SIMILAR PATTERNS OF AMINO ACIDS FOR 2P16_A_GG2A298

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
None
BEN  A 246 ( 3.9A)
BEN  A 246 (-3.3A)
None
 0.26A 2p16A-1a0jA:
35.4		 2p16A-1a0jA:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		8 TYR A  99
ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 0GJ  A 245 (-3.9A)
0GJ  A 245 (-3.1A)
0GJ  A 245 (-3.4A)
0GJ  A 245 (-1.4A)
None
0GJ  A 245 (-3.5A)
0GJ  A 245 ( 4.2A)
None
 0.44A 2p16A-1a5iA:
32.5		 2p16A-1a5iA:
35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		6 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0FG  C 301 ( 3.0A)
None
None
0FG  C 301 (-3.4A)
0FG  C 301 ( 4.4A)
None
 0.35A 2p16A-1afqC:
12.6		 2p16A-1afqC:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
None
0GJ  A   1 (-3.5A)
0GJ  A   1 ( 4.3A)
None
 0.37A 2p16A-1bqyA:
13.0		 2p16A-1bqyA:
28.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		6 SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
TYR B 228
 None
 0.30A 2p16A-1dlkB:
35.6		 2p16A-1dlkB:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		5 ASP B 189
SER B 195
GLY B 216
GLY B 226
TYR B 228
 None
 0.37A 2p16A-1ekbB:
36.4		 2p16A-1ekbB:
28.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 ASP A 611
SER A 617
VAL A 638
TRP A 640
GLY A 641
GLY A 648
TYR A 650
 None
SO4  A2001 ( 2.7A)
None
None
None
None
None
 0.35A 2p16A-1elvA:
31.4		 2p16A-1elvA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		7 ASP C 189
SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 None
 0.38A 2p16A-1eptC:
14.2		 2p16A-1eptC:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta) 		PF00089
(Trypsin) 		5 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 PMS  A1201 (-3.6A)
PMS  A1201 (-1.5A)
None
PMS  A1201 ( 4.5A)
None
 0.43A 2p16A-1eq9A:
12.9		 2p16A-1eq9A:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
None
 0.30A 2p16A-1fiwA:
35.3		 2p16A-1fiwA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
None
 0.41A 2p16A-1fizA:
34.1		 2p16A-1fizA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		8 TYR A  99
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-4.0A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
None
 0.55A 2p16A-1fxyA:
35.8		 2p16A-1fxyA:
65.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.80A 2p16A-1gvlA:
25.6		 2p16A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.39A 2p16A-1gvlA:
25.6		 2p16A-1gvlA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
None
 0.30A 2p16A-1h4wA:
35.8		 2p16A-1h4wA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		7 ASP E 189
SER E 195
VAL E 213
TRP E 215
GLY E 216
GLY E 226
TYR E 228
 None
 0.34A 2p16A-1h9hE:
36.0		 2p16A-1h9hE:
37.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		8 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 None
 0.41A 2p16A-1id5H:
35.3		 2p16A-1id5H:
40.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		10 TYR T  99
PHE T 174
ASP T 189
ALA T 190
SER T 195
VAL T 213
TRP T 215
GLY T 216
GLY T 226
TYR T 228
 ZEN  T   1 (-3.8A)
ZEN  T   1 (-3.8A)
ZEN  T   1 ( 3.8A)
ZEN  T   1 (-3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.4A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.7A)
ZEN  T   1 (-3.6A)
 0.37A 2p16A-1j17T:
36.4		 2p16A-1j17T:
39.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		10 TYR H  99
PHE H 174
ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 None
 0.54A 2p16A-1kigH:
41.9		 2p16A-1kigH:
84.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 TYR A  99
ALA A 190
SER A 195
TRP A 215
TYR A 228
 None
 0.82A 2p16A-1m9uA:
32.9		 2p16A-1m9uA:
29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
None
BEN  A1222 (-3.9A)
BEN  A1222 (-3.4A)
None
 0.36A 2p16A-1mbqA:
35.0		 2p16A-1mbqA:
37.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mir PROCATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		5 VAL A  45
TRP A  30
GLY A  70
GLY A  68
TYR A  75
 None
 1.12A 2p16A-1mirA:
undetectable		 2p16A-1mirA:
21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		5 SER K 195
VAL K 213
TRP K 215
GLY K 226
TYR K 228
 None
 0.52A 2p16A-1mkxK:
29.2		 2p16A-1mkxK:
40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A 429
ALA A 338
VAL A 342
GLY A  47
GLY A 145
 FAD  A3005 (-4.1A)
FAD  A3005 (-3.5A)
None
FAD  A3005 (-4.0A)
None
 1.10A 2p16A-1n5xA:
undetectable		 2p16A-1n5xA:
11.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1npm NEUROPSIN

(Mus musculus) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.30A 2p16A-1npmA:
34.0		 2p16A-1npmA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 CR9  H 256 (-2.4A)
CR9  H 256 (-2.9A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
None
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
None
 0.25A 2p16A-1o5fH:
34.8		 2p16A-1o5fH:
36.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.35A 2p16A-1op2A:
11.9		 2p16A-1op2A:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.3A)
0G6  A   1 (-3.5A)
None
 0.31A 2p16A-1orfA:
12.8		 2p16A-1orfA:
29.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		7 PHE C 174
ASP C 189
SER C 195
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.6A)
0G6  C 301 (-3.0A)
0G6  C 301 (-1.4A)
None
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 0.43A 2p16A-1pfxC:
37.5		 2p16A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		5 TYR C  99
ASP C 189
GLY C 216
GLY C 226
TYR C 228
 0G6  C 301 (-4.7A)
0G6  C 301 (-3.0A)
0G6  C 301 (-3.2A)
0G6  C 301 ( 3.5A)
None
 1.13A 2p16A-1pfxC:
37.5		 2p16A-1pfxC:
46.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 210
TRP A 212
GLY A 213
GLY A 223
TYR A 225
 ARG  A 703 (-2.0A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
None
ARG  A 703 ( 3.7A)
ARG  A 703 (-2.6A)
None
 0.31A 2p16A-1pq5A:
32.8		 2p16A-1pq5A:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		7 ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
None
 0.49A 2p16A-1q3xA:
34.1		 2p16A-1q3xA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		6 ASP G 189
SER G 195
TRP G 215
GLY G 216
GLY G 226
TYR G 228
 None
 0.46A 2p16A-1sgfG:
16.8		 2p16A-1sgfG:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sgf NERVE GROWTH FACTOR

(Mus musculus) 		PF00089
(Trypsin) 		6 TYR G  99
ASP G 189
TRP G 215
GLY G 216
GLY G 226
TYR G 228
 None
 0.78A 2p16A-1sgfG:
16.8		 2p16A-1sgfG:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 592
ALA A 593
CYH A 594
SER A 598
GLY A 629
TYR A 631
 None
 0.99A 2p16A-1ybwA:
31.7		 2p16A-1ybwA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.30A 2p16A-1ym0A:
36.6		 2p16A-1ym0A:
32.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 VAL A 653
TRP A 655
GLY A 656
GLY A 667
TYR A 669
 None
 0.27A 2p16A-1zjkA:
30.2		 2p16A-1zjkA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 368  A 901 (-2.8A)
368  A 901 (-3.7A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
None
 0.37A 2p16A-1zlrA:
35.1		 2p16A-1zlrA:
34.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
GLY A 216
GLY A 226
TYR A 228
 None
SO4  A 301 (-2.8A)
None
None
None
 0.44A 2p16A-2aipA:
12.3		 2p16A-2aipA:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
None
 0.31A 2p16A-2eekA:
34.9		 2p16A-2eekA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		10 TYR A  99
PHE A 174
ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 DT8  A 700 (-3.4A)
DT8  A 700 (-3.4A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
 0.28A 2p16A-2ei8A:
46.2		 2p16A-2ei8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 227
TYR A 229
 None
 0.36A 2p16A-2f91A:
36.3		 2p16A-2f91A:
37.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus) 		PF00089
(Trypsin) 		6 SER C 195
VAL C 213
TRP C 215
GLY C 216
GLY C 226
TYR C 228
 None
 0.69A 2p16A-2jetC:
10.7		 2p16A-2jetC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 TYR A 538
SER A 659
VAL A 677
TRP A 679
GLY A 680
 None
 0.58A 2p16A-2odpA:
23.4		 2p16A-2odpA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
None
 0.29A 2p16A-2oq5A:
35.7		 2p16A-2oq5A:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pka KALLIKREIN A

(Sus scrofa) 		PF00089
(Trypsin) 		6 TYR B  99
ASP B 189
SER B 195
TRP B 215
GLY B 216
TYR B 228
 None
BEN  B   1 (-3.0A)
BEN  B   1 ( 4.0A)
None
BEN  B   1 (-3.5A)
None
 0.70A 2p16A-2pkaB:
16.0		 2p16A-2pkaB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP C 229
ALA C 230
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
TYR C 270
 G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
None
 0.35A 2p16A-2pksC:
14.4		 2p16A-2pksC:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.38A 2p16A-2psyA:
34.4		 2p16A-2psyA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP B 631
ALA B 632
SER B 637
VAL B 657
TRP B 659
GLY B 660
GLY B 668
TYR B 670
 None
 0.43A 2p16A-2qy0B:
32.2		 2p16A-2qy0B:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.45A 2p16A-2r0lA:
34.2		 2p16A-2r0lA:
33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
TYR U 228
 4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
None
 0.35A 2p16A-2r2wU:
33.5		 2p16A-2r2wU:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 TYR S  99
PHE S 174
ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
TYR S 228
 None
 0.45A 2p16A-2wpmS:
38.9		 2p16A-2wpmS:
46.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrc HUMAN COMPLEMENT
FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00089
(Trypsin)
PF00530
(SRCR) 		5 TYR A 408
VAL A 526
TRP A 528
GLY A 539
TYR A 541
 None
 0.50A 2p16A-2xrcA:
22.1		 2p16A-2xrcA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
TYR A 242
 11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
None
 0.38A 2p16A-2zecA:
32.9		 2p16A-2zecA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		8 PHE A 174
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
None
BEN  A 247 (-3.7A)
BEN  A 247 (-3.5A)
None
 0.48A 2p16A-3beuA:
33.2		 2p16A-3beuA:
41.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
None
 0.34A 2p16A-3f6uH:
37.4		 2p16A-3f6uH:
37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP B 640
ALA B 641
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
TYR B 681
 None
 0.45A 2p16A-3govB:
34.1		 2p16A-3govB:
32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.36A 2p16A-3gymA:
34.3		 2p16A-3gymA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		8 ASP B 189
ALA B 190
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
TYR B 228
 None
 0.32A 2p16A-3r3gB:
35.0		 2p16A-3r3gB:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
VAL A 209
GLY A 212
GLY A 223
TYR A 225
 None
 0.47A 2p16A-3s69A:
11.9		 2p16A-3s69A:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA

(Daboia
siamensis) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 216
TYR A 228
 None
 0.51A 2p16A-3s9bA:
11.8		 2p16A-3s9bA:
29.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		5 ASP A 973
SER A 979
GLY A1000
GLY A1010
TYR A1012
 None
 0.25A 2p16A-3w94A:
36.3		 2p16A-3w94A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		8 TYR A 262
ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 393
TYR A 395
 0GJ  A1411 ( 3.5A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
None
 0.42A 2p16A-4bxwA:
38.9		 2p16A-4bxwA:
55.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Corynebacterium
diphtheriae) 		PF01625
(PMSR) 		5 TYR A  47
ALA A 190
SER A  70
VAL A  71
TYR A  53
 None
None
None
None
CAC  A1220 (-4.2A)
 1.00A 2p16A-4d7lA:
undetectable		 2p16A-4d7lA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
VAL A 213
GLY A 226
TYR A 228
 None
 0.32A 2p16A-4d9rA:
15.5		 2p16A-4d9rA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		6 PHE A 173
ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 None
 0.80A 2p16A-4e7nA:
11.5		 2p16A-4e7nA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
TYR H 669
 None
 0.32A 2p16A-4fxgH:
34.1		 2p16A-4fxgH:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		6 ASP A 172
SER A 178
VAL A 192
GLY A 195
GLY A 206
TYR A 208
 None
 0.45A 2p16A-4gsoA:
undetectable		 2p16A-4gsoA:
29.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h4f CHYMOTRYPSIN-C

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A 190
SER A 195
VAL A 213
GLY A 216
TYR A 228
 None
 0.36A 2p16A-4h4fA:
35.8		 2p16A-4h4fA:
34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 SER A 646
VAL A 666
TRP A 668
GLY A 679
TYR A 681
 None
None
GOL  A 702 (-3.9A)
None
None
 0.52A 2p16A-4igdA:
28.9		 2p16A-4igdA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
TYR E 682
 None
 0.51A 2p16A-4iw4E:
32.0		 2p16A-4iw4E:
35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		7 TYR E 531
ASP E 639
VAL E 665
TRP E 667
GLY E 668
GLY E 680
TYR E 682
 None
 0.76A 2p16A-4iw4E:
32.0		 2p16A-4iw4E:
35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 TYR A 648
PHE A 647
ALA A 619
GLY A 565
TYR A 665
 None
 1.13A 2p16A-4j1yA:
26.3		 2p16A-4j1yA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
TYR A 228
 None
 0.42A 2p16A-4k8yA:
32.7		 2p16A-4k8yA:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 ASP A 339
ALA A 338
VAL A 344
GLY A 322
GLY A 341
 None
 0.89A 2p16A-4kh3A:
undetectable		 2p16A-4kh3A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		6 TYR A 550
VAL A 684
TRP A 686
GLY A 687
GLY A 699
TYR A 701
 None
 0.66A 2p16A-4kkdA:
28.3		 2p16A-4kkdA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		5 VAL A 237
TRP A 239
GLY A 240
GLY A 251
TYR A 253
 None
 0.44A 2p16A-4lk4A:
27.4		 2p16A-4lk4A:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		6 ASP A 173
SER A 179
TRP A 195
GLY A 196
GLY A 206
TYR A 208
 None
 0.40A 2p16A-4m7gA:
33.4		 2p16A-4m7gA:
34.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nff KALLIKREIN-2

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 195
TRP A 215
GLY A 216
TYR A 228
 0G6  A 301 (-3.0A)
0G6  A 301 (-1.4A)
0G6  A 301 (-3.7A)
0G6  A 301 (-3.4A)
None
 0.47A 2p16A-4nffA:
13.2		 2p16A-4nffA:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
None
 0.28A 2p16A-4r0iA:
36.8		 2p16A-4r0iA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		5 ASP A 353
ALA A 352
CYH A 351
SER A  16
GLY A 348
 None
 1.10A 2p16A-4tqkA:
undetectable		 2p16A-4tqkA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.34A 2p16A-4wwyA:
35.9		 2p16A-4wwyA:
35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
TYR H 228
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
None
 0.30A 2p16A-4ylqH:
38.8		 2p16A-4ylqH:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		7 TYR E  99
ASP E 189
ALA E 190
TRP E 215
GLY E 216
GLY E 226
TYR E 228
 None
 0.43A 2p16A-5brrE:
34.1		 2p16A-5brrE:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 SER A 557
TRP A 577
GLY A 578
GLY A 588
TYR A 590
 None
 0.84A 2p16A-5eodA:
27.5		 2p16A-5eodA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
ALA A 190
SER A 195
GLY A 216
GLY A 226
TYR A 228
 None
 0.56A 2p16A-5f8zA:
35.6		 2p16A-5f8zA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 ASP A 189
ALA A 190
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.27A 2p16A-5f8zA:
35.6		 2p16A-5f8zA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		6 ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
5VT  A 302 ( 4.3A)
None
 0.85A 2p16A-5fahA:
14.1		 2p16A-5fahA:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		6 ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
None
 0.41A 2p16A-5fahA:
14.1		 2p16A-5fahA:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 6 ASP A 189
ALA A 190
SER A 195
GLY A 216
GLY A 226
TYR A 228
 None
 0.32A 2p16A-5gvtA:
35.3		 2p16A-5gvtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvt PLASMA KALLIKREIN

(Mus musculus) 		no annotation 6 ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 226
TYR A 228
 None
 1.14A 2p16A-5gvtA:
35.3		 2p16A-5gvtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms3 KALLIKREIN-8

(Homo sapiens) 		no annotation 6 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.29A 2p16A-5ms3A:
34.3		 2p16A-5ms3A:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		7 ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.82A 2p16A-5o32I:
30.9		 2p16A-5o32I:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00089
(Trypsin) 		7 TYR I 426
ASP I 519
VAL I 544
TRP I 546
GLY I 547
GLY I 557
TYR I 559
 None
 0.81A 2p16A-5o32I:
30.9		 2p16A-5o32I:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		7 ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 253
TYR B 255
 0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
None
 0.31A 2p16A-5to3B:
35.7		 2p16A-5to3B:
26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 7 ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
TYR A 665
 None
 0.50A 2p16A-5ubmA:
31.6		 2p16A-5ubmA:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 5 ALA A  25
VAL A 310
TRP A 359
GLY A 363
GLY A  23
 None
 1.00A 2p16A-5w4zA:
undetectable		 2p16A-5w4zA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 6 ASP A 200
SER A 206
VAL A 220
GLY A 223
GLY A 234
TYR A 236
 None
 0.65A 2p16A-5xrfA:
11.8		 2p16A-5xrfA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.46A 2p16A-5zfhA:
33.5		 2p16A-5zfhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 8 TYR B  99
ASP B 189
ALA B 190
SER B 195
TRP B 215
GLY B 216
GLY B 226
TYR B 228
 None
BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
None
 0.38A 2p16A-6b74B:
34.1		 2p16A-6b74B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b72 PROTEIN (HOMEOBOX
PROTEIN HOX-B1)

(Homo sapiens) 		PF00046
(Homeobox) 		3 ARG A 213
GLU A 217
GLN A 214
 None
 0.99A 2p16A-1b72A:
undetectable		 2p16A-1b72A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		3 ARG A 321
GLU A 320
GLN A 322
 None
 1.06A 2p16A-1bf5A:
0.0		 2p16A-1bf5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ARG A 341
GLU A 339
GLN A 340
 None
 0.90A 2p16A-1cliA:
0.0		 2p16A-1cliA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		3 ARG A 104
GLU A 101
GLN A 119
 None
 1.06A 2p16A-1di6A:
undetectable		 2p16A-1di6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 ARG A 176
GLU A 228
GLN A 226
 None
 0.96A 2p16A-1dmwA:
0.0		 2p16A-1dmwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ARG C 336
GLU C 337
GLN C 367
 None
 1.01A 2p16A-1ea9C:
0.0		 2p16A-1ea9C:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hnf CD2

(Homo sapiens) 		PF05790
(C2-set)
PF07686
(V-set) 		3 ARG A 105
GLU A 104
GLN A  15
 None
NAG  A 502 (-3.9A)
None
 0.96A 2p16A-1hnfA:
1.0		 2p16A-1hnfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 ARG A 402
GLU A 296
GLN A 288
 None
 0.94A 2p16A-1iv8A:
0.0		 2p16A-1iv8A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		3 ARG A 339
GLU A 336
GLN A 370
 None
 1.04A 2p16A-1j0hA:
0.0		 2p16A-1j0hA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jrm CONSERVED
HYPOTHETICAL PROTEIN
MTH637

(Methanothermobacter
thermautotrophicus) 		PF02594
(DUF167) 		3 ARG A  38
GLU A  40
GLN A  78
 None
 1.01A 2p16A-1jrmA:
0.0		 2p16A-1jrmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 ARG B 359
GLU B 352
GLN B 394
 None
 0.85A 2p16A-1lwuB:
undetectable		 2p16A-1lwuB:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7f CAMP-DEPENDENT RAP1
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP) 		3 ARG A 215
GLU A 277
GLN A 216
 None
 1.00A 2p16A-1o7fA:
undetectable		 2p16A-1o7fA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		3 ARG A 176
GLU A 228
GLN A 226
 None
 0.95A 2p16A-1phzA:
undetectable		 2p16A-1phzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 ARG A  87
GLU A  66
GLN A 634
 None
 1.08A 2p16A-1qlbA:
undetectable		 2p16A-1qlbA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 394
GLU A 395
GLN A 373
 None
 1.09A 2p16A-1snxA:
undetectable		 2p16A-1snxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ssl HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01437
(PSI) 		3 ARG A  33
GLU A  35
GLN A  23
 None
 0.86A 2p16A-1sslA:
undetectable		 2p16A-1sslA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7i HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06983
(3-dmu-9_3-mt) 		3 ARG A 115
GLU A  91
GLN A 114
 None
 0.87A 2p16A-1u7iA:
undetectable		 2p16A-1u7iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj3 IGG FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG B 340
GLU B 389
GLN B 343
 None
 0.76A 2p16A-1uj3B:
undetectable		 2p16A-1uj3B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wi5 RRP5 PROTEIN HOMOLOG

(Homo sapiens) 		PF00575
(S1) 		3 ARG A 238
GLU A 235
GLN A 234
 None
 0.94A 2p16A-1wi5A:
undetectable		 2p16A-1wi5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8m FIS1

(Saccharomyces
cerevisiae) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 ARG A  75
GLU A  78
GLN A  40
 None
 1.05A 2p16A-1y8mA:
undetectable		 2p16A-1y8mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6n HYPOTHETICAL PROTEIN
PA1234

(Pseudomonas
aeruginosa) 		PF14595
(Thioredoxin_9) 		3 ARG A 101
GLU A 107
GLN A 102
 None
 0.91A 2p16A-1z6nA:
undetectable		 2p16A-1z6nA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 ARG A  58
GLU A 289
GLN A 287
 None
 0.90A 2p16A-2aa4A:
undetectable		 2p16A-2aa4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjq MFP2A

(Ascaris suum) 		PF12150
(MFP2b) 		3 ARG A 167
GLU A   7
GLN A 112
 None
 1.00A 2p16A-2bjqA:
undetectable		 2p16A-2bjqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8x PROTEIN PINCH

(Homo sapiens) 		PF00412
(LIM) 		3 ARG A  33
GLU A  39
GLN A  38
 None
 1.04A 2p16A-2d8xA:
undetectable		 2p16A-2d8xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 ARG A 248
GLU A 450
GLN A 252
 None
 1.09A 2p16A-2dfsA:
undetectable		 2p16A-2dfsA:
12.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG A 143
GLU A 147
GLN A 192
 None
None
DT8  A 700 (-3.9A)
 1.03A 2p16A-2ei8A:
46.2		 2p16A-2ei8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		3 ARG A 431
GLU A 427
GLN A 430
 None
 1.00A 2p16A-2fwrA:
undetectable		 2p16A-2fwrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		3 ARG A 465
GLU A 185
GLN A 618
 None
 0.95A 2p16A-2g28A:
undetectable		 2p16A-2g28A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib1 DEATH DOMAIN
CONTAINING MEMBRANE
PROTEIN NRADD

(Mus musculus) 		PF00531
(Death) 		3 ARG A 147
GLU A 144
GLN A 146
 None
 1.03A 2p16A-2ib1A:
undetectable		 2p16A-2ib1A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		3 ARG A1731
GLU A1859
GLN A1865
 None
 1.00A 2p16A-2ix8A:
undetectable		 2p16A-2ix8A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnv NIFU-LIKE PROTEIN 1,
CHLOROPLAST

(Oryza sativa) 		PF01106
(NifU) 		3 ARG A 133
GLU A 136
GLN A  86
 None
 0.75A 2p16A-2jnvA:
undetectable		 2p16A-2jnvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kqr ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Brugia malayi) 		no annotation 3 ARG A  42
GLU A  18
GLN A  49
 None
 0.61A 2p16A-2kqrA:
undetectable		 2p16A-2kqrA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvr UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		3 ARG A  85
GLU A 127
GLN A  83
 None
 0.99A 2p16A-2kvrA:
undetectable		 2p16A-2kvrA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzn DNA PRIMASE

(Staphylococcus
aureus) 		PF00772
(DnaB) 		3 ARG A 579
GLU A 580
GLN A 595
 None
 1.05A 2p16A-2lznA:
undetectable		 2p16A-2lznA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		3 ARG A 192
GLU A 193
GLN A 153
 None
 1.07A 2p16A-2myiA:
undetectable		 2p16A-2myiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1s 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		3 ARG A 601
GLU A 598
GLN A 597
 None
 0.98A 2p16A-2o1sA:
undetectable		 2p16A-2o1sA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 ARG A 533
GLU A 530
GLN A 529
 None
 1.10A 2p16A-2ozuA:
undetectable		 2p16A-2ozuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		3 ARG A 629
GLU A 633
GLN A 626
 None
 1.04A 2p16A-2rfoA:
undetectable		 2p16A-2rfoA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A 632
GLU A 676
GLN A 678
 None
 1.10A 2p16A-2vkwA:
undetectable		 2p16A-2vkwA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 153
GLU A  21
GLN A 142
 None
 0.90A 2p16A-2yfkA:
undetectable		 2p16A-2yfkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edv SPECTRIN BETA CHAIN,
BRAIN 1

(Homo sapiens) 		PF00435
(Spectrin) 		3 ARG A1741
GLU A1738
GLN A1737
 MG  A1006 ( 3.9A)
None
MG  A1006 ( 4.5A)
 1.09A 2p16A-3edvA:
undetectable		 2p16A-3edvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etu PROTEIN TRANSPORT
PROTEIN DSL1

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		3 ARG A 193
GLU A 190
GLN A 189
 None
 0.92A 2p16A-3etuA:
undetectable		 2p16A-3etuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiq ODORANT-BINDING
PROTEIN 1F

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		3 ARG A  36
GLU A  31
GLN A 147
 None
EDO  A 158 ( 4.3A)
None
 1.02A 2p16A-3fiqA:
undetectable		 2p16A-3fiqA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gei TRNA MODIFICATION
GTPASE MNME

(Chlorobaculum
tepidum) 		PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical) 		3 ARG A 211
GLU A 208
GLN A 423
 None
 0.55A 2p16A-3geiA:
undetectable		 2p16A-3geiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE
RECEPTOR (HGHBP)

(Homo sapiens) 		PF00041
(fn3)
PF09067
(EpoR_lig-bind) 		3 ARG B  43
GLU B  44
GLN B 216
 None
 1.01A 2p16A-3hhrB:
undetectable		 2p16A-3hhrB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm2 PRECORRIN-6Y
C5,15-METHYLTRANSFER
ASE

(Corynebacterium
diphtheriae) 		no annotation 3 ARG A  59
GLU A  53
GLN A  79
 None
 0.96A 2p16A-3hm2A:
undetectable		 2p16A-3hm2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		3 ARG A1306
GLU A1313
GLN A1734
 None
 1.10A 2p16A-3ig3A:
undetectable		 2p16A-3ig3A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		3 ARG P 441
GLU P 442
GLN P 453
 None
 1.03A 2p16A-3izyP:
undetectable		 2p16A-3izyP:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 ARG A  43
GLU A  47
GLN A  40
 None
 1.05A 2p16A-3j3iA:
undetectable		 2p16A-3j3iA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kho B-CELL ANTIGEN
RECEPTOR
COMPLEX-ASSOCIATED
PROTEIN BETA CHAIN

(Mus musculus) 		no annotation 3 ARG B  93
GLU B  91
GLN B 111
 None
 1.10A 2p16A-3khoB:
undetectable		 2p16A-3khoB:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ARG A 305
GLU A 313
GLN A 306
 None
 0.97A 2p16A-3ll3A:
undetectable		 2p16A-3ll3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		3 ARG A 492
GLU A 489
GLN A 488
 GOL  A 783 (-4.3A)
GOL  A 783 ( 4.4A)
SO4  A   1 (-4.1A)
 0.97A 2p16A-3nawA:
undetectable		 2p16A-3nawA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 ARG A1061
GLU A1062
GLN A1015
 None
 1.02A 2p16A-3psiA:
undetectable		 2p16A-3psiA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6a UNCHARACTERIZED
PROTEIN

(Staphylococcus
saprophyticus) 		PF08327
(AHSA1) 		3 ARG A  13
GLU A  82
GLN A  66
 None
 0.95A 2p16A-3q6aA:
undetectable		 2p16A-3q6aA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		3 ARG A  65
GLU A  66
GLN A 331
 None
 0.85A 2p16A-3tevA:
undetectable		 2p16A-3tevA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 ARG A 401
GLU A 398
GLN A 455
 None
 0.90A 2p16A-3u5uA:
undetectable		 2p16A-3u5uA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 ARG A  30
GLU A  27
GLN A  26
 None
 0.78A 2p16A-3wstA:
undetectable		 2p16A-3wstA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-3x1oA:
undetectable		 2p16A-3x1oA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		3 ARG A 283
GLU A 280
GLN A 287
 None
 1.09A 2p16A-3zizA:
undetectable		 2p16A-3zizA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		3 ARG A 390
GLU A 392
GLN A 393
 None
 1.03A 2p16A-4b8sA:
undetectable		 2p16A-4b8sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 ARG A  24
GLU A  25
GLN A  20
 None
 1.00A 2p16A-4bedA:
undetectable		 2p16A-4bedA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL15

(Sus scrofa) 		PF00828
(Ribosomal_L27A) 		3 ARG P  59
GLU P  56
GLN P  58
 U  A 353 ( 3.2A)
G  A 351 ( 3.1A)
U  A 356 ( 3.1A)
 1.05A 2p16A-4ce4P:
undetectable		 2p16A-4ce4P:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		3 ARG A 131
GLU A  64
GLN A  66
 NAG  A1308 ( 4.3A)
NA  A1328 ( 4.5A)
None
 1.03A 2p16A-4cuoA:
undetectable		 2p16A-4cuoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dk0 PUTATIVE MACA

(Aggregatibacter
actinomycetemcomitans) 		PF16576
(HlyD_D23) 		3 ARG A 114
GLU A 155
GLN A 110
 None
 0.79A 2p16A-4dk0A:
undetectable		 2p16A-4dk0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		3 ARG A 214
GLU A 211
GLN A 210
 None
 1.08A 2p16A-4du6A:
undetectable		 2p16A-4du6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		3 ARG A  29
GLU A  27
GLN A 117
 None
 1.04A 2p16A-4ep0A:
0.9		 2p16A-4ep0A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		3 ARG A 138
GLU A 135
GLN A 141
 None
 1.07A 2p16A-4fmcA:
undetectable		 2p16A-4fmcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		3 ARG A 107
GLU A 143
GLN A 148
 None
CAF  A 169 ( 4.8A)
None
 1.08A 2p16A-4h5uA:
undetectable		 2p16A-4h5uA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		3 ARG B 316
GLU B 302
GLN B 317
 None
 0.93A 2p16A-4hstB:
undetectable		 2p16A-4hstB:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2b NTD BIOSYNTHESIS
OPERON PROTEIN NTDA

(Bacillus
subtilis) 		PF01041
(DegT_DnrJ_EryC1) 		3 ARG A 323
GLU A  52
GLN A 327
 None
 0.93A 2p16A-4k2bA:
undetectable		 2p16A-4k2bA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knt MULTICOPPER OXIDASE
TYPE 1

(Nitrosomonas
europaea) 		PF07732
(Cu-oxidase_3) 		3 ARG A 134
GLU A  35
GLN A 130
 None
 1.02A 2p16A-4kntA:
undetectable		 2p16A-4kntA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ARG A 345
GLU A 346
GLN A 334
 None
 0.95A 2p16A-4m0mA:
undetectable		 2p16A-4m0mA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 3 ARG A 565
GLU A 566
GLN A 561
 None
 1.03A 2p16A-4m0mA:
undetectable		 2p16A-4m0mA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxj C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 3

(Homo sapiens) 		PF16471
(JIP_LZII) 		3 ARG A 459
GLU A 456
GLN A 455
 EDO  A 504 ( 2.9A)
None
EDO  A 504 (-3.2A)
 1.08A 2p16A-4pxjA:
undetectable		 2p16A-4pxjA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qik ROQUIN-1

(Homo sapiens) 		no annotation 3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-4qikA:
undetectable		 2p16A-4qikA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		3 ARG A 120
GLU A 117
GLN A 114
 None
 0.64A 2p16A-4rmfA:
undetectable		 2p16A-4rmfA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		3 ARG A 231
GLU A 226
GLN A 298
 None
 1.04A 2p16A-4twfA:
undetectable		 2p16A-4twfA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-4txaA:
undetectable		 2p16A-4txaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 ARG A 209
GLU A 261
GLN A 259
 None
 1.02A 2p16A-4v06A:
undetectable		 2p16A-4v06A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2e FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 ARG A 341
GLU A 338
GLN A 335
 None
 0.91A 2p16A-4v2eA:
undetectable		 2p16A-4v2eA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		3 ARG A 137
GLU A   7
GLN A 138
 None
 0.93A 2p16A-4wlpA:
undetectable		 2p16A-4wlpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b88 ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF03880
(DbpA) 		3 ARG A 490
GLU A 492
GLN A 558
 None
 0.82A 2p16A-5b88A:
undetectable		 2p16A-5b88A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		3 ARG A 217
GLU A 214
GLN A 213
 None
 0.97A 2p16A-5bmoA:
undetectable		 2p16A-5bmoA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djn KINESIN-LIKE PROTEIN

(Mus musculus) 		PF16183
(Kinesin_assoc) 		3 ARG A 426
GLU A 423
GLN A 422
 None
 1.06A 2p16A-5djnA:
undetectable		 2p16A-5djnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		3 ARG A 210
GLU A 211
GLN A 206
 None
 1.06A 2p16A-5ej1A:
1.0		 2p16A-5ej1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 ARG A 491
GLU A 494
GLN A 520
 None
 0.96A 2p16A-5i68A:
undetectable		 2p16A-5i68A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic1 TALIN-1

(Mus musculus) 		no annotation 3 ARG A1469
GLU A1438
GLN A1466
 None
None
EDO  A1901 (-4.1A)
 1.02A 2p16A-5ic1A:
undetectable		 2p16A-5ic1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig4 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF08332
(CaMKII_AD) 		3 ARG A 352
GLU A 349
GLN A 348
 None
 0.85A 2p16A-5ig4A:
undetectable		 2p16A-5ig4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb1 MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 ARG A  71
GLU A 369
GLN A  69
 None
 0.98A 2p16A-5jb1A:
undetectable		 2p16A-5jb1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		3 ARG A 445
GLU A 444
GLN A 450
 None
 1.05A 2p16A-5k9tA:
undetectable		 2p16A-5k9tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 ARG A 449
GLU A 431
GLN A 430
 None
 0.92A 2p16A-5ko1A:
undetectable		 2p16A-5ko1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		3 ARG A 365
GLU A 416
GLN A 361
 ARG  A 365 ( 0.6A)
GLU  A 416 ( 0.5A)
GLN  A 361 ( 0.6A)
 0.82A 2p16A-5l5nA:
undetectable		 2p16A-5l5nA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 26S PROTEASE
REGULATORY SUBUNIT 4

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 ARG d 307
GLU d 304
GLN d 306
 None
 0.85A 2p16A-5m32d:
undetectable		 2p16A-5m32d:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myb ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A 580
GLU A 579
GLN A 589
 None
 0.85A 2p16A-5mybA:
undetectable		 2p16A-5mybA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ARG A 299
GLU A  36
GLN A 300
 None
 0.97A 2p16A-5tc4A:
undetectable		 2p16A-5tc4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhd RNA POLYMERASE SIGMA
FACTOR SIGA

(Mycobacterium
tuberculosis) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		3 ARG F 502
GLU F 501
GLN F 505
 None
 0.82A 2p16A-5uhdF:
undetectable		 2p16A-5uhdF:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 3 ARG A 397
GLU A 398
GLN A 445
 None
 1.10A 2p16A-5vanA:
undetectable		 2p16A-5vanA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy5 MELANOMA-ASSOCIATED
ANTIGEN G1
NON-STRUCTURAL
MAINTENANCE OF
CHROMOSOMES ELEMENT
1 HOMOLOG

(Homo sapiens) 		PF01454
(MAGE)
PF07574
(SMC_Nse1)
PF08746
(zf-RING-like) 		3 ARG A  17
GLU B 159
GLN A  20
 None
 1.02A 2p16A-5wy5A:
undetectable		 2p16A-5wy5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 419
GLU A 416
GLN A 415
 None
 1.07A 2p16A-5xfmA:
undetectable		 2p16A-5xfmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 ARG A  93
GLU A 710
GLN A  75
 None
 0.98A 2p16A-5xgjA:
undetectable		 2p16A-5xgjA:
19.67