SIMILAR PATTERNS OF AMINO ACIDS FOR 2P16_A_GG2A298_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b72 PROTEIN (HOMEOBOX
PROTEIN HOX-B1)

(Homo sapiens) 		PF00046
(Homeobox) 		3 ARG A 213
GLU A 217
GLN A 214
 None
 0.99A 2p16A-1b72A:
undetectable		 2p16A-1b72A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 ARG A 321
GLU A 320
GLN A 322
 None
 1.06A 2p16A-1bf5A:
0.0		 2p16A-1bf5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ARG A 341
GLU A 339
GLN A 340
 None
 0.90A 2p16A-1cliA:
0.0		 2p16A-1cliA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		3 ARG A 104
GLU A 101
GLN A 119
 None
 1.06A 2p16A-1di6A:
undetectable		 2p16A-1di6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 ARG A 176
GLU A 228
GLN A 226
 None
 0.96A 2p16A-1dmwA:
0.0		 2p16A-1dmwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ARG C 336
GLU C 337
GLN C 367
 None
 1.01A 2p16A-1ea9C:
0.0		 2p16A-1ea9C:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hnf CD2

(Homo sapiens) 		PF05790
(C2-set)
PF07686
(V-set) 		3 ARG A 105
GLU A 104
GLN A  15
 None
NAG  A 502 (-3.9A)
None
 0.96A 2p16A-1hnfA:
1.0		 2p16A-1hnfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 ARG A 402
GLU A 296
GLN A 288
 None
 0.94A 2p16A-1iv8A:
0.0		 2p16A-1iv8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ARG A 339
GLU A 336
GLN A 370
 None
 1.04A 2p16A-1j0hA:
0.0		 2p16A-1j0hA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jrm CONSERVED
HYPOTHETICAL PROTEIN
MTH637

(Methanothermobacter
thermautotrophicus) 		PF02594
(DUF167) 		3 ARG A  38
GLU A  40
GLN A  78
 None
 1.01A 2p16A-1jrmA:
0.0		 2p16A-1jrmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 ARG B 359
GLU B 352
GLN B 394
 None
 0.85A 2p16A-1lwuB:
undetectable		 2p16A-1lwuB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP) 		3 ARG A 215
GLU A 277
GLN A 216
 None
 1.00A 2p16A-1o7fA:
undetectable		 2p16A-1o7fA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		3 ARG A 176
GLU A 228
GLN A 226
 None
 0.95A 2p16A-1phzA:
undetectable		 2p16A-1phzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A  87
GLU A  66
GLN A 634
 None
 1.08A 2p16A-1qlbA:
undetectable		 2p16A-1qlbA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 394
GLU A 395
GLN A 373
 None
 1.09A 2p16A-1snxA:
undetectable		 2p16A-1snxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssl HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01437
(PSI) 		3 ARG A  33
GLU A  35
GLN A  23
 None
 0.86A 2p16A-1sslA:
undetectable		 2p16A-1sslA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7i HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		3 ARG A 115
GLU A  91
GLN A 114
 None
 0.87A 2p16A-1u7iA:
undetectable		 2p16A-1u7iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj3 IGG FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B 340
GLU B 389
GLN B 343
 None
 0.76A 2p16A-1uj3B:
undetectable		 2p16A-1uj3B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wi5 RRP5 PROTEIN HOMOLOG

(Homo sapiens) 		PF00575
(S1) 		3 ARG A 238
GLU A 235
GLN A 234
 None
 0.94A 2p16A-1wi5A:
undetectable		 2p16A-1wi5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8m FIS1

(Saccharomyces
cerevisiae) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 ARG A  75
GLU A  78
GLN A  40
 None
 1.05A 2p16A-1y8mA:
undetectable		 2p16A-1y8mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6n HYPOTHETICAL PROTEIN
PA1234

(Pseudomonas
aeruginosa) 		PF14595
(Thioredoxin_9) 		3 ARG A 101
GLU A 107
GLN A 102
 None
 0.91A 2p16A-1z6nA:
undetectable		 2p16A-1z6nA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 ARG A  58
GLU A 289
GLN A 287
 None
 0.90A 2p16A-2aa4A:
undetectable		 2p16A-2aa4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjq MFP2A

(Ascaris suum) 		PF12150
(MFP2b) 		3 ARG A 167
GLU A   7
GLN A 112
 None
 1.00A 2p16A-2bjqA:
undetectable		 2p16A-2bjqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8x PROTEIN PINCH

(Homo sapiens) 		PF00412
(LIM) 		3 ARG A  33
GLU A  39
GLN A  38
 None
 1.04A 2p16A-2d8xA:
undetectable		 2p16A-2d8xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 ARG A 248
GLU A 450
GLN A 252
 None
 1.09A 2p16A-2dfsA:
undetectable		 2p16A-2dfsA:
12.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG A 143
GLU A 147
GLN A 192
 None
None
DT8  A 700 (-3.9A)
 1.03A 2p16A-2ei8A:
46.2		 2p16A-2ei8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 ARG A 431
GLU A 427
GLN A 430
 None
 1.00A 2p16A-2fwrA:
undetectable		 2p16A-2fwrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		3 ARG A 465
GLU A 185
GLN A 618
 None
 0.95A 2p16A-2g28A:
undetectable		 2p16A-2g28A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib1 DEATH DOMAIN
CONTAINING MEMBRANE
PROTEIN NRADD

(Mus musculus) 		PF00531
(Death) 		3 ARG A 147
GLU A 144
GLN A 146
 None
 1.03A 2p16A-2ib1A:
undetectable		 2p16A-2ib1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		3 ARG A1731
GLU A1859
GLN A1865
 None
 1.00A 2p16A-2ix8A:
undetectable		 2p16A-2ix8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnv NIFU-LIKE PROTEIN 1,
CHLOROPLAST

(Oryza sativa) 		PF01106
(NifU) 		3 ARG A 133
GLU A 136
GLN A  86
 None
 0.75A 2p16A-2jnvA:
undetectable		 2p16A-2jnvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqr ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		no annotation 3 ARG A  42
GLU A  18
GLN A  49
 None
 0.61A 2p16A-2kqrA:
undetectable		 2p16A-2kqrA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvr UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		3 ARG A  85
GLU A 127
GLN A  83
 None
 0.99A 2p16A-2kvrA:
undetectable		 2p16A-2kvrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzn DNA PRIMASE

(Staphylococcus
aureus) 		PF00772
(DnaB) 		3 ARG A 579
GLU A 580
GLN A 595
 None
 1.05A 2p16A-2lznA:
undetectable		 2p16A-2lznA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		3 ARG A 192
GLU A 193
GLN A 153
 None
 1.07A 2p16A-2myiA:
undetectable		 2p16A-2myiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		3 ARG A 601
GLU A 598
GLN A 597
 None
 0.98A 2p16A-2o1sA:
undetectable		 2p16A-2o1sA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 ARG A 533
GLU A 530
GLN A 529
 None
 1.10A 2p16A-2ozuA:
undetectable		 2p16A-2ozuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		3 ARG A 629
GLU A 633
GLN A 626
 None
 1.04A 2p16A-2rfoA:
undetectable		 2p16A-2rfoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A 632
GLU A 676
GLN A 678
 None
 1.10A 2p16A-2vkwA:
undetectable		 2p16A-2vkwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 153
GLU A  21
GLN A 142
 None
 0.90A 2p16A-2yfkA:
undetectable		 2p16A-2yfkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		3 ARG A1741
GLU A1738
GLN A1737
 MG  A1006 ( 3.9A)
None
MG  A1006 ( 4.5A)
 1.09A 2p16A-3edvA:
undetectable		 2p16A-3edvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		3 ARG A 193
GLU A 190
GLN A 189
 None
 0.92A 2p16A-3etuA:
undetectable		 2p16A-3etuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiq ODORANT-BINDING
PROTEIN 1F

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		3 ARG A  36
GLU A  31
GLN A 147
 None
EDO  A 158 ( 4.3A)
None
 1.02A 2p16A-3fiqA:
undetectable		 2p16A-3fiqA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		3 ARG A 211
GLU A 208
GLN A 423
 None
 0.55A 2p16A-3geiA:
undetectable		 2p16A-3geiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		3 ARG B  43
GLU B  44
GLN B 216
 None
 1.01A 2p16A-3hhrB:
undetectable		 2p16A-3hhrB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 3 ARG A  59
GLU A  53
GLN A  79
 None
 0.96A 2p16A-3hm2A:
undetectable		 2p16A-3hm2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 ARG A1306
GLU A1313
GLN A1734
 None
 1.10A 2p16A-3ig3A:
undetectable		 2p16A-3ig3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 ARG P 441
GLU P 442
GLN P 453
 None
 1.03A 2p16A-3izyP:
undetectable		 2p16A-3izyP:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 ARG A  43
GLU A  47
GLN A  40
 None
 1.05A 2p16A-3j3iA:
undetectable		 2p16A-3j3iA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kho B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Mus musculus) 		no annotation 3 ARG B  93
GLU B  91
GLN B 111
 None
 1.10A 2p16A-3khoB:
undetectable		 2p16A-3khoB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ARG A 305
GLU A 313
GLN A 306
 None
 0.97A 2p16A-3ll3A:
undetectable		 2p16A-3ll3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		3 ARG A 492
GLU A 489
GLN A 488
 GOL  A 783 (-4.3A)
GOL  A 783 ( 4.4A)
SO4  A   1 (-4.1A)
 0.97A 2p16A-3nawA:
undetectable		 2p16A-3nawA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 ARG A1061
GLU A1062
GLN A1015
 None
 1.02A 2p16A-3psiA:
undetectable		 2p16A-3psiA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6a UNCHARACTERIZED
PROTEIN

(Staphylococcus
saprophyticus) 		PF08327
(AHSA1) 		3 ARG A  13
GLU A  82
GLN A  66
 None
 0.95A 2p16A-3q6aA:
undetectable		 2p16A-3q6aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		3 ARG A  65
GLU A  66
GLN A 331
 None
 0.85A 2p16A-3tevA:
undetectable		 2p16A-3tevA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 ARG A 401
GLU A 398
GLN A 455
 None
 0.90A 2p16A-3u5uA:
undetectable		 2p16A-3u5uA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 ARG A  30
GLU A  27
GLN A  26
 None
 0.78A 2p16A-3wstA:
undetectable		 2p16A-3wstA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-3x1oA:
undetectable		 2p16A-3x1oA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		3 ARG A 283
GLU A 280
GLN A 287
 None
 1.09A 2p16A-3zizA:
undetectable		 2p16A-3zizA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		3 ARG A 390
GLU A 392
GLN A 393
 None
 1.03A 2p16A-4b8sA:
undetectable		 2p16A-4b8sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ARG A  24
GLU A  25
GLN A  20
 None
 1.00A 2p16A-4bedA:
undetectable		 2p16A-4bedA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL15

(Sus scrofa) 		PF00828
(Ribosomal_L27A) 		3 ARG P  59
GLU P  56
GLN P  58
 U  A 353 ( 3.2A)
G  A 351 ( 3.1A)
U  A 356 ( 3.1A)
 1.05A 2p16A-4ce4P:
undetectable		 2p16A-4ce4P:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		3 ARG A 131
GLU A  64
GLN A  66
 NAG  A1308 ( 4.3A)
NA  A1328 ( 4.5A)
None
 1.03A 2p16A-4cuoA:
undetectable		 2p16A-4cuoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dk0 PUTATIVE MACA

(Aggregatibacter
actinomycetemcomitans) 		PF16576
(HlyD_D23) 		3 ARG A 114
GLU A 155
GLN A 110
 None
 0.79A 2p16A-4dk0A:
undetectable		 2p16A-4dk0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		3 ARG A 214
GLU A 211
GLN A 210
 None
 1.08A 2p16A-4du6A:
undetectable		 2p16A-4du6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		3 ARG A  29
GLU A  27
GLN A 117
 None
 1.04A 2p16A-4ep0A:
0.9		 2p16A-4ep0A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		3 ARG A 138
GLU A 135
GLN A 141
 None
 1.07A 2p16A-4fmcA:
undetectable		 2p16A-4fmcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		3 ARG A 107
GLU A 143
GLN A 148
 None
CAF  A 169 ( 4.8A)
None
 1.08A 2p16A-4h5uA:
undetectable		 2p16A-4h5uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		3 ARG B 316
GLU B 302
GLN B 317
 None
 0.93A 2p16A-4hstB:
undetectable		 2p16A-4hstB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		3 ARG A 323
GLU A  52
GLN A 327
 None
 0.93A 2p16A-4k2bA:
undetectable		 2p16A-4k2bA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		3 ARG A 134
GLU A  35
GLN A 130
 None
 1.02A 2p16A-4kntA:
undetectable		 2p16A-4kntA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ARG A 345
GLU A 346
GLN A 334
 None
 0.95A 2p16A-4m0mA:
undetectable		 2p16A-4m0mA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ARG A 565
GLU A 566
GLN A 561
 None
 1.03A 2p16A-4m0mA:
undetectable		 2p16A-4m0mA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxj C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 3

(Homo sapiens) 		PF16471
(JIP_LZII) 		3 ARG A 459
GLU A 456
GLN A 455
 EDO  A 504 ( 2.9A)
None
EDO  A 504 (-3.2A)
 1.08A 2p16A-4pxjA:
undetectable		 2p16A-4pxjA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens) 		no annotation 3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-4qikA:
undetectable		 2p16A-4qikA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 ARG A 120
GLU A 117
GLN A 114
 None
 0.64A 2p16A-4rmfA:
undetectable		 2p16A-4rmfA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		3 ARG A 231
GLU A 226
GLN A 298
 None
 1.04A 2p16A-4twfA:
undetectable		 2p16A-4twfA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-4txaA:
undetectable		 2p16A-4txaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 ARG A 209
GLU A 261
GLN A 259
 None
 1.02A 2p16A-4v06A:
undetectable		 2p16A-4v06A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 ARG A 341
GLU A 338
GLN A 335
 None
 0.91A 2p16A-4v2eA:
undetectable		 2p16A-4v2eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		3 ARG A 137
GLU A   7
GLN A 138
 None
 0.93A 2p16A-4wlpA:
undetectable		 2p16A-4wlpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b88 ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF03880
(DbpA) 		3 ARG A 490
GLU A 492
GLN A 558
 None
 0.82A 2p16A-5b88A:
undetectable		 2p16A-5b88A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		3 ARG A 217
GLU A 214
GLN A 213
 None
 0.97A 2p16A-5bmoA:
undetectable		 2p16A-5bmoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djn KINESIN-LIKE PROTEIN

(Mus musculus) 		PF16183
(Kinesin_assoc) 		3 ARG A 426
GLU A 423
GLN A 422
 None
 1.06A 2p16A-5djnA:
undetectable		 2p16A-5djnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		3 ARG A 210
GLU A 211
GLN A 206
 None
 1.06A 2p16A-5ej1A:
1.0		 2p16A-5ej1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ARG A 491
GLU A 494
GLN A 520
 None
 0.96A 2p16A-5i68A:
undetectable		 2p16A-5i68A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus) 		no annotation 3 ARG A1469
GLU A1438
GLN A1466
 None
None
EDO  A1901 (-4.1A)
 1.02A 2p16A-5ic1A:
undetectable		 2p16A-5ic1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig4 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF08332
(CaMKII_AD) 		3 ARG A 352
GLU A 349
GLN A 348
 None
 0.85A 2p16A-5ig4A:
undetectable		 2p16A-5ig4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb1 MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 ARG A  71
GLU A 369
GLN A  69
 None
 0.98A 2p16A-5jb1A:
undetectable		 2p16A-5jb1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		3 ARG A 445
GLU A 444
GLN A 450
 None
 1.05A 2p16A-5k9tA:
undetectable		 2p16A-5k9tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 449
GLU A 431
GLN A 430
 None
 0.92A 2p16A-5ko1A:
undetectable		 2p16A-5ko1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ARG A 365
GLU A 416
GLN A 361
 ARG  A 365 ( 0.6A)
GLU  A 416 ( 0.5A)
GLN  A 361 ( 0.6A)
 0.82A 2p16A-5l5nA:
undetectable		 2p16A-5l5nA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 26S PROTEASE
REGULATORY SUBUNIT 4

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 ARG d 307
GLU d 304
GLN d 306
 None
 0.85A 2p16A-5m32d:
undetectable		 2p16A-5m32d:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myb ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A 580
GLU A 579
GLN A 589
 None
 0.85A 2p16A-5mybA:
undetectable		 2p16A-5mybA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ARG A 299
GLU A  36
GLN A 300
 None
 0.97A 2p16A-5tc4A:
undetectable		 2p16A-5tc4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd RNA POLYMERASE SIGMA
FACTOR SIGA

(Mycobacterium
tuberculosis) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		3 ARG F 502
GLU F 501
GLN F 505
 None
 0.82A 2p16A-5uhdF:
undetectable		 2p16A-5uhdF:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 3 ARG A 397
GLU A 398
GLN A 445
 None
 1.10A 2p16A-5vanA:
undetectable		 2p16A-5vanA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy5 MELANOMA-ASSOCIATED
ANTIGEN G1
NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG

(Homo sapiens) 		PF01454
(MAGE)
PF07574
(SMC_Nse1)
PF08746
(zf-RING-like) 		3 ARG A  17
GLU B 159
GLN A  20
 None
 1.02A 2p16A-5wy5A:
undetectable		 2p16A-5wy5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 419
GLU A 416
GLN A 415
 None
 1.07A 2p16A-5xfmA:
undetectable		 2p16A-5xfmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 ARG A  93
GLU A 710
GLN A  75
 None
 0.98A 2p16A-5xgjA:
undetectable		 2p16A-5xgjA:
19.67