  38
 MET  A  59 ( 0.0A)
LEU  A  72 ( 0.6A)
LEU  A 119 ( 0.6A)
GLY  A  38 ( 0.0A)
 0.82A 2po5A-5x7yA:
undetectable		 2po5A-5x7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xii PROLYL-TRNA
SYNTHETASE (PRORS)

(Toxoplasma
gondii) 		no annotation 4 LEU A 510
PRO A 459
VAL A 391
GLY A 390
 None
 1.01A 2po5A-5xiiA:
3.6		 2po5A-5xiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa VARIABLE LYMPHOCYTE
RECEPTOR 2

(Petromyzon
marinus) 		no annotation 4 LEU C 109
LEU C 102
VAL C  92
GLY C  91
 None
 1.00A 2po5A-6bxaC:
undetectable		 2po5A-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 188
ARG A 122
GLY A  37
MET A  35
 None
 0.78A 2po5A-6cauA:
undetectable		 2po5A-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 4 PRO A 420
VAL A 229
GLY A 230
MET A 485
 None
None
CL  A1001 (-3.2A)
None
 0.99A 2po5A-6coyA:
undetectable		 2po5A-6coyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ct0 DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ARG 0 471
LEU 0 468
VAL 0 534
GLY 0 533
 None
 0.95A 2po5A-6ct00:
undetectable		 2po5A-6ct00:
undetectable