SIMILAR PATTERNS OF AMINO ACIDS FOR 2PNJ_B_CHDB503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aut ACTIVATED PROTEIN C

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.35A 2pnjB-1autL:
undetectable		 2pnjB-1autL:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9g PROTEIN (GROWTH
FACTOR IGF-1)

(Homo sapiens) 		PF00049
(Insulin) 		4 LEU A  41
PRO A   2
LEU A  44
ARG A  21
 None
 1.33A 2pnjB-1b9gA:
undetectable		 2pnjB-1b9gA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		4 LEU A 143
PRO A 152
LEU A 144
ARG A 257
 None
None
None
A3P  A 301 (-4.0A)
 1.19A 2pnjB-1bo6A:
undetectable		 2pnjB-1bo6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 LEU A 255
PRO A 257
LEU A 144
ARG A 534
 None
None
None
GLC  A 996 (-4.1A)
 1.39A 2pnjB-1e4oA:
3.6		 2pnjB-1e4oA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 LEU A 112
PRO A 113
LEU A 106
ARG A 108
 None
None
None
SO4  A 399 (-2.8A)
 1.38A 2pnjB-1g55A:
1.1		 2pnjB-1g55A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.27A 2pnjB-1hl2A:
2.2		 2pnjB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9s MRNA CAPPING ENZYME

(Mus musculus) 		PF00782
(DSPc) 		4 LEU A  25
PRO A  26
LEU A  27
ARG A  15
 None
None
None
IPA  A 600 (-4.1A)
 1.41A 2pnjB-1i9sA:
2.1		 2pnjB-1i9sA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 LEU A 304
PRO A 275
LEU A 291
ARG A 298
 None
 1.34A 2pnjB-1kczA:
undetectable		 2pnjB-1kczA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A1300
PRO A1301
LEU A1302
ARG A1311
 None
 1.18A 2pnjB-1p0cA:
3.9		 2pnjB-1p0cA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		4 LEU A  58
PRO A  57
LEU A  29
ARG A 216
 None
 1.43A 2pnjB-1u02A:
2.3		 2pnjB-1u02A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 151
PRO A 196
LEU A 414
ARG A 411
 None
 1.34A 2pnjB-1ufaA:
undetectable		 2pnjB-1ufaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdn RNA EDITING LIGASE
MP52

(Trypanosoma
brucei) 		PF09414
(RNA_ligase) 		4 LEU A 266
PRO A 267
LEU A 269
ARG A 244
 None
 1.30A 2pnjB-1xdnA:
undetectable		 2pnjB-1xdnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt8 PUTATIVE AMINO-ACID
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A  87
PRO A 206
LEU A  49
ARG A  52
 None
 1.24A 2pnjB-1xt8A:
undetectable		 2pnjB-1xt8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aoq DNA MISMATCH REPAIR
PROTEIN MUTH

(Haemophilus
influenzae) 		PF02976
(MutH) 		4 LEU A 207
PRO A 208
LEU A 209
ARG A 184
 None
 1.39A 2pnjB-2aoqA:
undetectable		 2pnjB-2aoqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A  44
PRO A  45
LEU A  28
ARG A  81
 None
 1.27A 2pnjB-2aw5A:
undetectable		 2pnjB-2aw5A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A1401 (-3.9A)
NAD  A1401 (-3.1A)
 1.31A 2pnjB-2dfvA:
3.0		 2pnjB-2dfvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duy COMPETENCE PROTEIN
COMEA-RELATED
PROTEIN

(Thermus
thermophilus) 		PF12836
(HHH_3) 		4 LEU A  66
PRO A  63
LEU A  56
ARG A  51
 None
 1.07A 2pnjB-2duyA:
undetectable		 2pnjB-2duyA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebj PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermus
thermophilus) 		PF01470
(Peptidase_C15) 		4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.44A 2pnjB-2ebjA:
4.3		 2pnjB-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glx 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Ensifer
adhaerens) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A  96
PRO A  95
LEU A 311
ARG A 104
 None
 1.43A 2pnjB-2glxA:
2.2		 2pnjB-2glxA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		4 LEU A 515
PRO A 514
LEU A 549
ARG A 552
 None
 1.38A 2pnjB-2hroA:
undetectable		 2pnjB-2hroA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		4 LEU A 500
PRO A 501
LEU A 522
ARG A 523
 None
 1.22A 2pnjB-2ktqA:
undetectable		 2pnjB-2ktqA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6a NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 12

(Homo sapiens) 		PF02758
(PYRIN) 		4 LEU A  19
PRO A  55
LEU A  27
ARG A  84
 None
 1.44A 2pnjB-2l6aA:
undetectable		 2pnjB-2l6aA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 LEU A 402
PRO A 403
LEU A 404
ARG A 271
 None
 1.20A 2pnjB-2m56A:
undetectable		 2pnjB-2m56A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 LEU A 155
PRO A 152
LEU A 269
ARG A 178
 None
 1.44A 2pnjB-2oucA:
undetectable		 2pnjB-2oucA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A1522
PRO A1521
LEU A1564
ARG A1566
 None
 1.40A 2pnjB-2pffA:
2.6		 2pnjB-2pffA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A  93
PRO A  94
LEU A 169
ARG A 170
 None
 1.32A 2pnjB-2rdyA:
undetectable		 2pnjB-2rdyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 LEU A 512
PRO A 513
LEU A 618
ARG A 677
 None
 1.36A 2pnjB-2vxoA:
3.0		 2pnjB-2vxoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 LEU A 613
PRO A 423
LEU A 610
ARG A 609
 None
 1.28A 2pnjB-2wkpA:
2.4		 2pnjB-2wkpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		4 LEU A 194
PRO A 307
LEU A 207
ARG A 217
 None
 1.38A 2pnjB-2ychA:
undetectable		 2pnjB-2ychA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 LEU A 221
PRO A 130
LEU A 218
ARG A 214
 None
 1.44A 2pnjB-2zq5A:
undetectable		 2pnjB-2zq5A:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 LEU A 101
PRO A 102
LEU A 107
ARG A 114
 CHD  A   3 ( 4.9A)
CHD  A   3 ( 4.7A)
CHD  A   3 ( 4.6A)
CHD  A   2 (-3.6A)
 0.37A 2pnjB-3aqiA:
59.7		 2pnjB-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 LEU A  92
PRO A  93
LEU A  95
ARG A 102
 None
 1.40A 2pnjB-3aqpA:
undetectable		 2pnjB-3aqpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.30A 2pnjB-3aytA:
undetectable		 2pnjB-3aytA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION

(Ruegeria sp.
TM1040) 		PF14563
(DUF4444)
PF16917
(BPL_LplA_LipB_2) 		4 LEU A 159
PRO A 156
LEU A  48
ARG A  49
 None
None
None
CA  A 235 ( 4.1A)
 1.31A 2pnjB-3bfmA:
undetectable		 2pnjB-3bfmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU B  97
PRO B  98
LEU B 190
ARG B 128
 None
 0.67A 2pnjB-3bn3B:
undetectable		 2pnjB-3bn3B:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 4 LEU A 356
PRO A 357
LEU A 319
ARG A 321
 None
 1.40A 2pnjB-3c4aA:
undetectable		 2pnjB-3c4aA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		4 LEU A 174
PRO A 136
LEU A 139
ARG A 268
 None
None
None
EDO  A 347 ( 4.3A)
 1.35A 2pnjB-3csvA:
undetectable		 2pnjB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 LEU A 184
PRO A 187
LEU A 381
ARG A 196
 None
 1.31A 2pnjB-3cv3A:
undetectable		 2pnjB-3cv3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6u VITAMIN K-DEPENDENT
PROTEIN C LIGHT
CHAIN

(Homo sapiens) 		PF00008
(EGF)
PF14670
(FXa_inhibition) 		4 LEU L  53
PRO L  54
LEU L  55
ARG L  87
 None
 1.31A 2pnjB-3f6uL:
undetectable		 2pnjB-3f6uL:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.39A 2pnjB-3fd2A:
undetectable		 2pnjB-3fd2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 182
PRO A 153
LEU A 179
ARG A 204
 None
None
NAD  A 500 (-4.1A)
NAD  A 500 (-2.6A)
 1.41A 2pnjB-3gfbA:
3.1		 2pnjB-3gfbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		4 LEU A 237
PRO A 238
LEU A 212
ARG A 272
 None
 1.31A 2pnjB-3gxoA:
3.1		 2pnjB-3gxoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  85
PRO A  86
LEU A  87
ARG A 166
 None
 1.41A 2pnjB-3hz6A:
undetectable		 2pnjB-3hz6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A  69
PRO A  88
LEU A  66
ARG A 301
 None
 1.22A 2pnjB-3ihvA:
undetectable		 2pnjB-3ihvA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.42A 2pnjB-3jacA:
undetectable		 2pnjB-3jacA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A  94
PRO A  95
LEU A 112
ARG A 110
 None
 1.37A 2pnjB-3mipA:
undetectable		 2pnjB-3mipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		4 LEU A 722
PRO A 721
LEU A 725
ARG A 699
 None
 1.27A 2pnjB-3nowA:
undetectable		 2pnjB-3nowA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A  61
PRO A  62
LEU A  48
ARG A 231
 None
 1.20A 2pnjB-3p2mA:
3.2		 2pnjB-3p2mA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9a DNA-PACKAGING
PROTEIN GP3

(Salmonella
virus P22) 		PF16677
(GP3_package) 		4 LEU A  28
PRO A  25
LEU A  92
ARG A  87
 None
 1.45A 2pnjB-3p9aA:
undetectable		 2pnjB-3p9aA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 147
PRO A 176
LEU A  94
ARG A  96
 None
 1.32A 2pnjB-3ri6A:
2.5		 2pnjB-3ri6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A 277
PRO A 279
LEU A 303
ARG A 297
 None
 1.24A 2pnjB-3s2uA:
2.5		 2pnjB-3s2uA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 LEU A 392
PRO A 271
LEU A 394
ARG A  41
 None
 1.44A 2pnjB-3sdoA:
undetectable		 2pnjB-3sdoA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A  77
PRO A  78
LEU A  22
ARG A  20
 None
 1.39A 2pnjB-3szbA:
2.7		 2pnjB-3szbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t24 PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 LEU A 111
PRO A 113
LEU A 150
ARG A 149
 None
None
None
C8E  A 401 ( 4.4A)
 1.23A 2pnjB-3t24A:
undetectable		 2pnjB-3t24A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU A 436
PRO A 437
LEU A 441
ARG A 443
 None
 1.45A 2pnjB-3tgwA:
undetectable		 2pnjB-3tgwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.30A 2pnjB-3thwB:
undetectable		 2pnjB-3thwB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A1543
PRO A1654
LEU A1545
ARG A1556
 None
 1.41A 2pnjB-3vkgA:
undetectable		 2pnjB-3vkgA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		4 LEU A 425
PRO A 422
LEU A 420
ARG A 419
 None
 1.42A 2pnjB-3zqjA:
undetectable		 2pnjB-3zqjA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LEU A 194
PRO A 193
LEU A 273
ARG A 271
 None
 1.33A 2pnjB-4bgbA:
2.5		 2pnjB-4bgbA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		4 LEU A 337
PRO A 338
LEU A 340
ARG A 325
 None
 1.36A 2pnjB-4e7wA:
undetectable		 2pnjB-4e7wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frw POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 4

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  50
PRO A  51
LEU A 141
ARG A 142
 None
 1.27A 2pnjB-4frwA:
undetectable		 2pnjB-4frwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		4 LEU A  81
PRO A  82
LEU A  72
ARG A  71
 None
0J9  A 302 (-4.5A)
None
None
 1.16A 2pnjB-4gkhA:
undetectable		 2pnjB-4gkhA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hse CHAPERONE PROTEIN
CLPB

(Thermus
thermophilus) 		PF00004
(AAA) 		4 LEU A 224
PRO A 221
LEU A 187
ARG A 188
 None
 1.33A 2pnjB-4hseA:
2.7		 2pnjB-4hseA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 LEU A 151
PRO A 196
LEU A 197
ARG A 429
 None
 1.45A 2pnjB-4hz8A:
undetectable		 2pnjB-4hz8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE
POLO-LIKE KINASE

(Danio rerio;
Danio rerio) 		PF00069
(Pkinase)
PF00659
(POLO_box) 		4 LEU A 300
PRO A 297
LEU B 496
ARG B 498
 None
 1.43A 2pnjB-4j7bA:
undetectable		 2pnjB-4j7bA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 LEU A 224
PRO A 225
LEU A 226
ARG A 288
 None
 1.20A 2pnjB-4j8bA:
undetectable		 2pnjB-4j8bA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.15A 2pnjB-4ogcA:
undetectable		 2pnjB-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 LEU A  97
PRO A  98
LEU A 190
ARG A 128
 None
 0.75A 2pnjB-4oibA:
undetectable		 2pnjB-4oibA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pba UNCHARACTERIZED
PROTEIN ABASI

(Acinetobacter
baumannii) 		no annotation 4 LEU B 222
PRO B 266
LEU B 214
ARG B 210
 None
 1.30A 2pnjB-4pbaB:
undetectable		 2pnjB-4pbaB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.40A 2pnjB-4raxA:
undetectable		 2pnjB-4raxA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 112
PRO A 291
LEU A 109
ARG A 107
 None
 1.41A 2pnjB-4rcnA:
2.3		 2pnjB-4rcnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		4 LEU A 390
PRO A 391
LEU A 393
ARG A 422
 None
 1.45A 2pnjB-4xguA:
2.5		 2pnjB-4xguA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 214
PRO A 215
LEU A 219
ARG A 226
 None
 1.19A 2pnjB-4zasA:
2.7		 2pnjB-4zasA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 199
PRO A 200
LEU A 204
ARG A 211
 None
 1.16A 2pnjB-4zwvA:
2.5		 2pnjB-4zwvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3g M50

(Murid
betaherpesvirus
1) 		PF04541
(Herpes_U34) 		4 LEU A  96
PRO A  93
LEU A  99
ARG A 101
 None
 1.45A 2pnjB-5a3gA:
undetectable		 2pnjB-5a3gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2

(Cardiovirus B;
Cardiovirus B) 		no annotation
PF00073
(Rhv) 		4 LEU A  73
PRO A  74
LEU C 182
ARG A 252
 None
 1.37A 2pnjB-5a8fA:
undetectable		 2pnjB-5a8fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 292
PRO A 291
LEU A 293
ARG A 456
 None
 1.40A 2pnjB-5agaA:
4.6		 2pnjB-5agaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 4 LEU A  59
PRO A  39
LEU A  42
ARG A 171
 None
 1.35A 2pnjB-5b01A:
undetectable		 2pnjB-5b01A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnz GLUTAMINE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 LEU A 241
PRO A 240
LEU A 187
ARG A 188
 None
 1.23A 2pnjB-5bnzA:
2.9		 2pnjB-5bnzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		4 LEU A 202
PRO A 239
LEU A 237
ARG A 163
 None
 1.42A 2pnjB-5by6A:
undetectable		 2pnjB-5by6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3f THERMUS THERMOPHILUS
MULTICOPPER OXIDASE

(Thermus
thermophilus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A  61
PRO A  48
LEU A  88
ARG A 141
 None
 1.42A 2pnjB-5g3fA:
undetectable		 2pnjB-5g3fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnw BLR0248 PROTEIN

(Bradyrhizobium
diazoefficiens) 		no annotation 4 LEU C 237
PRO C 238
LEU C 233
ARG C  42
 None
 1.44A 2pnjB-5gnwC:
2.9		 2pnjB-5gnwC:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1) 		no annotation 4 LEU G   7
PRO G   6
LEU G  20
ARG G  21
 None
 1.07A 2pnjB-5h0rG:
undetectable		 2pnjB-5h0rG:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.95A 2pnjB-5intA:
4.1		 2pnjB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k35 ANKYRIN-REPEAT
PROTEIN B

(Legionella
pneumophila) 		PF12937
(F-box-like) 		4 LEU A  98
PRO A  97
LEU A 113
ARG A 115
 None
 1.42A 2pnjB-5k35A:
undetectable		 2pnjB-5k35A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		4 LEU A 270
PRO A 269
LEU A 271
ARG A 281
 None
 1.29A 2pnjB-5lfrA:
undetectable		 2pnjB-5lfrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 LEU A1019
PRO A1018
LEU A 533
ARG A 535
 None
 1.32A 2pnjB-5lq3A:
undetectable		 2pnjB-5lq3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzo UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		4 LEU A1399
PRO A1400
LEU A1378
ARG A1377
 None
 1.34A 2pnjB-5mzoA:
undetectable		 2pnjB-5mzoA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 4 LEU A 168
PRO A 167
LEU A   8
ARG A   7
 None
 1.45A 2pnjB-5nywA:
undetectable		 2pnjB-5nywA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		4 LEU A  46
PRO A 140
LEU A 161
ARG A 165
 None
 1.26A 2pnjB-5opgA:
undetectable		 2pnjB-5opgA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A 503
PRO A 540
LEU A 538
ARG A 463
 None
 1.39A 2pnjB-5t0lA:
2.1		 2pnjB-5t0lA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3t FUSION PROTEIN OF
NUCLEOPROTEIN AND
MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF05505
(Ebola_NP)
PF11507
(Transcript_VP30) 		4 LEU A 249
PRO A 250
LEU A 188
ARG A 195
 None
 1.00A 2pnjB-5t3tA:
undetectable		 2pnjB-5t3tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 LEU A 251
PRO A 252
LEU A 140
ARG A  64
 None
 1.40A 2pnjB-5t65A:
undetectable		 2pnjB-5t65A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00415
(RCC1)
PF13540
(RCC1_2) 		4 LEU A 415
PRO A 446
LEU A 409
ARG A 400
 None
 1.39A 2pnjB-5xgsA:
undetectable		 2pnjB-5xgsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A2270
PRO A2269
LEU A2285
ARG A2288
 None
 1.44A 2pnjB-5y4dA:
undetectable		 2pnjB-5y4dA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		4 LEU A1391
PRO A1392
LEU A1370
ARG A1369
 None
 1.38A 2pnjB-5y7fA:
undetectable		 2pnjB-5y7fA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A 274
PRO A 271
LEU A 303
ARG A 299
 None
 1.41A 2pnjB-5ze4A:
2.3		 2pnjB-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 LEU A 440
PRO A 439
LEU A 443
ARG A 405
 None
 1.37A 2pnjB-6bo6A:
undetectable		 2pnjB-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 LEU A2444
PRO A2445
LEU A2434
ARG A2402
 None
 1.39A 2pnjB-6bpzA:
undetectable		 2pnjB-6bpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fvs CYS-LOOP
LIGAND-GATED ION
CHANNEL

(endosymbiont of
Tevnia
jerichonana) 		no annotation 4 LEU A 247
PRO A 248
LEU A 250
ARG A 120
 None
 1.29A 2pnjB-6fvsA:
undetectable		 2pnjB-6fvsA:
undetectable