SIMILAR PATTERNS OF AMINO ACIDS FOR 2PNJ_B_CHDB501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 LEU A 441
LEU A 102
ILE A 137
SER A 103
VAL A  84
 None
 1.23A 2pnjB-1a6dA:
undetectable		 2pnjB-1a6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		5 LEU A 239
LEU A  37
ILE A  18
VAL A  41
VAL A  64
 None
 1.33A 2pnjB-1ahaA:
undetectable		 2pnjB-1ahaA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A 313
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 1.04A 2pnjB-1lbqA:
47.9		 2pnjB-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 ILE A 313
SER A 167
PRO A 238
VAL A 241
TRP A 282
 None
 0.97A 2pnjB-1lbqA:
47.9		 2pnjB-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 LEU A  62
PHE A  63
ILE A  91
SER A 169
HIS A 235
PRO A 238
VAL A 241
VAL A 277
TRP A 282
 None
 0.47A 2pnjB-1lbqA:
47.9		 2pnjB-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		6 PHE A  63
LEU A  68
SER A 169
HIS A 235
VAL A 277
TRP A 282
 None
 1.36A 2pnjB-1lbqA:
47.9		 2pnjB-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A  64
PHE A  55
ILE A 169
VAL A  27
VAL A 177
 None
 1.15A 2pnjB-1qi7A:
undetectable		 2pnjB-1qi7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 MET A 140
LEU A 161
LEU A 388
ILE A 150
VAL A 272
 None
 1.26A 2pnjB-1serA:
undetectable		 2pnjB-1serA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 371
LEU A 363
ILE A 445
SER A 362
VAL A 467
 None
 1.28A 2pnjB-1uhlA:
undetectable		 2pnjB-1uhlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqz LIPOATE-PROTEIN
LIGASE, PUTATIVE

(Streptococcus
pneumoniae) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 MET A 205
LEU A 201
PHE A 197
LEU A  34
ILE A 106
 None
 1.18A 2pnjB-1vqzA:
undetectable		 2pnjB-1vqzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 LEU C  41
PHE C  61
LEU C  38
ILE C 109
PRO C  79
 None
 1.19A 2pnjB-1wa5C:
undetectable		 2pnjB-1wa5C:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yir NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Pseudomonas
aeruginosa) 		PF04095
(NAPRTase) 		5 LEU A  92
PHE A  88
LEU A  78
ILE A 123
PRO A 220
 None
 0.96A 2pnjB-1yirA:
undetectable		 2pnjB-1yirA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Homo sapiens) 		PF00551
(Formyl_trans_N) 		5 LEU A  17
PHE A 177
LEU A  14
ILE A  82
VAL A  40
 None
 1.37A 2pnjB-1zlyA:
2.8		 2pnjB-1zlyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		5 LEU A  13
LEU A  98
ILE A  61
VAL A  91
VAL A  71
 None
 1.17A 2pnjB-2a5vA:
3.5		 2pnjB-2a5vA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M) 		5 LEU A 174
PHE A 231
LEU A 171
PRO A 249
VAL A 250
 None
 1.30A 2pnjB-2aehA:
undetectable		 2pnjB-2aehA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 147
MET A 143
ILE A 220
SER A 148
VAL A 168
 None
None
CA  A 802 ( 4.7A)
None
None
 1.33A 2pnjB-2e3xA:
4.4		 2pnjB-2e3xA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fej CELLULAR TUMOR
ANTIGEN P53

(Homo sapiens) 		PF00870
(P53) 		5 PHE A 270
ILE A 195
PRO A 278
VAL A 122
VAL A 274
 None
 1.31A 2pnjB-2fejA:
undetectable		 2pnjB-2fejA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmi FAB FRAGMENT OF
MONOCLONAL ANTIBODY
28

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU D  69
MET D  85
ILE D  53
PRO D   9
VAL D  12
 None
 1.26A 2pnjB-2hmiD:
undetectable		 2pnjB-2hmiD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn3 CASPASE-1

(Spodoptera
frugiperda) 		PF00656
(Peptidase_C14) 		5 LEU C 236
PHE C 232
LEU C  89
ILE C 283
VAL C 102
 None
 1.29A 2pnjB-2nn3C:
3.1		 2pnjB-2nn3C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 LEU B 655
PHE B 643
LEU B 638
ILE B 570
VAL B 688
 None
 1.24A 2pnjB-2o8eB:
undetectable		 2pnjB-2o8eB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 LEU A1085
ILE A1102
PRO A1078
VAL A1008
TRP A1072
 None
 1.21A 2pnjB-2ooqA:
2.0		 2pnjB-2ooqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		5 MET A 241
LEU A 233
ILE A 144
PRO A 254
VAL A 255
 None
 1.33A 2pnjB-2qgqA:
2.6		 2pnjB-2qgqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus B) 		PF00073
(Rhv) 		5 LEU 2 191
LEU 2 228
SER 2 237
VAL 2 222
TRP 2  78
 None
 1.29A 2pnjB-2rs52:
undetectable		 2pnjB-2rs52:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G1958
SER G1850
PRO G1975
VAL G1842
VAL G1886
 None
 1.35A 2pnjB-2uv8G:
undetectable		 2pnjB-2uv8G:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		5 LEU A 161
PHE A 171
LEU A 178
VAL A 305
VAL A 354
 None
 1.29A 2pnjB-2x66A:
undetectable		 2pnjB-2x66A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xot AMPHOTERIN-INDUCED
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 139
PHE A 130
LEU A 160
MET A 157
ILE A 146
 None
 1.29A 2pnjB-2xotA:
undetectable		 2pnjB-2xotA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 LEU A 268
LEU A 290
ILE A  13
PRO A 170
VAL A 162
 None
 1.34A 2pnjB-2y5wA:
undetectable		 2pnjB-2y5wA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
PHE A 304
LEU A 280
VAL A 255
 None
 1.05A 2pnjB-2z63A:
undetectable		 2pnjB-2z63A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  72
PHE A  96
LEU A  78
ILE A  88
SER A  56
 None
 1.31A 2pnjB-2z81A:
undetectable		 2pnjB-2z81A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 LEU A 470
ILE A 354
SER A 528
PRO A 592
VAL A 425
 None
 1.34A 2pnjB-2zxqA:
undetectable		 2pnjB-2zxqA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
ALPHA

(Cavia porcellus) 		PF00042
(Globin) 		5 LEU A  29
PHE A  33
LEU A 101
ILE A  46
HIS A  87
 None
None
HEM  A 201 (-4.1A)
None
HEM  A 201 (-3.3A)
 1.19A 2pnjB-3a0gA:
undetectable		 2pnjB-3a0gA:
16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 ILE A 342
SER A 195
PRO A 266
VAL A 269
TRP A 310
 None
None
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 0.99A 2pnjB-3aqiA:
59.7		 2pnjB-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		12 MET A  76
LEU A  92
PHE A  93
LEU A  98
MET A  99
ILE A 119
SER A 197
HIS A 263
PRO A 266
VAL A 269
VAL A 305
TRP A 310
 CHD  A   1 ( 3.8A)
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
None
CHD  A   1 (-3.0A)
CHD  A   1 (-4.3A)
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
CHD  A   2 (-4.7A)
 0.44A 2pnjB-3aqiA:
59.7		 2pnjB-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 SER A 195
HIS A 263
PRO A 266
VAL A 269
TRP A 310
 None
CHD  A   1 (-4.3A)
CHD  A   2 ( 4.5A)
None
CHD  A   2 (-4.7A)
 1.14A 2pnjB-3aqiA:
59.7		 2pnjB-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		5 LEU A 105
LEU A  80
ILE A  38
SER A  79
VAL A 132
 None
 1.22A 2pnjB-3bvcA:
undetectable		 2pnjB-3bvcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cgh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		5 PHE A  78
LEU A  69
ILE A 351
VAL A 101
VAL A  56
 None
 1.06A 2pnjB-3cghA:
undetectable		 2pnjB-3cghA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		5 LEU A 226
PHE A 189
LEU A 223
HIS A 245
VAL A 252
 None
 0.91A 2pnjB-3csvA:
undetectable		 2pnjB-3csvA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		5 LEU A  13
LEU A 279
MET A 275
ILE A   4
SER A 280
 None
 1.33A 2pnjB-3do6A:
2.6		 2pnjB-3do6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		5 MET A 140
LEU A 161
LEU A 388
ILE A 150
VAL A 272
 None
None
None
None
AMP  A1507 (-4.1A)
 1.27A 2pnjB-3errA:
undetectable		 2pnjB-3errA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvv UNCHARACTERIZED
PROTEIN

(Bordetella
pertussis) 		PF12710
(HAD) 		5 MET A  85
LEU A  93
LEU A  16
SER A  20
VAL A 131
 None
 1.25A 2pnjB-3fvvA:
2.8		 2pnjB-3fvvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 MET A 243
LEU A 277
PHE A 304
LEU A 280
VAL A 255
 None
 1.10A 2pnjB-3fxiA:
undetectable		 2pnjB-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcd RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		5 MET A  38
LEU A 111
LEU A 115
PRO A 132
VAL A 168
 None
 1.38A 2pnjB-3gcdA:
2.6		 2pnjB-3gcdA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h77 PQS BIOSYNTHETIC
ENZYME

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 MET A 225
LEU A 193
PHE A 218
HIS A 257
VAL A 282
 COW  A 350 (-3.7A)
CSJ  A 112 (-4.5A)
CSJ  A 112 ( 4.0A)
COW  A 350 (-4.2A)
None
 1.36A 2pnjB-3h77A:
undetectable		 2pnjB-3h77A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 LEU A  23
LEU A 391
MET A  35
ILE A 155
VAL A 431
 None
 1.33A 2pnjB-3if2A:
undetectable		 2pnjB-3if2A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		6 LEU X   7
ILE X 143
PRO X   3
VAL X   2
VAL X 158
TRP X 162
 None
 1.34A 2pnjB-3j8gX:
2.9		 2pnjB-3j8gX:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A  89
LEU A 128
ILE A  49
VAL A 162
VAL A 119
 None
None
None
MES  A 361 (-3.6A)
None
 1.16A 2pnjB-3l6aA:
undetectable		 2pnjB-3l6aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lly AGGLUTININ ALPHA
CHAIN

(Maclura
pomifera) 		PF01419
(Jacalin) 		5 LEU A  28
LEU A 124
ILE A  12
VAL A  72
VAL A  68
 None
 0.97A 2pnjB-3llyA:
undetectable		 2pnjB-3llyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 228
PHE A 162
LEU A 110
PRO A 154
TRP A 246
 None
 1.22A 2pnjB-3m1mA:
undetectable		 2pnjB-3m1mA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n89 DEFECTIVE IN GERM
LINE DEVELOPMENT
PROTEIN 3, ISOFORM A

(Caenorhabditis
elegans) 		no annotation 5 LEU A 448
LEU A 443
ILE A 345
SER A 442
VAL A 296
 None
 1.35A 2pnjB-3n89A:
undetectable		 2pnjB-3n89A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 MET A 470
LEU A 430
ILE A 449
PRO A 423
TRP A 417
 None
 1.37A 2pnjB-3ps5A:
undetectable		 2pnjB-3ps5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		5 PHE A  77
LEU A 264
MET A 267
ILE A  38
SER A 260
 None
 1.37A 2pnjB-3qnqA:
undetectable		 2pnjB-3qnqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT A
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		PF00507
(Oxidored_q4)
no annotation
no annotation
no annotation 		5 LEU N 134
LEU J 147
SER K  67
VAL A  80
VAL A 109
 None
 1.28A 2pnjB-3rkoN:
undetectable		 2pnjB-3rkoN:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE
CASPASE

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF00656
(Peptidase_C14)
PF00656
(Peptidase_C14) 		5 LEU B 198
PHE B 194
LEU A  49
ILE B 245
VAL A  62
 None
 1.25A 2pnjB-3sipB:
undetectable		 2pnjB-3sipB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxm TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Thermotoga
maritima) 		PF07729
(FCD) 		5 LEU A 193
LEU A 197
ILE A 101
VAL A 160
TRP A 154
 None
 1.33A 2pnjB-3sxmA:
undetectable		 2pnjB-3sxmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
ILE A 550
VAL A 380
VAL A 458
 None
 1.32A 2pnjB-3v4oA:
3.1		 2pnjB-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
 None
 1.28A 2pnjB-3v4oA:
3.1		 2pnjB-3v4oA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woh SIAM

(Streptomyces
sp. A7248) 		PF13561
(adh_short_C2) 		5 LEU A 119
PHE A 123
LEU A 166
SER A 145
VAL A 240
 None
 1.26A 2pnjB-3wohA:
3.1		 2pnjB-3wohA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 MET A 217
ILE A 138
SER A 309
HIS A 496
VAL A 191
 None
None
EDO  A1515 (-3.2A)
CU  A 602 ( 3.3A)
None
 1.33A 2pnjB-3zx1A:
undetectable		 2pnjB-3zx1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 104
PHE A  95
LEU A 125
ILE A  87
VAL A 170
 None
 1.16A 2pnjB-3zyiA:
undetectable		 2pnjB-3zyiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C

(Homo sapiens) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 248
PHE A 239
LEU A 269
ILE A 255
PRO A 289
 None
 1.35A 2pnjB-3zyjA:
undetectable		 2pnjB-3zyjA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acj WU:FB25H12 PROTEIN,

(Danio rerio) 		PF07534
(TLD) 		5 LEU A 724
PHE A 779
LEU A 784
ILE A 744
SER A 785
 None
 1.36A 2pnjB-4acjA:
undetectable		 2pnjB-4acjA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE SUBUNIT
RPT4

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 MET L 312
LEU L 337
LEU L 343
ILE L 286
VAL L 196
 None
 1.28A 2pnjB-4cr4L:
undetectable		 2pnjB-4cr4L:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csw CUPIN 4 FAMILY
PROTEIN

(Rhodothermus
marinus) 		PF08007
(Cupin_4) 		5 LEU A  89
PHE A  79
LEU A  44
VAL A  98
VAL A  53
 None
 1.35A 2pnjB-4cswA:
undetectable		 2pnjB-4cswA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 263
LEU A 277
LEU A 269
ILE A 284
SER A 268
 None
 1.17A 2pnjB-4eutA:
undetectable		 2pnjB-4eutA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 263
LEU A 277
LEU A 269
ILE A 284
SER A 268
 None
 1.21A 2pnjB-4euuA:
undetectable		 2pnjB-4euuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		5 LEU A 182
LEU A  72
ILE A 322
PRO A  76
VAL A  58
 None
 1.28A 2pnjB-4h59A:
undetectable		 2pnjB-4h59A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq1 PROBABLE RECEPTOR
PROTEIN KINASE TMK1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A  84
LEU A  87
ILE A 100
PRO A  52
TRP A  55
 None
 1.21A 2pnjB-4hq1A:
undetectable		 2pnjB-4hq1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		6 LEU A 515
PHE A 511
LEU A 369
ILE A 550
VAL A 380
VAL A 458
 None
 1.46A 2pnjB-4i1pA:
2.3		 2pnjB-4i1pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 PHE A 193
LEU A 199
MET A 220
ILE A 185
SER A 177
 None
 1.27A 2pnjB-4lxrA:
undetectable		 2pnjB-4lxrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjk CRISPR PROTEIN

(Archaeoglobus
fulgidus) 		PF09704
(Cas_Cas5d) 		5 LEU A  62
LEU A  66
ILE A 143
VAL A 260
VAL A   6
 None
 1.30A 2pnjB-4mjkA:
undetectable		 2pnjB-4mjkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxe N-ACETYLTRANSFERASE
ESCO1

(Homo sapiens) 		PF13880
(Acetyltransf_13) 		5 LEU A 791
LEU A 709
MET A 669
ILE A 766
VAL A 682
 None
 1.33A 2pnjB-4mxeA:
undetectable		 2pnjB-4mxeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 MET A  68
LEU A 217
LEU A  40
ILE A 393
SER A  39
 None
 1.37A 2pnjB-4nkyA:
undetectable		 2pnjB-4nkyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 317
PHE A 242
LEU A 326
ILE A 331
SER A 320
 None
 1.37A 2pnjB-4nreA:
undetectable		 2pnjB-4nreA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozt RETINOID X RECEPTOR

(Pediculus
humanus) 		PF00104
(Hormone_recep) 		5 LEU U 233
LEU U 225
ILE U 307
SER U 224
VAL U 329
 None
 1.32A 2pnjB-4oztU:
undetectable		 2pnjB-4oztU:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		5 LEU A 180
LEU A 177
ILE A  82
PRO A 155
VAL A 205
 None
 1.19A 2pnjB-4q22A:
undetectable		 2pnjB-4q22A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		5 MET A 529
LEU A 550
PHE A 570
LEU A 547
ILE A 519
 None
 1.02A 2pnjB-4q8gA:
undetectable		 2pnjB-4q8gA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 485
LEU A 488
ILE A  69
VAL A 470
VAL A 463
 None
 1.27A 2pnjB-4qaxA:
3.6		 2pnjB-4qaxA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcw SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 428
PHE A 419
LEU A 449
ILE A 411
VAL A 494
 None
 1.22A 2pnjB-4rcwA:
undetectable		 2pnjB-4rcwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 156
PHE A 147
LEU A 176
ILE A 139
VAL A 166
 None
 1.25A 2pnjB-4z0cA:
undetectable		 2pnjB-4z0cA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 405
LEU A 430
ILE A 366
PRO A 442
VAL A 441
 None
 1.35A 2pnjB-4z61A:
undetectable		 2pnjB-4z61A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU C 146
LEU C 170
ILE C 109
SER C 194
VAL C 205
 None
 1.36A 2pnjB-4z64C:
undetectable		 2pnjB-4z64C:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb INSULIN RECEPTOR

(Homo sapiens) 		PF00041
(fn3)
PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.19A 2pnjB-4zxbE:
undetectable		 2pnjB-4zxbE:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 LEU A  33
PHE A  42
ILE A  90
VAL A 355
VAL A 309
 None
 1.31A 2pnjB-5b3jA:
4.3		 2pnjB-5b3jA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		5 LEU B  26
PHE B  28
LEU B 218
ILE B  64
SER B  44
 None
None
None
None
ANP  B 301 (-3.4A)
 1.17A 2pnjB-5d3mB:
undetectable		 2pnjB-5d3mB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
alginolyticus) 		PF00392
(GntR)
PF07840
(FadR_C) 		5 LEU A 188
PHE A 189
LEU A 192
SER A 124
VAL A 251
 None
 1.27A 2pnjB-5dv5A:
undetectable		 2pnjB-5dv5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		5 LEU A 472
PHE A 473
LEU A 478
VAL A 487
VAL A 491
 None
 1.29A 2pnjB-5gslA:
3.0		 2pnjB-5gslA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		5 LEU A 492
LEU A 491
ILE A 168
SER A 574
PRO A 561
 None
 1.36A 2pnjB-5i6zA:
undetectable		 2pnjB-5i6zA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 5 LEU A 236
PHE A 240
LEU A 290
ILE A 267
SER A 196
 None
 1.37A 2pnjB-5jkqA:
undetectable		 2pnjB-5jkqA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 MET A 530
LEU A 340
PHE A 417
LEU A 519
MET A 522
 None
 1.36A 2pnjB-5kgnA:
undetectable		 2pnjB-5kgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 LEU A 133
PHE A 128
LEU A 151
VAL A  90
VAL A 116
 None
None
ACT  A 405 ( 4.5A)
None
None
 1.34A 2pnjB-5ko3A:
undetectable		 2pnjB-5ko3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E 385
PHE E 382
LEU E 419
ILE E 336
SER E 446
 None
 1.22A 2pnjB-5kqvE:
undetectable		 2pnjB-5kqvE:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrj BETA-XYLANASE

(Acremonium
chrysogenum) 		no annotation 5 LEU A 378
LEU A  96
ILE A 335
VAL A 101
VAL A 330
 None
 1.30A 2pnjB-5mrjA:
undetectable		 2pnjB-5mrjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 31

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05983
(Med7)
PF05669
(Med31) 		5 LEU X  85
LEU X  58
ILE X  36
PRO U  17
VAL U  20
 None
 1.35A 2pnjB-5svaX:
undetectable		 2pnjB-5svaX:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 5 LEU D 124
ILE D 190
SER D 123
VAL D 145
VAL D 169
 None
 1.32A 2pnjB-5ui3D:
undetectable		 2pnjB-5ui3D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 119
PHE A 218
LEU A 157
ILE A 245
SER A  27
 None
 1.37A 2pnjB-5ujuA:
2.4		 2pnjB-5ujuA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wid -

(-) 		no annotation 5 MET A 109
LEU A  74
PHE A  69
ILE A   4
PRO A  97
 None
 1.37A 2pnjB-5widA:
3.7		 2pnjB-5widA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 590
PHE A 591
LEU A 410
ILE A 461
VAL A 398
 None
 1.33A 2pnjB-5xxoA:
3.7		 2pnjB-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 LEU A 443
PHE A 363
LEU A 421
PRO A 406
VAL A 397
 None
 1.32A 2pnjB-5z24A:
undetectable		 2pnjB-5z24A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0k IOTA-CARRAGEENAN
SULFATASE

(Pseudoalteromonas) 		no annotation 5 LEU A  34
PHE A 348
LEU A  85
SER A  81
VAL A 339
 None
 1.26A 2pnjB-6b0kA:
undetectable		 2pnjB-6b0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 LEU A 668
MET A 199
ILE A 683
SER A 388
HIS A 703
 None
 1.26A 2pnjB-6czaA:
undetectable		 2pnjB-6czaA:
undetectable