SIMILAR PATTERNS OF AMINO ACIDS FOR 2PCP_B_1PCB227

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wt5 ANTI EGFR ANTIBODY
FV REGION

(Homo sapiens) 		PF07686
(V-set) 		5 TYR C  37
PHE C  94
GLY C  96
HIS A  35
SER A  99
 None
 0.50A 2pcpA-1wt5C:
22.8
2pcpB-1wt5C:
15.0		 2pcpA-1wt5C:
48.77
2pcpB-1wt5C:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Schizosaccharomyces
pombe) 		PF00575
(S1)
PF00623
(RNA_pol_Rpb1_2)
PF03876
(SHS2_Rpb7-N)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 TYR A 434
GLY A 435
TYR G  18
HIS G  15
SER G  17
 None
 1.39A 2pcpA-3h0gA:
0.0
2pcpB-3h0gA:
0.0		 2pcpA-3h0gA:
7.67
2pcpB-3h0gA:
7.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		5 PHE A  94
GLY A  96
TYR A 101
HIS A 162
TYR A 160
 None
 1.11A 2pcpA-3wbdA:
22.6
2pcpB-3wbdA:
22.3		 2pcpA-3wbdA:
54.98
2pcpB-3wbdA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbd SINGLE CHAIN FV
FRAGMENT OF MAB735

(Mus musculus) 		PF07686
(V-set) 		6 TYR A  37
PHE A  94
GLY A  96
TYR A 101
TYR A 160
HIS A 162
 None
 0.64A 2pcpA-3wbdA:
22.6
2pcpB-3wbdA:
22.3		 2pcpA-3wbdA:
54.98
2pcpB-3wbdA:
35.86