SIMILAR PATTERNS OF AMINO ACIDS FOR 2PO5_A_CHDA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		5 LEU A 239
LEU A  37
ILE A  18
VAL A  41
VAL A  64
 None
 1.22A 2po5A-1ahaA:
undetectable		 2po5A-1ahaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  52
ILE A 148
SER A  53
PRO A  26
VAL A  79
 None
 1.19A 2po5A-1fnoA:
undetectable		 2po5A-1fnoA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A 313
SER A 167
PRO A 238
VAL A 241
TRP A 282
 None
 1.00A 2po5A-1lbqA:
48.2		 2po5A-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 ILE A 313
SER A 169
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 1.27A 2po5A-1lbqA:
48.2		 2po5A-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 LEU A  62
PHE A  63
ILE A  91
SER A 169
LEU A 237
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.58A 2po5A-1lbqA:
48.2		 2po5A-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 PHE A  63
LEU A  68
SER A 169
LEU A 237
VAL A 277
TRP A 282
 None
 1.31A 2po5A-1lbqA:
48.2		 2po5A-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 SER A 167
LEU A 237
PRO A 238
VAL A 241
TRP A 282
 None
 1.13A 2po5A-1lbqA:
48.2		 2po5A-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pff METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  98
LEU A 104
ILE A 240
SER A 106
LEU A 110
 None
 1.17A 2po5A-1pffA:
1.5		 2po5A-1pffA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pov POLIOVIRUS NATIVE
EMPTY CAPSID (TYPE
1)

(Enterovirus C) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		5 LEU 0 301
PHE 0 226
LEU 0 277
VAL 0 177
VAL 0 196
 None
 1.17A 2po5A-1pov0:
undetectable		 2po5A-1pov0:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A  64
PHE A  55
ILE A 169
VAL A  27
VAL A 177
 None
 1.19A 2po5A-1qi7A:
undetectable		 2po5A-1qi7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 LEU A 118
ILE A 160
LEU A  79
PRO A  49
VAL A  47
 None
 1.06A 2po5A-1rj6A:
undetectable		 2po5A-1rj6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rni ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.14A 2po5A-1rniA:
undetectable		 2po5A-1rniA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl5 UNKNOWN CONSERVED
PROTEIN BH2331

(Bacillus
halodurans) 		PF08241
(Methyltransf_11) 		5 LEU A  34
MET A  35
ILE A  84
LEU A 141
VAL A  46
 None
 1.13A 2po5A-1vl5A:
2.5		 2po5A-1vl5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlc 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00180
(Iso_dh) 		5 LEU A 259
ILE A 289
LEU A 119
PRO A 118
VAL A 116
 None
 1.13A 2po5A-1vlcA:
3.8		 2po5A-1vlcA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.18A 2po5A-1vqzA:
undetectable		 2po5A-1vqzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A  82
LEU A  41
ILE A  91
PRO A  22
VAL A  37
 None
 1.21A 2po5A-1wn1A:
undetectable		 2po5A-1wn1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 1.04A 2po5A-1yirA:
undetectable		 2po5A-1yirA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4w HYPOTHETICAL
PROTEIN, CONSERVED

(Leishmania
major) 		PF08950
(DUF1861) 		5 PHE A 309
ILE A  89
LEU A  81
PRO A  84
VAL A  60
 None
 1.20A 2po5A-2b4wA:
undetectable		 2po5A-2b4wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A 410
LEU A 429
PRO A 236
VAL A 233
VAL A 271
 None
 0.98A 2po5A-2dc0A:
undetectable		 2po5A-2dc0A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dos ATAXIN-3

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A  33
PHE A  28
LEU A  91
VAL A 165
VAL A  86
 None
 1.10A 2po5A-2dosA:
undetectable		 2po5A-2dosA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he9 NK-TUMOR RECOGNITION
PROTEIN

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 LEU A 109
PHE A  25
ILE A 150
SER A 121
VAL A 170
 None
 1.20A 2po5A-2he9A:
undetectable		 2po5A-2he9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 450
PHE A 451
LEU A 382
ILE A 372
VAL A 227
 HEM  A 900 (-4.0A)
HEM  A 900 (-4.1A)
HEM  A 900 (-4.0A)
None
None
 1.18A 2po5A-2hi4A:
undetectable		 2po5A-2hi4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 LEU A 311
LEU A 541
MET A 100
LEU A 603
VAL A  92
 None
 1.19A 2po5A-2inyA:
undetectable		 2po5A-2inyA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.16A 2po5A-2nn3C:
2.7		 2po5A-2nn3C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		5 LEU A 171
ILE A 149
LEU A  97
PRO A 127
VAL A 125
 None
 1.16A 2po5A-2nxoA:
undetectable		 2po5A-2nxoA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.19A 2po5A-2o8eB:
undetectable		 2po5A-2o8eB:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		5 MET A 146
LEU A  86
SER A 117
LEU A  63
VAL A  69
 None
 1.17A 2po5A-2qjgA:
undetectable		 2po5A-2qjgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 0.86A 2po5A-2w3wA:
undetectable		 2po5A-2w3wA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 154
LEU A 151
ILE A 139
LEU A 369
VAL A  67
 None
None
DIF  A1374 (-4.7A)
None
None
 0.99A 2po5A-2wekA:
3.3		 2po5A-2wekA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 1.02A 2po5A-2z63A:
undetectable		 2po5A-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU B 237
LEU B 240
ILE B 254
LEU B 192
VAL B 213
 None
 1.16A 2po5A-2z7xB:
undetectable		 2po5A-2z7xB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU A  29
PHE A  33
LEU A 101
ILE A  46
LEU A 136
 None
None
HEM  A 201 (-4.1A)
None
None
 1.09A 2po5A-3a0gA:
undetectable		 2po5A-3a0gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.90A 2po5A-3a8kA:
undetectable		 2po5A-3a8kA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 284
LEU A 363
ILE A 318
PRO A 154
VAL A 153
 None
 1.19A 2po5A-3abbA:
undetectable		 2po5A-3abbA:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 ILE A 342
SER A 195
PRO A 266
VAL A 269
TRP A 310
 None
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 1.03A 2po5A-3aqiA:
60.6		 2po5A-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		12 MET A  76
LEU A  92
PHE A  93
LEU A  98
MET A  99
ILE A 119
SER A 197
LEU A 265
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
None
CHD  A   1 (-3.0A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.63A 2po5A-3aqiA:
60.6		 2po5A-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 SER A 195
LEU A 265
PRO A 266
VAL A 269
TRP A 310
 None
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 1.16A 2po5A-3aqiA:
60.6		 2po5A-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 LEU A 340
LEU A 279
LEU A 247
VAL A 250
VAL A 386
 HEM  A 450 (-4.9A)
None
None
None
None
 1.21A 2po5A-3bdzA:
undetectable		 2po5A-3bdzA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		5 LEU A 105
LEU A  80
ILE A  38
SER A  79
VAL A 132
 None
 1.22A 2po5A-3bvcA:
undetectable		 2po5A-3bvcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnb DNA-BINDING RESPONSE
REGULATOR, MERR
FAMILY

(Colwellia
psychrerythraea) 		PF00072
(Response_reg) 		5 MET A 147
LEU A  81
LEU A 177
ILE A  96
LEU A 184
 None
 1.22A 2po5A-3cnbA:
5.7		 2po5A-3cnbA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvv UNCHARACTERIZED
PROTEIN

(Bordetella
pertussis) 		PF12710
(HAD) 		5 MET A  85
LEU A  93
LEU A  16
SER A  20
VAL A 131
 None
 1.19A 2po5A-3fvvA:
2.0		 2po5A-3fvvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 0.90A 2po5A-3fxiA:
undetectable		 2po5A-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
LEU A 280
LEU A 231
VAL A 255
 None
 0.92A 2po5A-3fxiA:
undetectable		 2po5A-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 285
ILE A 273
LEU A 113
PRO A 153
VAL A 156
 None
 1.15A 2po5A-3gp0A:
undetectable		 2po5A-3gp0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 LEU A  30
LEU A  34
ILE A  71
SER A  37
VAL A 288
 None
 1.16A 2po5A-3kl4A:
2.8		 2po5A-3kl4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans) 		PF00501
(AMP-binding) 		5 LEU A 136
LEU A 198
ILE A 139
LEU A 217
VAL A 212
 None
 1.15A 2po5A-3l2kA:
2.5		 2po5A-3l2kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.03A 2po5A-3l6aA:
undetectable		 2po5A-3l6aA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lly AGGLUTININ ALPHA
CHAIN

(Maclura
pomifera) 		PF01419
(Jacalin) 		5 LEU A  28
LEU A 124
ILE A  12
VAL A  72
VAL A  68
 None
 1.06A 2po5A-3llyA:
undetectable		 2po5A-3llyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.09A 2po5A-3m1mA:
undetectable		 2po5A-3m1mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A  82
PHE A  47
LEU A  95
ILE A  37
VAL A 112
 None
 1.21A 2po5A-3mczA:
undetectable		 2po5A-3mczA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxq SENSOR PROTEIN

(Vibrio cholerae) 		PF08448
(PAS_4) 		5 LEU A  86
PHE A  55
LEU A  62
VAL A 121
VAL A  31
 None
 1.22A 2po5A-3mxqA:
undetectable		 2po5A-3mxqA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0c THYMIDYLATE SYNTHASE
THYX

(Thermotoga
maritima) 		PF02511
(Thy1) 		5 LEU A 171
PHE A 170
LEU A 167
VAL A  16
VAL A  11
 None
 0.91A 2po5A-3n0cA:
undetectable		 2po5A-3n0cA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		5 MET A  27
LEU A 330
LEU A 355
ILE A 395
LEU A 302
 None
 1.01A 2po5A-3n0lA:
2.4		 2po5A-3n0lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		5 LEU A 104
PHE A 193
LEU A 190
LEU A 305
VAL A  68
 None
 1.12A 2po5A-3n28A:
2.4		 2po5A-3n28A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n91 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF08522
(DUF1735) 		5 LEU A 133
PHE A 137
LEU A 152
PRO A 151
VAL A  86
 None
 1.03A 2po5A-3n91A:
undetectable		 2po5A-3n91A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		5 LEU A 142
LEU A  88
ILE A  14
PRO A 123
VAL A  29
 None
 1.20A 2po5A-3nxsA:
3.4		 2po5A-3nxsA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 139
LEU A  88
ILE A   3
LEU A  64
VAL A  51
 EDO  A 507 (-4.1A)
None
None
None
None
 1.20A 2po5A-3peiA:
3.1		 2po5A-3peiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 267
LEU A 263
LEU A 211
VAL A 237
VAL A  45
 None
 1.12A 2po5A-3pkjA:
undetectable		 2po5A-3pkjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE
CASPASE

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF00656
(Peptidase_C14)
PF00656
(Peptidase_C14) 		5 LEU B 198
PHE B 194
LEU A  49
ILE B 245
VAL A  62
 None
 1.17A 2po5A-3sipB:
undetectable		 2po5A-3sipB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		6 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
VAL A 458
 None
 1.49A 2po5A-3v4oA:
2.1		 2po5A-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 224
LEU A 221
ILE A 231
LEU A 195
VAL A 189
 None
 1.05A 2po5A-3wpeA:
undetectable		 2po5A-3wpeA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 LEU A 665
LEU A 669
ILE A 658
SER A 672
LEU A 740
 None
 1.14A 2po5A-4a01A:
undetectable		 2po5A-4a01A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		5 LEU V 206
LEU V 235
ILE V 170
VAL V 272
VAL V 137
 None
 1.12A 2po5A-4a2iV:
3.4		 2po5A-4a2iV:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 263
LEU A 277
LEU A 269
ILE A 284
SER A 268
 None
 1.18A 2po5A-4eutA:
undetectable		 2po5A-4eutA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 263
LEU A 277
LEU A 269
ILE A 284
SER A 268
 None
 1.19A 2po5A-4euuA:
undetectable		 2po5A-4euuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 LEU A 182
LEU A  72
ILE A 322
LEU A 130
VAL A  58
 None
 1.11A 2po5A-4h59A:
undetectable		 2po5A-4h59A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
 None
 1.21A 2po5A-4hq1A:
undetectable		 2po5A-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		5 LEU B 187
PHE B 188
LEU B 191
PRO B 164
VAL B 159
 None
 1.14A 2po5A-4hzuB:
undetectable		 2po5A-4hzuB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		6 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
VAL A 458
 None
 1.47A 2po5A-4i1pA:
2.4		 2po5A-4i1pA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 LEU A  95
LEU A 119
LEU A 167
PRO A 168
VAL A 185
 None
 1.04A 2po5A-4irqA:
2.8		 2po5A-4irqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 823
PHE A 822
LEU A 819
ILE A 830
LEU A 660
 None
 0.89A 2po5A-4k0eA:
undetectable		 2po5A-4k0eA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.04A 2po5A-4mn8A:
undetectable		 2po5A-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 341
LEU A 365
ILE A 304
LEU A 376
PRO A 377
 None
 1.10A 2po5A-4mnaA:
undetectable		 2po5A-4mnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 381
PHE A 392
LEU A 385
MET A 387
LEU A 618
 None
 1.09A 2po5A-4pd3A:
2.8		 2po5A-4pd3A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 287
ILE A 352
LEU A 236
PRO A 237
VAL A 240
 None
 1.05A 2po5A-4rcdA:
undetectable		 2po5A-4rcdA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 183
LEU A 179
ILE A 143
LEU A 195
VAL A 164
 None
 0.97A 2po5A-4tx8A:
undetectable		 2po5A-4tx8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 LEU A 388
ILE A 394
PRO A 401
VAL A 381
VAL A 141
 None
 1.20A 2po5A-4wpzA:
undetectable		 2po5A-4wpzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		6 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
LEU E 426
 None
 1.45A 2po5A-4zxbE:
undetectable		 2po5A-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		5 LEU B  26
PHE B  28
LEU B 218
ILE B  64
SER B  44
 None
None
None
None
ANP  B 301 (-3.4A)
 1.05A 2po5A-5d3mB:
undetectable		 2po5A-5d3mB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 LEU A 169
PHE A 164
LEU A  91
PRO A   8
VAL A  52
 None
 1.20A 2po5A-5ddvA:
2.4		 2po5A-5ddvA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.17A 2po5A-5fmqA:
undetectable		 2po5A-5fmqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		5 LEU A 315
LEU A  67
LEU A 359
PRO A 358
VAL A  44
 None
 1.14A 2po5A-5fqlA:
undetectable		 2po5A-5fqlA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 LEU A  47
LEU A  56
ILE A 324
SER A  67
PRO A  10
 None
 1.09A 2po5A-5fzpA:
undetectable		 2po5A-5fzpA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.20A 2po5A-5gslA:
3.0		 2po5A-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		6 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
LEU E 426
 None
 1.47A 2po5A-5kqvE:
undetectable		 2po5A-5kqvE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 MET A 161
LEU A 187
LEU A 127
ILE A 220
VAL A 177
 None
 1.20A 2po5A-5lcwA:
undetectable		 2po5A-5lcwA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		5 LEU Z  92
ILE V 147
LEU Z 152
PRO Z 149
VAL Z 146
 None
 1.14A 2po5A-5mlcZ:
undetectable		 2po5A-5mlcZ:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 5 LEU A 375
PHE A  18
ILE A 292
LEU A 428
VAL A 430
 None
 1.21A 2po5A-5ndxA:
undetectable		 2po5A-5ndxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 267
PHE A 297
LEU A 257
ILE A 301
SER A 258
 None
 1.07A 2po5A-5tkyA:
undetectable		 2po5A-5tkyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucg STAGE II SPORULATION
PROTEIN E

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		5 LEU A 651
MET A 615
ILE A 664
LEU A 741
VAL A 802
 None
 1.17A 2po5A-5ucgA:
undetectable		 2po5A-5ucgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 LEU A 190
PHE A 195
LEU A 289
LEU A 409
TRP A 407
 None
 1.16A 2po5A-5vl1A:
undetectable		 2po5A-5vl1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		5 LEU A1369
PHE A1287
SER A1253
LEU A1228
VAL A1218
 None
None
ATP  A1502 (-3.5A)
None
None
 1.03A 2po5A-5w81A:
undetectable		 2po5A-5w81A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 225
LEU A 222
ILE A 232
LEU A 196
VAL A 190
 None
 0.96A 2po5A-5y3jA:
undetectable		 2po5A-5y3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 PHE C3967
LEU C3970
MET C3971
LEU C3900
VAL C3937
 None
 1.21A 2po5A-5y3rC:
undetectable		 2po5A-5y3rC:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.20A 2po5A-5yxgA:
undetectable		 2po5A-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 LEU A 225
LEU A 222
ILE A 232
LEU A 196
VAL A 190
 None
 0.95A 2po5A-5zlnA:
undetectable		 2po5A-5zlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE

(Pseudoalteromonas) 		no annotation 5 LEU A  34
PHE A 348
LEU A  85
ILE A 286
SER A  81
 None
 1.16A 2po5A-6b0kA:
undetectable		 2po5A-6b0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 LEU A 696
ILE A 761
LEU A 645
PRO A 646
VAL A 649
 None
 1.06A 2po5A-6ej2A:
undetectable		 2po5A-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6euv POLYMERASE BASIC
PROTEIN 2

(Influenza A
virus) 		no annotation 5 LEU A 298
MET A 315
ILE A 289
LEU A 513
VAL A 504
 None
 1.15A 2po5A-6euvA:
undetectable		 2po5A-6euvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 5 LEU A 690
LEU A 713
ILE A 654
LEU A 723
PRO A 724
 None
 1.20A 2po5A-6fnwA:
undetectable		 2po5A-6fnwA:
undetectable