SIMILAR PATTERNS OF AMINO ACIDS FOR 2OZ7_A_CA4A1_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dix EXTRACELLULAR
RIBONUCLEASE LE

(Solanum
lycopersicum) 		PF00445
(Ribonuclease_T2) 		4 LEU A 105
TRP A  76
MET A  72
LEU A  68
 None
 1.45A 2oz7A-1dixA:
undetectable		 2oz7A-1dixA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		4 LEU A 183
TRP A 175
MET A 169
LEU A 166
 None
 1.28A 2oz7A-1fd9A:
undetectable		 2oz7A-1fd9A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcb GAL6 HG (EMTS)
DERIVATIVE

(Saccharomyces
cerevisiae) 		PF03051
(Peptidase_C1_2) 		4 LEU A  75
TRP A 176
MET A 220
LEU A 108
 None
 1.44A 2oz7A-1gcbA:
0.0		 2oz7A-1gcbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ich TUMOR NECROSIS
FACTOR RECEPTOR-1

(Homo sapiens) 		PF00531
(Death) 		4 LEU A 405
TRP A 342
MET A 374
LEU A 330
 None
 1.34A 2oz7A-1ichA:
undetectable		 2oz7A-1ichA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		4 LEU A 144
TRP A 136
MET A 130
LEU A 127
 None
 1.27A 2oz7A-1jvwA:
undetectable		 2oz7A-1jvwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 LEU A 106
MET A 294
MET A 346
LEU A 391
 None
 1.03A 2oz7A-1li7A:
undetectable		 2oz7A-1li7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		4 LEU A 349
MET A 263
MET A  57
LEU A 310
 None
 1.33A 2oz7A-1mg7A:
0.5		 2oz7A-1mg7A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv0 MODULATOR OF THE
ACTIVITY OF ETS
CG15085-PA

(Drosophila
melanogaster) 		PF02198
(SAM_PNT) 		4 LEU C 151
TRP C 115
MET C 119
LEU C 131
 None
 1.44A 2oz7A-1sv0C:
undetectable		 2oz7A-1sv0C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 337
MET A 383
MET A 384
LEU A 371
 None
 1.47A 2oz7A-1u59A:
undetectable		 2oz7A-1u59A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 LEU A 195
TRP A 149
MET A 231
LEU A 240
 None
 1.39A 2oz7A-1z6tA:
0.8		 2oz7A-1z6tA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		4 LEU A 303
MET A 240
MET A 238
LEU A 210
 None
 1.45A 2oz7A-2a4mA:
undetectable		 2oz7A-2a4mA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 880
TRP A 741
MET A 742
MET A 787
 None
None
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
 1.29A 2oz7A-2ax9A:
39.2		 2oz7A-2ax9A:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 880
TRP A 741
MET A 745
MET A 787
 None
None
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
 1.42A 2oz7A-2ax9A:
39.2		 2oz7A-2ax9A:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 TRP A 741
MET A 742
MET A 787
LEU A 873
 None
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
 0.30A 2oz7A-2ax9A:
39.2		 2oz7A-2ax9A:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		4 LEU A  76
MET A 301
MET A 300
LEU A  31
 None
 1.36A 2oz7A-2c1hA:
undetectable		 2oz7A-2c1hA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7i PUTATIVE LIPOATE
PROTEIN LIGASE

(Thermoplasma
acidophilum) 		PF03099
(BPL_LplA_LipB) 		4 TRP A 160
MET A 106
MET A 102
LEU A 222
 None
 1.42A 2oz7A-2c7iA:
undetectable		 2oz7A-2c7iA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9q GRANULOCYTE
COLONY-STIMULATING
FACTOR RECEPTOR

(Homo sapiens) 		PF06328
(Lep_receptor_Ig) 		4 MET B 110
MET B 199
MET B 176
LEU B 117
 None
 1.36A 2oz7A-2d9qB:
undetectable		 2oz7A-2d9qB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 LEU A  28
TRP A  75
MET A  70
MET A  88
 None
 1.38A 2oz7A-2dr3A:
undetectable		 2oz7A-2dr3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhe GLUTATHIONE
S-TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 202
MET A 179
MET A 129
LEU A 158
 None
 1.46A 2oz7A-2fheA:
undetectable		 2oz7A-2fheA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwt PUTATIVE
REPLICASE-ASSOCIATED
PROTEIN

(Faba bean
necrotic
yellows virus) 		PF02407
(Viral_Rep) 		4 LEU A  12
MET A  25
MET A  48
LEU A  28
 None
 1.47A 2oz7A-2hwtA:
undetectable		 2oz7A-2hwtA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		4 LEU D 100
TRP D  71
MET D  72
LEU D 120
 None
 1.40A 2oz7A-2j5gD:
undetectable		 2oz7A-2j5gD:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 MET A 143
MET A 139
MET A 107
LEU A 146
 None
 1.20A 2oz7A-2optA:
undetectable		 2oz7A-2optA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A  29
TRP A  69
MET A  70
LEU A 201
 1CA  A 247 ( 3.6A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 4.2A)
 1.29A 2oz7A-2q3yA:
36.0		 2oz7A-2q3yA:
60.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 MET A  70
MET A  73
MET A 115
LEU A 201
 1CA  A 247 ( 3.8A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 0.79A 2oz7A-2q3yA:
36.0		 2oz7A-2q3yA:
60.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 TRP A  69
MET A  70
MET A 115
LEU A 201
 None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 1.14A 2oz7A-2q3yA:
36.0		 2oz7A-2q3yA:
60.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql3 PROBABLE
TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF03466
(LysR_substrate) 		4 LEU A 251
TRP A 247
MET A 202
LEU A 204
 None
 1.18A 2oz7A-2ql3A:
undetectable		 2oz7A-2ql3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfl PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE SIXA

(Agrobacterium
fabrum) 		PF00300
(His_Phos_1) 		4 LEU A  55
MET A 117
MET A 124
LEU A  11
 None
 1.18A 2oz7A-2rflA:
undetectable		 2oz7A-2rflA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 LEU A 613
TRP A 558
MET A 593
LEU A 587
 None
 1.31A 2oz7A-2vcaA:
undetectable		 2oz7A-2vcaA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzm ALDO-KETO REDUCTASE

(Mycolicibacterium
smegmatis) 		PF00248
(Aldo_ket_red) 		4 LEU A 204
TRP A 227
MET A 261
LEU A 267
 NA7  A1284 (-4.8A)
None
None
None
 1.41A 2oz7A-2wzmA:
undetectable		 2oz7A-2wzmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 LEU A 206
MET A 327
MET A 328
LEU A 269
 None
 1.48A 2oz7A-2yr5A:
undetectable		 2oz7A-2yr5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvw PROLIFERATING CELL
NUCLEAR ANTIGEN 2

(Arabidopsis
thaliana) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A   4
MET A  75
MET A  78
LEU A  16
 None
 1.42A 2oz7A-2zvwA:
undetectable		 2oz7A-2zvwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 TRP A 128
MET A 135
MET A  95
LEU A 139
 None
 1.24A 2oz7A-3a6pA:
undetectable		 2oz7A-3a6pA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b3d PUTATIVE MORPHINE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 LEU A 202
TRP A 225
MET A 259
LEU A 265
 None
 1.28A 2oz7A-3b3dA:
undetectable		 2oz7A-3b3dA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		4 LEU A   7
TRP A 242
MET A  90
LEU A  13
 None
 1.44A 2oz7A-3b9gA:
undetectable		 2oz7A-3b9gA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxv SULFUR
OXYGENASE/REDUCTASE

(Acidianus
tengchongensis) 		PF07682
(SOR) 		4 LEU A  75
MET A 108
MET A  22
LEU A  13
 None
 1.45A 2oz7A-3bxvA:
undetectable		 2oz7A-3bxvA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 LEU A  41
MET A 273
MET A 303
LEU A 276
 None
 1.20A 2oz7A-3cc1A:
undetectable		 2oz7A-3cc1A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3f YVGN PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 LEU A 198
TRP A 221
MET A 255
LEU A 261
 NDP  A   1 (-4.8A)
None
None
None
 1.32A 2oz7A-3d3fA:
undetectable		 2oz7A-3d3fA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf7 GLUTACONYL-COA
DECARBOXYLASE
SUBUNIT A

([Clostridium]
symbiosum) 		PF01039
(Carboxyl_trans) 		4 LEU A 144
TRP A  77
MET A  65
LEU A  71
 None
 1.46A 2oz7A-3gf7A:
undetectable		 2oz7A-3gf7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A 217
MET A  46
MET A 203
LEU A 240
 None
 1.28A 2oz7A-3hi8A:
undetectable		 2oz7A-3hi8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		4 LEU A 611
TRP A 368
MET A 366
LEU A 363
 None
 1.45A 2oz7A-3i5gA:
undetectable		 2oz7A-3i5gA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 LEU A  51
MET A  27
MET A 175
LEU A  34
 None
 1.20A 2oz7A-3k5wA:
undetectable		 2oz7A-3k5wA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 715
TRP A 755
MET A 756
LEU A 887
 WOW  A   1 (-3.9A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.0A)
 0.85A 2oz7A-3kbaA:
34.3		 2oz7A-3kbaA:
55.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 TRP A 755
MET A 756
MET A 801
LEU A 887
 None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
 0.82A 2oz7A-3kbaA:
34.3		 2oz7A-3kbaA:
55.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		4 LEU A 158
TRP A 430
MET A 179
LEU A  21
 None
 1.22A 2oz7A-3mznA:
undetectable		 2oz7A-3mznA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 205
MET A 263
MET A 218
LEU A 196
 None
 1.38A 2oz7A-3n3zA:
undetectable		 2oz7A-3n3zA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TRP H  36
MET H  80
MET H  69
LEU H  82
 None
 1.40A 2oz7A-3ntcH:
undetectable		 2oz7A-3ntcH:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		4 LEU A 108
MET A 147
MET A 193
LEU A 141
 None
 1.40A 2oz7A-3o31A:
undetectable		 2oz7A-3o31A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9t REPRESSOR

(Stenotrophomonas
maltophilia) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 LEU A  74
MET A 110
MET A 113
LEU A 174
 None
TCL  A 221 ( 3.4A)
TCL  A 222 ( 4.7A)
None
 1.38A 2oz7A-3p9tA:
undetectable		 2oz7A-3p9tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 TRP A1138
MET A1102
MET A1106
LEU A1099
 None
 1.29A 2oz7A-3pblA:
undetectable		 2oz7A-3pblA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 205
MET A 263
MET A 218
LEU A 196
 None
 1.47A 2oz7A-3qi3A:
undetectable		 2oz7A-3qi3A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  29
MET A  70
MET A  73
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.2A)
 1.03A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  29
TRP A  69
MET A  70
LEU A 201
 1CA  A 249 ( 3.8A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.2A)
 1.36A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 MET A  70
MET A  73
MET A 115
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.69A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 TRP A  69
MET A  70
MET A 115
LEU A 201
 None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 1.26A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 LEU A 195
TRP A 149
MET A 231
LEU A 240
 None
 1.34A 2oz7A-3sfzA:
undetectable		 2oz7A-3sfzA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slt SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 TRP A1042
MET A1029
MET A1112
LEU A1025
 None
 1.38A 2oz7A-3sltA:
undetectable		 2oz7A-3sltA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqo J16 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TRP H  36
MET H  80
MET H  69
LEU H  82
 None
 1.47A 2oz7A-3sqoH:
undetectable		 2oz7A-3sqoH:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0o RIBONUCLEASE T2

(Homo sapiens) 		PF00445
(Ribonuclease_T2) 		4 LEU A 128
TRP A  97
MET A  93
LEU A  89
 None
 1.43A 2oz7A-3t0oA:
undetectable		 2oz7A-3t0oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 LEU A 285
MET A 136
MET A  98
LEU A 114
 None
COD  A 289 (-4.7A)
None
None
 1.32A 2oz7A-3uf6A:
undetectable		 2oz7A-3uf6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Thermosynechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 220
MET A 177
MET A 176
LEU A 159
 None
 1.23A 2oz7A-3zdfA:
undetectable		 2oz7A-3zdfA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 LEU A 685
MET A 240
MET A 313
LEU A 444
 None
 1.34A 2oz7A-3zgbA:
2.6		 2oz7A-3zgbA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 LEU A 494
MET A 542
MET A 511
LEU A 549
 None
 1.08A 2oz7A-4dxbA:
undetectable		 2oz7A-4dxbA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 LEU A 136
MET A 148
MET A 149
LEU A 254
 None
 1.44A 2oz7A-4efcA:
undetectable		 2oz7A-4efcA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1d ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF13416
(SBP_bac_8) 		4 LEU A 213
TRP A 346
MET A 341
LEU A 201
 None
 1.43A 2oz7A-4i1dA:
undetectable		 2oz7A-4i1dA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)

(Homo sapiens) 		no annotation 4 TRP H  36
MET H  81
MET H  70
LEU H  83
 None
 1.46A 2oz7A-4imlH:
undetectable		 2oz7A-4imlH:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 LEU A 251
MET A 105
MET A 270
LEU A 115
 None
 1.34A 2oz7A-4iuwA:
undetectable		 2oz7A-4iuwA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6t RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1

(Homo sapiens) 		PF03985
(Paf1)
PF04004
(Leo1) 		4 MET A  53
MET A  80
MET A  85
LEU A 103
 None
 1.15A 2oz7A-4m6tA:
undetectable		 2oz7A-4m6tA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		4 LEU A 212
MET A 258
MET A 255
LEU A 284
 None
 1.38A 2oz7A-4nq1A:
undetectable		 2oz7A-4nq1A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 LEU A 203
TRP A 226
MET A 260
LEU A 266
 MLI  A 301 (-4.7A)
None
None
None
 1.36A 2oz7A-4otkA:
undetectable		 2oz7A-4otkA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 LEU A 107
MET A 324
MET A 194
LEU A 226
 None
 1.26A 2oz7A-4ppuA:
undetectable		 2oz7A-4ppuA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 LEU A 483
MET A 532
MET A 495
LEU A 503
 None
 1.32A 2oz7A-4u1rA:
undetectable		 2oz7A-4u1rA:
15.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 766
TRP A 806
MET A 807
LEU A 938
 CV7  A1987 (-3.6A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 3.9A)
 1.35A 2oz7A-4udbA:
33.0		 2oz7A-4udbA:
48.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 TRP A 806
MET A 807
MET A 852
LEU A 938
 None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
 1.25A 2oz7A-4udbA:
33.0		 2oz7A-4udbA:
48.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 268
MET A 227
MET A 234
LEU A 211
 None
 1.27A 2oz7A-4xmvA:
undetectable		 2oz7A-4xmvA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		4 TRP A  24
MET A  23
MET A  20
LEU A 157
 None
 1.22A 2oz7A-4xniA:
undetectable		 2oz7A-4xniA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yla AROMATIC
PRENYLTRANSFERASE

(Marinactinospora
thermotolerans) 		PF11991
(Trp_DMAT) 		4 LEU A 141
TRP A  67
MET A 162
LEU A  63
 None
 1.41A 2oz7A-4ylaA:
undetectable		 2oz7A-4ylaA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zke SUPERKILLER PROTEIN
7

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU) 		4 LEU A 469
MET A 299
MET A 296
LEU A 302
 LEU  A 469 (-0.6A)
MET  A 299 ( 0.0A)
MET  A 296 ( 0.0A)
LEU  A 302 ( 0.6A)
 1.45A 2oz7A-4zkeA:
undetectable		 2oz7A-4zkeA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TRP A 271
MET A 303
MET A 302
LEU A  25
 BGC  A 801 ( 3.8A)
None
BGC  A 802 ( 3.7A)
None
 1.22A 2oz7A-4zo6A:
undetectable		 2oz7A-4zo6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A  73
TRP A 196
MET A 203
LEU A 180
 None
 1.46A 2oz7A-5c5hA:
undetectable		 2oz7A-5c5hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 LEU B 254
TRP B 339
MET B 325
LEU B 200
 GTP  B 402 (-4.5A)
None
None
None
 1.06A 2oz7A-5ck3B:
undetectable		 2oz7A-5ck3B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dll AMINOPEPTIDASE N

(Francisella
tularensis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 LEU A 165
MET A 236
MET A 243
LEU A 220
 None
 1.32A 2oz7A-5dllA:
undetectable		 2oz7A-5dllA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eue PUTATIVE
SPHINGOSINE-1-PHOSPH
ATE LYASE

(Symbiobacterium
thermophilum) 		PF00282
(Pyridoxal_deC) 		4 LEU A 444
MET A 424
MET A 421
LEU A 461
 None
 1.20A 2oz7A-5eueA:
undetectable		 2oz7A-5eueA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 4 LEU C 357
TRP C 365
MET C 130
LEU C 139
 None
 1.26A 2oz7A-5ex6C:
undetectable		 2oz7A-5ex6C:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35

(Homo sapiens) 		PF03635
(Vps35) 		4 LEU A  53
MET A 190
MET A 197
LEU A 216
 None
 1.45A 2oz7A-5f0kA:
undetectable		 2oz7A-5f0kA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 LEU A 177
MET A 218
MET A 289
LEU A 212
 None
 1.44A 2oz7A-5fubA:
undetectable		 2oz7A-5fubA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		4 LEU A 296
MET A 168
MET A 206
LEU A 179
 None
 1.47A 2oz7A-5i5pA:
undetectable		 2oz7A-5i5pA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A  83
TRP A 110
MET A 111
LEU A 155
 None
 1.47A 2oz7A-5irpA:
undetectable		 2oz7A-5irpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 TRP A 806
MET A 807
MET A 852
LEU A 938
 None
ECV  A1101 (-3.6A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 1.31A 2oz7A-5mwpA:
35.7		 2oz7A-5mwpA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A3892
MET A4343
MET A4346
LEU A3909
 None
 1.43A 2oz7A-5nugA:
undetectable		 2oz7A-5nugA:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ob5 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 TRP H  36
MET H  81
MET H  70
LEU H  83
 None
 1.47A 2oz7A-5ob5H:
undetectable		 2oz7A-5ob5H:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A 378
TRP A 366
MET A 364
LEU A  53
 None
 1.31A 2oz7A-5t9jA:
undetectable		 2oz7A-5t9jA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqa DH270.6 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 TRP H  36
MET H  81
MET H  70
LEU H  83
 None
 1.44A 2oz7A-5tqaH:
undetectable		 2oz7A-5tqaH:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trp DH272 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TRP H  36
MET H  79
MET H  70
LEU H  81
 None
 1.41A 2oz7A-5trpH:
undetectable		 2oz7A-5trpH:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		4 MET A  70
MET A  73
MET A 115
LEU A 201
 1TA  A 301 ( 3.1A)
1TA  A 301 (-4.2A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 0.83A 2oz7A-5ufsA:
34.4		 2oz7A-5ufsA:
54.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		4 TRP A  69
MET A  70
MET A 115
LEU A 201
 None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 1.35A 2oz7A-5ufsA:
34.4		 2oz7A-5ufsA:
54.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgt GENE 7 PROTEIN

(Shigella virus
Sf6) 		no annotation 4 LEU A   5
TRP A  48
MET A  44
LEU A  86
 None
 1.47A 2oz7A-5vgtA:
undetectable		 2oz7A-5vgtA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 LEU A 651
MET A 687
MET A 695
LEU A 703
 None
 1.30A 2oz7A-5w21A:
undetectable		 2oz7A-5w21A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 105
MET A  40
MET A  37
LEU A 101
 None
None
None
PG4  A 804 (-4.6A)
 1.44A 2oz7A-5xxoA:
undetectable		 2oz7A-5xxoA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co1 TUDOR-INTERACTING
REPAIR REGULATOR
PROTEIN

(Homo sapiens) 		no annotation 4 LEU A  51
MET A 182
MET A 183
LEU A 180
 None
 1.31A 2oz7A-6co1A:
undetectable		 2oz7A-6co1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 4 LEU A 357
TRP A 365
MET A 130
LEU A 139
 None
 1.25A 2oz7A-6fshA:
undetectable		 2oz7A-6fshA:
14.17