SIMILAR PATTERNS OF AMINO ACIDS FOR 2PGZ_A_COCA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb0 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		5 TYR A  38
TYR A  74
GLN A  79
MET A  84
ILE A  78
 ACT  A 901 (-4.7A)
None
None
None
None
 1.39A 2pgzA-2fb0A:
0.0
2pgzB-2fb0A:
0.0		 2pgzA-2fb0A:
18.48
2pgzB-2fb0A:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 5 THR A  34
TYR A  53
GLN A  55
MET A 114
ILE A 116
 None
 0.51A 2pgzA-5xglA:
29.9
2pgzB-5xglA:
30.5		 2pgzA-5xglA:
98.75
2pgzB-5xglA:
98.75