SIMILAR PATTERNS OF AMINO ACIDS FOR 2OUB_A_2TNA134

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
aquaticus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 LEU A 131
ILE A  68
HIS A 127
LYS A 106
 None
 1.32A 2oubA-1hqmA:
0.0		 2oubA-1hqmA:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ILE A  19
HIS A  48
LYS A  69
 None
 0.50A 2oubA-1s8hA:
20.8		 2oubA-1s8hA:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 LEU A  87
ILE A 109
HIS A  55
LYS A   4
 None
 1.50A 2oubA-2jjmA:
0.0		 2oubA-2jjmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		4 LEU A 319
ILE A 384
HIS A 358
LYS A 197
 None
None
ZN  A 999 ( 3.2A)
None
 1.33A 2oubA-3p24A:
0.0		 2oubA-3p24A:
13.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h0s BASIC PHOSPHOLIPASE
A2 HOMOLOG CTS-R6

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ILE A  19
HIS A  48
LYS A  69
 None
 1.18A 2oubA-4h0sA:
20.3		 2oubA-4h0sA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9t UNCHARACTERIZED
PROTEIN UPF0065

(Polaromonas sp.
JS666) 		PF03401
(TctC) 		4 LEU A 310
ILE A 242
HIS A 162
LYS A 313
 None
 1.26A 2oubA-4x9tA:
0.0		 2oubA-4x9tA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 LEU A 933
ILE A 861
HIS A 926
LYS A 941
 None
 0.86A 2oubA-5h42A:
0.0		 2oubA-5h42A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 761
ILE A 767
HIS A 708
LYS A 723
 None
 1.46A 2oubA-5j6sA:
1.6		 2oubA-5j6sA:
8.81