SIMILAR PATTERNS OF AMINO ACIDS FOR 2OUZ_A_C3DA999_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens)
PF00079
(Serpin)
5 LEU A  64
LEU A  73
ILE A 308
GLY A  79
LEU A  80
None
0.91A 2ouzA-1as4A:
0.0
2ouzA-1as4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbr HYPOXANTHINE GUANINE
XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE


(Toxoplasma
gondii)
PF00156
(Pribosyltran)
5 LEU A 175
THR A 174
LEU A 143
LEU A  88
LEU A  87
None
1.08A 2ouzA-1dbrA:
0.0
2ouzA-1dbrA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE


(Thermus
thermophilus)
PF00115
(COX1)
5 LEU A 222
LEU A 202
LEU A 546
GLY A 551
LEU A 553
None
1.08A 2ouzA-1ehkA:
0.0
2ouzA-1ehkA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE


(Homo sapiens)
PF04209
(HgmA)
5 LEU A 301
THR A 302
LEU A 131
LEU A 201
ILE A 317
None
1.00A 2ouzA-1ey2A:
undetectable
2ouzA-1ey2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A


(Cellvibrio
japonicus)
PF04616
(Glyco_hydro_43)
5 LEU B 323
LEU B 279
LEU B 278
GLY B 290
LEU B 305
None
1.05A 2ouzA-1gydB:
undetectable
2ouzA-1gydB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
5 LEU A 101
THR A 118
LEU A 111
LEU A  67
LEU A  75
None
1.07A 2ouzA-1k7jA:
0.0
2ouzA-1k7jA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
5 THR A 297
LEU A 324
ILE A 315
GLY A 320
LEU A 286
None
0.97A 2ouzA-1lujA:
0.3
2ouzA-1lujA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24


(Saccharomyces
cerevisiae)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
5 LEU B 406
THR B 405
LEU B 333
LEU B 330
ILE B 345
None
0.95A 2ouzA-1m2vB:
undetectable
2ouzA-1m2vB:
13.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 343
LEU A 346
LEU A 402
ILE A 424
GLY A 521
HIS A 524
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
1.47A 2ouzA-1pcgA:
31.8
2ouzA-1pcgA:
98.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
12 MET A 343
LEU A 346
THR A 347
LEU A 354
LEU A 384
LEU A 387
MET A 388
LEU A 391
ILE A 424
GLY A 521
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
None
None
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 ( 4.5A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.74A 2ouzA-1pcgA:
31.8
2ouzA-1pcgA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qun PAPD-LIKE CHAPERONE
FIMC


(Escherichia
coli)
PF00345
(PapD_N)
PF02753
(PapD_C)
5 THR A 189
LEU A 166
LEU A 142
ILE A 185
LEU A 131
None
1.04A 2ouzA-1qunA:
undetectable
2ouzA-1qunA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srv PROTEIN (GROEL
(HSP60 CLASS))


(Thermus
thermophilus)
PF00118
(Cpn60_TCP1)
5 LEU A 314
THR A 313
LEU A 309
LEU A 221
GLY A 298
None
1.05A 2ouzA-1srvA:
undetectable
2ouzA-1srvA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqh CARBOXYLESTERASE
PRECURSOR


(Geobacillus
stearothermophilus)
PF12146
(Hydrolase_4)
5 THR A  45
LEU A  20
LEU A  21
GLY A  76
LEU A  80
None
1.03A 2ouzA-1tqhA:
0.0
2ouzA-1tqhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus)
PF00331
(Glyco_hydro_10)
5 LEU A 314
LEU A 263
ILE A 230
GLY A 232
LEU A 234
None
0.88A 2ouzA-1ur1A:
undetectable
2ouzA-1ur1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus)
PF00331
(Glyco_hydro_10)
5 LEU A 365
LEU A 263
ILE A 230
GLY A 232
LEU A 234
None
1.08A 2ouzA-1ur1A:
undetectable
2ouzA-1ur1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
5 LEU A  57
LEU A 282
LEU A 281
GLY A 271
LEU A 310
None
1.00A 2ouzA-1vcgA:
undetectable
2ouzA-1vcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Thermus
thermophilus)
PF01070
(FMN_dh)
5 LEU A 177
LEU A 174
LEU A 170
GLY A 133
LEU A 137
None
0.89A 2ouzA-1vcgA:
undetectable
2ouzA-1vcgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN D ALPHA
CHAIN


(Aldabrachelys
gigantea)
PF00042
(Globin)
5 LEU A   9
LEU A 129
GLY A 110
HIS A 112
LEU A 113
None
0.93A 2ouzA-1wmuA:
undetectable
2ouzA-1wmuA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrz XYLAN
BETA-1,4-XYLOSIDASE


(Bacillus
halodurans)
PF04616
(Glyco_hydro_43)
5 LEU A1202
LEU A1216
GLY A1251
HIS A1265
LEU A1263
None
1.02A 2ouzA-1yrzA:
undetectable
2ouzA-1yrzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayz SENSOR KINASE
PROTEIN RCSC


(Escherichia
coli)
PF00072
(Response_reg)
5 THR A 935
LEU A 929
LEU A 844
LEU A 847
LEU A 873
None
1.06A 2ouzA-2ayzA:
undetectable
2ouzA-2ayzA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bap DIAPHANOUS PROTEIN
HOMOLOG 1


(Mus musculus)
no annotation 5 LEU B 179
LEU B 159
LEU B 163
ILE B 208
LEU B 143
None
1.00A 2ouzA-2bapB:
undetectable
2ouzA-2bapB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
5 LEU A  97
LEU A  89
LEU A 149
ILE A 168
HIS A 172
None
1.06A 2ouzA-2ch1A:
undetectable
2ouzA-2ch1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk4 PROTEIN E6

(Alphapapillomavirus
9)
PF00518
(E6)
5 LEU A  19
LEU A  22
LEU A  23
HIS A  41
LEU A  42
None
1.02A 2ouzA-2fk4A:
undetectable
2ouzA-2fk4A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE


(Homo sapiens)
PF00171
(Aldedh)
5 LEU A 487
LEU A 433
LEU A 392
ILE A 515
LEU A 428
None
1.04A 2ouzA-2h5gA:
undetectable
2ouzA-2h5gA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA


(Mycobacterium
tuberculosis)
PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5)
5 THR A  73
LEU A  97
LEU A  89
ILE A 115
LEU A 101
None
1.04A 2ouzA-2h5xA:
undetectable
2ouzA-2h5xA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nra PI PROTEIN

(Escherichia
coli)
PF01051
(Rep_3)
5 LEU C  40
LEU C  84
LEU C  25
ILE C 141
LEU C 135
None
0.87A 2ouzA-2nraC:
undetectable
2ouzA-2nraC:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE


(Rhodobacter
sphaeroides)
PF00221
(Lyase_aromatic)
5 LEU A 229
THR A 230
LEU A 237
LEU A 380
ILE A 459
None
1.07A 2ouzA-2o78A:
undetectable
2ouzA-2o78A:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
6 MET A 343
LEU A 346
LEU A 402
ILE A 424
GLY A 521
HIS A 524
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
1.44A 2ouzA-2ocfA:
30.1
2ouzA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
THR A 347
LEU A 354
LEU A 384
LEU A 387
MET A 388
LEU A 391
ILE A 424
GLY A 521
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
None
None
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
0.64A 2ouzA-2ocfA:
30.1
2ouzA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
THR A 347
LEU A 384
LEU A 387
MET A 388
LEU A 391
GLY A 521
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
None
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.74A 2ouzA-2ocfA:
30.1
2ouzA-2ocfA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens)
PF00104
(Hormone_recep)
10 MET A 343
LEU A 346
THR A 347
LEU A 384
LEU A 387
MET A 388
LEU A 391
ILE A 424
GLY A 521
HIS A 524
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
None
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 ( 4.7A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
0.58A 2ouzA-2ocfA:
30.1
2ouzA-2ocfA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 LEU A 126
THR A 128
LEU A   9
ILE A  58
GLY A  12
None
1.04A 2ouzA-2odaA:
undetectable
2ouzA-2odaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00027
(cNMP_binding)
6 LEU A 113
LEU A 104
LEU A  22
GLY A 105
HIS A 106
LEU A  83
None
1.44A 2ouzA-2pqqA:
undetectable
2ouzA-2pqqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyx TRYPTOPHAN
HALOGENASE


(Shewanella
frigidimarina)
PF04820
(Trp_halogenase)
5 LEU A 374
THR A 370
LEU A  24
ILE A  11
GLY A  18
None
None
PG4  A 529 (-3.8A)
None
None
0.86A 2ouzA-2pyxA:
undetectable
2ouzA-2pyxA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsp RSV PROTEASE

(Rous sarcoma
virus)
PF00077
(RVP)
6 LEU A 119
LEU A 109
LEU A  36
LEU A  12
ILE A  32
LEU A  82
None
1.45A 2ouzA-2rspA:
undetectable
2ouzA-2rspA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Homo sapiens)
PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
5 LEU A 256
LEU A 422
LEU A 411
ILE A 227
LEU A 426
None
1.05A 2ouzA-2vxoA:
undetectable
2ouzA-2vxoA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1


(Bombyx mori)
PF01395
(PBP_GOBP)
5 MET A   5
THR A   9
LEU A  16
LEU A  61
ILE A  94
None
B7M  A1145 ( 4.1A)
None
B7M  A1145 ( 4.7A)
B7M  A1145 ( 4.5A)
0.86A 2ouzA-2wchA:
undetectable
2ouzA-2wchA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mycobacterium
tuberculosis)
PF00342
(PGI)
5 THR A 478
LEU A  51
LEU A 485
ILE A 301
GLY A  49
None
0.89A 2ouzA-2wu8A:
undetectable
2ouzA-2wu8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA


(Escherichia
coli)
PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone)
5 LEU A 551
LEU A 611
LEU A 578
GLY A 610
HIS A 609
None
1.08A 2ouzA-2xaxA:
undetectable
2ouzA-2xaxA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE


(Hepacivirus C)
PF00998
(RdRP_3)
5 LEU A 392
LEU A 425
MET A 426
ILE A 463
HIS A 467
None
1.08A 2ouzA-2xymA:
undetectable
2ouzA-2xymA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 MET A 527
LEU A 495
LEU A 519
ILE A 539
LEU A 488
None
1.07A 2ouzA-2z63A:
undetectable
2ouzA-2z63A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio)
PF00514
(Arm)
5 THR A 296
LEU A 323
ILE A 314
GLY A 319
LEU A 285
None
1.00A 2ouzA-2z6gA:
undetectable
2ouzA-2z6gA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
5 THR A 297
LEU A 324
ILE A 315
GLY A 320
LEU A 286
None
0.94A 2ouzA-2z6hA:
undetectable
2ouzA-2z6hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b12 FLUOROACETATE
DEHALOGENASE


(Burkholderia
sp.)
PF00561
(Abhydrolase_1)
5 MET A  40
LEU A  29
LEU A  28
GLY A 107
HIS A 103
None
1.06A 2ouzA-3b12A:
undetectable
2ouzA-3b12A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b13 DEDICATOR OF
CYTOKINESIS PROTEIN
2


(Homo sapiens)
PF06920
(DHR-2)
5 LEU A1244
LEU A1479
LEU A1208
LEU A1227
ILE A1221
None
0.92A 2ouzA-3b13A:
undetectable
2ouzA-3b13A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR


(Vibrio
parahaemolyticus)
PF13377
(Peripla_BP_3)
5 LEU A 272
LEU A 249
LEU A 243
GLY A 191
LEU A 252
None
1.07A 2ouzA-3d8uA:
undetectable
2ouzA-3d8uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN


(Clostridium
acetobutylicum)
PF12146
(Hydrolase_4)
5 LEU A 158
THR A 157
LEU A 150
LEU A 227
HIS A  20
OXE  A 243 (-4.7A)
None
None
None
None
1.07A 2ouzA-3e0xA:
undetectable
2ouzA-3e0xA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5


(Homo sapiens)
PF00149
(Metallophos)
PF08321
(PPP5)
5 THR A 306
LEU A 340
LEU A 220
HIS A 352
LEU A 385
None
None
None
ZN  A 500 ( 3.2A)
None
1.07A 2ouzA-3h68A:
undetectable
2ouzA-3h68A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhc INTERLEUKIN-28B

(Homo sapiens)
PF15177
(IL28A)
5 LEU A  69
LEU A 125
LEU A  61
ILE A  96
LEU A 148
None
1.06A 2ouzA-3hhcA:
undetectable
2ouzA-3hhcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr0 COG4

(Homo sapiens)
PF04437
(RINT1_TIP1)
5 LEU A 675
LEU A 678
MET A 679
LEU A 682
LEU A 545
None
0.72A 2ouzA-3hr0A:
undetectable
2ouzA-3hr0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21


(Homo sapiens)
PF00443
(UCH)
5 LEU A 507
LEU A 459
LEU A 416
LEU A 484
LEU A 463
None
0.95A 2ouzA-3i3tA:
undetectable
2ouzA-3i3tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9u HEME OXYGENASE 1

(Rattus
norvegicus)
PF01126
(Heme_oxygenase)
5 LEU A 128
LEU A  77
LEU A  13
LEU A 189
LEU A  17
None
1.06A 2ouzA-3i9uA:
2.7
2ouzA-3i9uA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1


(Homo sapiens)
PF01233
(NMT)
PF02799
(NMT_C)
5 LEU A 176
LEU A 161
LEU A 201
GLY A 213
LEU A 222
None
1.06A 2ouzA-3iu1A:
undetectable
2ouzA-3iu1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6g TELOMERIC
REPEAT-BINDING
FACTOR 2-INTERACTING
PROTEIN 1
TELOMERIC
REPEAT-BINDING
FACTOR 2


(Homo sapiens;
Homo sapiens)
PF11626
(Rap1_C)
PF16772
(TERF2_RBM)
5 LEU A 343
LEU A 321
MET A 322
LEU A 327
LEU D 288
None
1.07A 2ouzA-3k6gA:
undetectable
2ouzA-3k6gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb1 NUCLEOTIDE-BINDING
PROTEIN


(Archaeoglobus
fulgidus)
PF10609
(ParA)
6 LEU A 185
LEU A 133
LEU A  39
LEU A  38
ILE A  90
GLY A  51
None
1.38A 2ouzA-3kb1A:
undetectable
2ouzA-3kb1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE


(Yersinia pestis)
PF00185
(OTCace)
PF02729
(OTCace_N)
6 LEU A 173
LEU A  16
LEU A  25
LEU A 140
LEU A 141
LEU A 153
None
1.32A 2ouzA-3lxmA:
undetectable
2ouzA-3lxmA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum)
PF00069
(Pkinase)
5 LEU A 347
LEU A 141
ILE A 359
HIS A 367
LEU A 370
None
1.04A 2ouzA-3nieA:
undetectable
2ouzA-3nieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium)
PF00378
(ECH_1)
5 LEU A 156
LEU A 223
LEU A 233
ILE A 151
GLY A 121
None
1.03A 2ouzA-3oc7A:
undetectable
2ouzA-3oc7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfm GGDEF DOMAIN PROTEIN

(Pseudomonas
protegens)
PF00563
(EAL)
5 LEU A 546
LEU A 559
LEU A 577
GLY A 533
LEU A 537
None
1.01A 2ouzA-3pfmA:
undetectable
2ouzA-3pfmA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 153
LEU A 146
LEU A 216
LEU A 120
GLY A  96
None
0.96A 2ouzA-3popA:
undetectable
2ouzA-3popA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5w PROTEIN CUT8

(Schizosaccharomyces
pombe)
PF08559
(Cut8)
6 LEU A 169
THR A 170
LEU A 177
LEU A 126
HIS A 197
LEU A 194
None
1.43A 2ouzA-3q5wA:
undetectable
2ouzA-3q5wA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7p RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
FUSION PROTEIN


(Leptographium
truncatum)
PF00961
(LAGLIDADG_1)
5 LEU A  34
THR A  35
LEU A 147
LEU A 137
GLY A 146
None
1.05A 2ouzA-3r7pA:
undetectable
2ouzA-3r7pA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE


(Abies grandis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
5 THR A 351
LEU A 358
LEU A 302
LEU A 303
GLY A 340
None
0.95A 2ouzA-3sdqA:
undetectable
2ouzA-3sdqA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C)
5 LEU A1512
LEU A1503
LEU A1541
LEU A1539
ILE A1529
None
0.88A 2ouzA-3u9wA:
undetectable
2ouzA-3u9wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um9 HALOACID
DEHALOGENASE, TYPE
II


(Polaromonas sp.
JS666)
PF13419
(HAD_2)
5 LEU A  75
LEU A  79
GLY A  83
HIS A  86
LEU A  87
None
1.08A 2ouzA-3um9A:
undetectable
2ouzA-3um9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5n OXIDOREDUCTASE

(Sinorhizobium
meliloti)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 THR A 301
LEU A 309
LEU A 298
LEU A 310
ILE A 160
None
1.08A 2ouzA-3v5nA:
undetectable
2ouzA-3v5nA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1


(Homo sapiens)
PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2)
5 THR A  61
LEU A  34
LEU A  71
GLY A  65
HIS A  64
None
None
None
None
ZN  A1364 ( 3.2A)
1.07A 2ouzA-3zwfA:
undetectable
2ouzA-3zwfA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axi ETHANOLAMINE
CARBOXYSOME
STRUCTURAL PROTEIN


(Clostridioides
difficile)
PF00936
(BMC)
5 THR A 111
LEU A 102
ILE A  24
GLY A  47
HIS A  23
None
0.99A 2ouzA-4axiA:
undetectable
2ouzA-4axiA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR


(Saccharomyces
cerevisiae)
PF03372
(Exo_endo_phos)
PF13855
(LRR_8)
5 LEU D 385
LEU D 395
LEU D 372
GLY D 400
LEU D 425
None
0.99A 2ouzA-4b8cD:
undetectable
2ouzA-4b8cD:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btf MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 LEU A  61
LEU A  38
ILE A   8
GLY A  11
LEU A  68
None
1.07A 2ouzA-4btfA:
undetectable
2ouzA-4btfA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1


(Saccharomyces
cerevisiae)
PF04054
(Not1)
5 LEU A1600
LEU A1650
LEU A1651
ILE A1699
LEU A1643
None
1.04A 2ouzA-4by6A:
undetectable
2ouzA-4by6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica)
PF00069
(Pkinase)
PF09632
(Rac1)
5 LEU B 252
LEU B 251
ILE B 385
HIS B 402
LEU B 405
None
0.99A 2ouzA-4ci6B:
undetectable
2ouzA-4ci6B:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfc UVRABC SYSTEM
PROTEIN A


(Escherichia
coli)
no annotation 5 LEU B 245
LEU B 151
LEU B 150
MET B 149
LEU B 148
None
0.95A 2ouzA-4dfcB:
undetectable
2ouzA-4dfcB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga)
PF00704
(Glyco_hydro_18)
5 LEU A 183
LEU A 186
MET A 187
GLY A 284
LEU A 281
None
1.01A 2ouzA-4dwsA:
undetectable
2ouzA-4dwsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
5 MET A 793
LEU A 750
LEU A 756
LEU A 660
ILE A 817
None
0.90A 2ouzA-4e93A:
undetectable
2ouzA-4e93A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3


(Legionella
pneumophila)
no annotation 5 MET A 382
LEU A 294
THR A 293
LEU A 238
LEU A 287
None
1.02A 2ouzA-4fyeA:
undetectable
2ouzA-4fyeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN


(Veillonella
parvula)
PF13354
(Beta-lactamase2)
5 LEU A 171
LEU A 243
MET A 244
GLY A 256
LEU A 204
None
0.99A 2ouzA-4hesA:
undetectable
2ouzA-4hesA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5v 5',5'''-P-1,P-4-TETR
APHOSPHATE
PHOSPHORYLASE 2


(Saccharomyces
cerevisiae)
PF09830
(ATP_transf)
6 LEU A 127
THR A 254
LEU A 220
LEU A 120
MET A 121
LEU A 208
None
1.43A 2ouzA-4i5vA:
undetectable
2ouzA-4i5vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN


(Acinetobacter
baumannii)
PF04909
(Amidohydro_2)
5 LEU A 109
LEU A 140
LEU A 143
GLY A 160
HIS A 158
None
None
None
None
CIT  A 301 (-4.1A)
0.89A 2ouzA-4i6kA:
undetectable
2ouzA-4i6kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli)
PF15935
(RnlA_toxin)
5 LEU A 255
LEU A 179
LEU A 188
GLY A 234
LEU A 230
None
1.03A 2ouzA-4i8oA:
undetectable
2ouzA-4i8oA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae)
PF00266
(Aminotran_5)
5 LEU A 290
THR A 289
LEU A   4
ILE A 293
LEU A 269
None
1.00A 2ouzA-4ixoA:
undetectable
2ouzA-4ixoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE


(Agrobacterium
vitis)
PF05292
(MCD)
PF17408
(MCD_N)
5 LEU A  44
LEU A 134
LEU A 121
GLY A 130
LEU A  61
None
0.94A 2ouzA-4ksfA:
undetectable
2ouzA-4ksfA:
20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas)
PF00104
(Hormone_recep)
5 LEU A 283
LEU A 291
LEU A 324
ILE A 361
GLY A 447
None
0.68A 2ouzA-4n1yA:
26.3
2ouzA-4n1yA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1i TRANSCRIPTIONAL
REGULATORY PROTEIN


(Mycobacterium
tuberculosis)
no annotation 5 LEU A  64
LEU A  47
ILE A 104
HIS A  25
LEU A   4
None
0.94A 2ouzA-4o1iA:
undetectable
2ouzA-4o1iA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5)
5 LEU A 715
LEU A 593
ILE A 602
GLY A 668
LEU A 667
None
1.07A 2ouzA-4o1oA:
undetectable
2ouzA-4o1oA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR


(Gallus gallus)
PF13516
(LRR_6)
5 LEU A 142
LEU A 161
LEU A 167
GLY A 188
LEU A 185
None
0.97A 2ouzA-4perA:
undetectable
2ouzA-4perA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2b ENDO-1,4-BETA-D-GLUC
ANASE


(Pseudomonas
putida)
PF01270
(Glyco_hydro_8)
5 LEU A 163
LEU A 222
LEU A 208
GLY A 160
LEU A 156
None
1.04A 2ouzA-4q2bA:
undetectable
2ouzA-4q2bA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE


(Aspergillus
fumigatus)
PF01233
(NMT)
PF02799
(NMT_C)
5 LEU A 143
LEU A 128
LEU A 168
GLY A 180
LEU A 189
None
1.03A 2ouzA-4qbjA:
undetectable
2ouzA-4qbjA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz2 SITE-DETERMINING
PROTEIN


(Geobacillus
thermodenitrificans)
PF10609
(ParA)
5 LEU A  55
LEU A  88
LEU A 126
LEU A 123
LEU A  78
None
0.92A 2ouzA-4rz2A:
undetectable
2ouzA-4rz2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74


(Saccharomyces
cerevisiae)
PF05719
(GPP34)
5 LEU A  69
THR A  68
LEU A  96
ILE A 101
LEU A 141
None
1.04A 2ouzA-4tu3A:
undetectable
2ouzA-4tu3A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE


(Actinoplanes
teichomyceticus)
PF00668
(Condensation)
5 MET B 259
LEU B 262
LEU B 270
HIS B 245
LEU B 240
None
0.96A 2ouzA-4tx2B:
undetectable
2ouzA-4tx2B:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2


(Mycobacterium
tuberculosis)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
5 LEU A 102
LEU A  99
LEU A  95
GLY A 125
LEU A  62
None
0.85A 2ouzA-4uaqA:
undetectable
2ouzA-4uaqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE


(Streptomyces
bottropensis)
PF00296
(Bac_luciferase)
5 LEU A  78
LEU A 167
LEU A 166
LEU A 164
GLY A  74
None
0.96A 2ouzA-4us5A:
undetectable
2ouzA-4us5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw2 CSM1

(Thermococcus
onnurineus)
PF01966
(HD)
6 LEU A   9
LEU A  38
LEU A  53
LEU A  55
GLY A  34
HIS A  30
None
1.50A 2ouzA-4uw2A:
undetectable
2ouzA-4uw2A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 LEU A 592
THR A 588
LEU A 631
MET A 635
GLY A 600
None
1.04A 2ouzA-4xriA:
undetectable
2ouzA-4xriA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii)
PF01202
(SKI)
5 LEU A  23
THR A  94
LEU A  90
ILE A 113
GLY A 112
None
0.97A 2ouzA-4y0aA:
undetectable
2ouzA-4y0aA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylq COAGULATION FACTOR
VII


(Homo sapiens)
PF00089
(Trypsin)
5 LEU H  46
THR H  45
LEU H 105
LEU H 106
LEU H 108
None
0.98A 2ouzA-4ylqH:
undetectable
2ouzA-4ylqH:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a30 MITOCHONDRIAL
PROTEIN


(Gallus gallus)
PF03828
(PAP_assoc)
5 LEU A 334
LEU A 396
LEU A 393
LEU A 454
ILE A 390
None
1.05A 2ouzA-5a30A:
undetectable
2ouzA-5a30A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus)
PF04196
(Bunya_RdRp)
PF15518
(L_protein_N)
6 MET A1302
LEU A1305
THR A1306
LEU A1512
LEU A 519
MET A 515
None
None
None
C  B  10 ( 4.2A)
None
None
1.42A 2ouzA-5amqA:
undetectable
2ouzA-5amqA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A  31
LEU A  39
GLY A  56
HIS A  57
LEU A  55
None
0.95A 2ouzA-5bz4A:
undetectable
2ouzA-5bz4A:
22.03