SIMILAR PATTERNS OF AMINO ACIDS FOR 2OZ7_A_CA4A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b24 PROTEIN (I-DMOI)

(Desulfurococcus
mucosus) 		PF14528
(LAGLIDADG_3) 		5 LEU A 142
ASN A 143
LEU A 145
GLY A 146
VAL A 174
 None
 1.16A 2oz7A-1b24A:
undetectable		 2oz7A-1b24A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 167
LEU A 255
GLY A 256
LEU A 222
PHE A 268
 None
 1.10A 2oz7A-1c3rA:
undetectable		 2oz7A-1c3rA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 187
VAL A 119
ALA A 174
LEU A 175
PHE A 215
 None
 1.12A 2oz7A-1ko0A:
undetectable		 2oz7A-1ko0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 LEU C 480
LEU C 486
GLY C 485
ALA B 419
LEU B 418
 None
 1.16A 2oz7A-1o7dC:
undetectable		 2oz7A-1o7dC:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qk1 CREATINE KINASE,
UBIQUITOUS
MITOCHONDRIAL

(Homo sapiens) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 312
LEU A 334
ARG A 336
LEU A 294
PHE A 303
 None
 1.16A 2oz7A-1qk1A:
undetectable		 2oz7A-1qk1A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 250
ASN A 249
GLN A 247
ALA A 255
PHE A 215
 None
 0.99A 2oz7A-1ub7A:
undetectable		 2oz7A-1ub7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 LEU A 620
GLY A 595
VAL A 426
ALA A 609
LEU A 610
 None
 1.14A 2oz7A-1x9sA:
undetectable		 2oz7A-1x9sA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5y THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		5 LEU E  90
ASN E  91
LEU E  93
VAL E  71
LEU E 116
 None
 1.06A 2oz7A-1z5yE:
undetectable		 2oz7A-1z5yE:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 704
ASN A 705
LEU A 707
GLY A 708
GLN A 711
VAL A 746
ARG A 752
MET A 780
LEU A 880
PHE A 891
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
None
None
 0.60A 2oz7A-2ax9A:
39.2		 2oz7A-2ax9A:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 707
GLY A 708
GLN A 711
VAL A 746
ARG A 752
LEU A 880
MET A 895
 BHM  A   1 ( 4.2A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.6A)
BHM  A   1 (-3.8A)
None
None
 0.96A 2oz7A-2ax9A:
39.2		 2oz7A-2ax9A:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1l THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		5 LEU A  90
ASN A  91
LEU A  93
VAL A  71
LEU A 116
 None
 1.08A 2oz7A-2b1lA:
undetectable		 2oz7A-2b1lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7k SCO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02630
(SCO1-SenC) 		5 LEU A 177
LEU A 203
GLY A 204
ALA A 215
PHE A 143
 None
 1.14A 2oz7A-2b7kA:
undetectable		 2oz7A-2b7kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  70
GLY A 186
VAL A 280
ARG A 290
ALA A  76
 None
 1.04A 2oz7A-2ctzA:
undetectable		 2oz7A-2ctzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0f THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Escherichia
coli) 		PF08534
(Redoxin) 		5 LEU A  90
ASN A  91
LEU A  93
VAL A  71
LEU A 116
 None
 1.11A 2oz7A-2g0fA:
undetectable		 2oz7A-2g0fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		5 GLY A  87
VAL A 125
ALA A  51
LEU A  54
PHE A  82
 None
None
UNL  A 227 (-3.6A)
UNL  A 227 ( 4.9A)
UNL  A 227 (-3.8A)
 0.94A 2oz7A-2hszA:
undetectable		 2oz7A-2hszA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF02861
(Clp_N) 		5 LEU A 124
ASN A 125
LEU A 127
GLY A 128
LEU A 131
 None
 0.97A 2oz7A-2k77A:
undetectable		 2oz7A-2k77A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mgs C-X-C MOTIF
CHEMOKINE 5

(Homo sapiens) 		PF00048
(IL8) 		5 LEU A  63
GLY A  21
GLN A  20
ALA A  46
LEU A  30
 None
 1.06A 2oz7A-2mgsA:
undetectable		 2oz7A-2mgsA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 ASN A 173
LEU A 199
GLY A 172
VAL A  87
ALA A 135
 None
 1.18A 2oz7A-2o7rA:
undetectable		 2oz7A-2o7rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)

(Nitrosomonas
europaea) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		5 LEU A 144
VAL A 115
ALA A 105
LEU A 104
PHE A 134
 None
 1.09A 2oz7A-2pc6A:
undetectable		 2oz7A-2pc6A:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
ASN A  33
LEU A  35
GLN A  39
ARG A  80
MET A 108
PHE A 219
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 (-4.5A)
 0.63A 2oz7A-2q3yA:
36.0		 2oz7A-2q3yA:
60.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		5 LEU A  15
LEU A  16
GLY A  13
ALA A 337
LEU A 336
 None
 1.18A 2oz7A-2qtyA:
undetectable		 2oz7A-2qtyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU X  74
LEU X  77
GLY X  78
ALA X  82
LEU X  83
 None
 1.17A 2oz7A-2qvxX:
undetectable		 2oz7A-2qvxX:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 132
LEU A 135
GLN A 139
ALA A 159
MET A 151
 None
 1.17A 2oz7A-2vosA:
undetectable		 2oz7A-2vosA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 256
LEU A 260
GLN A 264
VAL A 362
LEU A 243
 None
 1.13A 2oz7A-2vxoA:
undetectable		 2oz7A-2vxoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		5 LEU A 549
ASN A 546
LEU A 548
ALA A 457
LEU A 461
 None
 1.15A 2oz7A-2w6dA:
undetectable		 2oz7A-2w6dA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xev YBGF

(Xanthomonas
campestris) 		PF13525
(YfiO) 		5 LEU A  78
LEU A  81
GLY A  82
GLN A  85
ALA A 102
 None
 0.97A 2oz7A-2xevA:
undetectable		 2oz7A-2xevA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 LEU A 432
LEU A 433
ARG A 339
ALA A 419
LEU A 420
 None
 1.18A 2oz7A-2xqyA:
undetectable		 2oz7A-2xqyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 216
GLY A 236
GLN A 273
ALA A 225
LEU A 228
 None
 1.09A 2oz7A-2z1aA:
undetectable		 2oz7A-2z1aA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		5 LEU A 356
GLY A 359
VAL A  77
ALA A 339
LEU A 338
 None
 0.91A 2oz7A-3a3iA:
undetectable		 2oz7A-3a3iA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		5 LEU A 106
LEU A 102
GLY A 101
VAL A 156
ALA A 166
 None
 1.13A 2oz7A-3b5oA:
undetectable		 2oz7A-3b5oA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 LEU A 315
LEU A 318
GLY A 319
GLN A 242
LEU A 323
 None
 1.16A 2oz7A-3cijA:
undetectable		 2oz7A-3cijA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A 307
GLY A 330
VAL A 452
LEU A 245
PHE A 243
 None
 1.16A 2oz7A-3decA:
undetectable		 2oz7A-3decA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 209
GLN A 210
VAL A 239
ALA A 158
LEU A 161
 None
 1.16A 2oz7A-3dipA:
undetectable		 2oz7A-3dipA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens) 		no annotation 5 LEU A  29
LEU A  32
GLY A  33
ALA A  37
LEU A  41
 None
 0.85A 2oz7A-3e4bA:
undetectable		 2oz7A-3e4bA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4b ALGK

(Pseudomonas
fluorescens) 		no annotation 5 LEU A  29
LEU A  32
GLY A  33
MET A 114
LEU A  41
 None
 0.81A 2oz7A-3e4bA:
undetectable		 2oz7A-3e4bA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A  47
GLY A  48
VAL A 133
ALA A 108
MET A  26
 None
 1.09A 2oz7A-3g79A:
undetectable		 2oz7A-3g79A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 239
ASN A 238
LEU A 236
GLY A 235
ALA A 204
 None
 1.16A 2oz7A-3g7sA:
undetectable		 2oz7A-3g7sA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		5 LEU A 366
GLY A 370
VAL A 245
ALA A 260
MET A 377
 None
 1.02A 2oz7A-3gzsA:
undetectable		 2oz7A-3gzsA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlk ACYL-COENZYME A
THIOESTERASE 2,
MITOCHONDRIAL

(Homo sapiens) 		PF04775
(Bile_Hydr_Trans)
PF08840
(BAAT_C) 		5 LEU A 299
GLY A 292
VAL A 320
ALA A 304
LEU A 307
 None
 1.11A 2oz7A-3hlkA:
undetectable		 2oz7A-3hlkA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  95
GLY A  91
ARG A 404
ALA A  20
LEU A  23
 None
 1.15A 2oz7A-3hn7A:
undetectable		 2oz7A-3hn7A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  43
LEU A  46
GLY A  47
ALA A  51
LEU A  52
 None
 1.18A 2oz7A-3io1A:
undetectable		 2oz7A-3io1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4w UNCHARACTERIZED
PROTEIN BB4693

(Bordetella
bronchiseptica) 		PF04909
(Amidohydro_2) 		5 ASN A 148
GLY A 149
GLN A 278
VAL A 184
ALA A 143
 None
 1.12A 2oz7A-3k4wA:
undetectable		 2oz7A-3k4wA:
18.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ASN A 719
GLY A 722
VAL A 760
PHE A 905
MET A 909
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-4.1A)
WOW  A   1 (-4.6A)
None
 0.87A 2oz7A-3kbaA:
34.3		 2oz7A-3kbaA:
55.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 718
ASN A 719
LEU A 721
GLY A 722
VAL A 760
ARG A 766
PHE A 905
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.6A)
 0.44A 2oz7A-3kbaA:
34.3		 2oz7A-3kbaA:
55.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 718
LEU A 721
GLY A 722
GLN A 725
VAL A 760
ARG A 766
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.1A)
WOW  A   1 (-3.8A)
 0.80A 2oz7A-3kbaA:
34.3		 2oz7A-3kbaA:
55.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ops MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Paenibacillus
sp. Y412MC10) 		PF13378
(MR_MLE_C) 		5 LEU A 100
LEU A 103
GLY A 104
GLN A 107
MET A 295
 None
 1.05A 2oz7A-3opsA:
undetectable		 2oz7A-3opsA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfm GGDEF DOMAIN PROTEIN

(Pseudomonas
protegens) 		PF00563
(EAL) 		5 LEU A 550
LEU A 553
GLY A 554
ALA A 578
LEU A 577
 None
 0.92A 2oz7A-3pfmA:
undetectable		 2oz7A-3pfmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pju CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL) 		5 LEU A 550
LEU A 553
GLY A 554
ALA A 578
LEU A 577
 None
 0.96A 2oz7A-3pjuA:
undetectable		 2oz7A-3pjuA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 LEU A 550
LEU A 553
GLY A 554
ALA A 578
LEU A 577
 EDO  A   3 ( 4.8A)
None
None
EDO  A   3 ( 4.7A)
None
 0.85A 2oz7A-3pjxA:
undetectable		 2oz7A-3pjxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qe7 URACIL PERMEASE

(Escherichia
coli) 		PF00860
(Xan_ur_permease) 		5 LEU A 134
GLY A 133
VAL A 344
ALA A  31
LEU A  34
 BNG  A 431 ( 4.7A)
BNG  A 431 (-3.2A)
None
URA  A 430 ( 3.8A)
None
 0.76A 2oz7A-3qe7A:
undetectable		 2oz7A-3qe7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT A
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J

(Escherichia
coli) 		PF00507
(Oxidored_q4)
no annotation 		5 LEU A 117
LEU A 114
GLY A 113
VAL A  76
ALA J 155
 None
 1.17A 2oz7A-3rkoA:
undetectable		 2oz7A-3rkoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 5 LEU K  19
LEU K  22
GLY K  21
ALA J 101
LEU J 104
 None
 1.07A 2oz7A-3rkoK:
undetectable		 2oz7A-3rkoK:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		5 LEU A 163
LEU A 166
GLY A 165
ALA A 145
LEU A 144
 None
 1.09A 2oz7A-3rkrA:
undetectable		 2oz7A-3rkrA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
ARG A  80
MET A 108
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.3A)
 0.60A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 214
LEU A 129
VAL A  82
ALA A 225
LEU A 224
 None
 1.19A 2oz7A-3u4gA:
undetectable		 2oz7A-3u4gA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxb UNCHARACTERIZED
PROTEIN

(Gallus gallus) 		PF00106
(adh_short) 		5 LEU A 185
ASN A 186
LEU A 188
GLN A 192
PHE A 249
 None
 0.84A 2oz7A-3wxbA:
undetectable		 2oz7A-3wxbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 LEU B 154
ASN B 155
GLY B 158
GLN B 161
VAL B 225
 None
 1.14A 2oz7A-3ze7B:
undetectable		 2oz7A-3ze7B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 LEU A 331
LEU A 334
GLY A 335
VAL A 360
ALA A 339
 None
 1.17A 2oz7A-3zvtA:
undetectable		 2oz7A-3zvtA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag9 GLUCOSAMINE-6-PHOSPH
ATE
N-ACETYLTRANSFERASE

(Caenorhabditis
elegans) 		PF00583
(Acetyltransf_1) 		5 LEU A 125
LEU A 128
GLY A 129
LEU A 139
PHE A 154
 None
None
None
16G  A1168 ( 4.0A)
None
 1.16A 2oz7A-4ag9A:
undetectable		 2oz7A-4ag9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ASN A 236
LEU A 234
GLY A 237
VAL A 164
ALA A 171
 None
 1.04A 2oz7A-4akoA:
undetectable		 2oz7A-4akoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 LEU A 372
GLY A 370
ALA A 328
LEU A 316
PHE A 318
 None
 1.12A 2oz7A-4dshA:
undetectable		 2oz7A-4dshA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7o RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg) 		5 LEU A  65
LEU A  62
GLY A  61
VAL A 101
ALA A  50
 None
 0.97A 2oz7A-4e7oA:
undetectable		 2oz7A-4e7oA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 376
LEU A 379
GLY A 380
GLN A 383
LEU A  14
 None
 1.06A 2oz7A-4f4cA:
undetectable		 2oz7A-4f4cA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 LEU A 215
ASN A 216
LEU A 218
ARG A 139
ALA A 274
 None
 0.99A 2oz7A-4g1uA:
undetectable		 2oz7A-4g1uA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 LEU A 182
LEU A 141
GLY A 142
MET A 209
ALA A 160
 None
 1.14A 2oz7A-4gl0A:
undetectable		 2oz7A-4gl0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 LEU A 148
LEU A 149
GLY A 146
VAL A 412
ALA A  88
 None
 0.91A 2oz7A-4gs1A:
undetectable		 2oz7A-4gs1A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 145
GLY A  85
ALA A 334
LEU A 337
PHE A 148
 None
CO2  A 505 ( 4.1A)
None
None
None
 0.96A 2oz7A-4ip4A:
undetectable		 2oz7A-4ip4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf6 GLYCOLIPID TRANSFER
PROTEIN
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08718
(GLTP) 		5 LEU A  43
ASN A  44
LEU A  46
GLY A  47
VAL A 158
 None
 1.13A 2oz7A-4kf6A:
undetectable		 2oz7A-4kf6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 GLY A  15
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 1.06A 2oz7A-4lbwA:
undetectable		 2oz7A-4lbwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
LEU A 286
ARG A 331
MET A 358
LEU A 454
PHE A 462
 None
 0.79A 2oz7A-4n1yA:
28.7		 2oz7A-4n1yA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		5 LEU A 250
ASN A 251
LEU A 253
GLY A 254
LEU A 187
 None
 1.10A 2oz7A-4nzpA:
undetectable		 2oz7A-4nzpA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 563
ASN A 564
LEU A 566
GLY A 567
GLN A 570
ARG A 611
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
 0.78A 2oz7A-4p6wA:
32.2		 2oz7A-4p6wA:
50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
ASN A 770
LEU A 772
GLN A 776
ARG A 817
PHE A 956
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 4.7A)
 0.74A 2oz7A-4udbA:
33.0		 2oz7A-4udbA:
48.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A 237
GLY A 192
ALA A 110
LEU A 107
PHE A 199
 None
 1.15A 2oz7A-4ueuA:
undetectable		 2oz7A-4ueuA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whm UDP-GLUCOSE:ANTHOCYA
NIDIN
3-O-GLUCOSYLTRANSFER
ASE

(Clitoria
ternatea) 		PF00201
(UDPGT) 		5 LEU A 289
GLY A 320
VAL A 337
ALA A 299
LEU A 300
 None
None
None
UDP  A1001 ( 3.7A)
None
 1.18A 2oz7A-4whmA:
undetectable		 2oz7A-4whmA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 247
ASN A 246
GLN A 244
ALA A 252
PHE A 212
 None
 1.03A 2oz7A-4z19A:
undetectable		 2oz7A-4z19A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zms RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 LEU A  65
LEU A  62
GLY A  61
VAL A 101
ALA A  50
 None
 1.08A 2oz7A-4zmsA:
undetectable		 2oz7A-4zmsA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A 110
LEU A 113
GLN A 117
MET A 147
LEU A 316
 None
 1.17A 2oz7A-5dt9A:
undetectable		 2oz7A-5dt9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF14681
(UPRTase) 		5 GLY A  81
VAL A  75
ALA A 199
LEU A 196
PHE A  28
 None
 1.05A 2oz7A-5e38A:
undetectable		 2oz7A-5e38A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A 215
LEU A 218
GLY A 219
ALA A 193
LEU A 197
 None
 1.06A 2oz7A-5f56A:
undetectable		 2oz7A-5f56A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 LEU A 111
LEU A 112
GLY A 109
VAL A 375
ALA A  47
 None
 0.95A 2oz7A-5fw4A:
undetectable		 2oz7A-5fw4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		6 LEU A 243
GLY A 244
GLN A 247
ALA A 195
LEU A  58
MET A  42
 None
 1.22A 2oz7A-5k8bA:
undetectable		 2oz7A-5k8bA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		5 LEU A1889
GLY A  91
GLN A  95
VAL A1850
LEU A1963
 None
 1.02A 2oz7A-5lkiA:
undetectable		 2oz7A-5lkiA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		5 ASN A 336
LEU A 201
GLY A 200
VAL A 180
MET A 324
 None
 1.14A 2oz7A-5ly3A:
undetectable		 2oz7A-5ly3A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		5 ASN A 463
LEU A 465
GLY A 466
VAL A 312
ALA A 383
 7O9  A 602 (-3.8A)
None
None
None
None
 0.87A 2oz7A-5mjuA:
undetectable		 2oz7A-5mjuA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 128
VAL A 327
ARG A 169
ALA A 297
LEU A 301
 None
 1.12A 2oz7A-5movA:
undetectable		 2oz7A-5movA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 LEU A 769
ASN A 770
LEU A 772
GLN A 776
ARG A 817
MET A 845
PHE A 956
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.7A)
 0.66A 2oz7A-5mwpA:
35.8		 2oz7A-5mwpA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 LEU A 559
ASN A 560
LEU A 562
GLY A 563
GLN A 566
ARG A 607
MET A 635
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.14A 2oz7A-5uc1A:
23.1		 2oz7A-5uc1A:
51.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
ARG A  80
MET A 108
PHE A 218
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-4.0A)
 1.09A 2oz7A-5ufsA:
34.4		 2oz7A-5ufsA:
54.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 5 LEU C 304
ASN C 307
LEU C 305
LEU C 206
MET C 261
 None
 1.18A 2oz7A-5v6nC:
undetectable		 2oz7A-5v6nC:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 5 LEU A 257
GLY A 150
GLN A 149
ALA A 243
LEU A 245
 None
 1.17A 2oz7A-5vfzA:
undetectable		 2oz7A-5vfzA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ASN A 187
LEU A 142
GLY A 143
VAL A   9
ALA A 100
 None
None
GTP  A 502 ( 4.3A)
None
GTP  A 502 ( 4.8A)
 1.18A 2oz7A-5w3fA:
undetectable		 2oz7A-5w3fA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w75 ELONGATION FACTOR TU

(Thermotoga
neapolitana) 		no annotation 5 GLY A  16
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 0.80A 2oz7A-5w75A:
undetectable		 2oz7A-5w75A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 5 GLY A  16
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 0.75A 2oz7A-5w76A:
undetectable		 2oz7A-5w76A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 5 GLY A  16
VAL A 133
ALA A 123
LEU A 122
MET A  99
 None
 0.86A 2oz7A-5w7qA:
undetectable		 2oz7A-5w7qA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 LEU A 373
ASN A 374
LEU A 372
VAL A 418
ALA A 324
 None
 1.15A 2oz7A-5wc2A:
undetectable		 2oz7A-5wc2A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 146
LEU A 143
GLY A 142
VAL A 165
ALA A 223
 None
 1.13A 2oz7A-5welA:
undetectable		 2oz7A-5welA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9y THIAZOLE SYNTHASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  61
ASN A  62
LEU A  64
GLY A  65
LEU A  92
 None
 1.06A 2oz7A-5z9yA:
undetectable		 2oz7A-5z9yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 LEU A 172
ASN A 173
GLY A 176
LEU A 227
MET A 106
 None
 0.99A 2oz7A-6en3A:
undetectable		 2oz7A-6en3A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
A, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 LEU a 195
GLY a 192
ALA a 141
LEU a 140
PHE a 231
 None
 1.13A 2oz7A-6fkha:
undetectable		 2oz7A-6fkha:
16.09