SIMILAR PATTERNS OF AMINO ACIDS FOR 2PNC_B_CLUB809_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 ALA A 129
TYR A 167
MET A 135
TYR A 104
 None
 1.39A 2pncB-1c3lA:
undetectable		 2pncB-1c3lA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 ALA A 403
ASP A  37
TYR A  97
HIS A 402
 None
 1.32A 2pncB-1lqtA:
0.0		 2pncB-1lqtA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 ALA A  61
TYR A  62
ASP A  67
TYR A 127
 None
 1.31A 2pncB-1olpA:
0.0		 2pncB-1olpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		4 ALA A 108
ASP A  21
TYR A  28
HIS A 113
 None
 0.94A 2pncB-1q25A:
0.0		 2pncB-1q25A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		5 ALA A 382
TYR A 396
ASP A 398
TYR A 480
HIS A 530
 TPQ  A 478 ( 4.6A)
IMD  A 821 (-3.5A)
IMD  A 821 (-2.6A)
TPQ  A 478 ( 3.9A)
CU  A 801 (-3.2A)
 0.48A 2pncB-1w7cA:
43.7		 2pncB-1w7cA:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6m GLUTATHIONE-DEPENDEN
T
FORMALDEHYDE-ACTIVAT
ING ENZYME

(Paracoccus
denitrificans) 		PF04828
(GFA) 		4 ALA A 142
TYR A 172
MET A 180
HIS A  52
 None
 1.49A 2pncB-1x6mA:
undetectable		 2pncB-1x6mA:
15.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ALA A 370
TYR A 384
ASP A 386
TYR A 473
HIS A 522
 PAQ  A 471 ( 3.2A)
PAQ  A 471 ( 3.6A)
PAQ  A 471 ( 2.6A)
PAQ  A 471 ( 4.5A)
CU  A1737 (-3.1A)
 0.31A 2pncB-2c11A:
58.1		 2pncB-2c11A:
81.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ALA A 367
TYR A 368
ASP A 314
TYR A 240
 None
P3T  A 501 (-3.5A)
P3T  A 501 (-3.7A)
None
 1.06A 2pncB-2pljA:
undetectable		 2pncB-2pljA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		4 ALA A  51
TYR A  48
MET A 217
HIS A  53
 None
 1.43A 2pncB-2q14A:
undetectable		 2pncB-2q14A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 ALA A  27
TYR A  30
ASP A  31
HIS A  20
 None
 1.38A 2pncB-2qjpA:
undetectable		 2pncB-2qjpA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F

(Enterococcus
faecium) 		PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N) 		4 ALA A 418
MET A 568
TYR A 555
HIS A 398
 None
 1.41A 2pncB-2qr4A:
undetectable		 2pncB-2qr4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		4 ALA A  61
TYR A  62
ASP A  67
TYR A 127
 None
 1.36A 2pncB-2wxuA:
0.1		 2pncB-2wxuA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		4 ALA A  71
TYR A  68
ASP A  67
HIS A  76
 None
 1.49A 2pncB-3e29A:
undetectable		 2pncB-3e29A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		4 ALA A  54
TYR A  56
ASP A  13
HIS A 135
 MG  A 357 ( 4.2A)
None
MG  A 357 (-1.8A)
None
 1.34A 2pncB-3fdgA:
undetectable		 2pncB-3fdgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 ALA A 274
TYR A 193
MET A 317
HIS A 321
 None
 1.36A 2pncB-3gzyA:
undetectable		 2pncB-3gzyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfq UNCHARACTERIZED
PROTEIN LP_2219

(Lactobacillus
plantarum) 		PF10282
(Lactonase) 		4 ALA A 244
ASP A 290
TYR A  44
HIS A 191
 None
 1.44A 2pncB-3hfqA:
1.9		 2pncB-3hfqA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ALA A 357
TYR A 371
ASP A 373
TYR A 463
HIS A 512
 TPQ  A 461 ( 4.9A)
BRN  A 901 (-3.3A)
BRN  A 901 (-3.3A)
TPQ  A 461 ( 4.5A)
CU  A 801 (-3.2A)
 0.66A 2pncB-3higA:
50.4		 2pncB-3higA:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l23 SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 ALA A 143
ASP A 147
MET A  92
TYR A  82
 EDO  A   4 ( 3.8A)
None
None
EDO  A   4 (-4.5A)
 1.48A 2pncB-3l23A:
undetectable		 2pncB-3l23A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 ALA A  30
ASP A 338
TYR A 313
HIS A  39
 None
None
TAR  A 504 (-4.5A)
TAR  A 504 ( 4.6A)
 1.34A 2pncB-3opsA:
undetectable		 2pncB-3opsA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		4 ALA A 321
TYR A 317
TYR A 350
HIS A 324
 None
 1.20A 2pncB-3opsA:
undetectable		 2pncB-3opsA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		5 ALA A 407
TYR A 421
ASP A 423
TYR A 506
HIS A 554
 TPQ  A 504 ( 3.9A)
TPQ  A 504 ( 3.8A)
TPQ  A 504 ( 4.3A)
TPQ  A 504 ( 4.2A)
CU  A 901 (-3.2A)
 0.48A 2pncB-3pgbA:
41.6		 2pncB-3pgbA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6a UNCHARACTERIZED
PROTEIN

(Methanosarcina
mazei) 		no annotation 4 ALA A  86
MET A 101
TYR A 113
HIS A 105
 None
 1.33A 2pncB-3r6aA:
undetectable		 2pncB-3r6aA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 ASP A 164
MET A 148
TYR A 141
HIS A 104
 None
None
None
ZN  A 299 (-3.4A)
 1.46A 2pncB-3rxzA:
undetectable		 2pncB-3rxzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 TYR A 296
ASP A 298
TYR A 384
HIS A 433
 TYQ  A 382 ( 4.8A)
None
TYQ  A 382 ( 4.2A)
CU  A 701 (-3.2A)
 0.90A 2pncB-3x3yA:
39.5		 2pncB-3x3yA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		4 ALA B 172
TYR B 178
ASP A 232
TYR A 234
 None
 1.22A 2pncB-4cakB:
1.0		 2pncB-4cakB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ALA A 301
TYR A 302
MET A 379
HIS A 297
 None
None
None
CS2  A 501 (-3.7A)
 1.27A 2pncB-4im7A:
undetectable		 2pncB-4im7A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ALA A 190
TYR A 165
ASP A 188
TYR A 210
 None
 1.18A 2pncB-4z61A:
undetectable		 2pncB-4z61A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ALA A 237
TYR A 196
MET A 138
TYR A 223
 None
 1.49A 2pncB-4zo6A:
undetectable		 2pncB-4zo6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		4 ALA A 119
MET A 418
TYR A 426
HIS A 118
 None
 1.46A 2pncB-5dm3A:
undetectable		 2pncB-5dm3A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE

(Bacillus
subtilis) 		PF09819
(ABC_cobalt) 		4 ALA A 172
TYR A 173
ASP A 169
TYR A  58
 None
 1.48A 2pncB-5edlA:
undetectable		 2pncB-5edlA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN
MYOSIN-IIIB

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5)
no annotation 		4 ALA A 105
ASP C1264
TYR C1268
HIS A  75
 None
 1.39A 2pncB-5et1A:
undetectable		 2pncB-5et1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		4 ALA A 164
TYR A 167
TYR A 556
HIS A 194
 None
 1.45A 2pncB-5gamA:
undetectable		 2pncB-5gamA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ALA A 422
ASP A 994
TYR A 989
HIS A 975
 None
 1.43A 2pncB-5m5pA:
undetectable		 2pncB-5m5pA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ml9 AFFIMER F4 WITH
SPECIFICITY FOR FC
GAMMA RECEPTOR IIIA

(synthetic
construct) 		no annotation 4 ALA B  37
ASP B  70
TYR B  77
HIS B  31
 None
 1.10A 2pncB-5ml9B:
undetectable		 2pncB-5ml9B:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl CBK1 KINASE
ACTIVATOR PROTEIN
MOB2

(Saccharomyces
cerevisiae) 		no annotation 4 ALA B 178
TYR B 181
TYR B 141
HIS B 233
 None
 1.45A 2pncB-5nclB:
undetectable		 2pncB-5nclB:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE

(Planktothrix
agardhii) 		no annotation 4 ALA A  52
TYR A 292
TYR A 261
HIS A  22
 None
 1.43A 2pncB-5tu4A:
undetectable		 2pncB-5tu4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn3 ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 TYR G 217
MET G 100
TYR G 486
HIS G 249
 None
 1.39A 2pncB-5vn3G:
undetectable		 2pncB-5vn3G:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y70 KINETOPLASTID
MEMBRANE PROTEIN 11

(Trypanosoma
brucei) 		no annotation 4 ALA A   9
ASP A  13
MET A  54
HIS A  47
 None
 1.42A 2pncB-5y70A:
undetectable		 2pncB-5y70A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bc5 AAC 3-VI PROTEIN

(Enterobacter
cloacae) 		no annotation 4 ALA A 158
ASP A 136
MET A 207
TYR A 205
 None
 1.39A 2pncB-6bc5A:
undetectable		 2pncB-6bc5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 120

(Human
immunodeficiency
virus 1) 		no annotation 4 TYR C 217
MET C 100
TYR C 486
HIS C 249
 None
 1.47A 2pncB-6ccbC:
undetectable		 2pncB-6ccbC:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch0 -

(-) 		no annotation 4 ALA C 199
TYR C 239
TYR C 158
HIS C 120
 None
None
None
CO  C 302 ( 3.1A)
 1.46A 2pncB-6ch0C:
undetectable		 2pncB-6ch0C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE

(Homo sapiens) 		no annotation 4 ALA A  58
TYR A  55
ASP A  54
TYR A 255
 None
None
PO4  A 601 (-3.8A)
None
 1.37A 2pncB-6dd3A:
undetectable		 2pncB-6dd3A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 ALA B 702
TYR B 424
ASP B 582
TYR B 216
 None
 1.46A 2pncB-6f0kB:
undetectable		 2pncB-6f0kB:
9.97