SIMILAR PATTERNS OF AMINO ACIDS FOR 2OXT_B_SAMB300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 4 SER A  39
GLY A  41
HIS A  35
ASP A 108
 None
 1.11A 2oxtB-1aqzA:
undetectable		 2oxtB-1aqzA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		4 SER A 586
GLY A 582
ASP A 602
ASP A 556
 None
 0.99A 2oxtB-1clwA:
undetectable		 2oxtB-1clwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		4 SER A  33
GLY A  64
ASP A  99
ASP A 124
 SAM  A 301 ( 4.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
 0.78A 2oxtB-1eizA:
15.3		 2oxtB-1eizA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 SER A 316
GLY A  68
HIS A 253
ASP A  66
 None
 1.02A 2oxtB-1i6qA:
undetectable		 2oxtB-1i6qA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 310
HIS A 350
ASP A 382
ASP A 397
 6FA  A 801 (-3.4A)
None
None
None
 1.10A 2oxtB-1naaA:
2.3		 2oxtB-1naaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE
ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF13561
(adh_short_C2)
PF13561
(adh_short_C2) 		4 SER C 388
GLY A 114
ASP A 156
ASP A 150
 None
 1.13A 2oxtB-1nhwC:
undetectable		 2oxtB-1nhwC:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 SER A 131
GLY A  97
HIS A  69
ASP A 194
 None
 0.95A 2oxtB-1nr9A:
undetectable		 2oxtB-1nr9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 SER A 947
GLY A 976
ASP A 327
ASP A 508
 None
 1.11A 2oxtB-1ofeA:
undetectable		 2oxtB-1ofeA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 SER A 191
HIS A 360
ASP A 391
ASP A 383
 None
 1.04A 2oxtB-1qguA:
undetectable		 2oxtB-1qguA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAH  A 887 ( 2.8A)
SAH  A 887 (-3.3A)
SO4  A 901 ( 3.9A)
SAH  A 887 ( 3.3A)
SAH  A 887 (-3.9A)
 0.46A 2oxtB-1r6aA:
39.4		 2oxtB-1r6aA:
48.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 SER A 439
GLY A 734
ASP A 666
ASP A 605
 MET  A 772 (-2.8A)
MET  A 772 (-3.2A)
None
MET  A 772 (-3.8A)
 1.09A 2oxtB-1u1hA:
undetectable		 2oxtB-1u1hA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 SER A 290
GLY A 348
HIS A  59
ASP A 307
 None
 0.66A 2oxtB-1uedA:
undetectable		 2oxtB-1uedA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwy CARBOXYPEPTIDASE M

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		4 SER A 197
GLY A 186
HIS A 322
ASP A 250
 None
 0.91A 2oxtB-1uwyA:
undetectable		 2oxtB-1uwyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		4 SER A 347
GLY A 343
ASP A 293
ASP A 410
 None
 1.10A 2oxtB-1wleA:
undetectable		 2oxtB-1wleA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 GLY A 212
HIS A 197
ASP A 144
ASP A 203
 None
None
FE  A 313 (-2.6A)
None
 1.03A 2oxtB-1xvxA:
undetectable		 2oxtB-1xvxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 GLY A  64
HIS A  82
ASP A 167
ASP A 126
 None
 1.06A 2oxtB-1ygaA:
undetectable		 2oxtB-1ygaA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynb HYPOTHETICAL PROTEIN
AF1432

(Archaeoglobus
fulgidus) 		PF13023
(HD_3) 		4 SER A  26
GLY A  27
HIS A  74
ASP A 122
 None
 1.14A 2oxtB-1ynbA:
undetectable		 2oxtB-1ynbA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2i MALATE DEHYDROGENASE

(Agrobacterium
tumefaciens) 		PF02615
(Ldh_2) 		4 SER A 210
GLY A 214
HIS A 163
ASP A 157
 None
 1.04A 2oxtB-1z2iA:
undetectable		 2oxtB-1z2iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azn PUTATIVE
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Methanocaldococcus
jannaschii) 		PF01872
(RibD_C) 		4 GLY A 156
HIS A  42
ASP A  97
ASP A  61
 NAP  A2001 (-3.3A)
None
None
NAP  A2001 (-3.1A)
 0.93A 2oxtB-2aznA:
undetectable		 2oxtB-2aznA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h92 CYTIDYLATE KINASE

(Staphylococcus
aureus) 		PF02224
(Cytidylate_kin) 		4 SER A  17
GLY A  15
ASP A 168
ASP A 156
 SO4  A1400 (-3.1A)
SO4  A1400 (-3.6A)
None
None
 1.08A 2oxtB-2h92A:
undetectable		 2oxtB-2h92A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 SER A 333
GLY A 263
HIS A 368
ASP A 372
 UDP  A1424 (-2.7A)
UDP  A1424 ( 3.9A)
None
None
 1.11A 2oxtB-2iyaA:
2.5		 2oxtB-2iyaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		4 SER A  54
GLY A 197
HIS A  99
ASP A 217
 None
 1.02A 2oxtB-2oq5A:
undetectable		 2oxtB-2oq5A:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		5 SER A  57
GLY A  87
HIS A 111
ASP A 132
ASP A 147
 SAM  A 300 (-2.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
 0.19A 2oxtB-2oxtA:
46.1		 2oxtB-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  86
ASP A 131
ASP A 146
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.2A)
 0.46A 2oxtB-2oy0A:
38.6		 2oxtB-2oy0A:
51.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  86
HIS A 110
ASP A 146
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.0A)
SAH  A 301 (-4.4A)
SAH  A 301 (-4.2A)
 0.33A 2oxtB-2oy0A:
38.6		 2oxtB-2oy0A:
51.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF02542
(YgbB) 		4 SER A  38
GLY A  40
ASP A 141
ASP A  11
 ZN  A 500 ( 4.6A)
None
PO4  A 701 (-3.4A)
ZN  A 500 (-2.3A)
 1.08A 2oxtB-2pmpA:
undetectable		 2oxtB-2pmpA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAH  A 500 (-2.5A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.9A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.6A)
 0.31A 2oxtB-2px5A:
39.5		 2oxtB-2px5A:
51.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 GLY A  64
HIS A  75
ASP A 372
ASP A  69
 None
 1.10A 2oxtB-2ragA:
undetectable		 2oxtB-2ragA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 GLY A 190
HIS A 273
ASP A 177
ASP A 187
 None
 1.15A 2oxtB-2xy9A:
undetectable		 2oxtB-2xy9A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 SER A  84
GLY A 176
HIS A 199
ASP A 182
 None
 1.06A 2oxtB-2y35A:
undetectable		 2oxtB-2y35A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		4 SER A  13
GLY A  17
ASP A 334
ASP A 298
 None
 1.07A 2oxtB-3bryA:
undetectable		 2oxtB-3bryA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brz TODX

(Pseudomonas
putida) 		PF03349
(Toluene_X) 		4 SER A  13
GLY A  17
ASP A 332
ASP A 298
 None
 1.00A 2oxtB-3brzA:
undetectable		 2oxtB-3brzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8u FRUCTOKINASE

(Ruegeria sp.
TM1040) 		no annotation 4 GLY A  59
HIS A  92
ASP A 142
ASP A  83
 None
 1.16A 2oxtB-3c8uA:
undetectable		 2oxtB-3c8uA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3m TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF13377
(Peripla_BP_3) 		4 SER A  89
GLY A 307
ASP A 257
ASP A 302
 None
 0.84A 2oxtB-3e3mA:
2.2		 2oxtB-3e3mA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
GLY A  86
HIS A 110
ASP A 146
 SAM  A4633 ( 2.7A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.6A)
SAM  A4633 (-3.7A)
 0.28A 2oxtB-3eluA:
38.7		 2oxtB-3eluA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAH  A 901 (-2.6A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.8A)
SAH  A 901 (-3.7A)
SAH  A 901 (-3.8A)
 0.37A 2oxtB-3evcA:
39.8		 2oxtB-3evcA:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.28A 2oxtB-3gczA:
40.6		 2oxtB-3gczA:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 SER A 217
GLY A 241
HIS A 286
ASP A 280
 None
None
None
NA  A   1 ( 2.2A)
 1.10A 2oxtB-3gq9A:
undetectable		 2oxtB-3gq9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld9 THYMIDYLATE KINASE

(Ehrlichia
chaffeensis) 		PF02223
(Thymidylate_kin) 		4 SER A  11
GLY A   7
HIS A 192
ASP A  92
 SO4  A 300 (-4.6A)
None
None
SO4  A 300 ( 4.7A)
 1.06A 2oxtB-3ld9A:
undetectable		 2oxtB-3ld9A:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  86
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.50A 2oxtB-3lkzA:
39.7		 2oxtB-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  86
HIS A 110
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.9A)
SFG  A 301 (-3.8A)
 0.22A 2oxtB-3lkzA:
39.7		 2oxtB-3lkzA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 GLY A  81
HIS A 125
ASP A 133
ASP A 107
 None
 0.95A 2oxtB-3lq1A:
2.2		 2oxtB-3lq1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE

(Cryphonectria
parasitica) 		PF13714
(PEP_mutase) 		4 GLY A 180
HIS A  79
ASP A  85
ASP A 254
 None
 1.10A 2oxtB-3lyeA:
undetectable		 2oxtB-3lyeA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndp ADENYLATE KINASE
ISOENZYME 4

(Homo sapiens) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 SER A  16
GLY A  12
ASP A 107
ASP A  88
 SO4  A 501 (-3.3A)
None
None
None
 0.98A 2oxtB-3ndpA:
undetectable		 2oxtB-3ndpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nro LMO1026 PROTEIN

(Listeria
monocytogenes) 		PF03816
(LytR_cpsA_psr) 		4 SER A 130
GLY A 125
ASP A 305
ASP A 114
 None
 1.14A 2oxtB-3nroA:
undetectable		 2oxtB-3nroA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obw PROTEIN PELOTA
HOMOLOG

(Sulfolobus
solfataricus) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 SER A 221
GLY A 226
HIS A  93
ASP A  81
 None
 1.14A 2oxtB-3obwA:
undetectable		 2oxtB-3obwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on9 TUMOUR NECROSIS
FACTOR RECEPTOR

(Ectromelia
virus) 		PF07190
(DUF1406) 		4 SER A 248
GLY A 249
ASP A 281
ASP A 275
 None
 1.06A 2oxtB-3on9A:
undetectable		 2oxtB-3on9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		4 GLY B  84
HIS B 137
ASP B 152
ASP B 128
 None
 1.11A 2oxtB-3pntB:
undetectable		 2oxtB-3pntB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp7 PYRUVATE KINASE

(Leishmania
mexicana) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLY A 119
HIS A 169
ASP A 145
ASP A 173
 None
 1.11A 2oxtB-3pp7A:
undetectable		 2oxtB-3pp7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A 562
GLY A 513
HIS A  94
ASP A 478
 None
None
CU  A 604 ( 3.1A)
None
 1.02A 2oxtB-3ppsA:
undetectable		 2oxtB-3ppsA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		4 SER A 528
GLY A 491
HIS A 514
ASP A 481
 None
 0.88A 2oxtB-3r75A:
2.9		 2oxtB-3r75A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7t ADENYLOSUCCINATE
SYNTHETASE

(Campylobacter
jejuni) 		PF00709
(Adenylsucc_synt) 		4 SER A 238
GLY A 243
HIS A 101
ASP A  98
 None
 1.07A 2oxtB-3r7tA:
undetectable		 2oxtB-3r7tA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bradyrhizobium
sp. ORS 278) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 200
GLY A 169
ASP A 217
ASP A 196
 None
None
None
CA  A 361 ( 2.9A)
 1.02A 2oxtB-3toyA:
undetectable		 2oxtB-3toyA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		4 SER A 391
GLY A 435
ASP A 428
ASP A 492
 None
 1.05A 2oxtB-3tr5A:
undetectable		 2oxtB-3tr5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uof BACTERIOFERRITIN

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		4 SER A 155
HIS A  43
ASP A  90
ASP A  33
 None
 1.13A 2oxtB-3uofA:
undetectable		 2oxtB-3uofA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v77 PUTATIVE
FUMARYLACETOACETATE
ISOMERASE/HYDROLASE

(Oleispira
antarctica) 		PF01557
(FAA_hydrolase) 		4 SER A  91
GLY A  77
ASP A 100
ASP A 186
 None
None
ZN  A 301 ( 3.1A)
None
 1.14A 2oxtB-3v77A:
undetectable		 2oxtB-3v77A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 SER A2097
GLY A4345
ASP A4311
ASP A4302
 None
 1.12A 2oxtB-3vkgA:
undetectable		 2oxtB-3vkgA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 SER A 385
GLY A 369
HIS A 274
ASP A 389
 None
 1.12A 2oxtB-4a1oA:
undetectable		 2oxtB-4a1oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 379
HIS A 371
ASP A 128
ASP A 144
 None
 1.15A 2oxtB-4a35A:
undetectable		 2oxtB-4a35A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB

(Methanococcus
maripaludis) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 SER A 286
GLY A 372
HIS A 103
ASP A  71
 CMH  A 371 ( 4.5A)
CMH  A 371 ( 2.4A)
None
None
 0.85A 2oxtB-4acaA:
undetectable		 2oxtB-4acaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		4 SER A 237
GLY A 235
HIS A 291
ASP A 277
 None
 1.09A 2oxtB-4bofA:
undetectable		 2oxtB-4bofA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12842
(DUF3819) 		4 SER A1245
GLY A1253
ASP A1132
ASP A1126
 None
 1.14A 2oxtB-4cv5A:
undetectable		 2oxtB-4cv5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 331
GLY A 157
HIS A 240
ASP A 204
 None
 1.07A 2oxtB-4dpkA:
undetectable		 2oxtB-4dpkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 SER A 246
GLY A 263
ASP A 409
ASP A 269
 LLP  A  75 ( 2.6A)
LLP  A  75 ( 3.5A)
SO4  A 503 (-4.6A)
None
 1.04A 2oxtB-4dyjA:
undetectable		 2oxtB-4dyjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 SER A 315
GLY A 152
HIS A 113
ASP A 344
 None
 1.15A 2oxtB-4eudA:
undetectable		 2oxtB-4eudA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		4 GLY A  12
HIS A  28
ASP A  51
ASP A  46
 None
 1.04A 2oxtB-4haoA:
undetectable		 2oxtB-4haoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 SER A 199
GLY A 134
HIS A 251
ASP A 255
 None
 1.15A 2oxtB-4hcxA:
undetectable		 2oxtB-4hcxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		4 SER A  99
GLY A 251
ASP A 210
ASP A 242
 None
None
None
MG  A 403 ( 3.9A)
 1.14A 2oxtB-4i0nA:
undetectable		 2oxtB-4i0nA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAH  A1001 (-2.8A)
SAH  A1001 (-3.2A)
SAH  A1001 ( 3.6A)
SAH  A1001 (-3.7A)
SAH  A1001 (-3.6A)
 0.31A 2oxtB-4k6mA:
39.4		 2oxtB-4k6mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		4 SER A  92
HIS A  73
ASP A 333
ASP A  85
 None
 0.94A 2oxtB-4lanA:
undetectable		 2oxtB-4lanA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		4 SER A  59
GLY A 285
ASP A 165
ASP A 154
 HIS  A 601 ( 4.8A)
None
None
None
 1.02A 2oxtB-4ls3A:
undetectable		 2oxtB-4ls3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 SER A 133
GLY A  68
HIS A 154
ASP A 188
 None
 1.00A 2oxtB-4nwvA:
undetectable		 2oxtB-4nwvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 SER A 133
GLY A  68
HIS A 154
ASP A 188
 None
 1.00A 2oxtB-4nwwA:
undetectable		 2oxtB-4nwwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		4 SER A 384
GLY A 419
ASP A 581
ASP A 422
 None
 1.10A 2oxtB-4pb6A:
undetectable		 2oxtB-4pb6A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 124
GLY A 149
ASP A 114
ASP A 120
 None
 1.00A 2oxtB-4r1dA:
undetectable		 2oxtB-4r1dA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		4 SER A 115
GLY A 208
ASP A 249
ASP A 240
 None
 1.04A 2oxtB-4r9nA:
undetectable		 2oxtB-4r9nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 155
HIS A 138
ASP A 132
ASP A 300
 None
 1.05A 2oxtB-4w6zA:
undetectable		 2oxtB-4w6zA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		4 SER A  47
GLY A 281
HIS A 225
ASP A  40
 None
 0.96A 2oxtB-4z9nA:
undetectable		 2oxtB-4z9nA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 SER A 187
GLY A 480
ASP A 553
ASP A 477
 None
 1.13A 2oxtB-4zohA:
undetectable		 2oxtB-4zohA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 SER C 147
GLY C 148
ASP C 196
ASP C 187
 None
 1.08A 2oxtB-5b57C:
2.2		 2oxtB-5b57C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		4 GLY A  53
HIS A  79
ASP A  75
ASP A  86
 None
EPE  A 302 (-4.4A)
None
None
 0.95A 2oxtB-5bncA:
undetectable		 2oxtB-5bncA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8p MOCVNH3 VARIANT

(Magnaporthe
oryzae) 		PF01476
(LysM)
PF08881
(CVNH) 		4 SER A  44
GLY A 101
HIS A  78
ASP A  90
 None
None
None
NAG  A 201 (-3.8A)
 1.12A 2oxtB-5c8pA:
undetectable		 2oxtB-5c8pA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.8A)
 0.53A 2oxtB-5e9qA:
39.3		 2oxtB-5e9qA:
50.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 SER A 159
GLY A 106
ASP A 167
ASP A 183
 None
None
None
PLP  A 401 (-2.7A)
 1.13A 2oxtB-5f9sA:
undetectable		 2oxtB-5f9sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7

(synthetic
construct;
Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 SER A1135
GLY A1151
HIS A1047
ASP A1075
 None
 1.13A 2oxtB-5gxjA:
undetectable		 2oxtB-5gxjA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hsi PUTATIVE
DECARBOXYLASE

(Lactobacillus
brevis) 		PF00282
(Pyridoxal_deC) 		4 SER A 127
GLY A 119
HIS A 153
ASP A 157
 None
 1.02A 2oxtB-5hsiA:
undetectable		 2oxtB-5hsiA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 SER A1135
GLY A1151
HIS A1047
ASP A1075
 6A8  A1201 (-1.5A)
6A8  A1201 (-4.2A)
None
6A8  A1201 ( 4.2A)
 1.13A 2oxtB-5idkA:
undetectable		 2oxtB-5idkA:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAM  A 311 ( 2.7A)
SAM  A 311 (-3.3A)
SAM  A 311 (-4.1A)
MLT  A 313 ( 2.6A)
SAM  A 311 (-3.8A)
 0.50A 2oxtB-5ikmA:
39.0		 2oxtB-5ikmA:
49.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
GLY A  86
ASP A 131
ASP A 146
 SAH  A1003 (-2.7A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.8A)
 0.48A 2oxtB-5jjrA:
39.1		 2oxtB-5jjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
GLY A  86
HIS A 110
ASP A 146
 SAH  A1003 (-2.7A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.7A)
SAH  A1003 (-3.8A)
 0.24A 2oxtB-5jjrA:
39.1		 2oxtB-5jjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAH  A1001 (-2.6A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.9A)
SAH  A1001 (-3.7A)
 0.22A 2oxtB-5njuA:
38.8		 2oxtB-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ouo PERFORIN-LIKE
PROTEIN 1

(Toxoplasma
gondii) 		no annotation 4 GLY A 933
HIS A 990
ASP A1001
ASP A 936
 None
 1.15A 2oxtB-5ouoA:
undetectable		 2oxtB-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 SER A 171
GLY A  86
HIS A 321
ASP A 164
 None
 1.08A 2oxtB-5t9gA:
undetectable		 2oxtB-5t9gA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		4 SER A 139
GLY A 142
ASP A 230
ASP A 238
 None
 1.14A 2oxtB-5tf4A:
5.5		 2oxtB-5tf4A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 SER A  56
GLY A  86
HIS A 110
ASP A 131
ASP A 146
 SAH  A1001 (-2.5A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.8A)
 0.48A 2oxtB-5tmhA:
38.2		 2oxtB-5tmhA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 202
GLY A 171
ASP A 219
ASP A 198
 None
None
None
MG  A 402 (-2.9A)
 1.09A 2oxtB-5xd7A:
undetectable		 2oxtB-5xd7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 4 SER U 151
GLY U 154
HIS U 158
ASP U 327
 None
 0.99A 2oxtB-5zvtU:
undetectable		 2oxtB-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 4 SER A 253
GLY A 575
ASP A 373
ASP A 318
 None
CA  A 903 ( 3.9A)
None
G39  A 908 ( 4.2A)
 1.13A 2oxtB-6eksA:
undetectable		 2oxtB-6eksA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 SER D 470
GLY D 466
ASP D 378
ASP D 441
 None
 1.14A 2oxtB-6f5dD:
undetectable		 2oxtB-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 SER A 163
GLY A 195
ASP A 225
ASP A 220
 None
 1.06A 2oxtB-6fv5A:
undetectable		 2oxtB-6fv5A:
undetectable