SIMILAR PATTERNS OF AMINO ACIDS FOR 2OUZ_A_C3DA999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ALA A 533
TRP A  31
ARG A 583
MET A  91
 None
 1.41A 2ouzA-1aorA:
undetectable		 2ouzA-1aorA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ALA A 238
ASP A 237
GLU A 242
ARG A 247
 None
 1.44A 2ouzA-1gk2A:
0.2		 2ouzA-1gk2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Mus musculus) 		PF08332
(CaMKII_AD) 		4 ALA A 360
ASP A 365
ARG A 433
MET A 377
 None
 1.12A 2ouzA-1hkxA:
undetectable		 2ouzA-1hkxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		4 ALA A  43
ASP A  44
TRP A 241
ARG A  88
 545  A 421 ( 4.7A)
None
None
None
 1.40A 2ouzA-1jikA:
undetectable		 2ouzA-1jikA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		4 ALA A 189
ASP A 192
GLU A 190
ARG A  72
 None
 0.99A 2ouzA-1jvwA:
undetectable		 2ouzA-1jvwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		4 ALA B  69
ASP B  68
GLU B  73
ARG B  88
 None
 1.44A 2ouzA-1kwcB:
undetectable		 2ouzA-1kwcB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lc7 L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		4 ALA A 130
ASP A 131
GLU A 129
ARG A 334
 None
 1.36A 2ouzA-1lc7A:
undetectable		 2ouzA-1lc7A:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 350
GLU A 353
TRP A 383
ARG A 394
 EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-3.7A)
 0.21A 2ouzA-1pcgA:
31.8		 2ouzA-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 350
GLU A 353
TRP A 383
MET A 421
 EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 ( 4.3A)
 0.73A 2ouzA-1pcgA:
31.8		 2ouzA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		4 ALA A 339
ASP A 319
ARG A 444
MET A 429
 None
 1.39A 2ouzA-1px8A:
undetectable		 2ouzA-1px8A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE ALPHA
SUBUNIT

(Thermus
thermophilus) 		PF00676
(E1_dh) 		4 GLU A  21
TRP A 291
ARG A 302
MET A  45
 None
 1.41A 2ouzA-1umbA:
undetectable		 2ouzA-1umbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 ALA A 223
ASP A 314
GLU A 224
MET A 174
 GOL  A 401 (-3.1A)
GOL  A 401 ( 4.5A)
GOL  A 401 (-4.2A)
None
 1.45A 2ouzA-1vgmA:
undetectable		 2ouzA-1vgmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		4 ALA A  25
ASP A  28
GLU A  26
ARG A 242
 None
 1.36A 2ouzA-1wznA:
undetectable		 2ouzA-1wznA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ASP A 329
GLU A 331
TRP A 361
ARG A 372
 None
 1.07A 2ouzA-1xb7A:
24.4		 2ouzA-1xb7A:
33.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 ALA A 381
ASP A 384
GLU A 380
ARG A 309
 None
 1.43A 2ouzA-1ya0A:
1.8		 2ouzA-1ya0A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		4 ALA A  50
ASP A  51
GLU A  49
MET A 293
 None
 1.15A 2ouzA-2ap1A:
undetectable		 2ouzA-2ap1A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 ALA A 340
ASP A 320
ARG A 445
MET A 430
 None
 1.28A 2ouzA-2bs9A:
undetectable		 2ouzA-2bs9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ALA A 126
GLU A 129
ARG A 366
MET A 184
 None
 1.18A 2ouzA-2d52A:
undetectable		 2ouzA-2d52A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		4 ALA A  96
ASP A  97
GLU A  99
TRP A  60
 None
 0.86A 2ouzA-2dykA:
undetectable		 2ouzA-2dykA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 ALA A  32
GLU A  33
ARG A 439
MET A 426
 None
 1.27A 2ouzA-2eyqA:
1.7		 2ouzA-2eyqA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gbz OLIGORIBONUCLEASE

(Xanthomonas
campestris) 		PF00929
(RNase_T) 		4 ALA A 163
ASP A  15
GLU A  30
ARG A  77
 None
MG  A5082 (-2.6A)
None
None
 1.41A 2ouzA-2gbzA:
undetectable		 2ouzA-2gbzA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
ASP A 273
GLU A 275
TRP A 305
ARG A 316
 OHT  A 500 (-3.5A)
OHT  A 500 (-3.1A)
OHT  A 500 (-2.6A)
None
OHT  A 500 (-3.8A)
 0.51A 2ouzA-2gpvA:
25.6		 2ouzA-2gpvA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 ALA A 398
ASP A 399
GLU A 411
ARG A 282
 None
 1.25A 2ouzA-2gwnA:
undetectable		 2ouzA-2gwnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 ALA A 102
ASP A 103
GLU A 101
ARG A 164
 None
 1.38A 2ouzA-2iuwA:
undetectable		 2ouzA-2iuwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naz TRANSCRIPTIONAL
REGULATORY PROTEIN
RSTA

(Acinetobacter
baumannii) 		PF00486
(Trans_reg_C) 		4 ALA A 163
ASP A 166
GLU A 164
ARG A 206
 None
 1.21A 2ouzA-2nazA:
undetectable		 2ouzA-2nazA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 350
GLU A 353
TRP A 383
ARG A 394
MET A 421
 EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.79A 2ouzA-2ocfA:
30.1		 2ouzA-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		4 ASP A 263
GLU A 261
TRP A  32
ARG A  42
 None
 0.88A 2ouzA-2p0lA:
undetectable		 2ouzA-2p0lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 ALA A 463
ASP A 467
GLU A 462
ARG A 489
 None
 1.11A 2ouzA-2r05A:
undetectable		 2ouzA-2r05A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9l PUTATIVE DNA
LIGASE-LIKE PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 258
ASP A 261
GLU A 259
ARG A 276
 None
 1.33A 2ouzA-2r9lA:
undetectable		 2ouzA-2r9lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 ALA A 250
ASP A 251
GLU A 249
TRP A 353
 None
 1.15A 2ouzA-2xzlA:
undetectable		 2ouzA-2xzlA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 ALA A 154
ASP A 112
TRP A 134
MET A 124
 None
 1.40A 2ouzA-3aquA:
undetectable		 2ouzA-3aquA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ALA A 199
ASP A 196
GLU A 193
ARG A  41
 None
 1.39A 2ouzA-3cvwA:
undetectable		 2ouzA-3cvwA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 ALA A 181
GLU A 182
TRP A 151
ARG A 203
 None
 1.19A 2ouzA-3dddA:
undetectable		 2ouzA-3dddA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddj CBS
DOMAIN-CONTAINING
PROTEIN

(Sulfolobus
solfataricus) 		PF00571
(CBS) 		4 ASP A 259
GLU A 123
ARG A  34
MET A 163
 AMP  A 278 (-2.7A)
AMP  A 278 ( 4.8A)
PEG  A 279 (-4.1A)
None
 1.31A 2ouzA-3ddjA:
undetectable		 2ouzA-3ddjA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh0 SAM DEPENDENT
METHYLTRANSFERASE

(Aquifex
aeolicus) 		PF13847
(Methyltransf_31) 		4 ALA A 171
ASP A 170
GLU A 127
MET A 112
 None
 1.37A 2ouzA-3dh0A:
undetectable		 2ouzA-3dh0A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  67
ASP A  69
GLU A  66
ARG A  12
 None
 1.35A 2ouzA-3ekgA:
undetectable		 2ouzA-3ekgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB4
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF03874
(RNA_pol_Rpb4)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 ALA G  33
ASP G  34
GLU G  36
ARG D  41
 None
 1.14A 2ouzA-3h0gG:
undetectable		 2ouzA-3h0gG:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htu VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25

(Homo sapiens) 		PF05871
(ESCRT-II) 		4 ALA A 147
ASP A 145
GLU A 146
ARG A 171
 None
 1.21A 2ouzA-3htuA:
undetectable		 2ouzA-3htuA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iah SHORT CHAIN
DEHYDROGENASE YCIK

(Salmonella
enterica) 		PF00106
(adh_short) 		4 ALA A 219
ASP A 220
GLU A  27
ARG A  26
 None
 1.40A 2ouzA-3iahA:
undetectable		 2ouzA-3iahA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3w PROTEIN KINASE C AND
CASEIN KINASE II
SUBSTRATE PROTEIN 3

(Mus musculus) 		PF00611
(FCH) 		4 ALA A  58
ASP A  59
GLU A  89
ARG A  90
 None
 1.41A 2ouzA-3m3wA:
undetectable		 2ouzA-3m3wA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 ALA A 119
ASP A 118
TRP A 202
MET A  76
 None
 1.37A 2ouzA-3mfdA:
undetectable		 2ouzA-3mfdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkz PROTEIN SOPB

(Escherichia
coli) 		no annotation 4 ALA A 185
ASP A 184
GLU A 186
ARG A 166
 None
CA  A   1 (-4.6A)
None
None
 1.38A 2ouzA-3mkzA:
undetectable		 2ouzA-3mkzA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk9 MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM44

(Saccharomyces
cerevisiae) 		PF04280
(Tim44) 		4 ALA A 371
ASP A 345
GLU A 373
ARG A 424
 None
 1.44A 2ouzA-3qk9A:
undetectable		 2ouzA-3qk9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty1 HYPOTHETICAL ALDOSE
1-EPIMERASE

(Klebsiella
pneumoniae) 		PF14486
(DUF4432) 		4 ALA A  20
ASP A 171
GLU A 168
ARG A 180
 None
 1.34A 2ouzA-3ty1A:
undetectable		 2ouzA-3ty1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ALA A1002
ASP A1003
GLU A1005
ARG A1168
 None
 0.82A 2ouzA-3ummA:
undetectable		 2ouzA-3ummA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		4 ALA A 126
ASP A 130
GLU A 125
ARG A  39
 None
 1.21A 2ouzA-3uoeA:
undetectable		 2ouzA-3uoeA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa) 		PF02223
(Thymidylate_kin) 		4 ALA A  63
ASP A  64
GLU A  66
ARG A 154
 None
 1.16A 2ouzA-3uxmA:
undetectable		 2ouzA-3uxmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ALA A 247
ASP A 248
GLU A 246
ARG A 324
 None
 1.38A 2ouzA-3wjpA:
undetectable		 2ouzA-3wjpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz4 DOTI

(Legionella
pneumophila) 		PF11393
(T4BSS_DotI_IcmL) 		4 ALA A 110
ASP A 114
GLU A 111
ARG A 155
 None
 1.25A 2ouzA-3wz4A:
undetectable		 2ouzA-3wz4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ALA A 142
ASP A 145
GLU A 143
ARG A  73
 None
 1.40A 2ouzA-4awnA:
undetectable		 2ouzA-4awnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgw PRE-MRNA-SPLICING
FACTOR PRP9

(Saccharomyces
cerevisiae) 		PF12171
(zf-C2H2_jaz)
PF16837
(SF3A3)
PF16958
(PRP9_N) 		4 ALA A 352
ASP A 355
GLU A 353
ARG A 341
 None
 1.45A 2ouzA-4dgwA:
undetectable		 2ouzA-4dgwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ALA A 158
ASP A 161
GLU A 156
ARG A  68
 None
 1.20A 2ouzA-4e2zA:
undetectable		 2ouzA-4e2zA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		4 ALA A 219
ASP A 222
GLU A 220
ARG A 256
 None
 1.11A 2ouzA-4ea1A:
undetectable		 2ouzA-4ea1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ALA A 150
ASP A 153
GLU A 151
ARG A  14
 None
 1.41A 2ouzA-4egeA:
undetectable		 2ouzA-4egeA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ALA A 130
ASP A 131
GLU A 133
ARG A  63
 None
 1.05A 2ouzA-4ev0A:
undetectable		 2ouzA-4ev0A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev0 TRANSCRIPTION
REGULATOR, CRP
FAMILY

(Thermus
thermophilus) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ALA A 130
ASP A 131
GLU A 133
MET A  77
 None
None
None
CMP  A 301 (-4.8A)
 0.85A 2ouzA-4ev0A:
undetectable		 2ouzA-4ev0A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ALA A 227
ASP A 228
GLU A 226
ARG A 143
 None
 1.27A 2ouzA-4fquA:
undetectable		 2ouzA-4fquA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		4 ALA A 190
ASP A 344
GLU A 347
ARG A  81
 None
 1.33A 2ouzA-4g0bA:
undetectable		 2ouzA-4g0bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 ALA A 264
ASP A 263
ARG A 131
MET A 303
 None
 1.44A 2ouzA-4gr4A:
undetectable		 2ouzA-4gr4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		4 ALA A 264
ASP A 263
ARG A 131
MET A 303
 None
 1.41A 2ouzA-4gr5A:
undetectable		 2ouzA-4gr5A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		4 ALA A  53
ASP A  57
GLU A  52
ARG A  44
 None
 1.39A 2ouzA-4gysA:
undetectable		 2ouzA-4gysA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 ALA A 424
ASP A 421
GLU A 425
ARG A 432
 None
 1.45A 2ouzA-4hpfA:
undetectable		 2ouzA-4hpfA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		4 ALA A  15
ASP A  16
ARG A 137
MET A 226
 None
 0.86A 2ouzA-4jc0A:
undetectable		 2ouzA-4jc0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc0 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E RIMO

(Thermotoga
maritima) 		PF00919
(UPF0004)
PF04055
(Radical_SAM) 		4 ALA A  15
ASP A  16
GLU A  18
ARG A 137
 None
 1.21A 2ouzA-4jc0A:
undetectable		 2ouzA-4jc0A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		4 ALA A 199
ASP A 358
GLU A 361
ARG A  90
 None
 1.35A 2ouzA-4ke4A:
undetectable		 2ouzA-4ke4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr ESPG5

(Mycobacterium
tuberculosis) 		PF14011
(ESX-1_EspG) 		4 ALA C  22
ASP C  25
ARG C  36
MET C  56
 None
 1.11A 2ouzA-4kxrC:
undetectable		 2ouzA-4kxrC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lb8 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF16140
(DUF4848) 		4 ALA A  90
ASP A  91
GLU A  93
MET A 149
 None
 0.80A 2ouzA-4lb8A:
undetectable		 2ouzA-4lb8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		4 ALA A  78
ASP A  77
GLU A  19
ARG A 103
 None
 1.11A 2ouzA-4mynA:
undetectable		 2ouzA-4mynA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 ALA A 287
GLU A 290
TRP A 320
ARG A 331
MET A 358
 None
 1.01A 2ouzA-4n1yA:
26.3		 2ouzA-4n1yA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk6 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 ASP A 225
GLU A 226
TRP A 290
ARG A 215
 None
 0.82A 2ouzA-4nk6A:
undetectable		 2ouzA-4nk6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozy POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13229
(Beta_helix) 		4 ASP A 225
GLU A 226
TRP A 290
ARG A 215
 None
 0.81A 2ouzA-4ozyA:
undetectable		 2ouzA-4ozyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ALA A  92
ASP A  93
GLU A  91
ARG A 243
 None
 1.46A 2ouzA-4p08A:
undetectable		 2ouzA-4p08A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ALA A 423
ASP A 597
GLU A 422
ARG A 308
 None
 1.40A 2ouzA-4pd3A:
undetectable		 2ouzA-4pd3A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		4 ALA A 107
ASP A 102
GLU A 106
ARG A 156
 None
 1.11A 2ouzA-4pmdA:
undetectable		 2ouzA-4pmdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qei GLYCINE--TRNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 ALA A 605
ASP A 608
GLU A 609
ARG A  76
 A  C  37 ( 3.6A)
None
A  C  37 ( 3.4A)
A  C  37 ( 4.5A)
 1.25A 2ouzA-4qeiA:
undetectable		 2ouzA-4qeiA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upi SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 ALA A 133
ASP A 132
GLU A 128
MET A 206
 None
 1.37A 2ouzA-4upiA:
undetectable		 2ouzA-4upiA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 310
ASP A 335
GLU A 311
ARG A 322
 None
 1.45A 2ouzA-4z6kA:
undetectable		 2ouzA-4z6kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		4 ALA A 218
ASP A 217
GLU A 221
ARG A  51
 None
 1.13A 2ouzA-4zi5A:
undetectable		 2ouzA-4zi5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ALA M  43
ASP M  41
GLU M  47
ARG M  19
 None
 1.19A 2ouzA-5a5tM:
undetectable		 2ouzA-5a5tM:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 ALA A 901
GLU A 904
TRP A1487
ARG A1073
 None
 1.46A 2ouzA-5d0fA:
undetectable		 2ouzA-5d0fA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		4 ALA A 533
ASP A 534
GLU A 536
ARG A 611
 None
 1.38A 2ouzA-5e3cA:
undetectable		 2ouzA-5e3cA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4y PROTEIN SHROOM2

(Homo sapiens) 		PF08687
(ASD2) 		4 ALA A1572
ASP A1573
GLU A1575
ARG A1556
 None
 1.22A 2ouzA-5f4yA:
4.2		 2ouzA-5f4yA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli;
Escherichia
coli) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA C 636
GLU C 640
ARG A 209
MET C 607
 None
 1.39A 2ouzA-5g5gC:
undetectable		 2ouzA-5g5gC:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 ALA A 773
ASP A 772
TRP A 798
ARG A 834
 None
None
None
FMT  A1022 (-3.6A)
 1.45A 2ouzA-5hjrA:
undetectable		 2ouzA-5hjrA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 ALA A 213
ASP A 430
GLU A 205
ARG A 248
 None
 1.39A 2ouzA-5hqbA:
undetectable		 2ouzA-5hqbA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ALA A 211
ASP A 210
GLU A 214
ARG A 218
 None
 1.18A 2ouzA-5i1wA:
undetectable		 2ouzA-5i1wA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 ALA A 360
ASP A 365
ARG A 433
MET A 377
 None
 1.16A 2ouzA-5ig3A:
undetectable		 2ouzA-5ig3A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 106
ASP A  66
GLU A 107
MET A 270
 None
 1.34A 2ouzA-5keiA:
undetectable		 2ouzA-5keiA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2

(Homo sapiens) 		no annotation 4 ALA A 574
ASP A 577
GLU A 575
ARG A 616
 None
 1.31A 2ouzA-5n7fA:
undetectable		 2ouzA-5n7fA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9x ADENYLATION DOMAIN

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASP A  40
GLU A  42
ARG A 143
MET A  75
 None
 1.21A 2ouzA-5n9xA:
undetectable		 2ouzA-5n9xA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 302
GLU A 305
TRP A 335
ARG A 346
 EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
None
EST  A 601 (-4.1A)
 0.38A 2ouzA-5toaA:
28.4		 2ouzA-5toaA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 ALA A 283
ASP A 284
GLU A 288
ARG A  85
 None
 1.46A 2ouzA-5txfA:
undetectable		 2ouzA-5txfA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		4 ALA A 251
ASP A  67
GLU A  70
ARG A 129
 None
 1.22A 2ouzA-5u9cA:
undetectable		 2ouzA-5u9cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 ALA A 288
ASP A 287
GLU A 289
ARG A 100
 None
 1.01A 2ouzA-5vf3A:
undetectable		 2ouzA-5vf3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa0 PUTATIVE SULFITE
OXIDASE

(Sinorhizobium
meliloti) 		no annotation 4 ALA A 111
ASP A  93
GLU A 112
ARG A 106
 None
 1.46A 2ouzA-5wa0A:
undetectable		 2ouzA-5wa0A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe3 ENDORIBONUCLEASE
MAZF4

(Mycobacterium
tuberculosis) 		no annotation 4 ALA C  66
ASP C  67
ARG C   6
MET C  54
 None
 1.27A 2ouzA-5xe3C:
undetectable		 2ouzA-5xe3C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvh 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
NAD-BINDING PROTEIN

(Pyrobaculum
calidifontis) 		no annotation 4 ALA A  67
ASP A  66
GLU A  71
ARG A 107
 None
 1.43A 2ouzA-5xvhA:
undetectable		 2ouzA-5xvhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES21
RIBOSOMAL PROTEIN
US8

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF01249
(Ribosomal_S21e)
PF00410
(Ribosomal_S8) 		4 ALA V  66
ASP V  65
GLU V  63
ARG W  22
 None
None
None
A  21036 ( 4.0A)
 1.16A 2ouzA-5xxuV:
undetectable		 2ouzA-5xxuV:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN AMO1

(Chaetomium
thermophilum) 		no annotation 4 ALA D 511
ASP D 512
GLU D 514
ARG D 549
 None
 1.18A 2ouzA-6b4hD:
undetectable		 2ouzA-6b4hD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 4 ALA A 694
ASP A 697
GLU A 693
ARG A 779
 None
 1.25A 2ouzA-6b4wA:
undetectable		 2ouzA-6b4wA:
18.47