SIMILAR PATTERNS OF AMINO ACIDS FOR 2PIV_A_T3A933_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		5 PRO A 199
ILE A 198
PHE A 197
GLU A 172
ASN A 173
 None
 1.16A 2pivA-1kk0A:
0.0		 2pivA-1kk0A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		5 ILE A 308
GLY A  36
TYR A 316
GLU A 431
ARG A 453
 None
 1.43A 2pivA-1qafA:
0.0		 2pivA-1qafA:
15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ILE A 672
PHE A 673
GLY A 724
GLU A 829
ASN A 833
TYR A 834
GLU A 837
 None
 0.90A 2pivA-2ax9A:
40.8		 2pivA-2ax9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 672
PHE A 673
GLY A 724
TYR A 834
GLU A 837
ARG A 840
 None
 1.06A 2pivA-2ax9A:
40.8		 2pivA-2ax9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 PRO A 357
ILE A 358
GLY A  68
ASN A 361
GLU A 360
 None
 1.47A 2pivA-2i14A:
0.0		 2pivA-2i14A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1i PR DOMAIN ZINC
FINGER PROTEIN 16

(Homo sapiens) 		PF00856
(SET) 		5 ILE A 188
GLY A 127
GLU A 129
GLU A 190
ARG A 118
 None
 1.35A 2pivA-2n1iA:
undetectable		 2pivA-2n1iA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 GLY A  52
GLU A 157
ASN A 161
TYR A 162
GLU A 165
 None
 0.78A 2pivA-2q3yA:
37.7		 2pivA-2q3yA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B

(Mus musculus) 		PF03643
(Vps26) 		5 ILE A 262
GLY A 121
GLU A 224
ASN A 123
TYR A  77
 None
 1.38A 2pivA-2r51A:
undetectable		 2pivA-2r51A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		5 ILE A 239
PHE A 238
GLU A 210
ASN A 214
TYR A 215
 None
 0.80A 2pivA-2rfoA:
0.0		 2pivA-2rfoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 974
GLY A1012
TYR A 211
GLU A 978
ARG A 351
 None
None
None
OMT  A2473 ( 4.9A)
None
 1.18A 2pivA-2vdcA:
0.0		 2pivA-2vdcA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		5 PHE A 246
GLY A 234
GLU A 174
GLU A 250
ARG A 166
 None
 1.35A 2pivA-3clhA:
undetectable		 2pivA-3clhA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S25,
MITOCHONDRIAL

(Bos taurus) 		PF14955
(MRP-S24) 		5 PRO c  53
ILE c  52
PHE c  50
GLY c  43
GLU c  97
 None
 1.20A 2pivA-3jd5c:
undetectable		 2pivA-3jd5c:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx3 SUSD HOMOLOG

(Bacteroides
fragilis) 		PF12771
(SusD-like_2) 		5 PRO A 148
GLY A 131
GLU A 129
TYR A 472
GLU A 476
 None
None
EPE  A 602 (-3.0A)
None
None
 1.37A 2pivA-3mx3A:
undetectable		 2pivA-3mx3A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ILE A 410
GLY A 401
GLU A 440
TYR A 431
GLU A 428
 None
 1.39A 2pivA-3ua4A:
undetectable		 2pivA-3ua4A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 PRO A 388
ILE A 385
GLY A 460
ASN A 382
ARG A 296
 None
 1.30A 2pivA-4bugA:
undetectable		 2pivA-4bugA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 PRO A 506
ILE A 507
GLY A 529
GLU A 532
ARG A 500
 None
P6G  A 715 (-4.8A)
None
None
None
 1.36A 2pivA-4hhrA:
undetectable		 2pivA-4hhrA:
15.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 789
GLU A 894
ASN A 898
TYR A 899
GLU A 902
 None
 0.58A 2pivA-4udbA:
34.3		 2pivA-4udbA:
48.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 ILE A 234
GLY A  91
ASN A  86
GLU A  87
ARG A 227
 None
 1.50A 2pivA-4wpzA:
2.3		 2pivA-4wpzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		5 PRO A 704
ILE A 724
GLY A 733
GLU A 784
TYR A 781
 None
 1.50A 2pivA-5e55A:
undetectable		 2pivA-5e55A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 5 ILE B 590
GLY B 584
GLU B 581
ASN B 579
GLU B 577
 None
 1.25A 2pivA-5kdjB:
undetectable		 2pivA-5kdjB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLY A 789
GLU A 894
ASN A 898
TYR A 899
GLU A 902
 None
 0.46A 2pivA-5mwpA:
37.2		 2pivA-5mwpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		5 ILE A 468
GLY A 418
TYR A 448
GLU A 449
ARG A 454
 None
 1.07A 2pivA-5o0sA:
undetectable		 2pivA-5o0sA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqj KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Staphylococcus
aureus) 		no annotation 5 PRO A  81
ILE A  84
GLY A 297
GLU A 300
TYR A 302
 NDP  A 407 (-3.7A)
NDP  A 407 (-4.3A)
None
None
None
 1.43A 2pivA-6aqjA:
undetectable		 2pivA-6aqjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTH
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT

(Rhodothermus
marinus) 		no annotation 5 PRO E  95
ILE E  94
GLY E 106
GLU E 101
TYR H 159
 None
 1.50A 2pivA-6f0kE:
undetectable		 2pivA-6f0kE:
15.32