SIMILAR PATTERNS OF AMINO ACIDS FOR 2P2F_A_ACTA653

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bfo CAMPATH-1G ANTIBODY

(Rattus rattus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL A 132
VAL A 158
GLY A 157
TRP A 148
 None
 1.14A 2p2fA-1bfoA:
undetectable		 2p2fA-1bfoA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1egz ENDOGLUCANASE Z

(Dickeya
chrysanthemi) 		PF00150
(Cellulase) 		4 VAL A 224
THR A 223
VAL A 280
GLY A 277
 None
 1.01A 2p2fA-1egzA:
undetectable		 2p2fA-1egzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		4 VAL A 223
VAL A 231
GLY A 230
TRP A 233
 None
 0.91A 2p2fA-1epxA:
2.3		 2p2fA-1epxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		4 VAL A 223
VAL A 231
GLY A 230
TRP A 233
 None
 0.96A 2p2fA-1f2jA:
2.2		 2p2fA-1f2jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5q NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Agaricus
bisporus) 		PF13561
(adh_short_C2) 		4 VAL A  55
THR A  52
VAL A  40
GLY A  19
 None
 1.14A 2p2fA-1h5qA:
2.6		 2p2fA-1h5qA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 VAL A 181
THR A 182
VAL A 472
TRP A 469
 None
 1.06A 2p2fA-1hbzA:
undetectable		 2p2fA-1hbzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		4 VAL A 106
THR A 107
VAL A 145
GLY A 144
 None
 1.15A 2p2fA-1hl2A:
undetectable		 2p2fA-1hl2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		4 VAL A 685
THR A 682
VAL A 732
TRP A 735
 None
 1.15A 2p2fA-1oxjA:
undetectable		 2p2fA-1oxjA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3y MRSD PROTEIN

(Bacillus sp.
HIL-Y85/54728) 		PF02441
(Flavoprotein) 		4 VAL 1 111
THR 1 110
VAL 1  41
GLY 1  14
 None
 0.89A 2p2fA-1p3y1:
3.6		 2p2fA-1p3y1:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpo QUINOLINATE ACID
PHOSPHORIBOSYL
TRANSFERASE

(Mycobacterium
tuberculosis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 226
THR A 229
VAL A 264
GLY A 263
 None
 1.05A 2p2fA-1qpoA:
2.0		 2p2fA-1qpoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 267
THR A 305
VAL A 251
GLY A 252
 None
 1.04A 2p2fA-1rcqA:
undetectable		 2p2fA-1rcqA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 THR A 367
VAL A 442
GLY A 443
TRP A 470
 None
AMP  A 720 ( 4.7A)
AMP  A 720 (-3.9A)
None
 0.38A 2p2fA-1ry2A:
55.0		 2p2fA-1ry2A:
45.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		4 VAL A 226
THR A 225
VAL A 284
GLY A 281
 None
 1.02A 2p2fA-1tvpA:
2.1		 2p2fA-1tvpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		4 VAL A  62
THR A  87
VAL A 130
GLY A 131
 None
 0.99A 2p2fA-1u5vA:
undetectable		 2p2fA-1u5vA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 VAL A  15
THR A  12
GLY A 114
TRP A 118
 None
 1.03A 2p2fA-1uarA:
undetectable		 2p2fA-1uarA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uax RIBONUCLEASE HII

(Pyrococcus
horikoshii) 		PF01351
(RNase_HII) 		4 VAL A 150
THR A 151
VAL A  65
GLY A  21
 None
 0.74A 2p2fA-1uaxA:
undetectable		 2p2fA-1uaxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufl NITROGEN REGULATORY
PROTEIN P-II

(Thermus
thermophilus) 		PF00543
(P-II) 		4 VAL A  74
THR A  73
VAL A  65
GLY A  64
 None
 1.15A 2p2fA-1uflA:
2.5		 2p2fA-1uflA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc3 PUTATIVE
FRUCTOKINASE

(Bacillus
subtilis) 		PF00480
(ROK) 		4 VAL A 104
THR A 102
VAL A  61
GLY A  59
 GOL  A 305 ( 4.6A)
GOL  A 305 ( 4.1A)
None
GOL  A 305 (-3.2A)
 1.14A 2p2fA-1xc3A:
2.4		 2p2fA-1xc3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zan FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 133
VAL L 160
GLY L 159
TRP L 149
 None
 1.13A 2p2fA-1zanL:
undetectable		 2p2fA-1zanL:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x ANTIBODY AQC2 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 136
VAL L 163
GLY L 162
TRP L 152
 None
 1.15A 2p2fA-2b2xL:
undetectable		 2p2fA-2b2xL:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 VAL A 478
THR A 479
VAL A 498
GLY A 500
 None
 1.14A 2p2fA-2b3xA:
2.6		 2p2fA-2b3xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 VAL A 479
THR A 478
VAL A 448
GLY A 449
 None
 0.96A 2p2fA-2d3tA:
undetectable		 2p2fA-2d3tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		4 VAL A  25
THR A   7
VAL A 126
GLY A 123
 None
 1.13A 2p2fA-2dt8A:
2.8		 2p2fA-2dt8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f86 HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF08332
(CaMKII_AD) 		4 VAL B 356
THR B 357
VAL B 429
TRP B 455
 None
 0.62A 2p2fA-2f86B:
undetectable		 2p2fA-2f86B:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l04 MAJOR TAIL PROTEIN V

(Escherichia
virus Lambda) 		PF02368
(Big_2) 		4 VAL A 207
THR A 206
VAL A 219
GLY A 218
 None
 1.04A 2p2fA-2l04A:
undetectable		 2p2fA-2l04A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 VAL C 257
THR C 258
VAL C 244
GLY C 247
 None
 1.15A 2p2fA-2nymC:
undetectable		 2p2fA-2nymC:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 VAL A 310
THR A 311
VAL A 386
GLY A 387
TRP A 414
 None
PRX  A 998 (-4.3A)
None
PRX  A 998 (-3.4A)
PRX  A 998 (-3.4A)
 0.17A 2p2fA-2p2mA:
66.8		 2p2fA-2p2mA:
99.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		4 VAL A 201
THR A 203
VAL A 195
GLY A 196
 None
 1.10A 2p2fA-2q8nA:
3.7		 2p2fA-2q8nA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 232
VAL A 205
GLY A 204
TRP A 201
 None
 1.11A 2p2fA-2w4kA:
undetectable		 2p2fA-2w4kA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 VAL A 485
THR A 484
VAL A 462
GLY A 482
 None
 1.15A 2p2fA-3a9sA:
3.4		 2p2fA-3a9sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 VAL A 307
THR A 308
VAL A 287
GLY A 288
 None
 1.09A 2p2fA-3aquA:
undetectable		 2p2fA-3aquA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 VAL A  34
THR A  38
VAL A 399
GLY A  60
 None
 1.10A 2p2fA-3b46A:
undetectable		 2p2fA-3b46A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 232
VAL A 205
GLY A 204
TRP A 201
 None
 1.07A 2p2fA-3bqrA:
undetectable		 2p2fA-3bqrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c28 RECOMBINASE CRE

(Escherichia
virus P1) 		PF00589
(Phage_integrase) 		4 VAL A 242
VAL A 230
GLY A 229
TRP A 224
 None
 1.15A 2p2fA-3c28A:
undetectable		 2p2fA-3c28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 131
VAL L 158
GLY L 157
TRP L 147
 None
 1.14A 2p2fA-3cvhL:
undetectable		 2p2fA-3cvhL:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		4 VAL A  58
THR A  57
VAL A 223
GLY A 224
 None
 1.13A 2p2fA-3czpA:
undetectable		 2p2fA-3czpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		4 VAL A 234
THR A 232
VAL A 203
GLY A 202
 None
 1.10A 2p2fA-3k8vA:
undetectable		 2p2fA-3k8vA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktd PREPHENATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF02153
(PDH) 		4 VAL A 171
VAL A 120
GLY A 121
TRP A 167
 None
 1.15A 2p2fA-3ktdA:
4.4		 2p2fA-3ktdA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		4 VAL A 451
THR A 452
VAL A 397
GLY A 398
 1ZZ  A 589 (-4.4A)
None
None
None
 1.06A 2p2fA-3kxwA:
32.6		 2p2fA-3kxwA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		4 VAL A  27
THR A  28
VAL A  55
GLY A  54
 None
 1.14A 2p2fA-3ndoA:
2.3		 2p2fA-3ndoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r ANTIBODY FAB
FRAGMENT LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 132
VAL L 159
GLY L 158
TRP L 148
 None
 1.15A 2p2fA-3o0rL:
undetectable		 2p2fA-3o0rL:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		4 VAL A 456
THR A 457
VAL A 411
GLY A 412
 1ZZ  A   1 (-4.1A)
None
None
None
 1.07A 2p2fA-3pbkA:
31.3		 2p2fA-3pbkA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		4 VAL A 359
THR A 356
GLY A 198
TRP A 319
 None
 0.98A 2p2fA-3q3vA:
2.9		 2p2fA-3q3vA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		4 VAL A 359
THR A 356
GLY A 199
TRP A 319
 None
 1.15A 2p2fA-3q3vA:
2.9		 2p2fA-3q3vA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE

(Campylobacter
jejuni) 		PF00162
(PGK) 		4 VAL A 359
VAL A 351
GLY A 352
TRP A 319
 None
 0.82A 2p2fA-3q3vA:
2.9		 2p2fA-3q3vA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 VAL A 109
THR A 110
VAL A 193
GLY A 190
 None
 1.09A 2p2fA-3qnqA:
undetectable		 2p2fA-3qnqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 VAL A  23
THR A  57
VAL A  48
GLY A  52
 None
None
IOD  A 367 ( 4.8A)
None
 1.07A 2p2fA-3s99A:
6.2		 2p2fA-3s99A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdf DIHYDRODIPICOLINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF00701
(DHDPS) 		4 VAL A 103
THR A 104
VAL A 141
GLY A 140
 None
 1.08A 2p2fA-3tdfA:
undetectable		 2p2fA-3tdfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A 236
VAL A 205
GLY A 204
TRP A 201
 None
 1.08A 2p2fA-3ujgA:
undetectable		 2p2fA-3ujgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 VAL A 264
THR A 265
VAL A 251
GLY A 254
 None
 1.12A 2p2fA-3v4yA:
undetectable		 2p2fA-3v4yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 VAL A 604
THR A 605
VAL A 187
GLY A 188
 None
 1.10A 2p2fA-3vf1A:
undetectable		 2p2fA-3vf1A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		4 VAL A 157
VAL A 211
GLY A 210
TRP A 213
 None
None
CL  A 808 (-3.3A)
None
 0.97A 2p2fA-3w5fA:
1.2		 2p2fA-3w5fA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		4 VAL A  69
THR A  50
VAL A  75
GLY A  82
 None
 1.10A 2p2fA-3zidA:
2.8		 2p2fA-3zidA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 288
VAL A 261
GLY A 260
TRP A 257
 None
 1.02A 2p2fA-4af3A:
undetectable		 2p2fA-4af3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 VAL A 250
THR A 191
VAL A 119
GLY A 118
 None
 1.10A 2p2fA-4amfA:
undetectable		 2p2fA-4amfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 VAL A 191
THR A 192
VAL A 499
TRP A 496
 None
 1.03A 2p2fA-4b7gA:
undetectable		 2p2fA-4b7gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX
ERF1 IN
RIBOSOME-BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 VAL X 398
THR X 399
VAL P 614
GLY P 597
 None
 1.15A 2p2fA-4crnX:
undetectable		 2p2fA-4crnX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		4 VAL A  77
THR A  78
VAL A   9
GLY A  10
 None
 1.02A 2p2fA-4ctaA:
2.5		 2p2fA-4ctaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
ambifaria) 		PF02222
(ATP-grasp) 		4 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 0.98A 2p2fA-4e4tA:
2.8		 2p2fA-4e4tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE

(Burkholderia
cenocepacia) 		PF00294
(PfkB) 		4 VAL A 272
THR A 271
VAL A 300
GLY A 298
 None
None
K  A 503 (-4.6A)
ANP  A 501 ( 4.8A)
 1.11A 2p2fA-4e84A:
2.3		 2p2fA-4e84A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esp PROFILIN

(Arachis
hypogaea) 		PF00235
(Profilin) 		4 VAL A  92
THR A  93
VAL A  82
GLY A  77
 None
None
None
EDO  A 205 ( 3.6A)
 1.14A 2p2fA-4espA:
undetectable		 2p2fA-4espA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		4 VAL A  89
THR A  88
VAL A  66
GLY A 100
 None
 1.15A 2p2fA-4hnnA:
undetectable		 2p2fA-4hnnA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS) 		4 VAL S  20
THR S  19
VAL S  59
GLY S  60
 None
 1.01A 2p2fA-4hzuS:
undetectable		 2p2fA-4hzuS:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilf THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBC

(Salmonella
enterica) 		PF10411
(DsbC_N)
PF13098
(Thioredoxin_2) 		4 VAL A  62
THR A  63
VAL A  36
GLY A  49
 None
 1.14A 2p2fA-4ilfA:
undetectable		 2p2fA-4ilfA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
thailandensis) 		PF02222
(ATP-grasp) 		4 VAL A  20
THR A  81
VAL A 107
GLY A 104
 None
 1.01A 2p2fA-4izoA:
5.0		 2p2fA-4izoA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 VAL A 430
VAL A 426
GLY A 427
TRP A 260
 None
None
None
15P  A 603 (-4.9A)
 1.15A 2p2fA-4maeA:
undetectable		 2p2fA-4maeA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		4 VAL A  90
THR A  91
VAL A 106
GLY A 107
 None
 1.07A 2p2fA-4ml9A:
4.2		 2p2fA-4ml9A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb0 AB53 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL L 132
VAL L 159
GLY L 158
TRP L 148
 None
 1.11A 2p2fA-4pb0L:
undetectable		 2p2fA-4pb0L:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcm METHYLATED
RNA-BINDING PROTEIN
1

(Saccharomyces
cerevisiae) 		PF04146
(YTH) 		4 VAL A 168
VAL A 243
GLY A 175
TRP A 245
 None
None
UNX  A 405 ( 4.2A)
None
 1.11A 2p2fA-4rcmA:
undetectable		 2p2fA-4rcmA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		4 VAL A 101
THR A 217
VAL A  11
GLY A  12
 None
 1.11A 2p2fA-4u4eA:
undetectable		 2p2fA-4u4eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 VAL A 593
THR A 592
VAL A 530
GLY A 529
 PGE  A1698 (-4.4A)
None
None
None
 1.12A 2p2fA-4uozA:
undetectable		 2p2fA-4uozA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 THR A1679
VAL A1461
GLY A1460
TRP A1446
 None
 1.08A 2p2fA-4yknA:
undetectable		 2p2fA-4yknA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypn LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA) 		4 VAL A 262
VAL A 256
GLY A 257
TRP A 298
 None
 1.14A 2p2fA-4ypnA:
undetectable		 2p2fA-4ypnA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 VAL A 774
THR A 771
VAL A 828
GLY A 827
 None
 1.03A 2p2fA-4zm6A:
undetectable		 2p2fA-4zm6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 VAL A 258
THR A 257
VAL A 216
GLY A 210
 None
 1.11A 2p2fA-4zoyA:
undetectable		 2p2fA-4zoyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 VAL A 335
THR A 333
VAL A 303
GLY A 302
 None
 1.10A 2p2fA-5az4A:
undetectable		 2p2fA-5az4A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 VAL A 320
THR A 319
VAL A 163
GLY A 161
 None
 1.00A 2p2fA-5c65A:
undetectable		 2p2fA-5c65A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dy1 TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 VAL A  75
THR A  74
VAL A 114
GLY A 115
 None
 0.89A 2p2fA-5dy1A:
undetectable		 2p2fA-5dy1A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		4 VAL A 304
VAL A 277
GLY A 276
TRP A 273
 None
 1.04A 2p2fA-5eykA:
undetectable		 2p2fA-5eykA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 VAL B 109
THR B 108
VAL B  31
GLY B  32
 None
 0.81A 2p2fA-5gq0B:
undetectable		 2p2fA-5gq0B:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		4 VAL A 194
THR A 195
VAL A 199
GLY A 200
 None
 0.90A 2p2fA-5gwoA:
undetectable		 2p2fA-5gwoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h75 MERSACIDIN
DECARBOXYLASE,IMMUNO
GLOBULIN G-BINDING
PROTEIN A

(Staphylococcus
aureus;
Bacillus sp.
HIL-Y85/54728) 		PF02216
(B)
PF02441
(Flavoprotein) 		4 VAL A 111
THR A 110
VAL A  41
GLY A  14
 None
 0.87A 2p2fA-5h75A:
3.1		 2p2fA-5h75A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		4 VAL A1248
THR A1251
VAL A1270
TRP A1273
 None
 1.10A 2p2fA-5hccA:
undetectable		 2p2fA-5hccA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Candida
albicans) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 VAL A 429
THR A 430
VAL A 416
GLY A 419
 None
 1.10A 2p2fA-5jpeA:
undetectable		 2p2fA-5jpeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 VAL A 337
THR A 335
VAL A 305
GLY A 304
 None
 1.09A 2p2fA-5jxlA:
undetectable		 2p2fA-5jxlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		4 VAL T  28
THR T  27
VAL T 309
GLY T 303
 None
 1.13A 2p2fA-5k0yT:
undetectable		 2p2fA-5k0yT:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 THR A 336
VAL A 411
GLY A 412
TRP A 439
 6R9  A 704 ( 4.9A)
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
6R9  A 704 ( 3.5A)
 0.31A 2p2fA-5k8fA:
57.2		 2p2fA-5k8fA:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m11 IMMUNOREACTIVE 84KD
ANTIGEN PG93

(Porphyromonas
gingivalis) 		no annotation 4 VAL A 750
VAL A 707
GLY A 706
TRP A 740
 None
 0.99A 2p2fA-5m11A:
undetectable		 2p2fA-5m11A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n03 GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT B

(Myxococcus
xanthus) 		no annotation 4 VAL D 163
THR D 165
VAL D 132
GLY D 131
 None
 1.01A 2p2fA-5n03D:
4.4		 2p2fA-5n03D:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 VAL A1821
THR A1822
VAL A1785
TRP A1758
 None
 1.03A 2p2fA-5nugA:
undetectable		 2p2fA-5nugA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 233
THR A 232
VAL A 165
GLY A 169
 None
 1.10A 2p2fA-5nz7A:
undetectable		 2p2fA-5nz7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 VAL A 282
THR A 283
VAL A 204
GLY A 205
 None
 1.13A 2p2fA-5u09A:
2.9		 2p2fA-5u09A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui3 DIHYDRODIPICOLINATE
SYNTHASE

(Chlamydomonas
reinhardtii) 		no annotation 4 VAL D  87
THR D  86
VAL D  64
GLY D  98
 None
 1.12A 2p2fA-5ui3D:
undetectable		 2p2fA-5ui3D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwy THIOREDOXIN
REDUCTASE

(Streptococcus
pyogenes) 		PF07992
(Pyr_redox_2) 		4 VAL A  27
THR A   4
VAL A 296
GLY A 293
 None
 1.02A 2p2fA-5uwyA:
2.1		 2p2fA-5uwyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x41 COBALT TRANSPORT
PROTEIN CBIM

(Rhodobacter
capsulatus) 		no annotation 4 VAL M 154
THR M 155
VAL M 118
GLY M 119
 None
 0.60A 2p2fA-5x41M:
undetectable		 2p2fA-5x41M:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 THR A 679
VAL A 461
GLY A 460
TRP A 446
 None
 1.10A 2p2fA-5xgjA:
undetectable		 2p2fA-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 4 VAL A 332
THR A 309
VAL A  42
GLY A  41
 None
 0.89A 2p2fA-5xnwA:
undetectable		 2p2fA-5xnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		no annotation 4 VAL A   6
THR A   9
VAL A  40
GLY A  41
 None
 1.12A 2p2fA-6az6A:
undetectable		 2p2fA-6az6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 ANTIBODY FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 4 VAL B 135
VAL B 162
GLY B 161
TRP B 151
 None
 1.10A 2p2fA-6c08B:
undetectable		 2p2fA-6c08B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
BETA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 VAL D 249
THR D 252
VAL D 100
GLY D 115
 None
 1.08A 2p2fA-6fkhD:
undetectable		 2p2fA-6fkhD:
undetectable