SIMILAR PATTERNS OF AMINO ACIDS FOR 2OZR_F_HAEF3004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 800 (-3.2A)
ZN  A 800 (-3.3A)
ZN  A 800 (-3.3A)
 0.25A 2ozrF-1budA:
10.5		 2ozrF-1budA:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 403
HIS A 407
HIS A 413
 ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.24A 2ozrF-1ck7A:
27.4		 2ozrF-1ck7A:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eak 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 403
HIS A 407
HIS A 413
 ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
 0.35A 2ozrF-1eakA:
27.5		 2ozrF-1eakA:
30.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbl FIBROBLAST
(INTERSTITIAL)
COLLAGENASE (MMP-1)

(Sus scrofa) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 HIS A 218
HIS A 222
HIS A 228
 ZN  A 998 ( 3.5A)
ZN  A 998 ( 3.8A)
ZN  A 998 ( 3.6A)
 0.17A 2ozrF-1fblA:
27.2		 2ozrF-1fblA:
29.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 HIS P 169
HIS P 173
HIS P 179
 ZN  P 600 (-3.4A)
ZN  P 600 (-3.4A)
ZN  P 600 (-3.4A)
 0.24A 2ozrF-1h71P:
13.1		 2ozrF-1h71P:
17.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hfs STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 201
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.32A 2ozrF-1hfsA:
28.7		 2ozrF-1hfsA:
60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
 0.23A 2ozrF-1htdA:
10.6		 2ozrF-1htdA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hv5 STROMELYSIN 3

(Mus musculus) 		PF00413
(Peptidase_M10) 		3 HIS A 219
HIS A 223
HIS A 229
 ZN  A5502 ( 3.4A)
ZN  A5502 (-3.4A)
ZN  A5502 (-3.5A)
 0.28A 2ozrF-1hv5A:
23.0		 2ozrF-1hv5A:
47.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 HIS A  92
HIS A  96
HIS A 102
 CO  A 999 (-3.2A)
CO  A 999 (-3.3A)
CO  A 999 (-3.1A)
 0.35A 2ozrF-1iabA:
10.2		 2ozrF-1iabA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 HIS A 144
HIS A 148
HIS A 154
 CD  A 981 (-3.5A)
CD  A 981 (-3.4A)
CD  A 981 (-3.4A)
 0.24A 2ozrF-1kugA:
10.4		 2ozrF-1kugA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 401
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
 0.19A 2ozrF-1l6jA:
23.9		 2ozrF-1l6jA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		3 HIS A 264
HIS A 268
HIS A 334
 ZN  A 578 ( 3.5A)
ZN  A 578 ( 3.4A)
ZN  A 578 ( 3.4A)
 0.33A 2ozrF-1lmlA:
4.1		 2ozrF-1lmlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A  61
HIS A  70
HIS A  41
 CU  A5001 (-3.6A)
CU  A5001 ( 3.1A)
CU  A5001 (-2.9A)
 0.54A 2ozrF-1lnlA:
undetectable		 2ozrF-1lnlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m68 HYPOTHETICAL PROTEIN
YCDX

(Escherichia
coli) 		PF02811
(PHP) 		3 HIS A 194
HIS A  15
HIS A  40
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
 0.52A 2ozrF-1m68A:
undetectable		 2ozrF-1m68A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 400 (-3.2A)
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 0.24A 2ozrF-1nd1A:
8.2		 2ozrF-1nd1A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oz9 HYPOTHETICAL PROTEIN
AQ_1354

(Aquifex
aeolicus) 		PF02130
(UPF0054) 		3 HIS A 115
HIS A 119
HIS A 125
 None
 0.38A 2ozrF-1oz9A:
6.3		 2ozrF-1oz9A:
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 201
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
 0.19A 2ozrF-1qibA:
27.7		 2ozrF-1qibA:
65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qua ACUTOLYSIN-C

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 999 (-3.2A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.1A)
 0.30A 2ozrF-1quaA:
10.6		 2ozrF-1quaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 345
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
 0.28A 2ozrF-1r55A:
9.6		 2ozrF-1r55A:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rm8 MATRIX
METALLOPROTEINASE-16

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 246
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
 0.25A 2ozrF-1rm8A:
26.6		 2ozrF-1rm8A:
47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1slm STROMELYSIN-1

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 201
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
 0.31A 2ozrF-1slmA:
28.1		 2ozrF-1slmA:
43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 218
HIS A 222
HIS A 228
 ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
 0.24A 2ozrF-1su3A:
24.8		 2ozrF-1su3A:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 999 (-3.5A)
ZN  A 999 (-3.5A)
ZN  A 999 (-3.4A)
 0.19A 2ozrF-1wniA:
10.6		 2ozrF-1wniA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY

(Escherichia
coli) 		PF02130
(UPF0054) 		3 HIS A1114
HIS A1118
HIS A1124
 NI  A5001 (-3.4A)
NI  A5001 (-3.4A)
NI  A5001 (-3.3A)
 0.38A 2ozrF-1xm5A:
5.8		 2ozrF-1xm5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 999 (-3.3A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.28A 2ozrF-1yp1A:
10.7		 2ozrF-1yp1A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 333
HIS A 337
HIS A 343
 ZN  A 700 ( 3.4A)
ZN  A 700 ( 3.2A)
ZN  A 700 ( 3.2A)
 0.33A 2ozrF-2dw1A:
9.8		 2ozrF-2dw1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 145
HIS A 149
HIS A 155
 ZN  A 800 ( 3.3A)
ZN  A 800 ( 3.2A)
ZN  A 800 ( 3.1A)
 0.36A 2ozrF-2e3xA:
9.8		 2ozrF-2e3xA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 335
HIS A 339
HIS A 345
 ZN  A 700 (-3.4A)
ZN  A 700 (-3.4A)
ZN  A 700 (-3.0A)
 0.33A 2ozrF-2erqA:
9.3		 2ozrF-2erqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6k METAL-DEPENDENT
HYDROLASE

(Lactobacillus
plantarum) 		PF04909
(Amidohydro_2) 		3 HIS A   7
HIS A   9
HIS A 154
 MN  A 402 (-3.3A)
MN  A 402 (-3.5A)
MN  A 402 (-3.3A)
 0.46A 2ozrF-2f6kA:
undetectable		 2ozrF-2f6kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		3 HIS A 405
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
 0.23A 2ozrF-2fv5A:
9.4		 2ozrF-2fv5A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 226
HIS A 230
HIS A 236
 NGH  A 277 ( 3.0A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
 0.40A 2ozrF-2jsdA:
24.5		 2ozrF-2jsdA:
57.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o03 PROBABLE ZINC UPTAKE
REGULATION PROTEIN
FURB

(Mycobacterium
tuberculosis) 		PF01475
(FUR) 		3 HIS A  80
HIS A  82
HIS A 118
 ZN  A 203 (-3.3A)
ZN  A 203 (-3.1A)
ZN  A 203 (-3.3A)
 0.55A 2ozrF-2o03A:
undetectable		 2ozrF-2o03A:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 197
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
 0.17A 2ozrF-2oy4A:
28.4		 2ozrF-2oy4A:
60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		3 HIS A 234
HIS A  22
HIS A  57
 ZN  A 272 (-3.2A)
ZN  A 272 (-3.6A)
ZN  A 272 (-3.4A)
 0.55A 2ozrF-2pw6A:
undetectable		 2ozrF-2pw6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjq ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 410
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
 0.23A 2ozrF-2rjqA:
9.9		 2ozrF-2rjqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7m ARCHAEMETZINCIN

(Methanopyrus
kandleri) 		PF07998
(Peptidase_M54) 		3 HIS A 125
HIS A 129
HIS A 135
 ZN  A1174 (-3.2A)
ZN  A1174 (-3.2A)
ZN  A1174 (-3.2A)
 0.35A 2ozrF-2x7mA:
9.6		 2ozrF-2x7mA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y6c MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 219
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
 0.26A 2ozrF-2y6cA:
25.0		 2ozrF-2y6cA:
51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		3 HIS A 226
HIS A  13
HIS A  38
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
 0.53A 2ozrF-2z4gA:
undetectable		 2ozrF-2z4gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znv AMSH-LIKE PROTEASE

(Homo sapiens) 		PF01398
(JAB) 		3 HIS A 410
HIS A 408
HIS A 362
 ZN  A   1 (-3.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 3.3A)
 0.40A 2ozrF-2znvA:
undetectable		 2ozrF-2znvA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		3 HIS A 197
HIS A 217
HIS A  10
 FE2  A 275 ( 3.6A)
None
FE2  A 275 ( 3.6A)
 0.49A 2ozrF-2zoaA:
undetectable		 2ozrF-2zoaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 134
HIS A 396
HIS A 459
 C2O  A 702 (-3.3A)
C2O  A 702 ( 3.3A)
C2O  A 702 (-3.4A)
 0.56A 2ozrF-3aw5A:
undetectable		 2ozrF-3aw5A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 361
HIS A 365
HIS A 371
 ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
 0.24A 2ozrF-3b2zA:
9.7		 2ozrF-3b2zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 410
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
 0.32A 2ozrF-3b8zA:
10.1		 2ozrF-3b8zA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba0 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 HIS A 218
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
 0.35A 2ozrF-3ba0A:
26.1		 2ozrF-3ba0A:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN

(Solanum
tuberosum) 		PF00225
(Kinesin) 		3 HIS A 932
HIS A 922
HIS A1198
 None
 0.55A 2ozrF-3cobA:
undetectable		 2ozrF-3cobA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 145
HIS A 149
HIS A 155
 ZN  A 503 ( 3.3A)
ZN  A 503 ( 3.3A)
ZN  A 503 ( 3.3A)
 0.29A 2ozrF-3dslA:
9.4		 2ozrF-3dslA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edi TOLLOID-LIKE PROTEIN
1

(Homo sapiens) 		PF01400
(Astacin) 		3 HIS A  92
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
 0.30A 2ozrF-3ediA:
9.8		 2ozrF-3ediA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		3 HIS A 140
HIS A 144
HIS A 150
 ZN  A 302 (-3.3A)
ZN  A 302 (-3.3A)
ZN  A 302 (-3.2A)
 0.30A 2ozrF-3gboA:
10.0		 2ozrF-3gboA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 333
HIS A 337
HIS A 343
 ZN  A 620 (-3.4A)
ZN  A 620 (-3.3A)
ZN  A 620 (-3.1A)
 0.23A 2ozrF-3hdbA:
9.8		 2ozrF-3hdbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 341
HIS A 345
HIS A 351
 ZN  A 704 (-3.1A)
ZN  A 704 (-3.3A)
ZN  A 704 (-3.2A)
 0.37A 2ozrF-3k7nA:
10.1		 2ozrF-3k7nA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkc TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		PF00440
(TetR_N)
PF14278
(TetR_C_8) 		3 HIS A  87
HIS A  83
HIS A  67
 NI  A 201 ( 3.3A)
NI  A 201 (-3.4A)
NI  A 201 (-3.4A)
 0.49A 2ozrF-3kkcA:
undetectable		 2ozrF-3kkcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmc PEPTIDASE,
ZINC-DEPENDENT

(Methanocorpusculum
labreanum) 		PF07998
(Peptidase_M54) 		3 HIS A 149
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 2ozrF-3lmcA:
7.0		 2ozrF-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 HIS A  92
HIS A  96
HIS A 102
 ZN  A 999 (-3.3A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.3A)
 0.39A 2ozrF-3lq0A:
9.6		 2ozrF-3lq0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqb LOC792177 PROTEIN

(Danio rerio) 		PF01400
(Astacin) 		3 HIS A  99
HIS A 103
HIS A 109
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
ZN  A 201 ( 3.2A)
 0.34A 2ozrF-3lqbA:
10.4		 2ozrF-3lqbA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		3 HIS A 228
HIS A 232
HIS A 238
 ZN  A 999 (-3.1A)
ZN  A 999 (-3.1A)
ZN  A 999 (-3.0A)
 0.36A 2ozrF-3lunA:
7.8		 2ozrF-3lunA:
21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A1222
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
 0.31A 2ozrF-3o2xA:
30.2		 2ozrF-3o2xA:
98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		3 HIS A 348
HIS A 352
HIS A 358
 ZN  A 999 (-3.2A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 3.2A)
 0.26A 2ozrF-3p24A:
8.6		 2ozrF-3p24A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 149
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
 0.24A 2ozrF-3q2hA:
10.1		 2ozrF-3q2hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rzu STAM-BINDING PROTEIN

(Homo sapiens) 		PF01398
(JAB) 		3 HIS A 398
HIS A 396
HIS A 350
 ZN  A   2 (-3.4A)
ZN  A   2 (-3.5A)
ZN  A   2 (-3.5A)
 0.54A 2ozrF-3rzuA:
undetectable		 2ozrF-3rzuA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3shi INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 218
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.22A 2ozrF-3shiA:
28.1		 2ozrF-3shiA:
58.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		3 HIS A 446
HIS A 450
HIS A 456
 ZN  A   1 (-3.2A)
ZN  A   1 (-3.2A)
ZN  A   1 (-3.3A)
 0.38A 2ozrF-3ujzA:
3.2		 2ozrF-3ujzA:
12.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v96 STROMELYSIN-2

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS B 217
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
 0.30A 2ozrF-3v96B:
28.9		 2ozrF-3v96B:
61.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		3 HIS A 176
HIS A 180
HIS A 186
 ZN  A 500 (-3.2A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.2A)
 0.26A 2ozrF-3vi1A:
13.5		 2ozrF-3vi1A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtg HIGH CHORIOLYTIC
ENZYME 1

(Oryzias latipes) 		PF01400
(Astacin) 		3 HIS A  99
HIS A 103
HIS A 109
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
 0.30A 2ozrF-3vtgA:
10.1		 2ozrF-3vtgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3w ARCHAEMETZINCIN

(Archaeoglobus
fulgidus) 		PF07998
(Peptidase_M54) 		3 HIS A 117
HIS A 121
HIS A 127
 ZN  A1159 ( 3.2A)
ZN  A1159 ( 3.3A)
ZN  A1159 ( 3.2A)
 0.24A 2ozrF-4a3wA:
7.3		 2ozrF-4a3wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.31A 2ozrF-4aigA:
10.5		 2ozrF-4aigA:
25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 HIS A 199
HIS A 203
HIS A 209
 ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
 0.26A 2ozrF-4auoA:
27.5		 2ozrF-4auoA:
31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A1311
HIS A1320
HIS A1293
 CUO  A9004 (-3.4A)
CUO  A9004 (-3.5A)
CUO  A9004 (-3.2A)
 0.48A 2ozrF-4bedA:
undetectable		 2ozrF-4bedA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 334
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
 0.18A 2ozrF-4dd8A:
9.8		 2ozrF-4dd8A:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		3 HIS A 222
HIS A 226
HIS A 232
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
 0.28A 2ozrF-4fvlA:
29.2		 2ozrF-4fvlA:
99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gr8 MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 218
HIS A 222
HIS A 228
 R4C  A 306 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
 0.26A 2ozrF-4gr8A:
26.9		 2ozrF-4gr8A:
58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		3 HIS A 152
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
 0.34A 2ozrF-4gwnA:
9.5		 2ozrF-4gwnA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		3 HIS A  12
HIS A  14
HIS A 195
 ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
 0.40A 2ozrF-4hjwA:
undetectable		 2ozrF-4hjwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		3 HIS A 251
HIS A  12
HIS A 195
 None
ZN  A 401 (-3.6A)
ZN  A 401 (-3.5A)
 0.50A 2ozrF-4hjwA:
undetectable		 2ozrF-4hjwA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		3 HIS A   9
HIS A  11
HIS A 177
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.6A)
 0.32A 2ozrF-4ifrA:
undetectable		 2ozrF-4ifrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		3 HIS A   6
HIS A   8
HIS A 174
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
 0.42A 2ozrF-4igmA:
undetectable		 2ozrF-4igmA:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		3 HIS A 155
HIS A 159
HIS A 165
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
 0.31A 2ozrF-4in9A:
22.9		 2ozrF-4in9A:
45.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		3 HIS A 144
HIS A 148
HIS A 154
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
 0.21A 2ozrF-4j4mA:
10.5		 2ozrF-4j4mA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiu PROABYLYSIN

(Pyrococcus
abyssi) 		PF01863
(DUF45) 		3 HIS A  60
HIS A  64
HIS A  72
 ZN  A 201 (-3.2A)
ZN  A 201 (-3.2A)
ZN  A 201 (-3.2A)
 0.37A 2ozrF-4jiuA:
4.5		 2ozrF-4jiuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jix PROJANNALYSIN

(Methanocaldococcus
jannaschii) 		PF01863
(DUF45) 		3 HIS A  69
HIS A  73
HIS A  81
 ZN  A 201 (-3.3A)
ZN  A 201 ( 3.3A)
ZN  A 201 (-3.3A)
 0.31A 2ozrF-4jixA:
4.6		 2ozrF-4jixA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		3 HIS A 179
HIS A 183
HIS A 189
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.20A 2ozrF-4l63A:
11.5		 2ozrF-4l63A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		3 HIS A 406
HIS A 404
HIS A 356
 ZN  A 501 (-3.2A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
 0.38A 2ozrF-4nqlA:
undetectable		 2ozrF-4nqlA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		3 HIS A 351
HIS A 355
HIS A 361
 ZN  A 400 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-3.1A)
 0.28A 2ozrF-4on1A:
8.1		 2ozrF-4on1A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 302 (-3.2A)
ZN  A 302 (-3.1A)
ZN  A 302 (-3.1A)
 0.31A 2ozrF-4q1lA:
10.3		 2ozrF-4q1lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		3 HIS A  69
HIS A  73
HIS A  80
 ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.1A)
ZN  A 201 ( 3.2A)
 0.34A 2ozrF-4qhiA:
6.0		 2ozrF-4qhiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 HIS A  68
HIS A  66
HIS A 243
 FE  A 481 (-3.9A)
FE  A 481 (-3.9A)
FE  A 481 (-4.1A)
 0.50A 2ozrF-4v1yA:
undetectable		 2ozrF-4v1yA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 361
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
 0.27A 2ozrF-4wk7A:
10.2		 2ozrF-4wk7A:
25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 226
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
 0.28A 2ozrF-4xctA:
27.9		 2ozrF-4xctA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		3 HIS A 406
HIS A 404
HIS A 356
 ZN  A 502 (-3.1A)
ZN  A 502 (-3.1A)
ZN  A 502 (-3.2A)
 0.41A 2ozrF-4zd5A:
undetectable		 2ozrF-4zd5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		3 HIS A 142
HIS A 146
HIS A 152
 ZN  A 301 ( 3.4A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.1A)
 0.31A 2ozrF-5czwA:
10.9		 2ozrF-5czwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		3 HIS A 176
HIS A 180
HIS A 186
 HIS  A 176 (-1.0A)
HIS  A 180 (-1.0A)
HIS  A 186 (-1.0A)
 0.28A 2ozrF-5d7wA:
14.6		 2ozrF-5d7wA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 HIS A 239
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
 0.19A 2ozrF-5h0uA:
27.2		 2ozrF-5h0uA:
47.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		3 HIS A  97
HIS A 101
HIS A 107
 NI  A 201 ( 3.3A)
NI  A 201 ( 3.3A)
NI  A 201 (-3.3A)
 0.36A 2ozrF-5jigA:
4.1		 2ozrF-5jigA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 401
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
 0.22A 2ozrF-5th6A:
23.7		 2ozrF-5th6A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ue2 MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		3 HIS A 194
HIS A 198
HIS A 204
 ZN  A 304 (-3.3A)
ZN  A 304 (-3.3A)
ZN  A 304 (-3.2A)
 0.37A 2ozrF-5ue2A:
20.3		 2ozrF-5ue2A:
37.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		3 HIS A   6
HIS A   8
HIS A 179
 ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
ZN  A 400 (-3.2A)
 0.37A 2ozrF-5vn5A:
undetectable		 2ozrF-5vn5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		3 HIS A 223
HIS A   6
HIS A 179
 None
ZN  A 400 (-3.3A)
ZN  A 400 (-3.2A)
 0.50A 2ozrF-5vn5A:
undetectable		 2ozrF-5vn5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbn WSS1P

(Saccharomyces
cerevisiae) 		no annotation 3 HIS A 115
HIS A 119
HIS A 125
 ZN  A 201 (-3.2A)
ZN  A 201 (-3.3A)
ZN  A 201 (-3.2A)
 0.27A 2ozrF-5xbnA:
3.7		 2ozrF-5xbnA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 3 HIS A 383
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
 0.45A 2ozrF-6bdzA:
9.6		 2ozrF-6bdzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btp -

(-) 		no annotation 3 HIS A  93
HIS A  97
HIS A 103
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.4A)
ZN  A 302 ( 3.3A)
 0.22A 2ozrF-6btpA:
9.7		 2ozrF-6btpA:
undetectable