SIMILAR PATTERNS OF AMINO ACIDS FOR 2P2F_B_ACTB653_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		4 VAL A 224
THR A 223
VAL A 280
GLY A 277
 None
 0.99A 2p2fB-1egzA:
undetectable		 2p2fB-1egzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 VAL A  55
THR A  52
VAL A  40
GLY A  19
 None
 1.16A 2p2fB-1h5qA:
5.6		 2p2fB-1h5qA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 VAL A 106
THR A 107
VAL A 145
GLY A 144
 None
 1.18A 2p2fB-1hl2A:
undetectable		 2p2fB-1hl2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3y MRSD PROTEIN

(Bacillus sp.
HIL-Y85/54728) 		PF02441
(Flavoprotein) 		4 VAL 1 111
THR 1 110
VAL 1  41
GLY 1  14
 None
 0.87A 2p2fB-1p3y1:
3.6		 2p2fB-1p3y1:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 226
THR A 229
VAL A 264
GLY A 263
 None
 1.06A 2p2fB-1qpoA:
2.4		 2p2fB-1qpoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 267
THR A 305
VAL A 251
GLY A 252
 None
 1.02A 2p2fB-1rcqA:
undetectable		 2p2fB-1rcqA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 VAL A 138
THR A 111
VAL A 116
GLY A 115
 None
 1.18A 2p2fB-1t8hA:
undetectable		 2p2fB-1t8hA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		4 VAL A 226
THR A 225
VAL A 284
GLY A 281
 None
 1.00A 2p2fB-1tvpA:
undetectable		 2p2fB-1tvpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 VAL A  62
THR A  87
VAL A 130
GLY A 131
 None
 0.98A 2p2fB-1u5vA:
2.1		 2p2fB-1u5vA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		4 VAL A 150
THR A 151
VAL A  65
GLY A  21
 None
 0.77A 2p2fB-1uaxA:
undetectable		 2p2fB-1uaxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufl NITROGEN REGULATORY
PROTEIN P-II

(Thermus
thermophilus) 		PF00543
(P-II) 		4 VAL A  74
THR A  73
VAL A  65
GLY A  64
 None
 1.14A 2p2fB-1uflA:
2.1		 2p2fB-1uflA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 VAL A 104
THR A 102
VAL A  61
GLY A  59
 GOL  A 305 ( 4.6A)
GOL  A 305 ( 4.1A)
None
GOL  A 305 (-3.2A)
 1.18A 2p2fB-1xc3A:
undetectable		 2p2fB-1xc3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 VAL B  90
THR B  89
VAL B  58
GLY B  56
 None
 1.16A 2p2fB-1y75B:
undetectable		 2p2fB-1y75B:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 VAL A 158
THR A 157
VAL A 375
GLY A 374
 None
 1.10A 2p2fB-2cxeA:
undetectable		 2p2fB-2cxeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 479
THR A 478
VAL A 448
GLY A 449
 None
 0.96A 2p2fB-2d3tA:
3.8		 2p2fB-2d3tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		4 VAL A  25
THR A   7
VAL A 126
GLY A 123
 None
 1.12A 2p2fB-2dt8A:
undetectable		 2p2fB-2dt8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f02 TAGATOSE-6-PHOSPHATE
KINASE

(Enterococcus
faecalis) 		PF00294
(PfkB) 		4 VAL A 131
THR A 132
VAL A  42
GLY A  39
 None
 1.16A 2p2fB-2f02A:
6.0		 2p2fB-2f02A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpn YWMB

(Bacillus
subtilis) 		PF08680
(DUF1779) 		4 VAL A 205
THR A 206
VAL A 212
GLY A 208
 None
 1.16A 2p2fB-2fpnA:
undetectable		 2p2fB-2fpnA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 VAL A 145
THR A 108
VAL A 104
GLY A 105
 None
 1.14A 2p2fB-2gouA:
undetectable		 2p2fB-2gouA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqw FERREDOXIN REDUCTASE

(Pseudomonas sp.
KKS102) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 VAL A 274
THR A 275
VAL A 257
GLY A 261
 None
 1.15A 2p2fB-2gqwA:
2.8		 2p2fB-2gqwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l04 MAJOR TAIL PROTEIN V

(Escherichia
virus Lambda) 		PF02368
(Big_2) 		4 VAL A 207
THR A 206
VAL A 219
GLY A 218
 None
 1.01A 2p2fB-2l04A:
undetectable		 2p2fB-2l04A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 VAL C 257
THR C 258
VAL C 244
GLY C 247
 None
 1.15A 2p2fB-2nymC:
undetectable		 2p2fB-2nymC:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 VAL A 310
THR A 311
VAL A 386
GLY A 387
 None
PRX  A 998 (-4.3A)
None
PRX  A 998 (-3.4A)
 0.13A 2p2fB-2p2mA:
67.0		 2p2fB-2p2mA:
99.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 VAL A 629
THR A 630
VAL A 574
GLY A 572
 None
 1.16A 2p2fB-2pi5A:
undetectable		 2p2fB-2pi5A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		4 VAL A 201
THR A 203
VAL A 195
GLY A 196
 None
 1.13A 2p2fB-2q8nA:
2.8		 2p2fB-2q8nA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF02390
(Methyltransf_4) 		4 VAL E 131
THR E 132
VAL E 157
GLY E 124
 None
 1.19A 2p2fB-2vdvE:
2.8		 2p2fB-2vdvE:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1q ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A  95
THR A  94
VAL A 324
GLY A 325
 None
 1.16A 2p2fB-2z1qA:
undetectable		 2p2fB-2z1qA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 VAL A 485
THR A 484
VAL A 462
GLY A 482
 None
 1.14A 2p2fB-3a9sA:
3.1		 2p2fB-3a9sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 VAL A 307
THR A 308
VAL A 287
GLY A 288
 None
 1.14A 2p2fB-3aquA:
undetectable		 2p2fB-3aquA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 VAL A  34
THR A  38
VAL A 399
GLY A  60
 None
 1.11A 2p2fB-3b46A:
undetectable		 2p2fB-3b46A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		4 VAL A 302
THR A 284
VAL A 289
GLY A 288
 None
None
None
UDP  A1081 (-3.7A)
 1.18A 2p2fB-3beoA:
2.5		 2p2fB-3beoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		4 VAL A  58
THR A  57
VAL A 223
GLY A 224
 None
 1.14A 2p2fB-3czpA:
undetectable		 2p2fB-3czpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkn PREPROTEIN
TRANSLOCASE SUBUNIT
SECY

(Canis lupus) 		PF00344
(SecY) 		4 VAL A 409
THR A 405
VAL A 178
GLY A 177
 None
 0.93A 2p2fB-3dknA:
undetectable		 2p2fB-3dknA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		4 VAL A 205
THR A 207
VAL A 199
GLY A 200
 None
 1.19A 2p2fB-3ff1A:
3.7		 2p2fB-3ff1A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 VAL A 300
THR A 301
VAL A 328
GLY A 329
 None
 1.09A 2p2fB-3h4iA:
3.1		 2p2fB-3h4iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 VAL A  61
THR A  62
VAL A 470
GLY A 471
 None
 1.15A 2p2fB-3hs0A:
undetectable		 2p2fB-3hs0A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvu HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		4 VAL A 148
THR A 147
VAL A 144
GLY A 145
 None
 1.09A 2p2fB-3hvuA:
5.3		 2p2fB-3hvuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		4 VAL A 350
THR A 349
VAL A 295
GLY A 296
 None
 1.12A 2p2fB-3j97A:
undetectable		 2p2fB-3j97A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		4 VAL A 234
THR A 232
VAL A 203
GLY A 202
 None
 1.10A 2p2fB-3k8vA:
undetectable		 2p2fB-3k8vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		4 VAL A  27
THR A  28
VAL A  55
GLY A  54
 None
 1.12A 2p2fB-3ndoA:
2.3		 2p2fB-3ndoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		4 VAL A 301
THR A 283
VAL A 288
GLY A 287
 None
 1.16A 2p2fB-3ot5A:
5.2		 2p2fB-3ot5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		4 VAL A 456
THR A 457
VAL A 411
GLY A 412
 1ZZ  A   1 (-4.1A)
None
None
None
 1.07A 2p2fB-3pbkA:
26.4		 2p2fB-3pbkA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 VAL A 109
THR A 110
VAL A 193
GLY A 190
 None
 1.09A 2p2fB-3qnqA:
undetectable		 2p2fB-3qnqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 VAL A  23
THR A  57
VAL A  48
GLY A  52
 None
None
IOD  A 367 ( 4.8A)
None
 1.08A 2p2fB-3s99A:
4.6		 2p2fB-3s99A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdf DIHYDRODIPICOLINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF00701
(DHDPS) 		4 VAL A 103
THR A 104
VAL A 141
GLY A 140
 None
 1.09A 2p2fB-3tdfA:
undetectable		 2p2fB-3tdfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		4 VAL A 382
THR A 383
VAL A 538
GLY A 537
 None
 1.15A 2p2fB-3txaA:
2.8		 2p2fB-3txaA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upg OUTER MEMBRANE
PROTEIN C

(Salmonella
enterica) 		PF00267
(Porin_1) 		4 VAL A 208
THR A 183
VAL A  96
GLY A  95
 None
 1.10A 2p2fB-3upgA:
undetectable		 2p2fB-3upgA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 VAL A 264
THR A 265
VAL A 251
GLY A 254
 None
 1.11A 2p2fB-3v4yA:
undetectable		 2p2fB-3v4yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 VAL A 604
THR A 605
VAL A 187
GLY A 188
 None
 1.08A 2p2fB-3vf1A:
undetectable		 2p2fB-3vf1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		PF01597
(GCV_H) 		4 VAL A  72
THR A  73
VAL A  18
GLY A  19
 None
 1.17A 2p2fB-3wdnA:
undetectable		 2p2fB-3wdnA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		4 VAL A  69
THR A  50
VAL A  75
GLY A  82
 None
 1.10A 2p2fB-3zidA:
3.8		 2p2fB-3zidA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 VAL A 250
THR A 191
VAL A 119
GLY A 118
 None
 1.09A 2p2fB-4amfA:
undetectable		 2p2fB-4amfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		4 VAL A 157
THR A 156
VAL A  49
GLY A 154
 None
 1.19A 2p2fB-4c3sA:
3.7		 2p2fB-4c3sA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 VAL X 398
THR X 399
VAL P 614
GLY P 597
 None
 1.15A 2p2fB-4crnX:
undetectable		 2p2fB-4crnX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		4 VAL A1093
THR A1075
VAL A1069
GLY A1066
 None
 1.08A 2p2fB-4d86A:
undetectable		 2p2fB-4d86A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 VAL A 127
THR A 126
VAL A 104
GLY A 138
 None
 1.13A 2p2fB-4dppA:
undetectable		 2p2fB-4dppA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
ambifaria) 		PF02222
(ATP-grasp) 		4 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 0.93A 2p2fB-4e4tA:
2.0		 2p2fB-4e4tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esp PROFILIN

(Arachis
hypogaea) 		PF00235
(Profilin) 		4 VAL A  92
THR A  93
VAL A  82
GLY A  77
 None
None
None
EDO  A 205 ( 3.6A)
 1.10A 2p2fB-4espA:
undetectable		 2p2fB-4espA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		4 VAL A 300
THR A 282
VAL A 287
GLY A 286
 None
None
UDP  A 402 ( 4.9A)
UDP  A 402 (-3.5A)
 1.16A 2p2fB-4fkzA:
4.7		 2p2fB-4fkzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		4 VAL A   1
THR A 173
VAL A 192
GLY A 180
 None
 1.18A 2p2fB-4gsoA:
undetectable		 2p2fB-4gsoA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 VAL A  89
THR A  88
VAL A  66
GLY A 100
 None
 1.17A 2p2fB-4hnnA:
undetectable		 2p2fB-4hnnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS) 		4 VAL S  20
THR S  19
VAL S  59
GLY S  60
 None
 0.99A 2p2fB-4hzuS:
undetectable		 2p2fB-4hzuS:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilf THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Salmonella
enterica) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		4 VAL A  62
THR A  63
VAL A  36
GLY A  49
 None
 1.15A 2p2fB-4ilfA:
undetectable		 2p2fB-4ilfA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 VAL A 106
THR A 107
VAL A 144
GLY A 143
 None
 1.17A 2p2fB-4imdA:
undetectable		 2p2fB-4imdA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
thailandensis) 		PF02222
(ATP-grasp) 		4 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 0.98A 2p2fB-4izoA:
5.1		 2p2fB-4izoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		4 VAL A 863
THR A 862
VAL A 936
GLY A 935
 ACT  A1209 ( 3.1A)
None
None
None
 1.16A 2p2fB-4k6jA:
undetectable		 2p2fB-4k6jA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		4 VAL A  90
THR A  91
VAL A 106
GLY A 107
 None
 1.09A 2p2fB-4ml9A:
3.5		 2p2fB-4ml9A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npb PROTEIN DISULFIDE
ISOMERASE II

(Yersinia pestis) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		4 VAL A  83
THR A  84
VAL A  57
GLY A  70
 None
 1.20A 2p2fB-4npbA:
undetectable		 2p2fB-4npbA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 VAL A 101
THR A 217
VAL A  11
GLY A  12
 None
 1.16A 2p2fB-4u4eA:
undetectable		 2p2fB-4u4eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 VAL A 593
THR A 592
VAL A 530
GLY A 529
 PGE  A1698 (-4.4A)
None
None
None
 1.14A 2p2fB-4uozA:
3.7		 2p2fB-4uozA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		4 VAL A 117
THR A 118
VAL A 155
GLY A 154
 None
 1.18A 2p2fB-4woqA:
undetectable		 2p2fB-4woqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 VAL A 774
THR A 771
VAL A 828
GLY A 827
 None
 1.06A 2p2fB-4zm6A:
undetectable		 2p2fB-4zm6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 VAL A 258
THR A 257
VAL A 216
GLY A 210
 None
 1.12A 2p2fB-4zoyA:
undetectable		 2p2fB-4zoyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 VAL A 335
THR A 333
VAL A 303
GLY A 302
 None
 1.09A 2p2fB-5az4A:
undetectable		 2p2fB-5az4A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 VAL A 320
THR A 319
VAL A 163
GLY A 161
 None
 0.98A 2p2fB-5c65A:
undetectable		 2p2fB-5c65A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dy1 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 VAL A  75
THR A  74
VAL A 114
GLY A 115
 None
 0.94A 2p2fB-5dy1A:
undetectable		 2p2fB-5dy1A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2f BETA-LACTAMASE YBXI

(Bacillus
subtilis) 		PF00905
(Transpeptidase) 		4 VAL A 241
THR A 242
VAL A 244
GLY A  48
 None
 1.17A 2p2fB-5e2fA:
undetectable		 2p2fB-5e2fA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fds PROFILIN-2

(Hevea
brasiliensis) 		PF00235
(Profilin) 		4 VAL A  92
THR A  93
VAL A  82
GLY A  77
 None
 1.15A 2p2fB-5fdsA:
undetectable		 2p2fB-5fdsA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftx SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 VAL A 603
THR A 602
VAL A 622
GLY A 621
 None
 1.16A 2p2fB-5ftxA:
undetectable		 2p2fB-5ftxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 VAL B 109
THR B 108
VAL B  31
GLY B  32
 None
 0.81A 2p2fB-5gq0B:
undetectable		 2p2fB-5gq0B:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		4 VAL A 194
THR A 195
VAL A 199
GLY A 200
 None
 0.94A 2p2fB-5gwoA:
undetectable		 2p2fB-5gwoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6j PIERISIN-1

(Pieris rapae) 		no annotation 4 VAL A  88
THR A  89
VAL A  17
GLY A 170
 None
 1.18A 2p2fB-5h6jA:
undetectable		 2p2fB-5h6jA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6n PIERISIN-1

(Pieris rapae) 		no annotation 4 VAL A  88
THR A  89
VAL A  17
GLY A 170
 None
 1.18A 2p2fB-5h6nA:
undetectable		 2p2fB-5h6nA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A

(Staphylococcus
aureus;
Bacillus sp.
HIL-Y85/54728) 		PF02216
(B)
PF02441
(Flavoprotein) 		4 VAL A 111
THR A 110
VAL A  41
GLY A  14
 None
 0.84A 2p2fB-5h75A:
3.2		 2p2fB-5h75A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Candida
albicans) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 VAL A 429
THR A 430
VAL A 416
GLY A 419
 None
 1.08A 2p2fB-5jpeA:
undetectable		 2p2fB-5jpeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 VAL A 337
THR A 335
VAL A 305
GLY A 304
 None
 1.09A 2p2fB-5jxlA:
undetectable		 2p2fB-5jxlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		4 VAL T  28
THR T  27
VAL T 309
GLY T 303
 None
 1.12A 2p2fB-5k0yT:
undetectable		 2p2fB-5k0yT:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 VAL A  57
THR A  56
VAL A 150
GLY A 149
 None
 1.16A 2p2fB-5lnqA:
undetectable		 2p2fB-5lnqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 4 VAL D 163
THR D 165
VAL D 132
GLY D 131
 None
 0.99A 2p2fB-5n03D:
2.9		 2p2fB-5n03D:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 233
THR A 232
VAL A 165
GLY A 169
 None
 1.11A 2p2fB-5nz7A:
undetectable		 2p2fB-5nz7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 VAL A 282
THR A 283
VAL A 204
GLY A 205
 None
 1.10A 2p2fB-5u09A:
3.1		 2p2fB-5u09A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 4 VAL D  87
THR D  86
VAL D  64
GLY D  98
 None
 1.13A 2p2fB-5ui3D:
undetectable		 2p2fB-5ui3D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		4 VAL A  27
THR A   4
VAL A 296
GLY A 293
 None
 1.04A 2p2fB-5uwyA:
undetectable		 2p2fB-5uwyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus) 		no annotation 4 VAL M 154
THR M 155
VAL M 118
GLY M 119
 None
 0.66A 2p2fB-5x41M:
undetectable		 2p2fB-5x41M:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A 332
THR A 309
VAL A  42
GLY A  41
 None
 0.86A 2p2fB-5xnwA:
undetectable		 2p2fB-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6i -

(-) 		no annotation 4 VAL A 137
THR A 138
VAL A 124
GLY A 141
 None
 1.14A 2p2fB-5y6iA:
undetectable		 2p2fB-5y6iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		no annotation 4 VAL A   6
THR A   9
VAL A  40
GLY A  41
 None
 1.14A 2p2fB-6az6A:
undetectable		 2p2fB-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 4 VAL A 271
THR A 268
VAL A 163
GLY A 162
 None
 1.16A 2p2fB-6c7sA:
2.4		 2p2fB-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 VAL A 347
THR A 346
VAL A 343
GLY A 344
 None
 1.12A 2p2fB-6d4jA:
undetectable		 2p2fB-6d4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 VAL D 249
THR D 252
VAL D 100
GLY D 115
 None
 1.12A 2p2fB-6fkhD:
undetectable		 2p2fB-6fkhD:
undetectable