SIMILAR PATTERNS OF AMINO ACIDS FOR 2PNJ_B_CHDB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9w HEMOGLOBIN (BETA
CHAIN)

(Homo sapiens) 		PF00042
(Globin) 		4 MET E  18
ILE E 113
ARG E  30
GLY E 119
 None
 1.01A 2pnjB-1a9wE:
undetectable		 2pnjB-1a9wE:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		4 MET A 184
ILE A 174
PRO A 344
GLY A 250
 None
 1.14A 2pnjB-1fn9A:
undetectable		 2pnjB-1fn9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 MET A 417
ILE A 278
PRO A 343
GLY A 337
 None
 1.10A 2pnjB-1gkrA:
0.0		 2pnjB-1gkrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 258
ARG A 235
PRO A  32
GLY A  96
 None
ILE  A 500 (-3.1A)
None
ADP  A 400 ( 4.0A)
 1.06A 2pnjB-1h74A:
0.0		 2pnjB-1h74A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhj APC10

(Homo sapiens) 		PF03256
(ANAPC10) 		4 ILE A  94
PRO A  13
GLY A 118
TRP A 119
 None
 0.95A 2pnjB-1jhjA:
undetectable		 2pnjB-1jhjA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ILE A 294
PRO A 232
GLY A 271
MET A 257
 None
 1.17A 2pnjB-1l5jA:
0.1		 2pnjB-1l5jA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		4 ILE A  83
PRO A 238
GLY A 278
TRP A 282
 None
 0.56A 2pnjB-1lbqA:
47.9		 2pnjB-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		4 ILE B 309
ARG B 214
GLY B 253
TRP B 254
 None
 1.08A 2pnjB-1m1jB:
undetectable		 2pnjB-1m1jB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		4 ILE X 280
PRO X 208
GLY X 292
MET X 206
 None
 1.24A 2pnjB-1ogoX:
0.0		 2pnjB-1ogoX:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ILE A 140
ARG A 134
PRO A 181
GLY A 159
 None
 1.24A 2pnjB-1p88A:
undetectable		 2pnjB-1p88A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 ILE A1156
ARG A1160
PRO A1599
GLY A1433
 None
 0.88A 2pnjB-1qhmA:
undetectable		 2pnjB-1qhmA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlk HYPOTHETICAL PROTEIN
TA0108

(Thermoplasma
acidophilum) 		PF01981
(PTH2) 		4 MET A  36
PRO A 101
GLY A  50
TRP A  46
 None
 1.23A 2pnjB-1rlkA:
undetectable		 2pnjB-1rlkA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tif TRANSLATION
INITIATION FACTOR 3

(Geobacillus
stearothermophilus) 		PF05198
(IF3_N) 		4 ILE A  59
ARG A  41
PRO A  54
GLY A  27
 None
 1.25A 2pnjB-1tifA:
undetectable		 2pnjB-1tifA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ILE A 794
ARG A  82
PRO A 785
GLY A 732
 None
 1.22A 2pnjB-1tmoA:
undetectable		 2pnjB-1tmoA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		4 ILE A  47
PRO A  81
GLY A  89
MET A  87
 None
FMN  A 200 (-3.9A)
None
None
 1.06A 2pnjB-1x77A:
3.9		 2pnjB-1x77A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 MET A1115
ARG A1077
PRO A1106
TRP A1100
 None
 1.23A 2pnjB-1yguA:
undetectable		 2pnjB-1yguA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdv PHAGE-RELATED
CONSERVED
HYPOTHETICAL
PROTEIN, BB2244

(Bordetella
bronchiseptica) 		PF02586
(SRAP) 		4 ILE A  17
PRO A 166
GLY A 101
TRP A 102
 None
 1.16A 2pnjB-2bdvA:
undetectable		 2pnjB-2bdvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 ILE A 810
ARG A 822
PRO A 756
GLY A 759
 None
 1.13A 2pnjB-2bmbA:
2.4		 2pnjB-2bmbA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		4 MET A 228
ARG A 180
PRO A 231
GLY A 234
 None
CAN  A   1 (-4.2A)
None
None
 1.23A 2pnjB-2canA:
3.5		 2pnjB-2canA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		4 MET A 144
ILE A 204
PRO A 169
GLY A 196
 None
 1.06A 2pnjB-2dulA:
3.1		 2pnjB-2dulA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 MET B 756
PRO B 779
MET B 787
TRP B 788
 None
 1.03A 2pnjB-2fjaB:
undetectable		 2pnjB-2fjaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpj SIDEROPHORE-INTERACT
ING PROTEIN

(Shewanella
putrefaciens) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 ILE A 126
PRO A 191
GLY A 139
TRP A 113
 None
None
CA  A 252 ( 4.6A)
None
 1.19A 2pnjB-2gpjA:
2.2		 2pnjB-2gpjA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 ILE A 429
ARG A 452
GLY A 369
TRP A 291
 None
 1.07A 2pnjB-2gq3A:
undetectable		 2pnjB-2gq3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 215
PRO A 174
GLY A 130
TRP A 152
 None
 1.11A 2pnjB-2hk7A:
5.6		 2pnjB-2hk7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke5 RAS-RELATED PROTEIN
RAL-B

(Homo sapiens) 		PF00071
(Ras) 		4 MET A 173
ARG A  52
PRO A 122
GLY A  86
 None
 1.19A 2pnjB-2ke5A:
4.9		 2pnjB-2ke5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxp UBIQUITIN-CONJUGATIN
G ENZYME E2 G2

(Homo sapiens) 		PF00179
(UQ_con) 		4 MET A  71
ILE A  41
GLY A  27
MET A  29
 None
 1.09A 2pnjB-2lxpA:
undetectable		 2pnjB-2lxpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  82
PRO A 377
GLY A  65
TRP A  66
 None
 1.10A 2pnjB-2nqlA:
undetectable		 2pnjB-2nqlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.11A 2pnjB-2ovjA:
undetectable		 2pnjB-2ovjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  82
PRO A 378
GLY A  65
TRP A  66
 None
 1.02A 2pnjB-2ppgA:
2.7		 2pnjB-2ppgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  69
PRO A 355
GLY A  46
TRP A  47
 None
 1.20A 2pnjB-2qddA:
3.8		 2pnjB-2qddA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		4 ILE A 293
PRO A 239
GLY A 200
TRP A 199
 None
 1.16A 2pnjB-2qzuA:
undetectable		 2pnjB-2qzuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r25 OSMOSENSING
HISTIDINE PROTEIN
KINASE SLN1

(Saccharomyces
cerevisiae) 		PF00072
(Response_reg) 		4 ILE B1197
PRO B1168
GLY B1191
MET B1189
 None
NA  B   5 (-4.4A)
None
None
 1.24A 2pnjB-2r25B:
3.6		 2pnjB-2r25B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 MET A  51
ILE A  79
PRO A  96
GLY A 163
 None
None
EDO  A1508 (-4.4A)
EDO  A1510 (-3.4A)
 1.08A 2pnjB-2w40A:
undetectable		 2pnjB-2w40A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		4 ILE A 107
ARG A 108
GLY A  21
TRP A  20
 GOL  A1343 (-3.9A)
None
None
None
 1.14A 2pnjB-2wymA:
undetectable		 2pnjB-2wymA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 ILE A 196
ARG A 197
PRO A 153
GLY A 148
 None
None
None
UNU  A 522 (-3.8A)
 1.03A 2pnjB-3a1iA:
undetectable		 2pnjB-3a1iA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 255
ARG A 253
PRO A  34
GLY A 278
TRP A 277
 None
 1.34A 2pnjB-3a3jA:
undetectable		 2pnjB-3a3jA:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		7 MET A  99
ILE A 111
ARG A 114
PRO A 266
GLY A 306
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 ( 4.7A)
CHD  A   2 (-3.6A)
CHD  A   2 ( 4.5A)
CHD  A   2 ( 3.8A)
None
CHD  A   2 (-4.7A)
 0.34A 2pnjB-3aqiA:
59.7		 2pnjB-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  69
PRO A 355
GLY A  46
TRP A  47
 None
 1.19A 2pnjB-3eezA:
4.3		 2pnjB-3eezA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fca CYSTEINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		4 ILE A 226
ARG A 223
PRO A 281
GLY A 166
 None
 1.17A 2pnjB-3fcaA:
2.4		 2pnjB-3fcaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 MET A 412
ILE A 300
GLY A 292
MET A 421
 None
 1.11A 2pnjB-3g4fA:
undetectable		 2pnjB-3g4fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 799
PRO A 921
GLY A 866
MET A 923
 None
 1.15A 2pnjB-3hmjA:
2.0		 2pnjB-3hmjA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 464
ARG A 463
PRO A 401
GLY A 470
 None
 1.14A 2pnjB-3i4gA:
undetectable		 2pnjB-3i4gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibt 1H-3-HYDROXY-4-OXOQU
INOLINE
2,4-DIOXYGENASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		4 MET A  91
ILE A  81
PRO A 206
GLY A 109
 None
 1.23A 2pnjB-3ibtA:
3.0		 2pnjB-3ibtA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 232
ARG A 230
PRO A   9
GLY A 255
TRP A 254
 None
 1.23A 2pnjB-3itaA:
undetectable		 2pnjB-3itaA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju7 PUTATIVE
PLP-DEPENDENT
AMINOTRANSFERASE

(Bacillus cereus) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 342
GLY A 276
MET A 273
TRP A 277
 None
 1.21A 2pnjB-3ju7A:
undetectable		 2pnjB-3ju7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juj UDP-GLUCOSE
PYROPHOSPHORYLASE
(GALU)

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 MET A 145
ILE A 204
PRO A 139
GLY A 250
 None
 1.24A 2pnjB-3jujA:
2.9		 2pnjB-3jujA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 MET A 150
ILE A 140
PRO A 196
GLY A 207
 None
 0.97A 2pnjB-3mi9A:
undetectable		 2pnjB-3mi9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myv SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 MET A  63
ARG A 429
GLY A  71
MET A  74
 None
 1.05A 2pnjB-3myvA:
undetectable		 2pnjB-3myvA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D
ENDOGLUCANASE D

(Clostridium
cellulovorans;
Clostridium
cellulovorans) 		PF00150
(Cellulase)
PF00553
(CBM_2) 		4 MET A  22
ILE A 223
ARG A 269
GLY E 447
 None
 1.17A 2pnjB-3ndyA:
undetectable		 2pnjB-3ndyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nea PEPTIDYL-TRNA
HYDROLASE

(Francisella
tularensis) 		PF01195
(Pept_tRNA_hydro) 		4 ILE A 104
ARG A 105
PRO A 154
GLY A 138
 None
None
None
CL  A 500 ( 3.7A)
 1.14A 2pnjB-3neaA:
5.1		 2pnjB-3neaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 4 MET A 281
ILE A 388
ARG A 268
PRO A 503
 None
 1.19A 2pnjB-3nlcA:
undetectable		 2pnjB-3nlcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A 744
PRO A 749
GLY A 754
TRP A 752
 None
 1.25A 2pnjB-3qdeA:
undetectable		 2pnjB-3qdeA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2

(Arabidopsis
thaliana) 		no annotation 4 ILE C 328
PRO C 314
GLY C 290
TRP C 291
 None
 1.23A 2pnjB-3r0qC:
undetectable		 2pnjB-3r0qC:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4k TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Ruegeria sp.
TM1040) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 MET A  41
ILE A  21
ARG A  18
GLY A  31
 None
 1.15A 2pnjB-3r4kA:
undetectable		 2pnjB-3r4kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		4 MET A  33
ARG A  26
PRO A  89
GLY A 113
 None
 1.25A 2pnjB-3swxA:
undetectable		 2pnjB-3swxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt2 GCN5-RELATED
N-ACETYLTRANSFERASE

(Sphaerobacter
thermophilus) 		PF00583
(Acetyltransf_1) 		4 MET A 301
ILE A 246
PRO A 162
GLY A 270
 None
 1.21A 2pnjB-3tt2A:
undetectable		 2pnjB-3tt2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 ILE A 180
ARG A 177
PRO A 118
GLY A 301
 None
 1.20A 2pnjB-3u3iA:
undetectable		 2pnjB-3u3iA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uid PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF08327
(AHSA1) 		4 ILE A 145
PRO A  44
GLY A  68
MET A  66
 None
 1.22A 2pnjB-3uidA:
undetectable		 2pnjB-3uidA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 MET A 322
ILE A 117
ARG A 114
GLY A 310
 None
 1.16A 2pnjB-3v4bA:
2.5		 2pnjB-3v4bA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		4 ILE A 132
PRO A 101
GLY A 516
TRP A 517
 None
None
FRU  A 604 ( 4.7A)
FRU  A 604 (-4.0A)
 1.20A 2pnjB-3vssA:
undetectable		 2pnjB-3vssA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 326
ARG A  93
PRO A 395
GLY A 379
 None
 1.23A 2pnjB-3zz1A:
undetectable		 2pnjB-3zz1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a64 CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin) 		4 MET A 356
ILE A 318
GLY A 310
TRP A 307
 None
 1.16A 2pnjB-4a64A:
undetectable		 2pnjB-4a64A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 MET A 342
ILE A 359
PRO A 325
GLY A 270
 None
 1.13A 2pnjB-4ay1A:
undetectable		 2pnjB-4ay1A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Borreliella
burgdorferi) 		PF00300
(His_Phos_1) 		4 ILE A 138
PRO A 125
GLY A  96
MET A 127
 None
 1.07A 2pnjB-4embA:
undetectable		 2pnjB-4embA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emk U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM5
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		4 ILE C  46
PRO A   7
GLY C  90
MET C  57
 None
 1.20A 2pnjB-4emkC:
undetectable		 2pnjB-4emkC:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1
RNA-BINDING PROTEIN
FUS

(Homo sapiens;
Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation 		4 MET A 308
ILE A 398
PRO B 525
TRP A 460
 None
 1.20A 2pnjB-4fddA:
undetectable		 2pnjB-4fddA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 106
ARG A 110
PRO A 301
GLY A   9
 IOD  A 516 ( 4.5A)
IOD  A 516 (-3.2A)
None
None
 1.10A 2pnjB-4hjhA:
2.3		 2pnjB-4hjhA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqn SPOROZOITE SURFACE
PROTEIN 2

(Plasmodium
vivax) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 ILE A 227
GLY A  70
MET A  67
TRP A 216
 None
 1.25A 2pnjB-4hqnA:
4.6		 2pnjB-4hqnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		4 ARG A 336
PRO A 237
GLY A 244
TRP A 243
 None
 0.83A 2pnjB-4ipaA:
undetectable		 2pnjB-4ipaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmo TELOMERASE REVERSE
TRANSCRIPTASE

(Takifugu
rubripes) 		PF12009
(Telomerase_RBD) 		4 MET A 460
ARG A 487
GLY A 430
TRP A 429
 None
 1.12A 2pnjB-4lmoA:
undetectable		 2pnjB-4lmoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A4314
PRO A4259
GLY A4285
TRP A4286
 None
 1.14A 2pnjB-4opeA:
3.0		 2pnjB-4opeA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 259
ARG A 235
PRO A  30
GLY A  97
 None
 1.17A 2pnjB-4p52A:
undetectable		 2pnjB-4p52A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 MET A 541
ILE A 724
PRO A 512
GLY A 598
 None
 1.02A 2pnjB-4q1vA:
3.1		 2pnjB-4q1vA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 ILE A 432
ARG A 428
PRO A 127
GLY A 124
 None
 0.75A 2pnjB-4rasA:
undetectable		 2pnjB-4rasA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		4 ILE A 192
PRO A 252
GLY A 243
MET A 245
 None
None
None
EDO  A 517 (-4.5A)
 1.04A 2pnjB-4tlgA:
undetectable		 2pnjB-4tlgA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A  15
ARG A  18
GLY A 200
TRP A 199
 None
 1.13A 2pnjB-4wv3A:
3.6		 2pnjB-4wv3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 892
PRO A 857
MET A 855
TRP A 872
 None
 1.18A 2pnjB-4xufA:
undetectable		 2pnjB-4xufA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 MET A 127
ILE A  49
GLY A  20
MET A  18
 None
 0.91A 2pnjB-4zm6A:
2.7		 2pnjB-4zm6A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00071
(Ras)
PF00620
(RhoGAP) 		4 MET A 212
ARG A 299
PRO A 225
MET A 223
 None
 1.18A 2pnjB-5c2kA:
2.4		 2pnjB-5c2kA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN

(Colletotrichum
graminicola) 		PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 MET A 198
ILE A 236
GLY A 224
MET A 222
 None
 0.98A 2pnjB-5c92A:
undetectable		 2pnjB-5c92A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 525
ARG A 605
GLY A 520
TRP A 450
 None
 1.18A 2pnjB-5fjjA:
undetectable		 2pnjB-5fjjA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 234
ARG A 232
PRO A  11
GLY A 257
TRP A 256
 None
 1.38A 2pnjB-5fsrA:
undetectable		 2pnjB-5fsrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5a GLUTATHIONE
S-TRANSFERASE U25

(Arabidopsis
thaliana) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A 175
PRO A 200
GLY A 159
MET A  14
 None
None
None
GSH  A1222 ( 4.5A)
 1.23A 2pnjB-5g5aA:
undetectable		 2pnjB-5g5aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gol CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		no annotation 4 MET A  77
ILE A  71
ARG A  92
GLY A  55
 None
 1.24A 2pnjB-5golA:
undetectable		 2pnjB-5golA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5c MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 ILE A 126
PRO A  52
GLY A  48
MET A  50
 None
 1.23A 2pnjB-5h5cA:
undetectable		 2pnjB-5h5cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5c MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 MET A 131
PRO A  52
GLY A  48
MET A  50
 None
 1.17A 2pnjB-5h5cA:
undetectable		 2pnjB-5h5cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqw PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 MET A2419
ILE A2449
PRO A2441
TRP A2289
 None
 1.10A 2pnjB-5hqwA:
undetectable		 2pnjB-5hqwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		4 ILE A 105
ARG A 106
PRO A  84
GLY A  81
 None
 1.24A 2pnjB-5l75A:
undetectable		 2pnjB-5l75A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 MET A  74
ILE A  60
PRO A 126
GLY A 123
 None
 1.02A 2pnjB-5mt2A:
undetectable		 2pnjB-5mt2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus;
Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 MET A 326
ILE B 381
ARG B 384
GLY A 474
 AGM  A 274 (-3.9A)
AGM  A 274 (-3.7A)
None
None
 1.20A 2pnjB-5n28A:
undetectable		 2pnjB-5n28A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ILE A 391
ARG A 120
PRO A 457
GLY A 441
 None
 1.20A 2pnjB-5nbsA:
undetectable		 2pnjB-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile) 		no annotation 4 ILE A 246
ARG A 243
PRO A 266
GLY A 283
 None
FAD  A 401 (-3.6A)
None
None
 1.24A 2pnjB-5ol2A:
2.1		 2pnjB-5ol2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		4 MET A 215
ARG A 203
PRO A 166
GLY A 171
 None
 1.04A 2pnjB-5swnA:
2.9		 2pnjB-5swnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 ILE A 540
PRO A  29
GLY A 504
TRP A 503
 None
 1.05A 2pnjB-5tj3A:
undetectable		 2pnjB-5tj3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 4 ILE A 161
ARG A 127
GLY A 144
MET A 154
 None
P6G  A 503 (-3.5A)
None
None
 1.10A 2pnjB-5xj1A:
3.7		 2pnjB-5xj1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 4 ILE A 415
PRO A 166
GLY A 379
MET A 376
 None
None
None
HEM  A 501 ( 4.2A)
 1.06A 2pnjB-5ysmA:
undetectable		 2pnjB-5ysmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 ILE A 174
ARG A 122
GLY A  37
MET A  35
 None
 1.07A 2pnjB-6cauA:
2.5		 2pnjB-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 ILE G  21
PRO F  49
GLY G 111
TRP G 110
 None
 1.20A 2pnjB-6cnkG:
undetectable		 2pnjB-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 4 MET 8  69
ILE 8  48
ARG 8  38
GLY 8  65
 None
 1.20A 2pnjB-6cuf8:
undetectable		 2pnjB-6cuf8:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
5

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 ILE Z  85
ARG Z  81
PRO e  93
GLY e  99
 None
 1.18A 2pnjB-6g72Z:
undetectable		 2pnjB-6g72Z:
undetectable