SIMILAR PATTERNS OF AMINO ACIDS FOR 2PLW_A_SAMA203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		3 SER A  56
ASP A  13
ASP A 160
 None
 0.72A 2plwA-13pkA:
undetectable		 2plwA-13pkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		3 SER A 196
ASP A 131
ASP A 136
 None
 0.79A 2plwA-1airA:
undetectable		 2plwA-1airA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		3 SER A  44
ASP A 311
ASP A  38
 None
 0.72A 2plwA-1axnA:
undetectable		 2plwA-1axnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 SER A 453
ASP A 432
ASP A 456
 None
 0.66A 2plwA-1c0aA:
undetectable		 2plwA-1c0aA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		3 SER A 447
ASP A 402
ASP A 422
 None
 0.60A 2plwA-1dabA:
undetectable		 2plwA-1dabA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 SER A 131
ASP A  73
ASP A  42
 None
 0.78A 2plwA-1e5dA:
2.0		 2plwA-1e5dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		3 SER A  35
ASP A 226
ASP A  29
 HEM  A 350 (-2.7A)
None
None
 0.80A 2plwA-1fhfA:
undetectable		 2plwA-1fhfA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		3 SER 1 176
ASP 1 296
ASP 1 249
 None
 0.53A 2plwA-1g6q1:
7.0		 2plwA-1g6q1:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gey HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 SER A 141
ASP A 167
ASP A 136
 None
 0.66A 2plwA-1geyA:
2.6		 2plwA-1geyA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02306
(Phage_G) 		3 SER 2 132
ASP 2 140
ASP 2  63
 None
 0.76A 2plwA-1gff2:
undetectable		 2plwA-1gff2:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 SER P 379
ASP P 362
ASP P 341
 None
CA  P 505 ( 2.4A)
None
 0.80A 2plwA-1h71P:
undetectable		 2plwA-1h71P:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		3 SER A  97
ASP A  16
ASP A  23
 None
 0.76A 2plwA-1i2lA:
undetectable		 2plwA-1i2lA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		3 SER A 628
ASP A 356
ASP A 633
 None
 0.73A 2plwA-1m9iA:
undetectable		 2plwA-1m9iA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		3 SER A  26
ASP A 114
ASP A 108
 None
 0.74A 2plwA-1psqA:
undetectable		 2plwA-1psqA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 SER A 309
ASP A 180
ASP A 213
 None
CA  A 909 (-2.5A)
CA  A 908 (-2.5A)
 0.00A 2plwA-1q5aA:
undetectable		 2plwA-1q5aA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 SER A 309
ASP A 246
ASP A 216
 None
CA  A 910 (-2.3A)
CA  A 909 ( 2.6A)
 0.00A 2plwA-1q5aA:
undetectable		 2plwA-1q5aA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		3 SER A 125
ASP A 139
ASP A 119
 None
 0.74A 2plwA-1su7A:
4.0		 2plwA-1su7A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqz NECAP1

(Mus musculus) 		PF07933
(DUF1681) 		3 SER A  18
ASP A  62
ASP A  16
 None
 0.80A 2plwA-1tqzA:
undetectable		 2plwA-1tqzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvd T CELL RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 SER A  29
ASP A  32
ASP A  52
 None
 0.75A 2plwA-1tvdA:
undetectable		 2plwA-1tvdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 SER A 205
ASP A  27
ASP A 207
 None
 0.79A 2plwA-1vqvA:
undetectable		 2plwA-1vqvA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 SER A 133
ASP A  75
ASP A  44
 None
 0.66A 2plwA-1ycgA:
undetectable		 2plwA-1ycgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		3 SER A  37
ASP A  50
ASP A 171
 SAH  A 401 (-2.4A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.8A)
 0.41A 2plwA-1yfjA:
9.1		 2plwA-1yfjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		3 SER A 379
ASP A 195
ASP A 221
 None
 0.75A 2plwA-1z6rA:
undetectable		 2plwA-1z6rA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		3 SER A 460
ASP A 403
ASP A 435
 None
 0.79A 2plwA-2bexA:
undetectable		 2plwA-2bexA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		3 SER A 343
ASP A 158
ASP A  16
 None
 0.67A 2plwA-2eaeA:
undetectable		 2plwA-2eaeA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0y PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece sp.
ATCC 51142) 		PF00805
(Pentapeptide) 		3 SER A  40
ASP A  36
ASP A  18
 CA  A 142 (-3.2A)
CA  A 140 (-3.7A)
CA  A 141 (-4.9A)
 0.69A 2plwA-2g0yA:
undetectable		 2plwA-2g0yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go2 KUNITZ-TYPE SERINE
PROTEASE INHIBITOR
BBKI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		3 SER A 107
ASP A 104
ASP A  89
 None
 0.59A 2plwA-2go2A:
undetectable		 2plwA-2go2A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN

(Bordetella
bronchiseptica) 		PF03212
(Pertactin) 		3 SER G 480
ASP G 435
ASP G 455
 None
 0.60A 2plwA-2iouG:
undetectable		 2plwA-2iouG:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		3 SER A  86
ASP A 116
ASP A  82
 None
 0.74A 2plwA-2la7A:
undetectable		 2plwA-2la7A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		3 SER A  70
ASP A 110
ASP A  72
 None
 0.77A 2plwA-2mizA:
undetectable		 2plwA-2mizA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		3 SER A  39
ASP A  64
ASP A  37
 None
 0.74A 2plwA-2mt9A:
undetectable		 2plwA-2mt9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm1 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 SER A 903
ASP A1047
ASP A1049
 None
 0.55A 2plwA-2nm1A:
undetectable		 2plwA-2nm1A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		3 SER A  20
ASP A  16
ASP A   2
 None
 0.79A 2plwA-2ocaA:
undetectable		 2plwA-2ocaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0k POLYCOMB PROTEIN
SCMH1

(Homo sapiens) 		PF02820
(MBT) 		3 SER A 107
ASP A 215
ASP A 218
 None
 0.78A 2plwA-2p0kA:
undetectable		 2plwA-2p0kA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		3 SER A   4
ASP A  55
ASP A 113
 SAM  A 203 ( 4.5A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.72A 2plwA-2plwA:
38.5		 2plwA-2plwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		3 SER A  35
ASP A  55
ASP A 113
 SAM  A 203 (-2.4A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.02A 2plwA-2plwA:
38.5		 2plwA-2plwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhh CG3027-PA

(Drosophila
melanogaster) 		PF00795
(CN_hydrolase) 		3 SER A 317
ASP A  54
ASP A 334
 None
 0.75A 2plwA-2vhhA:
2.2		 2plwA-2vhhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqr PUTATIVE SULFATASE

(Rhizobium
leguminosarum) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 SER A  63
ASP A 372
ASP A 390
 None
 0.76A 2plwA-2vqrA:
2.1		 2plwA-2vqrA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		3 SER A  92
ASP A  65
ASP A 354
 None
 0.80A 2plwA-2vr2A:
undetectable		 2plwA-2vr2A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		3 SER A 471
ASP A 432
ASP A 477
 None
 0.70A 2plwA-2w5fA:
undetectable		 2plwA-2w5fA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 SER A  63
ASP A 372
ASP A 390
 None
 0.78A 2plwA-2w8sA:
2.2		 2plwA-2w8sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
vinaceus) 		PF02668
(TauD) 		3 SER A 161
ASP A 190
ASP A 329
 None
 0.79A 2plwA-2wbpA:
undetectable		 2plwA-2wbpA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm8 MAGNESIUM-DEPENDENT
PHOSPHATASE 1

(Homo sapiens) 		PF12689
(Acid_PPase) 		3 SER A  33
ASP A  40
ASP A  45
 EDO  A1163 (-4.6A)
None
None
 0.73A 2plwA-2wm8A:
3.4		 2plwA-2wm8A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE
LECTIN-LIKE FOLD
PROTEIN

(Agaricus
bisporus;
Agaricus
bisporus) 		PF00264
(Tyrosinase)
no annotation 		3 SER A   2
ASP A 348
ASP E  60
 None
 0.77A 2plwA-2y9xA:
undetectable		 2plwA-2y9xA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Flavobacterium
sp.) 		PF00144
(Beta-lactamase) 		3 SER A 240
ASP A 275
ASP A 252
 None
None
SO4  A 509 (-3.5A)
 0.53A 2plwA-2zm2A:
undetectable		 2plwA-2zm2A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		3 SER A 373
ASP A 342
ASP A 353
 None
 0.54A 2plwA-3a5vA:
undetectable		 2plwA-3a5vA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayd GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 SER A 194
ASP A 241
ASP A 239
 None
 0.67A 2plwA-3aydA:
undetectable		 2plwA-3aydA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7m THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA-LIKE

(Escherichia
coli) 		PF01323
(DSBA) 		3 SER A 181
ASP A   6
ASP A 187
 None
None
CD  A 198 (-2.1A)
 0.67A 2plwA-3c7mA:
undetectable		 2plwA-3c7mA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		3 SER A  98
ASP A 402
ASP A  89
 None
 0.75A 2plwA-3c9fA:
undetectable		 2plwA-3c9fA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doj DEHYDROGENASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 SER A  94
ASP A  97
ASP A  66
 None
 0.72A 2plwA-3dojA:
5.3		 2plwA-3dojA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 297
ASP A 324
ASP A 329
 None
 0.64A 2plwA-3eezA:
2.8		 2plwA-3eezA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)

(Salmonella
enterica) 		PF09982
(DUF2219) 		3 SER A 286
ASP A 283
ASP A  29
 None
None
ZN  A 300 (-2.1A)
 0.80A 2plwA-3fidA:
undetectable		 2plwA-3fidA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		3 SER A 196
ASP A 161
ASP A 116
 None
 0.67A 2plwA-3h14A:
undetectable		 2plwA-3h14A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		3 SER A  84
ASP A  50
ASP A 110
 None
 0.78A 2plwA-3h4xA:
undetectable		 2plwA-3h4xA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		3 SER A 230
ASP A 225
ASP A 236
 None
 0.66A 2plwA-3h5oA:
undetectable		 2plwA-3h5oA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		3 SER B 199
ASP B 178
ASP B 201
 None
 0.79A 2plwA-3j9oB:
undetectable		 2plwA-3j9oB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz3 SENSOR PROTEIN QSEC

(Escherichia
coli) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		3 SER A 354
ASP A 362
ASP A 323
 None
 0.71A 2plwA-3jz3A:
undetectable		 2plwA-3jz3A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		3 SER A 126
ASP A  73
ASP A  51
 None
 0.71A 2plwA-3kl7A:
undetectable		 2plwA-3kl7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mor CATHEPSIN B-LIKE
CYSTEINE PROTEASE

(Trypanosoma
brucei) 		PF00112
(Peptidase_C1) 		3 SER A 129
ASP A 143
ASP A 182
 GOL  A   3 (-3.3A)
None
GOL  A   3 ( 4.3A)
 0.63A 2plwA-3morA:
undetectable		 2plwA-3morA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 SER A 526
ASP A 529
ASP A 532
 None
 0.79A 2plwA-3ng9A:
undetectable		 2plwA-3ng9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		3 SER A 101
ASP A 117
ASP A 111
 None
 0.77A 2plwA-3o3pA:
undetectable		 2plwA-3o3pA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN

(Geobacter
sulfurreducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 SER A  95
ASP A  98
ASP A  67
 None
 0.60A 2plwA-3pduA:
6.5		 2plwA-3pduA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pef 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING

(Geobacter
metallireducens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 SER A  95
ASP A  98
ASP A  67
 None
None
GOL  A 289 (-3.7A)
 0.59A 2plwA-3pefA:
5.4		 2plwA-3pefA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qq8 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 SER A  73
ASP A  79
ASP A  47
 None
 0.69A 2plwA-3qq8A:
undetectable		 2plwA-3qq8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 SER A 299
ASP A 303
ASP A 149
 None
 0.71A 2plwA-3s8dA:
undetectable		 2plwA-3s8dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		3 SER A  88
ASP A 247
ASP A 211
 ADE  A 400 (-2.7A)
None
ADE  A 400 (-2.8A)
 0.80A 2plwA-3s99A:
3.5		 2plwA-3s99A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 SER A3842
ASP A3301
ASP A3294
 None
 0.64A 2plwA-3vkgA:
undetectable		 2plwA-3vkgA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu4 KMHSV2

(Kluyveromyces
marxianus) 		no annotation 3 SER A 117
ASP A 114
ASP A  95
 None
 0.80A 2plwA-3vu4A:
undetectable		 2plwA-3vu4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		3 SER A 110
ASP A  66
ASP A  96
 None
 0.79A 2plwA-3wx7A:
undetectable		 2plwA-3wx7A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 SER A  84
ASP A 107
ASP A  88
 None
 0.74A 2plwA-4a2lA:
undetectable		 2plwA-4a2lA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5g ANIONIC PEROXIDASE

(Raphanus
sativus) 		PF00141
(peroxidase) 		3 SER A  37
ASP A 228
ASP A  31
 HEM  A1307 (-2.6A)
None
None
 0.81A 2plwA-4a5gA:
undetectable		 2plwA-4a5gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cc1 PROTEIN JAGGED-1

(Homo sapiens) 		PF00008
(EGF)
PF01414
(DSL)
PF07657
(MNNL) 		3 SER A 141
ASP A  69
ASP A 144
 None
 0.68A 2plwA-4cc1A:
undetectable		 2plwA-4cc1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d82 AAA ATPASE, CENTRAL
DOMAIN PROTEIN

(Metallosphaera
sedula) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 SER A 166
ASP A 205
ASP A 202
 None
 0.78A 2plwA-4d82A:
undetectable		 2plwA-4d82A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		3 SER A   7
ASP A 149
ASP A 177
 None
 0.78A 2plwA-4dg5A:
undetectable		 2plwA-4dg5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 SER A 115
ASP A 133
ASP A 126
 None
 0.62A 2plwA-4dnsA:
undetectable		 2plwA-4dnsA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 SER A 160
ASP A 165
ASP A 136
 None
 0.70A 2plwA-4epaA:
undetectable		 2plwA-4epaA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		3 SER A  51
ASP A 421
ASP A 395
 None
 0.66A 2plwA-4f0lA:
undetectable		 2plwA-4f0lA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 SER A 398
ASP A 432
ASP A 335
 None
GOL  A 512 ( 3.2A)
None
 0.81A 2plwA-4fvlA:
undetectable		 2plwA-4fvlA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 SER A 360
ASP A 386
ASP A 354
 None
 0.75A 2plwA-4g1pA:
undetectable		 2plwA-4g1pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gom DNA ADENINE
METHYLASE

(Escherichia
coli) 		PF02086
(MethyltransfD12) 		3 SER D  40
ASP D  54
ASP D 181
 None
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.2A)
 0.77A 2plwA-4gomD:
3.4		 2plwA-4gomD:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		3 SER A  86
ASP A  10
ASP A  14
 None
CA  A 401 (-3.0A)
None
 0.76A 2plwA-4i70A:
undetectable		 2plwA-4i70A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 SER A  62
ASP A 139
ASP A  68
 None
 0.81A 2plwA-4j3qA:
undetectable		 2plwA-4j3qA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw3 ALPHA-HELICAL
ARTIFICIAL PROTEINS

(synthetic
construct) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		3 SER C  64
ASP C  89
ASP C  58
 None
 0.71A 2plwA-4jw3C:
undetectable		 2plwA-4jw3C:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 SER A 252
ASP A 367
ASP A 289
 None
 0.73A 2plwA-4lutA:
undetectable		 2plwA-4lutA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		3 SER A 147
ASP A 176
ASP A 316
 None
 0.70A 2plwA-4m2gA:
undetectable		 2plwA-4m2gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		3 SER A 114
ASP A  70
ASP A 100
 None
 0.80A 2plwA-4nz5A:
undetectable		 2plwA-4nz5A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		3 SER A 566
ASP A 826
ASP A 510
 None
 0.71A 2plwA-4q8gA:
undetectable		 2plwA-4q8gA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		3 SER A 432
ASP A 424
ASP A 480
 None
 0.60A 2plwA-4q9tA:
undetectable		 2plwA-4q9tA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpw GLYCOSYL HYDROLASE
FAMILY 10

(Bacteroides
intestinalis) 		no annotation 3 SER A 269
ASP A 163
ASP A 160
 None
 0.77A 2plwA-4qpwA:
undetectable		 2plwA-4qpwA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94

(Drosophila
melanogaster) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 SER A  70
ASP A  76
ASP A  44
 None
 0.81A 2plwA-4rv0A:
undetectable		 2plwA-4rv0A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		3 SER A  59
ASP A 364
ASP A 382
 None
 0.75A 2plwA-4upkA:
1.7		 2plwA-4upkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8l ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF00331
(Glyco_hydro_10) 		3 SER A 535
ASP A 529
ASP A 541
 None
 0.70A 2plwA-4w8lA:
undetectable		 2plwA-4w8lA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER C 357
ASP C 246
ASP C 378
 None
 0.76A 2plwA-4x0lC:
undetectable		 2plwA-4x0lC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		no annotation 3 SER G 566
ASP G 826
ASP G 510
 None
 0.68A 2plwA-4xr7G:
undetectable		 2plwA-4xr7G:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0w YEAZ

(Pseudomonas
aeruginosa) 		PF00814
(Peptidase_M22) 		3 SER A  26
ASP A   8
ASP A 190
 None
NA  A 302 (-3.6A)
None
 0.81A 2plwA-4y0wA:
undetectable		 2plwA-4y0wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y8f TRIOSEPHOSPHATE
ISOMERASE

(Clostridium
perfringens) 		PF00121
(TIM) 		3 SER A   2
ASP A 229
ASP A 206
 None
 0.70A 2plwA-4y8fA:
undetectable		 2plwA-4y8fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y8f TRIOSEPHOSPHATE
ISOMERASE

(Clostridium
perfringens) 		PF00121
(TIM) 		3 SER A   2
ASP A 231
ASP A 206
 None
 0.76A 2plwA-4y8fA:
undetectable		 2plwA-4y8fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		3 SER A 283
ASP A 101
ASP A 134
 None
 0.68A 2plwA-4zwvA:
undetectable		 2plwA-4zwvA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a51 AT3G17980

(Arabidopsis
thaliana) 		PF00168
(C2) 		3 SER A 107
ASP A  56
ASP A 110
 None
CA  A1196 (-3.4A)
CA  A1195 ( 4.5A)
 0.74A 2plwA-5a51A:
undetectable		 2plwA-5a51A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a53 REGULATOR OF
RIBOSOME
BIOSYNTHESIS
REGULATOR OF
RIBOSOME
BIOSYNTHESIS
RIBOSOME BIOGENESIS
PROTEIN RPF2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04939
(RRS1)
no annotation
PF04427
(Brix) 		3 SER C 159
ASP A  22
ASP B  98
 None
 0.74A 2plwA-5a53C:
undetectable		 2plwA-5a53C:
20.78