SIMILAR PATTERNS OF AMINO ACIDS FOR 2PNJ_A_CHDA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxe TRANSCRIPTIONAL
REGULATOR ERG

(Homo sapiens) 		PF02198
(SAM_PNT) 		4 MET A 171
PRO A 131
VAL A 139
TRP A 134
 None
 1.43A 2pnjA-1sxeA:
undetectable		 2pnjA-1sxeA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkx SAM POINTED
DOMAIN-CONTAINING
ETS TRANSCRIPTION
FACTOR

(Homo sapiens) 		PF02198
(SAM_PNT) 		4 MET A  63
PRO A  24
VAL A  32
TRP A  27
 None
 1.33A 2pnjA-2dkxA:
undetectable		 2pnjA-2dkxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 MET B 756
PRO B 779
MET B 787
TRP B 788
 None
 1.06A 2pnjA-2fjaB:
undetectable		 2pnjA-2fjaB:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 MET A  99
PRO A 266
VAL A 305
MET A 308
TRP A 310
 CHD  A   2 (-4.0A)
CHD  A   2 ( 4.5A)
CHD  A   1 ( 4.9A)
None
CHD  A   2 (-4.7A)
 0.14A 2pnjA-3aqiA:
59.5		 2pnjA-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrh FOLATE RECEPTOR
ALPHA

(Homo sapiens) 		PF03024
(Folate_rec) 		4 MET A  16
PRO A  93
VAL A 110
TRP A  94
 None
 1.45A 2pnjA-4lrhA:
0.0		 2pnjA-4lrhA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6o PUTATIVE POLYKETIDE
SYNTHASE

(Brevibacillus
brevis) 		PF14765
(PS-DH) 		4 MET A2132
PRO A2163
VAL A2000
TRP A2002
 None
 1.28A 2pnjA-5j6oA:
0.0		 2pnjA-5j6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyj SPERM-EGG FUSION
PROTEIN JUNO

(Mus musculus) 		PF03024
(Folate_rec) 		4 MET A  28
PRO A 105
VAL A 123
TRP A 106
 None
 1.48A 2pnjA-5jyjA:
0.0		 2pnjA-5jyjA:
19.51