SIMILAR PATTERNS OF AMINO ACIDS FOR 2PGR_A_DCFA501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
12as ASPARAGINE
SYNTHETASE

(Escherichia
coli) 		PF03590
(AsnA) 		3 LEU A 133
LEU A  27
PHE A 197
 None
 0.72A 2pgrA-12asA:
undetectable		 2pgrA-12asA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU A  26
LEU A 137
PHE A  82
 None
 0.69A 2pgrA-1as4A:
undetectable		 2pgrA-1as4A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus) 		PF00079
(Serpin) 		3 LEU A 336
LEU A  79
PHE A 107
 None
 0.55A 2pgrA-1attA:
undetectable		 2pgrA-1attA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b47 CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		3 LEU A 300
LEU A  87
PHE A 271
 None
 0.73A 2pgrA-1b47A:
undetectable		 2pgrA-1b47A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqi PROTEIN
(SUCCINYL-COA
SYNTHETASE BETA
CHAIN)

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		3 LEU B 110
LEU B 149
PHE B 177
 None
 0.72A 2pgrA-1cqiB:
2.1		 2pgrA-1cqiB:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		3 LEU A 163
LEU A 141
PHE A 161
 None
 0.68A 2pgrA-1cvmA:
undetectable		 2pgrA-1cvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 LEU C 210
LEU C 381
PHE C 233
 None
 0.73A 2pgrA-1d7wC:
undetectable		 2pgrA-1d7wC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 LEU A  92
LEU B 264
PHE A 118
 None
 0.58A 2pgrA-1ezvA:
undetectable		 2pgrA-1ezvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0v PROTEINASE A

(Saccharomyces
cerevisiae) 		PF00026
(Asp) 		3 LEU A 123
LEU A  94
PHE A 153
 None
 0.74A 2pgrA-1g0vA:
undetectable		 2pgrA-1g0vA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		3 LEU A 102
LEU A 254
PHE A 148
 None
 0.65A 2pgrA-1gcbA:
undetectable		 2pgrA-1gcbA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		3 LEU 1 351
LEU 1 283
PHE 1 314
 None
 0.72A 2pgrA-1gt91:
undetectable		 2pgrA-1gt91:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		3 LEU A 313
LEU A 359
PHE A 273
 None
 0.69A 2pgrA-1gz5A:
undetectable		 2pgrA-1gz5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 LEU A 335
LEU A 326
PHE A 160
 None
 0.71A 2pgrA-1hlgA:
undetectable		 2pgrA-1hlgA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 LEU A  55
LEU A  95
PHE A  70
 None
 0.71A 2pgrA-1igrA:
undetectable		 2pgrA-1igrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 LEU A 734
LEU A 487
PHE A 774
 None
 0.72A 2pgrA-1j0nA:
undetectable		 2pgrA-1j0nA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0w DOWNSTREAM OF
TYROSINE KINASE 5

(Homo sapiens) 		PF02174
(IRS) 		3 LEU A  40
LEU A  55
PHE A  85
 None
 0.58A 2pgrA-1j0wA:
undetectable		 2pgrA-1j0wA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 LEU A 182
LEU A 451
PHE A 141
 None
 0.73A 2pgrA-1jf5A:
3.8		 2pgrA-1jf5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  80
LEU A 117
PHE A 105
 None
 0.71A 2pgrA-1kgsA:
undetectable		 2pgrA-1kgsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		3 LEU A 175
LEU A 126
PHE A 152
 None
 0.70A 2pgrA-1kl9A:
undetectable		 2pgrA-1kl9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 LEU A  32
LEU A 309
PHE A  11
 None
 0.71A 2pgrA-1lwhA:
3.9		 2pgrA-1lwhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		3 LEU A 249
LEU A  44
PHE A 245
 None
 0.70A 2pgrA-1m33A:
2.5		 2pgrA-1m33A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		3 LEU A 392
LEU A 612
PHE A 422
 None
 0.72A 2pgrA-1ms8A:
undetectable		 2pgrA-1ms8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvo PHOP RESPONSE
REGULATOR

(Bacillus
subtilis) 		PF00072
(Response_reg) 		3 LEU A  80
LEU A  49
PHE A 105
 None
 0.61A 2pgrA-1mvoA:
undetectable		 2pgrA-1mvoA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LEU X  37
LEU X  67
PHE X 170
 None
 0.67A 2pgrA-1mw9X:
undetectable		 2pgrA-1mw9X:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 LEU A 104
LEU A  94
PHE A 169
 None
 0.63A 2pgrA-1ns3A:
undetectable		 2pgrA-1ns3A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4s ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 LEU A 340
LEU A 363
PHE A 319
 None
 0.64A 2pgrA-1o4sA:
undetectable		 2pgrA-1o4sA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 LEU A 216
LEU A 161
PHE A 258
 None
 0.68A 2pgrA-1osnA:
undetectable		 2pgrA-1osnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2x RAS
GTPASE-ACTIVATING-LI
KE PROTEIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 LEU A 143
LEU A  55
PHE A 110
 None
 0.70A 2pgrA-1p2xA:
undetectable		 2pgrA-1p2xA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5s RAS
GTPASE-ACTIVATING-LI
KE PROTEIN RNG2

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 LEU A 143
LEU A  55
PHE A 110
 HG  A 191 ( 4.8A)
None
None
 0.60A 2pgrA-1p5sA:
undetectable		 2pgrA-1p5sA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdr HUMAN DISCS LARGE
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 LEU A 495
LEU A 532
PHE A 493
 None
 0.67A 2pgrA-1pdrA:
undetectable		 2pgrA-1pdrA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 LEU A  66
LEU A 122
PHE A  62
 None
 0.70A 2pgrA-1pgjA:
undetectable		 2pgrA-1pgjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzt BETA-1,4-GALACTOSYLT
RANSFERASE 1

(Bos taurus) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		3 LEU A 240
LEU A 378
PHE A 248
 None
 0.72A 2pgrA-1pztA:
undetectable		 2pgrA-1pztA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		3 LEU A 112
LEU A   6
PHE A 116
 None
 0.68A 2pgrA-1qrdA:
undetectable		 2pgrA-1qrdA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 LEU X 109
LEU X  58
PHE X 113
 None
 0.71A 2pgrA-1r6bX:
undetectable		 2pgrA-1r6bX:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		3 LEU A  98
LEU A  33
PHE A  51
 None
 0.55A 2pgrA-1s8eA:
3.4		 2pgrA-1s8eA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		3 LEU A  15
LEU A  76
PHE A  82
 None
 0.62A 2pgrA-1sc6A:
undetectable		 2pgrA-1sc6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sd5 PUTATIVE
ANTITERMINATOR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF03861
(ANTAR) 		3 LEU A  91
LEU A  61
PHE A 116
 None
None
IOD  A 414 (-3.9A)
 0.56A 2pgrA-1sd5A:
undetectable		 2pgrA-1sd5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		3 LEU A 318
LEU A  94
PHE A 338
 None
 0.67A 2pgrA-1sh2A:
undetectable		 2pgrA-1sh2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5b ACYL CARRIER PROTEIN
PHOSPHODIESTERASE

(Salmonella
enterica) 		PF02525
(Flavodoxin_2) 		3 LEU A 105
LEU A   5
PHE A 109
 None
 0.69A 2pgrA-1t5bA:
undetectable		 2pgrA-1t5bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		3 LEU A 581
LEU A 573
PHE A 601
 None
 0.74A 2pgrA-1t6pA:
undetectable		 2pgrA-1t6pA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7k GAG POLYPROTEIN

(Murine leukemia
virus) 		PF02093
(Gag_p30) 		3 LEU A  58
LEU A 115
PHE A  15
 None
 0.72A 2pgrA-1u7kA:
undetectable		 2pgrA-1u7kA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhl OXYSTEROLS RECEPTOR
LXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU B 217
LEU B 381
PHE B 271
 None
 0.66A 2pgrA-1uhlB:
undetectable		 2pgrA-1uhlB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3

(Pseudomonas
savastanoi) 		PF03543
(Peptidase_C58) 		3 LEU A  82
LEU A 204
PHE A 233
 None
 0.70A 2pgrA-1ukfA:
undetectable		 2pgrA-1ukfA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2
UPF3X

(Homo sapiens) 		PF02854
(MIF4G)
PF03467
(Smg4_UPF3) 		3 LEU B 910
LEU A  89
PHE B 899
 None
 0.67A 2pgrA-1uw4B:
undetectable		 2pgrA-1uw4B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		3 LEU A   5
LEU A 219
PHE A  97
 None
 0.68A 2pgrA-1uxtA:
undetectable		 2pgrA-1uxtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 LEU A 483
LEU A  48
PHE A  82
 None
 0.69A 2pgrA-1v4gA:
undetectable		 2pgrA-1v4gA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		3 LEU A 146
LEU A  87
PHE A 105
 None
 0.63A 2pgrA-1v4vA:
undetectable		 2pgrA-1v4vA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		3 LEU A 257
LEU A 187
PHE A  52
 None
 0.47A 2pgrA-1v72A:
2.1		 2pgrA-1v72A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		3 LEU A  28
LEU A  98
PHE A 119
 None
 0.60A 2pgrA-1vc4A:
5.5		 2pgrA-1vc4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		3 LEU A  97
LEU A 246
PHE A  75
 None
None
SAM  A3142 (-3.2A)
 0.72A 2pgrA-1wg8A:
undetectable		 2pgrA-1wg8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv2 THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Pseudomonas
aeruginosa) 		PF05690
(ThiG) 		3 LEU A1163
LEU A1152
PHE A1118
 None
 0.73A 2pgrA-1wv2A:
6.1		 2pgrA-1wv2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 LEU A 416
LEU A 141
PHE A 265
 None
 0.61A 2pgrA-1x55A:
undetectable		 2pgrA-1x55A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		3 LEU A 346
LEU A 390
PHE A 261
 None
 0.53A 2pgrA-1x9sA:
undetectable		 2pgrA-1x9sA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LEU A  85
LEU A 122
PHE A 110
 None
 0.71A 2pgrA-1ys7A:
undetectable		 2pgrA-1ys7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzv HYPOTHETICAL PROTEIN

(Trypanosoma
cruzi) 		PF00857
(Isochorismatase) 		3 LEU A 123
LEU A   5
PHE A  16
 None
 0.68A 2pgrA-1yzvA:
undetectable		 2pgrA-1yzvA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1s HYPOTHETICAL PROTEIN
PA3332

(Pseudomonas
aeruginosa) 		PF12680
(SnoaL_2) 		3 LEU A  32
LEU A  11
PHE A  34
 None
 0.67A 2pgrA-1z1sA:
undetectable		 2pgrA-1z1sA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		3 LEU A 359
LEU A  28
PHE A 124
 None
 0.70A 2pgrA-1z3vA:
undetectable		 2pgrA-1z3vA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9a NAD(P)H-DEPENDENT
D-XYLOSE REDUCTASE

([Candida]
tenuis) 		PF00248
(Aldo_ket_red) 		3 LEU A  26
LEU A 103
PHE A  21
 None
 0.72A 2pgrA-1z9aA:
5.7		 2pgrA-1z9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 LEU A 148
LEU A 137
PHE A  69
 None
 0.72A 2pgrA-1z9nA:
undetectable		 2pgrA-1z9nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		3 LEU A  89
LEU A  72
PHE A  57
 None
 0.68A 2pgrA-1za4A:
undetectable		 2pgrA-1za4A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		3 LEU X 151
LEU X 163
PHE X 113
 None
 0.64A 2pgrA-1zv4X:
undetectable		 2pgrA-1zv4X:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		3 LEU A 381
LEU A   4
PHE A 247
 None
 0.47A 2pgrA-1zzgA:
undetectable		 2pgrA-1zzgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am4 ALPHA-1,3-MANNOSYL-G
LYCOPROTEIN
2-BETA-N-ACETYLGLUCO
SAMINYLTRANSFERASE

(Oryctolagus
cuniculus) 		PF03071
(GNT-I) 		3 LEU A 260
LEU A 272
PHE A 343
 None
 0.69A 2pgrA-2am4A:
undetectable		 2pgrA-2am4A:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		3 LEU A  60
LEU A  98
PHE A 145
 None
 0.54A 2pgrA-2amxA:
56.9		 2pgrA-2amxA:
69.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU I 335
LEU I  78
PHE I 106
 None
 0.57A 2pgrA-2b4xI:
undetectable		 2pgrA-2b4xI:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhn XPF ENDONUCLEASE

(Aeropyrum
pernix) 		PF02732
(ERCC4)
PF14520
(HHH_5) 		3 LEU A 127
LEU A  85
PHE A  69
 None
 0.50A 2pgrA-2bhnA:
undetectable		 2pgrA-2bhnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bka TAT-INTERACTING
PROTEIN TIP30

(Homo sapiens) 		PF13460
(NAD_binding_10) 		3 LEU A  92
LEU A  55
PHE A  72
 NDP  A 506 (-4.3A)
None
NDP  A 506 (-4.5A)
 0.72A 2pgrA-2bkaA:
undetectable		 2pgrA-2bkaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		3 LEU A 195
LEU A 150
PHE A 269
 None
 0.69A 2pgrA-2bxyA:
4.6		 2pgrA-2bxyA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyj HYPOTHETICAL PROTEIN
PH1505

(Pyrococcus
horikoshii) 		PF04430
(DUF498) 		3 LEU A  57
LEU A  48
PHE A  61
 None
 0.61A 2pgrA-2cyjA:
undetectable		 2pgrA-2cyjA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d07 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		3 LEU A 181
LEU A 292
PHE A 189
 None
 0.71A 2pgrA-2d07A:
undetectable		 2pgrA-2d07A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		3 LEU A 555
LEU A 485
PHE A 589
 None
 0.59A 2pgrA-2d7iA:
undetectable		 2pgrA-2d7iA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwg PROTEIN RUFY3

(Mus musculus) 		PF02759
(RUN) 		3 LEU A 230
LEU A 217
PHE A 122
 None
 0.65A 2pgrA-2dwgA:
undetectable		 2pgrA-2dwgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		3 LEU A  89
LEU A  72
PHE A  57
 None
 0.60A 2pgrA-2es3A:
undetectable		 2pgrA-2es3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN

(Escherichia
coli) 		PF03255
(ACCA) 		3 LEU A  58
LEU A 272
PHE A   8
 None
 0.62A 2pgrA-2f9yA:
undetectable		 2pgrA-2f9yA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbl HYPOTHETICAL PROTEIN
NE1496

(Nitrosomonas
europaea) 		PF01928
(CYTH) 		3 LEU A  91
LEU A  18
PHE A 131
 None
 0.72A 2pgrA-2fblA:
undetectable		 2pgrA-2fblA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fic BRIDGING INTEGRATOR
1

(Homo sapiens) 		PF03114
(BAR) 		3 LEU A  71
LEU A  79
PHE A 221
 None
 0.73A 2pgrA-2ficA:
undetectable		 2pgrA-2ficA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft3 BIGLYCAN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 LEU A  83
LEU A 114
PHE A  74
 None
 0.69A 2pgrA-2ft3A:
undetectable		 2pgrA-2ft3A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 LEU A 561
LEU A  57
PHE A 559
 None
 0.70A 2pgrA-2g5tA:
undetectable		 2pgrA-2g5tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g85 CHORISMATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF01264
(Chorismate_synt) 		3 LEU A 159
LEU A 244
PHE A 370
 None
 0.73A 2pgrA-2g85A:
undetectable		 2pgrA-2g85A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu2 ASPA PROTEIN

(Rattus
norvegicus) 		PF04952
(AstE_AspA) 		3 LEU A  68
LEU A  85
PHE A  72
 None
 0.73A 2pgrA-2gu2A:
undetectable		 2pgrA-2gu2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdo PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
plantarum) 		PF13419
(HAD_2) 		3 LEU A 206
LEU A 100
PHE A 197
 None
 0.53A 2pgrA-2hdoA:
undetectable		 2pgrA-2hdoA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdx SH2-B PH DOMAIN
CONTAINING SIGNALING
MEDIATOR 1 GAMMA
ISOFORM

(Mus musculus) 		PF00017
(SH2) 		3 LEU A 577
LEU A 581
PHE A 604
 None
 0.71A 2pgrA-2hdxA:
undetectable		 2pgrA-2hdxA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hly HYPOTHETICAL PROTEIN
ATU2299

(Agrobacterium
fabrum) 		PF09641
(DUF2026) 		3 LEU A  45
LEU A 123
PHE A 100
 None
 0.56A 2pgrA-2hlyA:
undetectable		 2pgrA-2hlyA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 LEU A  17
LEU A  33
PHE A  46
 None
None
GOL  A 610 (-4.9A)
 0.58A 2pgrA-2hr7A:
undetectable		 2pgrA-2hr7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		3 LEU A 368
LEU A 408
PHE A 382
 None
 0.72A 2pgrA-2hr7A:
undetectable		 2pgrA-2hr7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		3 LEU A  93
LEU A 267
PHE A 113
 None
 0.73A 2pgrA-2hxrA:
undetectable		 2pgrA-2hxrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 214
LEU A 173
PHE A 108
 None
 0.72A 2pgrA-2iagA:
undetectable		 2pgrA-2iagA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 LEU A  15
LEU A  88
PHE A 282
 None
 0.68A 2pgrA-2ip4A:
undetectable		 2pgrA-2ip4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m64 PHLP5

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		3 LEU A  78
LEU A 129
PHE A  93
 None
 0.73A 2pgrA-2m64A:
undetectable		 2pgrA-2m64A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9p SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		3 LEU A   8
LEU A 161
PHE A 107
 None
 0.68A 2pgrA-2m9pA:
undetectable		 2pgrA-2m9pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 LEU A 289
LEU A 148
PHE A 291
 None
None
DHK  A9241 (-3.4A)
 0.61A 2pgrA-2o7qA:
3.7		 2pgrA-2o7qA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8e DNA MISMATCH REPAIR
PROTEIN MSH6

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 LEU B 684
LEU B 638
PHE B 706
 None
 0.46A 2pgrA-2o8eB:
undetectable		 2pgrA-2o8eB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LEU A 200
LEU A 207
PHE A 186
 None
 0.73A 2pgrA-2ongA:
undetectable		 2pgrA-2ongA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 LEU A 478
LEU A 416
PHE A 558
 None
 0.69A 2pgrA-2ongA:
undetectable		 2pgrA-2ongA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		3 LEU B 186
LEU B 218
PHE B 179
 None
 0.66A 2pgrA-2p1nB:
undetectable		 2pgrA-2p1nB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		3 LEU A  30
LEU A   4
PHE A  26
 None
 0.73A 2pgrA-2pthA:
undetectable		 2pgrA-2pthA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		3 LEU A 155
LEU A 180
PHE A 151
 None
 0.71A 2pgrA-2q9tA:
undetectable		 2pgrA-2q9tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qas HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF04386
(SspB) 		3 LEU A 119
LEU A  29
PHE A 117
 None
 0.69A 2pgrA-2qasA:
undetectable		 2pgrA-2qasA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qaz SSPB PROTEIN

(Caulobacter
vibrioides) 		PF04386
(SspB) 		3 LEU A 119
LEU A  29
PHE A 117
 None
 0.71A 2pgrA-2qazA:
undetectable		 2pgrA-2qazA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8b UNCHARACTERIZED
PROTEIN ATU2452

(Agrobacterium
fabrum) 		PF01738
(DLH) 		3 LEU A 242
LEU A 169
PHE A  63
 None
 0.73A 2pgrA-2r8bA:
undetectable		 2pgrA-2r8bA:
20.94