SIMILAR PATTERNS OF AMINO ACIDS FOR 2PNJ_A_CHDA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1af5 I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		5 LEU A  91
LEU A  88
PHE A  87
LEU A  84
VAL A  45
 None
 1.07A 2pnjA-1af5A:
undetectable		 2pnjA-1af5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al3 CYS REGULON
TRANSCRIPTIONAL
ACTIVATOR CYSB

(Klebsiella
aerogenes) 		PF03466
(LysR_substrate) 		5 LEU A 124
LEU A  95
ILE A 112
LEU A 161
VAL A 159
 None
 1.01A 2pnjA-1al3A:
undetectable		 2pnjA-1al3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8z TUBBY PROTEIN

(Mus musculus) 		PF01167
(Tub) 		6 LEU A 287
LEU A 297
LEU A 298
ILE A 245
LEU A 366
VAL A 342
 None
 1.09A 2pnjA-1c8zA:
undetectable		 2pnjA-1c8zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF
PELLE

(Drosophila
melanogaster) 		PF00531
(Death) 		5 LEU A 101
LEU A 104
PHE A 105
LEU A 108
ILE A  34
 None
 1.12A 2pnjA-1d2zA:
undetectable		 2pnjA-1d2zA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 613
MET A 625
ILE A 648
VAL A 630
VAL A 680
 None
 0.95A 2pnjA-1dedA:
undetectable		 2pnjA-1dedA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm1 MYOGLOBIN

(Aplysia
limacina) 		PF00042
(Globin) 		5 LEU A  29
LEU A  32
PHE A  33
ILE A  67
VAL A 100
 None
None
None
HEM  A 148 (-4.2A)
HEM  A 148 (-4.5A)
 1.08A 2pnjA-1dm1A:
undetectable		 2pnjA-1dm1A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 LEU A 249
LEU A 245
PHE A 248
ILE A 407
VAL A 198
 None
 1.10A 2pnjA-1floA:
undetectable		 2pnjA-1floA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		5 LEU A  28
LEU A  29
LEU A  18
LEU A 138
VAL A 202
 None
 1.09A 2pnjA-1jdzA:
4.1		 2pnjA-1jdzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 908
LEU A 849
LEU A 920
ILE A 883
VAL A 960
 None
 1.09A 2pnjA-1jx2A:
undetectable		 2pnjA-1jx2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 908
LEU A 849
LEU A 920
ILE A 883
VAL A 989
 None
 1.08A 2pnjA-1jx2A:
undetectable		 2pnjA-1jx2A:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		9 LEU A  59
LEU A  62
PHE A  63
ILE A  91
HIS A 235
LEU A 237
PRO A 238
VAL A 241
VAL A 277
 None
 0.61A 2pnjA-1lbqA:
47.9		 2pnjA-1lbqA:
49.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbq FERROCHELATASE

(Saccharomyces
cerevisiae) 		PF00762
(Ferrochelatase) 		5 MET A  46
HIS A 235
LEU A 237
PRO A 238
VAL A 241
 None
 1.05A 2pnjA-1lbqA:
47.9		 2pnjA-1lbqA:
49.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		5 LEU A 180
LEU A 183
HIS A 235
PRO A 211
VAL A 214
 None
3OH  A 300 (-4.3A)
3OH  A 300 (-4.3A)
None
None
 1.09A 2pnjA-1m33A:
2.9		 2pnjA-1m33A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A  83
LEU A 107
LEU A 129
ILE A  62
VAL A  72
 None
 1.11A 2pnjA-1oznA:
undetectable		 2pnjA-1oznA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 281
LEU A 278
LEU A 706
ILE A 295
LEU A 267
 None
 1.01A 2pnjA-1q8yA:
undetectable		 2pnjA-1q8yA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi7 PROTEIN
(N-GLYCOSIDASE)

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A  64
PHE A  55
ILE A 169
VAL A  27
VAL A 177
 None
 1.07A 2pnjA-1qi7A:
undetectable		 2pnjA-1qi7A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkq HYPOTHETICAL PROTEIN
YIDA

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 LEU A 100
LEU A  97
PHE A  96
LEU A  89
ILE A 171
 None
 1.11A 2pnjA-1rkqA:
2.7		 2pnjA-1rkqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy6 T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN

(Homo sapiens) 		PF16680
(Ig_4)
PF16681
(Ig_5) 		5 LEU A 167
LEU A 132
LEU A 197
ILE A 160
VAL A  11
 None
 1.02A 2pnjA-1sy6A:
undetectable		 2pnjA-1sy6A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9i DNA ENDONUCLEASE
I-CREI

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		5 LEU A  91
LEU A  88
PHE A  87
LEU A  84
VAL A  45
 None
 1.11A 2pnjA-1t9iA:
undetectable		 2pnjA-1t9iA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		5 LEU D 152
LEU D 155
LEU D 159
ILE D 196
VAL D 216
 None
 1.02A 2pnjA-1unlD:
undetectable		 2pnjA-1unlD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 221
LEU A 222
LEU A 175
ILE A 127
VAL A 325
 None
 1.13A 2pnjA-1ys4A:
3.6		 2pnjA-1ys4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2

(Archaeoglobus
fulgidus) 		PF02552
(CO_dh) 		5 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 0.97A 2pnjA-1ytlA:
3.6		 2pnjA-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 MET A  58
LEU A 473
LEU A 477
LEU A 481
LEU A 574
 None
 1.13A 2pnjA-1z8lA:
undetectable		 2pnjA-1z8lA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zd0 HYPOTHETICAL PROTEIN
PF0523

(Pyrococcus
furiosus) 		PF08617
(CGI-121) 		5 LEU A 118
LEU A 114
ILE A 123
PRO A  74
VAL A  73
 None
 1.13A 2pnjA-1zd0A:
undetectable		 2pnjA-1zd0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		5 LEU A  51
LEU A  54
PHE A  55
LEU A  58
VAL A  89
 None
 1.00A 2pnjA-2eg3A:
2.2		 2pnjA-2eg3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fim TUBBY RELATED
PROTEIN 1

(Homo sapiens) 		PF01167
(Tub) 		5 LEU A 275
LEU A 283
LEU A 284
LEU A 350
VAL A 328
 None
 1.01A 2pnjA-2fimA:
undetectable		 2pnjA-2fimA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 LEU A 135
LEU A 127
ILE A 221
LEU A 104
VAL A 103
 None
 1.09A 2pnjA-2g7lA:
undetectable		 2pnjA-2g7lA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 365
LEU A 368
PHE A 469
ILE A 351
VAL A 192
 None
 1.12A 2pnjA-2hi4A:
undetectable		 2pnjA-2hi4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A 231
LEU A 152
LEU A 250
ILE A 216
VAL A 297
 None
 1.06A 2pnjA-2hjsA:
3.2		 2pnjA-2hjsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		6 LEU A 387
LEU A 429
ILE A 372
LEU A 438
VAL A 462
VAL A 453
 None
 1.47A 2pnjA-2ilrA:
undetectable		 2pnjA-2ilrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		5 LEU A 345
ILE A 175
LEU A 441
VAL A 444
VAL A 158
 None
 1.09A 2pnjA-2obmA:
2.4		 2pnjA-2obmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE

(Thermobifida
fusca) 		PF13378
(MR_MLE_C) 		5 LEU A  12
LEU A 261
LEU A 258
ILE A  19
VAL A 240
 None
 1.05A 2pnjA-2opjA:
3.1		 2pnjA-2opjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhe BENCE-JONES PROTEIN
RHE (LIGHT CHAIN)

(Homo sapiens) 		PF07686
(V-set) 		5 LEU A   4
ILE A  29
LEU A  55
PRO A  56
VAL A  59
 None
 1.12A 2pnjA-2rheA:
undetectable		 2pnjA-2rheA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU B 326
LEU B 350
LEU B 371
ILE B 305
LEU B 363
 None
 1.01A 2pnjA-2v9tB:
undetectable		 2pnjA-2v9tB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU B 350
LEU B 374
LEU B 395
ILE B 329
LEU B 387
 None
 1.04A 2pnjA-2v9tB:
undetectable		 2pnjA-2v9tB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE

(Mycobacterium
avium) 		PF00186
(DHFR_1) 		5 LEU A  32
ILE A 125
LEU A  54
PRO A  55
VAL A  58
 VG9  A1168 (-4.7A)
None
None
VG9  A1168 ( 4.6A)
None
 1.06A 2pnjA-2w3wA:
undetectable		 2pnjA-2w3wA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Neisseria
meningitidis) 		PF00132
(Hexapep) 		5 LEU A  59
LEU A  80
ILE A  50
LEU A 146
VAL A 144
 None
 1.13A 2pnjA-2wlcA:
undetectable		 2pnjA-2wlcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5n 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Schizosaccharomyces
pombe) 		PF13519
(VWA_2) 		6 LEU A 125
LEU A 128
PHE A 156
MET A 132
ILE A 118
LEU A  96
 None
 1.44A 2pnjA-2x5nA:
3.0		 2pnjA-2x5nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  79
LEU A  16
LEU A  72
ILE A  88
VAL A  99
 None
 1.06A 2pnjA-2zvwA:
undetectable		 2pnjA-2zvwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 LEU A 110
LEU A  98
ILE A 133
LEU A  88
VAL A  94
 None
 0.99A 2pnjA-3a8kA:
undetectable		 2pnjA-3a8kA:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		6 LEU A 115
ILE A 119
HIS A 263
LEU A 265
PRO A 266
VAL A 269
 CHD  A   2 ( 4.8A)
None
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
 1.37A 2pnjA-3aqiA:
59.5		 2pnjA-3aqiA:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		12 MET A  76
LEU A  89
LEU A  92
PHE A  93
LEU A  98
MET A  99
ILE A 119
HIS A 263
LEU A 265
PRO A 266
VAL A 269
VAL A 305
 CHD  A   1 ( 3.8A)
None
CHD  A   1 (-4.8A)
CHD  A   1 ( 4.7A)
CHD  A   1 (-4.3A)
CHD  A   2 (-4.0A)
None
CHD  A   1 (-4.3A)
None
CHD  A   2 ( 4.5A)
None
CHD  A   1 ( 4.9A)
 0.35A 2pnjA-3aqiA:
59.5		 2pnjA-3aqiA:
99.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 418
LEU A 423
ILE A 414
LEU A 398
VAL A 140
 None
 1.09A 2pnjA-3b0hA:
undetectable		 2pnjA-3b0hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 729
LEU A 690
PHE A 694
LEU A 689
ILE A 757
 None
 1.03A 2pnjA-3c4fA:
undetectable		 2pnjA-3c4fA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		6 LEU A 119
LEU A 125
LEU A 262
LEU A 317
PRO A 318
VAL A 321
 None
 1.45A 2pnjA-3caxA:
undetectable		 2pnjA-3caxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 356
LEU A 353
ILE A  14
PRO A  92
VAL A 191
 None
 1.13A 2pnjA-3eoqA:
undetectable		 2pnjA-3eoqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9u PUTATIVE EXPORTED
CYTOCHROME C
BIOGENESIS-RELATED
PROTEIN

(Bacteroides
fragilis) 		PF13899
(Thioredoxin_7) 		5 LEU A 549
LEU A 585
PHE A 551
ILE A 634
VAL A 597
 None
 1.12A 2pnjA-3f9uA:
undetectable		 2pnjA-3f9uA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 601
LEU A 574
LEU A 549
ILE A 594
LEU A 511
 None
 0.94A 2pnjA-3fxiA:
undetectable		 2pnjA-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		6 MET A 243
LEU A 277
PHE A 304
LEU A 280
LEU A 231
VAL A 255
 None
 1.17A 2pnjA-3fxiA:
undetectable		 2pnjA-3fxiA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 LEU A 344
LEU A 364
LEU A 384
LEU A 397
PRO A 398
 None
 1.13A 2pnjA-3g06A:
undetectable		 2pnjA-3g06A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3y CARBOHYDRATE KINASE

(Klebsiella
pneumoniae) 		PF00294
(PfkB) 		5 LEU A 239
LEU A 235
ILE A 132
LEU A 189
PRO A 191
 None
 0.91A 2pnjA-3i3yA:
2.0		 2pnjA-3i3yA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lly AGGLUTININ ALPHA
CHAIN

(Maclura
pomifera) 		PF01419
(Jacalin) 		5 LEU A  28
LEU A 124
ILE A  12
VAL A  72
VAL A  68
 None
 1.07A 2pnjA-3llyA:
undetectable		 2pnjA-3llyA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		5 LEU A  91
LEU A  88
PHE A  87
LEU A  84
VAL A  45
 None
 1.10A 2pnjA-3mx9A:
undetectable		 2pnjA-3mx9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		5 LEU A 184
LEU A 157
LEU A 160
LEU A  92
VAL A 134
 None
 0.93A 2pnjA-3nnkA:
2.7		 2pnjA-3nnkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 352
LEU A 354
LEU A 396
ILE A 340
LEU A 142
 None
 1.07A 2pnjA-3otrA:
undetectable		 2pnjA-3otrA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf2 30S RIBOSOMAL
PROTEIN S8

(Aquifex
aeolicus) 		PF00410
(Ribosomal_S8) 		5 LEU A  98
LEU A  37
ILE A  18
VAL A 148
VAL A 167
 None
 1.11A 2pnjA-3rf2A:
undetectable		 2pnjA-3rf2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 MET A 308
LEU A 261
LEU A 284
VAL A 275
VAL A  16
 None
 0.95A 2pnjA-3sweA:
undetectable		 2pnjA-3sweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 729
LEU A 690
PHE A 694
LEU A 689
ILE A 757
 None
 1.07A 2pnjA-3tt0A:
undetectable		 2pnjA-3tt0A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 MET A 307
LEU A 260
LEU A 283
VAL A 274
VAL A  17
 None
 1.07A 2pnjA-3vcyA:
undetectable		 2pnjA-3vcyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6j SCPB

(Geobacillus
stearothermophilus) 		PF04079
(SMC_ScpB) 		5 LEU B 134
LEU B 137
LEU B 142
ILE B 122
LEU B 170
 None
 1.05A 2pnjA-3w6jB:
undetectable		 2pnjA-3w6jB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 LEU A 315
LEU A 316
LEU A 361
MET A 383
ILE A 324
 None
 1.05A 2pnjA-3zh4A:
undetectable		 2pnjA-3zh4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuz PROTEIN SHQ1

(Saccharomyces
cerevisiae) 		PF04925
(SHQ1) 		5 LEU A 338
LEU A 434
ILE A 180
LEU A 285
PRO A 286
 None
 1.11A 2pnjA-3zuzA:
undetectable		 2pnjA-3zuzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P
SAR1P

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00025
(Arf) 		5 LEU B 122
LEU A 304
ILE B  94
LEU A 308
VAL A 300
 None
 1.03A 2pnjA-4bziB:
4.8		 2pnjA-4bziB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		5 LEU A 546
LEU A 549
LEU A 555
ILE A 334
LEU A 447
 None
 0.99A 2pnjA-4dxbA:
undetectable		 2pnjA-4dxbA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 LEU A 216
LEU A 148
LEU A 362
PRO A 363
VAL A 366
 None
 1.07A 2pnjA-4ei8A:
2.1		 2pnjA-4ei8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 LEU A 298
LEU A 319
LEU A 342
ILE A 278
VAL A 308
 None
 0.97A 2pnjA-4fs7A:
undetectable		 2pnjA-4fs7A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7f ENOLASE

(Trypanosoma
cruzi) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 340
LEU A 342
LEU A 384
ILE A 328
LEU A 135
 None
 1.07A 2pnjA-4g7fA:
undetectable		 2pnjA-4g7fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jas HISTIDINE KINASE

(Thermotoga
maritima) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 LEU A 444
LEU A 309
LEU A 306
LEU A 266
PRO A 265
 None
 1.06A 2pnjA-4jasA:
undetectable		 2pnjA-4jasA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jsb ENOYL-COA HYDRATASE

(Thermobifida
fusca) 		PF00378
(ECH_1) 		5 LEU A  12
LEU A  17
LEU A  30
VAL A 129
VAL A  61
 None
 1.07A 2pnjA-4jsbA:
undetectable		 2pnjA-4jsbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		5 LEU A 823
PHE A 822
LEU A 819
ILE A 830
LEU A 660
 None
 0.99A 2pnjA-4k0eA:
undetectable		 2pnjA-4k0eA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k82 LV-RANASPUMIN
(LV-RSN-1)

(Leptodactylus
vastus) 		no annotation 5 LEU A 198
PHE A 191
LEU A 201
LEU A 138
VAL A 145
 None
 1.06A 2pnjA-4k82A:
undetectable		 2pnjA-4k82A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB

(Salmonella
enterica) 		PF03466
(LysR_substrate) 		5 LEU B 124
LEU B  95
ILE B 112
LEU B 161
VAL B 159
 None
 1.07A 2pnjA-4lp2B:
undetectable		 2pnjA-4lp2B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2x DIHYDROFOLATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF00186
(DHFR_1) 		5 LEU A 149
ILE A 117
LEU A  50
PRO A  51
VAL A  54
 None
None
None
TMQ  A 202 (-4.2A)
None
 0.82A 2pnjA-4m2xA:
undetectable		 2pnjA-4m2xA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 359
LEU A 362
LEU A 386
ILE A 332
PRO A 401
 None
 1.05A 2pnjA-4mn8A:
undetectable		 2pnjA-4mn8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 LEU A 859
LEU A 862
PHE A 863
ILE A 834
LEU A 927
 None
 1.08A 2pnjA-4n3nA:
2.0		 2pnjA-4n3nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 LEU A 649
LEU A 652
PHE A 653
LEU A 400
LEU A 332
 None
 1.12A 2pnjA-4o5pA:
2.7		 2pnjA-4o5pA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 LEU B 527
LEU B 524
LEU B 521
ILE B 491
LEU B 477
 None
 1.09A 2pnjA-4oavB:
undetectable		 2pnjA-4oavB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		5 MET A 366
LEU A 417
LEU A 420
ILE A 406
PRO A 274
 None
 1.01A 2pnjA-4ogcA:
undetectable		 2pnjA-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A 251
LEU A 275
LEU A 295
LEU A 308
PRO A 309
 None
 1.11A 2pnjA-4ow2A:
undetectable		 2pnjA-4ow2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow2 YOP EFFECTOR YOPM

(Yersinia
enterocolitica) 		PF12468
(TTSSLRR) 		5 LEU A 271
LEU A 295
LEU A 315
LEU A 328
PRO A 329
 None
 1.12A 2pnjA-4ow2A:
undetectable		 2pnjA-4ow2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		6 LEU A 310
LEU A 338
LEU A 332
LEU A 372
VAL A 353
VAL A 315
 None
 1.40A 2pnjA-4perA:
undetectable		 2pnjA-4perA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pph CONGLUTIN GAMMA

(Lupinus
angustifolius) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 LEU A 317
LEU A 287
LEU A 333
VAL A 242
VAL A 247
 None
 1.01A 2pnjA-4pphA:
undetectable		 2pnjA-4pphA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9v TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8-LIKE
PROTEIN 3

(Homo sapiens) 		PF05527
(DUF758) 		5 LEU A 222
LEU A 226
LEU A 169
VAL A 252
VAL A 151
 None
 1.10A 2pnjA-4q9vA:
undetectable		 2pnjA-4q9vA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2f EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudarthrobacter
chlorophenolicus) 		PF01547
(SBP_bac_1) 		5 LEU A 140
LEU A 350
LEU A 353
ILE A 137
VAL A 153
 None
 1.12A 2pnjA-4r2fA:
undetectable		 2pnjA-4r2fA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU A  96
LEU A 120
LEU A 144
ILE A  77
LEU A 161
 None
 1.13A 2pnjA-4r6jA:
undetectable		 2pnjA-4r6jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		5 LEU A 183
LEU A 179
ILE A 143
LEU A 195
VAL A 164
 None
 1.10A 2pnjA-4tx8A:
undetectable		 2pnjA-4tx8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A  90
LEU A 113
LEU A 133
LEU A 126
PRO A 127
 None
 1.13A 2pnjA-4tzhA:
undetectable		 2pnjA-4tzhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u06 LIC10831

(Leptospira
interrogans) 		PF12799
(LRR_4)
PF13855
(LRR_8) 		5 LEU A 209
LEU A 232
LEU A 252
LEU A 245
PRO A 246
 None
 1.06A 2pnjA-4u06A:
undetectable		 2pnjA-4u06A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A  54
LEU A  77
LEU A 100
ILE A  41
PRO A 111
 None
 1.09A 2pnjA-4u08A:
undetectable		 2pnjA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 166
LEU A 189
LEU A 209
LEU A 202
PRO A 203
 None
 1.01A 2pnjA-4u08A:
undetectable		 2pnjA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u08 LIC11098

(Leptospira
interrogans) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 189
LEU A 212
LEU A 232
LEU A 225
PRO A 226
 None
 1.09A 2pnjA-4u08A:
undetectable		 2pnjA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 296
LEU A 319
LEU A 339
LEU A 332
PRO A 333
 None
 1.08A 2pnjA-4u09A:
undetectable		 2pnjA-4u09A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 LEU A 802
LEU A 767
LEU A 754
ILE A 793
VAL A 750
 None
 1.10A 2pnjA-4u48A:
undetectable		 2pnjA-4u48A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Listeria
monocytogenes;
Eptatretus
burgeri;
synthetic
construct) 		PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 LEU B  98
LEU B 122
LEU B 146
ILE B  79
LEU B 163
 None
 1.12A 2pnjA-4uipB:
undetectable		 2pnjA-4uipB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5x DIABODY 310 VH
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 LEU B   4
ILE B  29
LEU B  55
PRO B  56
VAL B  59
 None
None
None
None
PEG  B 201 ( 4.8A)
 1.08A 2pnjA-4y5xB:
undetectable		 2pnjA-4y5xB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2817
LEU A2781
LEU A2828
ILE A2813
VAL A2832
 None
 1.07A 2pnjA-4z37A:
2.2		 2pnjA-4z37A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 729
LEU A 690
PHE A 694
LEU A 689
ILE A 757
 None
 1.08A 2pnjA-5a46A:
undetectable		 2pnjA-5a46A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis;
Coccidioides
immitis) 		PF00149
(Metallophos)
PF00254
(FKBP_C) 		5 LEU C 115
PHE C 117
ILE C 109
LEU A 330
VAL A 332
 None
FK5  C 201 (-4.7A)
None
None
None
 0.84A 2pnjA-5b8iC:
undetectable		 2pnjA-5b8iC:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Homo sapiens;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		5 LEU A1115
LEU A1112
PHE A1111
ILE A1153
VAL A1160
 None
 1.09A 2pnjA-5bz6A:
undetectable		 2pnjA-5bz6A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		6 LEU A 530
LEU A 527
LEU A 547
ILE A 532
LEU A 562
VAL A 321
 None
 1.46A 2pnjA-5cslA:
3.4		 2pnjA-5cslA:
9.23