SIMILAR PATTERNS OF AMINO ACIDS FOR 2OXT_A_SAMA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 293
GLY A  23
GLY A  18
ASP A 474
VAL A 473
 FAD  A 510 ( 4.3A)
None
FAD  A 510 (-3.2A)
FAD  A 510 (-4.7A)
None
 0.95A 2oxtA-1coyA:
undetectable		 2oxtA-1coyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)
[FE]-HYDROGENASE
(SMALL SUBUNIT)

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9)
PF02256
(Fe_hyd_SSU) 		5 GLY A  70
GLY A 380
THR A 299
ILE D  47
VAL A 383
 SF4  A   2 (-3.8A)
None
None
None
None
 1.04A 2oxtA-1e08A:
undetectable		 2oxtA-1e08A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		5 GLY A  59
GLY A  64
TRP A  65
LEU A  84
ASP A 124
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.6A)
 0.45A 2oxtA-1eizA:
15.2		 2oxtA-1eizA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 101
GLY A  36
GLY A  31
GLY A 103
LEU A 290
 None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.5A)
None
 0.95A 2oxtA-1gpeA:
2.3		 2oxtA-1gpeA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leo NUCLEOSIDE
DIPHOSPHATE KINASE

(Dictyostelium
discoideum) 		PF00334
(NDK) 		5 GLY A  86
GLY A  84
GLY A  36
GLU A  83
VAL A  88
 None
 1.05A 2oxtA-1leoA:
undetectable		 2oxtA-1leoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 GLY A  56
GLY A 478
GLY A 518
LEU A 409
VAL A 309
 None
 1.07A 2oxtA-1lrwA:
undetectable		 2oxtA-1lrwA:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A 887 (-3.0A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
SAH  A 887 (-4.5A)
SAH  A 887 (-3.9A)
 0.33A 2oxtA-1r6aA:
39.3		 2oxtA-1r6aA:
48.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
 SAH  A 887 (-3.0A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.6A)
SAH  A 887 (-3.3A)
SAH  A 887 (-3.5A)
SAH  A 887 (-4.5A)
None
 0.59A 2oxtA-1r6aA:
39.3		 2oxtA-1r6aA:
48.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 GLY A 163
GLY A 120
LEU A 165
ASP A 286
VAL A 287
 None
 1.04A 2oxtA-1sh2A:
undetectable		 2oxtA-1sh2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 553
GLY B 470
GLY B 468
GLY B 549
LEU B 635
 None
None
None
MCN  B4921 (-3.2A)
None
 1.07A 2oxtA-1t3qB:
undetectable		 2oxtA-1t3qB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 GLY A  68
GLY A  98
GLY A  40
THR A 139
VAL A 102
 None
NAP  A 800 (-3.2A)
NAP  A 800 (-3.4A)
NAP  A 800 (-3.8A)
None
 0.75A 2oxtA-1vljA:
undetectable		 2oxtA-1vljA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 GLY A 195
GLY A 537
THR A 138
LEU A 139
GLU A 153
 None
 0.88A 2oxtA-1w18A:
undetectable		 2oxtA-1w18A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkk NUCLEOSIDE
DIPHOSPHATE KINASE

(Thermus
thermophilus) 		PF00334
(NDK) 		5 GLY A  79
GLY A  77
GLY A  29
GLU A  76
VAL A  81
 None
 0.96A 2oxtA-1wkkA:
undetectable		 2oxtA-1wkkA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 GLY A 148
GLY A  14
GLY A  11
GLY A 144
ILE A  17
 None
None
GSP  A2466 (-3.1A)
GSP  A2466 (-3.0A)
None
 0.99A 2oxtA-1z5vA:
undetectable		 2oxtA-1z5vA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 142
GLY A  42
GLY A 197
ILE A  52
VAL A  31
 None
 1.01A 2oxtA-1zlrA:
undetectable		 2oxtA-1zlrA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 GLY A 345
GLY A  12
GLY A  10
GLY A 234
ILE A 202
 None
FAD  A1385 (-3.4A)
FAD  A1385 (-3.1A)
FAD  A1385 (-3.5A)
None
 1.03A 2oxtA-2bi7A:
3.5		 2oxtA-2bi7A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		5 GLY A 293
GLY A 289
ILE A 269
ASP A 291
VAL A 318
 None
 0.86A 2oxtA-2ie8A:
2.6		 2oxtA-2ie8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jo7 GLYCOSYLPHOSPHATIDYL
INOSITOL-ANCHORED
MEROZOITE SURFACE
PROTEIN

(Babesia
divergens) 		PF11641
(Antigen_Bd37) 		5 GLY A  81
GLY A  77
ILE A 289
ASP A 112
VAL A 108
 None
 1.07A 2oxtA-2jo7A:
undetectable		 2oxtA-2jo7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml2 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		no annotation 5 GLY A  24
GLY A  38
GLY A  41
THR A  55
ILE A  83
 CA  A 202 ( 4.8A)
CA  A 202 (-3.9A)
CA  A 204 (-4.4A)
None
None
 0.96A 2oxtA-2ml2A:
undetectable		 2oxtA-2ml2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2num UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT

(Rhodobacter
sphaeroides) 		PF00355
(Rieske) 		5 GLY A 120
THR A 115
LEU A 116
GLU A 121
ASP A  81
 None
 0.99A 2oxtA-2numA:
undetectable		 2oxtA-2numA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
GLU A 112
ILE A 133
HIS A 134
ASP A 147
VAL A 148
 SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
None
SAM  A 300 (-3.8A)
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
 0.02A 2oxtA-2oxtA:
48.9		 2oxtA-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
SAH  A 301 (-4.2A)
 0.47A 2oxtA-2oy0A:
38.6		 2oxtA-2oy0A:
51.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.7A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.2A)
 0.78A 2oxtA-2oy0A:
38.6		 2oxtA-2oy0A:
51.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY X  73
GLY X  71
LEU X 203
GLU X 145
ASP X 207
 F10  X 401 ( 4.1A)
F10  X 401 ( 4.3A)
None
None
F10  X 401 (-3.4A)
 0.88A 2oxtA-2p3gX:
undetectable		 2oxtA-2p3gX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		5 GLY A  26
GLY A  29
THR A  36
LEU A 133
VAL A 157
 None
 0.76A 2oxtA-2ph1A:
undetectable		 2oxtA-2ph1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pw6 UNCHARACTERIZED
PROTEIN YGID

(Escherichia
coli) 		PF02900
(LigB) 		5 GLY A 173
GLY A 125
GLY A  23
GLY A  21
ILE A 128
 None
 0.91A 2oxtA-2pw6A:
undetectable		 2oxtA-2pw6A:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A 500 (-3.3A)
SAH  A 500 (-3.4A)
SAH  A 500 ( 3.7A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.6A)
 0.36A 2oxtA-2px5A:
39.6		 2oxtA-2px5A:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
 SAH  A 500 (-3.3A)
SAH  A 500 ( 3.7A)
SAH  A 500 (-3.2A)
SAH  A 500 (-3.4A)
SAH  A 500 ( 4.6A)
SAH  A 500 ( 3.2A)
SAH  A 500 (-3.6A)
 0.68A 2oxtA-2px5A:
39.6		 2oxtA-2px5A:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		7 GLY A  59
GLY A  82
GLY A  84
TRP A  88
THR A 105
LEU A 106
ASP A 147
 SAM  A1248 ( 3.7A)
SAM  A1248 (-3.3A)
SAM  A1248 (-3.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-4.5A)
SAM  A1248 (-4.1A)
SAM  A1248 (-3.7A)
 0.32A 2oxtA-2wa2A:
34.9		 2oxtA-2wa2A:
53.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wa2 NON-STRUCTURAL
PROTEIN 5

(Modoc virus) 		PF01728
(FtsJ) 		7 GLY A  82
GLY A  84
TRP A  88
THR A 105
LEU A 106
GLU A 112
ASP A 147
 SAM  A1248 (-3.3A)
SAM  A1248 (-3.4A)
SAM  A1248 (-3.7A)
SAM  A1248 (-4.5A)
SAM  A1248 (-4.1A)
None
SAM  A1248 (-3.7A)
 0.51A 2oxtA-2wa2A:
34.9		 2oxtA-2wa2A:
53.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY S 142
GLY S  44
GLY S 197
ILE S  52
VAL S  31
 None
 0.96A 2oxtA-2wpmS:
undetectable		 2oxtA-2wpmS:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 GLY A 210
GLY A 315
GLY A 156
GLY A 311
LEU A 349
 None
GAL  A   1 (-3.2A)
None
None
None
 0.94A 2oxtA-2z8eA:
undetectable		 2oxtA-2z8eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 GLY A  46
GLY A  51
TRP A  52
LEU A  68
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.0A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.7A)
 0.49A 2oxtA-3douA:
14.5		 2oxtA-3douA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
THR A 104
LEU A 105
GLU A 111
 SAM  A4633 ( 3.7A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.1A)
None
 0.71A 2oxtA-3eluA:
38.9		 2oxtA-3eluA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		8 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
ASP A 146
 SAM  A4633 ( 3.7A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.5A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.1A)
SAM  A4633 (-3.7A)
 0.44A 2oxtA-3eluA:
38.9		 2oxtA-3eluA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		10 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
ILE A 132
HIS A 133
ASP A 146
 SAH  A 901 (-3.2A)
SAH  A 901 (-3.4A)
SAH  A 901 (-3.3A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-4.5A)
SAH  A 901 (-4.0A)
SAH  A 901 (-3.8A)
SAH  A 901 (-4.2A)
SAH  A 901 (-3.8A)
 0.35A 2oxtA-3evcA:
39.8		 2oxtA-3evcA:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		6 GLY A  58
GLY A  83
GLY A  86
TRP A  87
GLU A 111
ASP A 146
 SAH  A 901 (-3.2A)
SAH  A 901 (-3.3A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.6A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.8A)
 0.81A 2oxtA-3evcA:
39.8		 2oxtA-3evcA:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SAH  A 901 (-3.4A)
SAH  A 901 (-3.2A)
SAH  A 901 (-3.1A)
SAH  A 901 (-3.3A)
None
SAH  A 901 (-3.8A)
 1.33A 2oxtA-3evcA:
39.8		 2oxtA-3evcA:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
THR A 104
LEU A 105
GLU A 111
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
None
 0.65A 2oxtA-3gczA:
40.6		 2oxtA-3gczA:
49.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		8 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
LEU A 105
ASP A 146
 SAM  A4633 (-3.5A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-3.6A)
SAM  A4633 (-4.5A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
 0.36A 2oxtA-3gczA:
40.6		 2oxtA-3gczA:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 133
GLY A 320
GLY A 302
GLU A 319
ILE A 441
 None
 0.89A 2oxtA-3gg4A:
undetectable		 2oxtA-3gg4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		5 GLY A 366
GLY A 257
GLY A 255
GLY A 338
THR A 258
 None
 1.00A 2oxtA-3gq9A:
undetectable		 2oxtA-3gq9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		5 GLY A 167
GLY A 149
GLY A 144
ILE A 139
VAL A 214
 None
None
ATP  A 301 (-3.1A)
None
None
 0.98A 2oxtA-3h1qA:
undetectable		 2oxtA-3h1qA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi0 PUTATIVE
EXOPOLYPHOSPHATASE

(Agrobacterium
fabrum) 		PF02541
(Ppx-GppA) 		5 GLY A  53
GLY A 171
GLY A 149
GLY A  51
LEU A 151
 None
 0.76A 2oxtA-3hi0A:
undetectable		 2oxtA-3hi0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp7 HEMOLYSIN, PUTATIVE

(Streptococcus
thermophilus) 		PF01479
(S4)
PF01728
(FtsJ) 		5 GLY A  66
GLY A  90
GLY A  95
ASP A 155
VAL A 156
 None
EOH  A 301 ( 3.7A)
None
None
None
 0.74A 2oxtA-3hp7A:
14.6		 2oxtA-3hp7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hst PROTEIN
RV2228C/MT2287

(Mycobacterium
tuberculosis) 		PF13456
(RVT_3) 		5 GLY B  10
GLY B  52
GLY B  19
LEU B  57
ASP B   8
 None
 1.00A 2oxtA-3hstB:
undetectable		 2oxtA-3hstB:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		8 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
 SFG  A 301 (-2.9A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.3A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.7A)
SFG  A 301 ( 4.7A)
SFG  A 301 (-3.7A)
SFG  A 301 (-3.8A)
 0.64A 2oxtA-3lkzA:
39.7		 2oxtA-3lkzA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SFG  A 301 (-3.5A)
SFG  A 301 (-2.9A)
SFG  A 301 (-3.4A)
SFG  A 301 (-3.3A)
None
SFG  A 301 (-3.8A)
 1.39A 2oxtA-3lkzA:
39.7		 2oxtA-3lkzA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3num SERINE PROTEASE
HTRA1

(Homo sapiens) 		PF13365
(Trypsin_2) 		5 GLY A 206
GLY A 329
GLY A 326
THR A 217
ILE A 215
 None
 1.08A 2oxtA-3numA:
undetectable		 2oxtA-3numA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prv NUCLEOSIDE
DIPHOSPHATE KINASE

(Trypanosoma
cruzi) 		PF00334
(NDK) 		5 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 0.98A 2oxtA-3prvA:
undetectable		 2oxtA-3prvA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		6 GLY A 139
GLY A  43
GLY A 196
GLY A 193
THR A  53
LEU A  52
 None
 1.43A 2oxtA-3s69A:
undetectable		 2oxtA-3s69A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY X 290
GLY X 247
GLY X 286
LEU X 127
ILE X  77
 None
 0.99A 2oxtA-3ss7X:
undetectable		 2oxtA-3ss7X:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sti PROTEASE DEGQ

(Escherichia
coli) 		PF13365
(Trypsin_2) 		5 GLY A 149
GLY A 189
GLY A 145
ILE A 201
VAL A  68
 None
 0.84A 2oxtA-3stiA:
undetectable		 2oxtA-3stiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1w FOUR-DOMAIN
FIBRONECTIN FRAGMENT

(Homo sapiens) 		PF00041
(fn3) 		5 GLY A1308
GLY A1306
THR A1356
GLU A1329
ILE A1283
 None
 1.05A 2oxtA-3t1wA:
undetectable		 2oxtA-3t1wA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2

(Escherichia
coli) 		PF00294
(PfkB) 		5 GLY A 255
GLY A  40
THR A   8
LEU A   9
ASP A 166
 ATP  A 401 (-3.3A)
None
None
None
MG  A 403 (-3.1A)
 1.07A 2oxtA-3uqeA:
undetectable		 2oxtA-3uqeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		5 GLY A 103
GLY A  14
GLY A  11
GLY A  99
ILE A  17
 None
 0.92A 2oxtA-3v3tA:
3.2		 2oxtA-3v3tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		5 GLY A 103
GLY A  14
GLY A  11
GLY A  99
VAL A  93
 None
 0.85A 2oxtA-3v3tA:
3.2		 2oxtA-3v3tA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		5 GLY A 105
GLY A 107
GLY A 110
THR A 127
LEU A 128
 SAH  A 302 (-3.4A)
SAH  A 302 (-3.3A)
None
SAH  A 302 (-4.0A)
SAH  A 302 (-4.1A)
 0.70A 2oxtA-3vc1A:
8.8		 2oxtA-3vc1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 110
GLY A  12
GLY A   9
GLY A 106
VAL A 100
 None
None
GSP  A1342 (-3.5A)
GSP  A1342 (-3.9A)
None
 0.98A 2oxtA-4b45A:
2.9		 2oxtA-4b45A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 114
GLY A  12
GLY A   9
GLY A 110
VAL A 104
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-3.6A)
None
 1.04A 2oxtA-4b46A:
undetectable		 2oxtA-4b46A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		5 GLY A1363
GLY A1285
GLY A1381
GLY A1378
VAL A1280
 None
 0.97A 2oxtA-4bkwA:
undetectable		 2oxtA-4bkwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7n SNAKE-VENOM
THROMBIN-LIKE ENZYME

(Gloydius halys) 		PF00089
(Trypsin) 		6 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
 1.42A 2oxtA-4e7nA:
undetectable		 2oxtA-4e7nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f36 NUCLEOSIDE
DIPHOSPHATE KINASE

(Trypanosoma
brucei) 		PF00334
(NDK) 		5 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 1.03A 2oxtA-4f36A:
undetectable		 2oxtA-4f36A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		5 GLY A 113
GLY A 115
GLY A 118
THR A 135
LEU A 136
 None
 0.74A 2oxtA-4f85A:
8.9		 2oxtA-4f85A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 290
GLY A 157
GLY A 294
ILE A 166
VAL A 131
 None
 0.96A 2oxtA-4ic6A:
undetectable		 2oxtA-4ic6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		6 GLY A 107
GLY A 185
GLY A  56
GLY A 103
THR A 186
ILE A 197
 None
 1.35A 2oxtA-4iheA:
undetectable		 2oxtA-4iheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		5 GLY A 130
GLY A   4
ILE A 131
ASP A  83
VAL A 128
 None
 0.93A 2oxtA-4jj6A:
2.9		 2oxtA-4jj6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A1001 (-3.1A)
SAH  A1001 (-3.3A)
SAH  A1001 ( 3.7A)
SAH  A1001 (-3.2A)
SAH  A1001 (-3.9A)
SAH  A1001 (-4.7A)
SAH  A1001 (-3.6A)
 0.51A 2oxtA-4k6mA:
39.4		 2oxtA-4k6mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 GLY A  81
GLY A  83
GLY A  86
THR A 104
GLU A 111
 SAH  A1001 (-3.3A)
SAH  A1001 ( 3.7A)
SAH  A1001 (-3.2A)
SAH  A1001 (-4.7A)
SO4  A1011 (-4.9A)
 0.65A 2oxtA-4k6mA:
39.4		 2oxtA-4k6mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 GLY A 279
GLY A 282
THR A 301
LEU A 302
ASP A 364
 SAM  A 601 (-3.5A)
SAM  A 601 (-3.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-4.1A)
SAM  A 601 (-3.6A)
 0.52A 2oxtA-4n49A:
16.3		 2oxtA-4n49A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		5 GLY A 171
GLY A 146
LEU A  73
ILE A 301
VAL A 167
 15P  A 401 (-3.6A)
None
None
None
None
 0.86A 2oxtA-4opmA:
undetectable		 2oxtA-4opmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 261
GLY A 211
GLY A 213
THR A 209
LEU A 208
 None
 0.95A 2oxtA-4rvsA:
5.4		 2oxtA-4rvsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		5 GLY A 103
GLY A  14
GLY A  11
GLY A  99
ILE A  17
 None
None
GDP  A 401 (-3.4A)
GDP  A 401 (-3.3A)
None
 0.93A 2oxtA-4xcqA:
2.7		 2oxtA-4xcqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcq TUBZ

(Clostridium
phage c-st) 		PF00091
(Tubulin) 		5 GLY A 103
GLY A  14
GLY A  11
GLY A  99
VAL A  93
 None
None
GDP  A 401 (-3.4A)
GDP  A 401 (-3.3A)
None
 0.88A 2oxtA-4xcqA:
2.7		 2oxtA-4xcqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 341
GLY A 122
GLY A 336
THR A 120
ILE A  95
 None
AZI  A 402 (-3.6A)
NDP  A 401 (-3.3A)
None
None
 1.05A 2oxtA-4xybA:
5.3		 2oxtA-4xybA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A  66
GLY A 192
GLY A 188
ILE A  76
VAL A  22
 None
 0.95A 2oxtA-4ynnA:
undetectable		 2oxtA-4ynnA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.6A)
SAM  A 301 (-3.8A)
 0.33A 2oxtA-5e9qA:
39.4		 2oxtA-5e9qA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  58
GLY A  83
GLY A  86
TRP A  87
GLU A 111
ASP A 146
 SAM  A 301 (-3.2A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.1A)
SAM  A 301 (-3.6A)
SAM  A 301 ( 3.4A)
SAM  A 301 (-3.8A)
 0.73A 2oxtA-5e9qA:
39.4		 2oxtA-5e9qA:
50.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 5 GLY E  73
GLY E  43
GLY E  39
THR E  42
LEU E 135
 None
 1.07A 2oxtA-5h36E:
undetectable		 2oxtA-5h36E:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxw L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		5 GLY A  98
GLY A 437
GLY A 439
THR A 436
ILE A 413
 FAD  A 501 (-3.8A)
16A  A 504 ( 3.8A)
FAD  A 501 (-3.1A)
FAD  A 501 (-4.0A)
16A  A 504 ( 4.1A)
 0.84A 2oxtA-5hxwA:
undetectable		 2oxtA-5hxwA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 122
GLY A 130
GLY A 128
LEU A  81
ILE A 197
 FAD  A 601 (-3.2A)
FAD  A 601 (-3.6A)
FAD  A 601 (-3.7A)
FAD  A 601 (-4.7A)
FAD  A 601 (-3.6A)
 1.06A 2oxtA-5i1wA:
undetectable		 2oxtA-5i1wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		5 GLY A  98
GLY A 437
GLY A 439
THR A 436
ILE A 413
 FAD  A 501 (-3.7A)
EDO  A 507 ( 3.7A)
FAD  A 501 (-3.2A)
FAD  A 501 (-3.9A)
EDO  A 507 ( 4.3A)
 0.80A 2oxtA-5i39A:
undetectable		 2oxtA-5i39A:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
SAM  A 311 (-4.5A)
SAM  A 311 (-3.8A)
 0.31A 2oxtA-5ikmA:
38.9		 2oxtA-5ikmA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
 SAM  A 311 (-3.3A)
SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.5A)
SAM  A 311 (-4.5A)
None
 0.50A 2oxtA-5ikmA:
38.9		 2oxtA-5ikmA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		6 GLY A  81
GLY A  58
GLY A  86
GLY A  83
THR A  59
ASP A 146
 SAM  A 311 (-3.2A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
SAM  A 311 (-3.3A)
None
SAM  A 311 (-3.8A)
 1.32A 2oxtA-5ikmA:
38.9		 2oxtA-5ikmA:
49.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A1003 (-3.2A)
SAH  A1003 (-3.4A)
SAH  A1003 (-3.5A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
SAH  A1003 (-4.6A)
SAH  A1003 (-3.8A)
 0.27A 2oxtA-5jjrA:
39.0		 2oxtA-5jjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		7 GLY A  58
GLY A  83
GLY A  86
TRP A  87
THR A 104
GLU A 111
ASP A 146
 SAH  A1003 (-3.2A)
SAH  A1003 (-3.5A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.4A)
SAH  A1003 (-4.6A)
SAH  A1003 (-3.3A)
SAH  A1003 (-3.8A)
 0.69A 2oxtA-5jjrA:
39.0		 2oxtA-5jjrA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLY A  98
GLY A 283
LEU A 280
ILE A 656
VAL A 676
 None
 0.94A 2oxtA-5ksdA:
undetectable		 2oxtA-5ksdA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 GLY A 482
GLY A  12
GLY A  14
GLY A  19
VAL A 280
 None
FAD  A1801 (-3.2A)
FAD  A1801 (-3.3A)
None
FAD  A1801 (-4.1A)
 0.82A 2oxtA-5laeA:
undetectable		 2oxtA-5laeA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 GLY A 176
GLY A 216
GLY A 325
THR A 197
LEU A 201
 None
FMN  A 401 (-3.5A)
FMN  A 401 ( 4.1A)
None
None
 1.01A 2oxtA-5lsmA:
undetectable		 2oxtA-5lsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 6 GLY A  58
GLY A  81
GLY A  83
GLY A  86
THR A 104
GLU A 111
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-4.4A)
None
 0.52A 2oxtA-5njuA:
38.8		 2oxtA-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A1001 (-3.3A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.5A)
SAH  A1001 (-4.4A)
SAH  A1001 (-3.7A)
 0.20A 2oxtA-5njuA:
38.8		 2oxtA-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 GLY A 624
GLY A 547
GLY A 627
GLY A 509
ASP A 545
 None
 1.05A 2oxtA-5svcA:
undetectable		 2oxtA-5svcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		7 GLY A  58
GLY A  81
GLY A  83
GLY A  86
TRP A  87
THR A 104
ASP A 146
 SAH  A1001 (-3.2A)
SAH  A1001 (-3.4A)
SAH  A1001 ( 3.8A)
SAH  A1001 (-3.6A)
SAH  A1001 (-3.5A)
SAH  A1001 ( 4.9A)
SAH  A1001 (-3.8A)
 0.34A 2oxtA-5tmhA:
38.1		 2oxtA-5tmhA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2i NUCLEOSIDE
DIPHOSPHATE KINASE

(Naegleria
fowleri) 		PF00334
(NDK) 		5 GLY A  81
GLY A  79
GLY A  31
GLU A  78
VAL A  83
 None
 1.03A 2oxtA-5u2iA:
undetectable		 2oxtA-5u2iA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud0 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Helicobacter
pylori) 		no annotation 5 GLY A  84
GLY A  51
THR A  85
ILE A 103
ASP A  82
 None
None
None
None
NA  A 401 (-3.8A)
 0.96A 2oxtA-5ud0A:
undetectable		 2oxtA-5ud0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 GLY A  87
GLY A 509
GLY A 549
LEU A 440
VAL A 340
 None
 1.05A 2oxtA-5xm3A:
undetectable		 2oxtA-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze3 LYSYL OXIDASE
HOMOLOG 2

(Homo sapiens) 		no annotation 5 GLY A 750
GLY A 345
GLU A 346
ILE A 403
VAL A 341
 None
 1.04A 2oxtA-5ze3A:
undetectable		 2oxtA-5ze3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqy GDP-L-FUCOSE
SYNTHETASE

(Naegleria
fowleri) 		PF01370
(Epimerase) 		5 GLY A  23
GLY A  49
GLY A  53
THR A  25
VAL A  21
 None
 0.98A 2oxtA-6aqyA:
4.4		 2oxtA-6aqyA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 GLY D 224
GLY D 228
GLY D 153
GLY D 215
HIS D 134
 None
 1.01A 2oxtA-6f45D:
undetectable		 2oxtA-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biu HIV-1 INTEGRASE

(Human
immunodeficiency
virus 1) 		PF00665
(rve) 		3 SER A 153
HIS A  78
ASP A 202
 None
 0.85A 2oxtA-1biuA:
undetectable		 2oxtA-1biuA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddk IMP-1 METALLO
BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 SER A 179
HIS A  77
ASP A 109
 None
ZN  A 500 (-3.4A)
None
 0.72A 2oxtA-1ddkA:
undetectable		 2oxtA-1ddkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		3 SER A1013
HIS A 975
ASP A 923
 None
 0.84A 2oxtA-1fx2A:
undetectable		 2oxtA-1fx2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny9 TRANSCRIPTIONAL
ACTIVATOR TIPA-S

(Streptomyces
lividans) 		PF07739
(TipAS) 		3 SER A 186
HIS A 196
ASP A 168
 None
 0.82A 2oxtA-1ny9A:
undetectable		 2oxtA-1ny9A:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		3 SER A  56
HIS A 110
ASP A 131
 SAH  A 887 ( 2.8A)
SO4  A 901 ( 3.9A)
SAH  A 887 ( 3.3A)
 0.47A 2oxtA-1r6aA:
39.3		 2oxtA-1r6aA:
48.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 SER A 537
HIS A 651
ASP A 453
 None
 0.85A 2oxtA-1ryyA:
undetectable		 2oxtA-1ryyA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Zea mays) 		PF00903
(Glyoxalase) 		3 SER A 423
HIS A 301
ASP A 218
 None
FE2  A 500 (-3.4A)
None
 0.78A 2oxtA-1sp8A:
undetectable		 2oxtA-1sp8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
PROTEIN B

([Haemophilus]
ducreyi) 		PF03372
(Exo_endo_phos) 		3 SER B 171
HIS B 160
ASP B 112
 None
BR  B 523 (-4.5A)
None
 0.40A 2oxtA-1sr4B:
2.1		 2oxtA-1sr4B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 SER A 314
HIS A 285
ASP A 196
 None
 0.58A 2oxtA-1svdA:
undetectable		 2oxtA-1svdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 SER A 290
HIS A  59
ASP A 307
 None
 0.64A 2oxtA-1uedA:
undetectable		 2oxtA-1uedA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 SER A 615
HIS A 697
ASP A 683
 None
 0.80A 2oxtA-1z8lA:
undetectable		 2oxtA-1z8lA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III

(Homo sapiens) 		PF05822
(UMPH-1) 		3 SER A 228
HIS A  57
ASP A 158
 None
 0.83A 2oxtA-2cn1A:
undetectable		 2oxtA-2cn1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy4 EPIDERMAL GROWTH
FACTOR RECEPTOR
PATHWAY SUBSTRATE
8-LIKE PROTEIN 1

(Mus musculus) 		PF08416
(PTB) 		3 SER A  92
HIS A  40
ASP A 133
 None
 0.77A 2oxtA-2cy4A:
undetectable		 2oxtA-2cy4A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		3 SER A 333
HIS A 368
ASP A 372
 UDP  A1424 (-2.7A)
None
None
 0.72A 2oxtA-2iyaA:
2.4		 2oxtA-2iyaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus) 		PF01115
(F_actin_cap_B) 		3 SER B 390
HIS B 509
ASP B 505
 None
 0.78A 2oxtA-2kxpB:
undetectable		 2oxtA-2kxpB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 124
HIS A 345
ASP A 294
 None
 0.76A 2oxtA-2o56A:
undetectable		 2oxtA-2o56A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 SER A  57
HIS A 111
ASP A 132
 SAM  A 300 (-2.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
 0.01A 2oxtA-2oxtA:
48.9		 2oxtA-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		3 SER A  56
HIS A 110
ASP A 131
 SAH  A 500 (-2.5A)
SAH  A 500 (-3.9A)
SAH  A 500 (-3.5A)
 0.34A 2oxtA-2px5A:
39.6		 2oxtA-2px5A:
51.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7d RIBONUCLEASE II
FAMILY PROTEIN

(Deinococcus
radiodurans) 		PF00773
(RNB) 		3 SER A  25
HIS A  41
ASP A  51
 None
 0.84A 2oxtA-2r7dA:
undetectable		 2oxtA-2r7dA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5w KINESIN HEAVY CHAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 SER A 208
HIS A 100
ASP A 108
 None
ADP  A 600 (-3.6A)
None
 0.68A 2oxtA-2y5wA:
undetectable		 2oxtA-2y5wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		3 SER A 499
HIS A 129
ASP A 151
 None
None
CA  A1525 (-2.4A)
 0.65A 2oxtA-2yeqA:
undetectable		 2oxtA-2yeqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 2

(Mus musculus) 		PF00169
(PH) 		3 SER A 715
HIS A 734
ASP A 594
 None
 0.74A 2oxtA-3a8pA:
undetectable		 2oxtA-3a8pA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		3 SER X 363
HIS X  76
ASP X  82
 None
 0.83A 2oxtA-3brkX:
undetectable		 2oxtA-3brkX:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 3 SER A  77
HIS A  55
ASP A 107
 None
 0.86A 2oxtA-3c8vA:
undetectable		 2oxtA-3c8vA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		3 SER A  98
HIS A  42
ASP A 393
 None
 0.79A 2oxtA-3c9fA:
undetectable		 2oxtA-3c9fA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		3 SER A  65
HIS A 121
ASP A 145
 None
 0.67A 2oxtA-3cn7A:
2.2		 2oxtA-3cn7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cob KINESIN HEAVY
CHAIN-LIKE PROTEIN

(Solanum
tuberosum) 		PF00225
(Kinesin) 		3 SER A1094
HIS A1090
ASP A1022
 None
 0.74A 2oxtA-3cobA:
undetectable		 2oxtA-3cobA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfy MUCONATE
CYCLOISOMERASE

(Thermotoga
maritima) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  52
HIS A  21
ASP A 169
 None
 0.85A 2oxtA-3dfyA:
undetectable		 2oxtA-3dfyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0f PUTATIVE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bifidobacterium
adolescentis) 		PF02811
(PHP) 		3 SER A  62
HIS A  42
ASP A 278
 None
 0.70A 2oxtA-3e0fA:
undetectable		 2oxtA-3e0fA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5z PUTATIVE
GLUCONOLACTONASE

(Deinococcus
radiodurans) 		PF08450
(SGL) 		3 SER A 104
HIS A  87
ASP A 138
 None
 0.84A 2oxtA-3e5zA:
undetectable		 2oxtA-3e5zA:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		3 SER A  56
HIS A 110
ASP A 131
 SAH  A 901 (-2.6A)
SAH  A 901 (-3.8A)
SAH  A 901 (-3.7A)
 0.52A 2oxtA-3evcA:
39.8		 2oxtA-3evcA:
48.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 SER A  75
HIS A 178
ASP A 170
 None
 0.85A 2oxtA-3fgbA:
undetectable		 2oxtA-3fgbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		3 SER A  79
HIS A 123
ASP A 138
 None
 0.75A 2oxtA-3fpzA:
undetectable		 2oxtA-3fpzA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		3 SER A  56
HIS A 110
ASP A 131
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.5A)
SAM  A4633 (-3.7A)
 0.28A 2oxtA-3gczA:
40.6		 2oxtA-3gczA:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwi MAGNESIUM-TRANSPORTI
NG ATPASE, P-TYPE 1

(Escherichia
coli) 		PF13246
(Cation_ATPase) 		3 SER A 432
HIS A 388
ASP A 390
 None
 0.81A 2oxtA-3gwiA:
undetectable		 2oxtA-3gwiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 SER A 191
HIS A 377
ASP A 209
 None
 0.81A 2oxtA-3hn7A:
undetectable		 2oxtA-3hn7A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpc SNX5 PROTEIN

(Rattus
norvegicus) 		PF00787
(PX) 		3 SER X  30
HIS X 153
ASP X  84
 None
 0.82A 2oxtA-3hpcX:
undetectable		 2oxtA-3hpcX:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iac GLUCURONATE
ISOMERASE

(Salmonella
enterica) 		PF02614
(UxaC) 		3 SER A  67
HIS A  59
ASP A 414
 None
 0.74A 2oxtA-3iacA:
undetectable		 2oxtA-3iacA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		3 SER A 541
HIS A 392
ASP A 316
 None
 0.78A 2oxtA-3iukA:
undetectable		 2oxtA-3iukA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 SER A 212
HIS A 279
ASP A 388
 None
 0.86A 2oxtA-3jq0A:
undetectable		 2oxtA-3jq0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		3 SER A 121
HIS A  52
ASP A  30
 None
 0.83A 2oxtA-3jroA:
undetectable		 2oxtA-3jroA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkl PROBABLE CHAPERONE
PROTEIN HSP33

(Saccharomyces
cerevisiae) 		no annotation 3 SER A 223
HIS A 108
ASP A 176
 None
 0.85A 2oxtA-3kklA:
2.6		 2oxtA-3kklA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 SER A 353
HIS A 286
ASP A 179
 None
None
CA  A 380 (-3.3A)
 0.82A 2oxtA-3maxA:
3.2		 2oxtA-3maxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN
PROTEIN DOM34

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 SER B 360
HIS A 542
ASP B 288
 None
 0.81A 2oxtA-3mcaB:
undetectable		 2oxtA-3mcaB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 SER A  46
HIS A  37
ASP A  18
 None
 0.83A 2oxtA-3p5mA:
undetectable		 2oxtA-3p5mA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		3 SER A 148
HIS A 275
ASP A 297
 None
 0.78A 2oxtA-3q9oA:
undetectable		 2oxtA-3q9oA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		3 SER A 321
HIS A 339
ASP A 397
 None
 0.67A 2oxtA-3swgA:
undetectable		 2oxtA-3swgA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxp ADP-L-GLYCERO-D-MANN
OHEPTOSE-6-EPIMERASE

(Helicobacter
pylori) 		PF01370
(Epimerase) 		3 SER A 128
HIS A  96
ASP A  43
 None
None
NAD  A2402 (-2.6A)
 0.78A 2oxtA-3sxpA:
5.0		 2oxtA-3sxpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
PANCREATIC

(Mus musculus) 		PF00074
(RnaseA) 		3 SER A  20
HIS A  13
ASP A 122
 None
 0.68A 2oxtA-3tsrA:
undetectable		 2oxtA-3tsrA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A  91
HIS A  68
ASP A  39
 None
 0.82A 2oxtA-3ugvA:
undetectable		 2oxtA-3ugvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 SER A 175
HIS A 194
ASP A 494
 None
 0.86A 2oxtA-3vexA:
undetectable		 2oxtA-3vexA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 SER A 331
HIS A 269
ASP A 198
 None
 0.77A 2oxtA-4cj0A:
undetectable		 2oxtA-4cj0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		3 SER A  36
HIS A 356
ASP A  81
 None
 0.66A 2oxtA-4dteA:
undetectable		 2oxtA-4dteA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 SER A 549
HIS A 456
ASP A 485
 None
 0.85A 2oxtA-4h1sA:
undetectable		 2oxtA-4h1sA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		3 SER A 199
HIS A 251
ASP A 255
 None
 0.72A 2oxtA-4hcxA:
undetectable		 2oxtA-4hcxA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcm CYCLODEXTRIN
GLUCANOTRANSFERASE

([Bacillus]
clarkii) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		3 SER A 180
HIS A 261
ASP A 303
 None
 0.52A 2oxtA-4jcmA:
undetectable		 2oxtA-4jcmA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH) 		3 SER A 644
HIS A 663
ASP A 523
 None
 0.70A 2oxtA-4k2pA:
undetectable		 2oxtA-4k2pA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 SER A  56
HIS A 110
ASP A 131
 SAH  A1001 (-2.8A)
SAH  A1001 ( 3.6A)
SAH  A1001 (-3.7A)
 0.39A 2oxtA-4k6mA:
39.4		 2oxtA-4k6mA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq6 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

([Candida]
glabrata) 		PF00885
(DMRL_synthase) 		3 SER A 103
HIS A 149
ASP A 141
 None
 0.83A 2oxtA-4kq6A:
undetectable		 2oxtA-4kq6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		3 SER A 251
HIS A  86
ASP A 146
 None
ZN  A 301 (-3.4A)
None
 0.81A 2oxtA-4ly4A:
undetectable		 2oxtA-4ly4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 SER A 321
HIS A 292
ASP A 203
 None
None
RUB  A 501 (-3.2A)
 0.71A 2oxtA-4mkvA:
undetectable		 2oxtA-4mkvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Saccharomyces
cerevisiae) 		PF00078
(RVT_1) 		3 SER A 139
HIS A 417
ASP A 449
 None
 0.74A 2oxtA-4ol8A:
undetectable		 2oxtA-4ol8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p17 RABGAP/TBC PROTEIN

(Chlamydomonas
reinhardtii) 		PF00566
(RabGAP-TBC) 		3 SER A 236
HIS A 113
ASP A 106
 None
 0.83A 2oxtA-4p17A:
undetectable		 2oxtA-4p17A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9t NUCLEOPORIN NUP133

(Vanderwaltozyma
polyspora) 		PF08801
(Nucleoporin_N) 		3 SER A 146
HIS A 413
ASP A 352
 None
 0.80A 2oxtA-4q9tA:
undetectable		 2oxtA-4q9tA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 SER B 846
HIS B 999
ASP A 463
 None
None
MG  A1001 (-3.0A)
 0.82A 2oxtA-4qiwB:
undetectable		 2oxtA-4qiwB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		3 SER A 250
HIS A 239
ASP A 264
 None
 0.78A 2oxtA-4qx8A:
undetectable		 2oxtA-4qx8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2h STIV B204 ATPASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 3 SER A  15
HIS A 201
ASP A 192
 None
 0.67A 2oxtA-4r2hA:
2.3		 2oxtA-4r2hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		3 SER G 137
HIS G 169
ASP G 317
 None
None
AMP  G 403 (-2.9A)
 0.85A 2oxtA-4rerG:
undetectable		 2oxtA-4rerG:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpd CAPSID PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 SER A 356
HIS A 299
ASP A 375
 None
 0.84A 2oxtA-4rpdA:
undetectable		 2oxtA-4rpdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		3 SER A 234
HIS A 226
ASP A 220
 None
3YN  A 503 (-4.5A)
None
 0.76A 2oxtA-4rvhA:
6.8		 2oxtA-4rvhA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		3 SER A 277
HIS A 267
ASP A 251
 None
 0.85A 2oxtA-4tmuA:
2.3		 2oxtA-4tmuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uad IMPORTIN SUBUNIT
ALPHA-7

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 SER A 347
HIS A 305
ASP A 267
 None
 0.76A 2oxtA-4uadA:
undetectable		 2oxtA-4uadA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubq BETA-LACTAMASE

(Acinetobacter
baumannii) 		no annotation 3 SER A 180
HIS A  78
ASP A 110
 None
ZN  A 301 (-3.4A)
None
 0.53A 2oxtA-4ubqA:
undetectable		 2oxtA-4ubqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		3 SER A 152
HIS A  76
ASP A 102
 None
 0.74A 2oxtA-4wj3A:
undetectable		 2oxtA-4wj3A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynu GLUCOSE OXIDASE,
PUTATIVE

(Aspergillus
flavus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		3 SER A 257
HIS A 228
ASP A   7
 None
 0.78A 2oxtA-4ynuA:
undetectable		 2oxtA-4ynuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 SER A 189
HIS A 264
ASP A 149
 None
 0.82A 2oxtA-4yufA:
undetectable		 2oxtA-4yufA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		3 SER A 221
HIS A 300
ASP A 265
 None
 0.75A 2oxtA-5afdA:
undetectable		 2oxtA-5afdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 3 SER A 197
HIS A  95
ASP A 127
 None
ZN  A2001 ( 3.4A)
None
 0.85A 2oxtA-5b3rA:
undetectable		 2oxtA-5b3rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo6 SIA-ALPHA-2,3-GAL-BE
TA-1,4-GLCNAC-R:ALPH
A
2,8-SIALYLTRANSFERAS
E

(Homo sapiens) 		PF00777
(Glyco_transf_29) 		3 SER A 174
HIS A 317
ASP A 184
 None
FUC  A 408 (-4.7A)
None
 0.82A 2oxtA-5bo6A:
undetectable		 2oxtA-5bo6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 SER A 276
HIS A 220
ASP A 174
 4YB  A 502 (-3.9A)
None
None
 0.82A 2oxtA-5c5hA:
2.3		 2oxtA-5c5hA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 SER A 146
HIS A  32
ASP A  82
 MD1  A1004 ( 4.7A)
SF4  A1001 (-3.3A)
NA  A1015 ( 4.9A)
 0.81A 2oxtA-5chcA:
undetectable		 2oxtA-5chcA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		3 SER A 260
HIS A 145
ASP A  83
 None
ZN  A 403 ( 3.3A)
AMP  A 701 ( 2.6A)
 0.79A 2oxtA-5fbbA:
undetectable		 2oxtA-5fbbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC98

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		3 SER B 737
HIS B 728
ASP B 722
 None
 0.67A 2oxtA-5flzB:
undetectable		 2oxtA-5flzB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 3 SER A 118
HIS A 135
ASP A 178
 None
 0.71A 2oxtA-5fzpA:
undetectable		 2oxtA-5fzpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		3 SER A 247
HIS A 114
ASP A 111
 None
 0.84A 2oxtA-5i33A:
undetectable		 2oxtA-5i33A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus;
Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		3 SER A  58
HIS A  39
ASP B 552
 None
 0.72A 2oxtA-5kenA:
undetectable		 2oxtA-5kenA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksp MITOCHONDRIAL RHO
GTPASE 1

(Homo sapiens) 		PF00071
(Ras) 		3 SER A 479
HIS A 474
ASP A 490
 None
 0.70A 2oxtA-5kspA:
2.9		 2oxtA-5kspA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 SER A  27
HIS A 252
ASP A 158
 None
 0.70A 2oxtA-5mdhA:
4.8		 2oxtA-5mdhA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlq CDPS

(Nocardia
brasiliensis) 		no annotation 3 SER A  61
HIS A 186
ASP A 123
 None
CIT  A 301 (-3.8A)
None
 0.53A 2oxtA-5mlqA:
undetectable		 2oxtA-5mlqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		3 SER R 196
HIS R 217
ASP R 183
 None
 0.80A 2oxtA-5mpdR:
undetectable		 2oxtA-5mpdR:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 3 SER A  56
HIS A 110
ASP A 131
 SAH  A1001 (-2.6A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.9A)
 0.25A 2oxtA-5njuA:
38.8		 2oxtA-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 3 SER A 559
HIS A 484
ASP A 487
 None
None
NSQ  A 709 ( 4.8A)
 0.74A 2oxtA-5ohsA:
undetectable		 2oxtA-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 3 SER A 242
HIS A 201
ASP A 451
 None
 0.72A 2oxtA-5oklA:
undetectable		 2oxtA-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		3 SER A 233
HIS A 225
ASP A 219
 None
JHZ  A 503 (-4.1A)
None
 0.86A 2oxtA-5t67A:
6.5		 2oxtA-5t67A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		3 SER A 258
HIS A 254
ASP A  69
 None
 0.65A 2oxtA-5u4hA:
undetectable		 2oxtA-5u4hA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uth THIOREDOXIN
REDUCTASE

(Mycolicibacterium
smegmatis) 		PF07992
(Pyr_redox_2) 		3 SER A  15
HIS A 105
ASP A 102
 FAD  A 400 (-3.6A)
SO4  A 402 (-3.6A)
None
 0.65A 2oxtA-5uthA:
undetectable		 2oxtA-5uthA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		3 SER A 548
HIS A 391
ASP A 222
 None
 0.59A 2oxtA-5wu3A:
undetectable		 2oxtA-5wu3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		3 SER A 548
HIS A 391
ASP A 222
 None
 0.59A 2oxtA-5wu6A:
undetectable		 2oxtA-5wu6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0g PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 3 SER A  45
HIS A  59
ASP A 191
 None
 0.78A 2oxtA-6d0gA:
undetectable		 2oxtA-6d0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 3 SER A 492
HIS A 350
ASP A 314
 None
 0.84A 2oxtA-6ei1A:
undetectable		 2oxtA-6ei1A:
undetectable