SIMILAR PATTERNS OF AMINO ACIDS FOR 2OTV_A_NCAA1301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1a0j | TRYPSIN (Salmo salar) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | BEN A 246 (-3.0A)BEN A 246 (-3.0A)SO4 A 248 ( 2.5A)NoneBEN A 246 ( 3.9A)BEN A 246 (-3.3A) | 0.15A | 2otvA-1a0jA:41.6 | 2otvA-1a0jA:73.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1a5i | PLASMINOGENACTIVATOR (Desmodusrotundus) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | 0GJ A 245 (-3.1A)0GJ A 245 (-1.4A)0GJ A 245 (-3.5A)0GJ A 245 ( 4.2A) | 0.32A | 2otvA-1a5iA:11.7 | 2otvA-1a5iA:37.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1afq | BOVINEGAMMA-CHYMOTRYPSIN (Bos taurus) |
PF00089(Trypsin) | 5 | SER C 190SER C 195VAL C 213GLY C 216GLY C 226 | None0FG C 301 ( 3.0A)None0FG C 301 (-3.4A)0FG C 301 ( 4.4A) | 0.51A | 2otvA-1afqC:11.5 | 2otvA-1afqC:22.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bqy | PLASMINOGENACTIVATOR (Trimeresurusstejnegeri) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 213GLY A 216GLY A 226 | 0GJ A 1 (-3.1A)0GJ A 1 ( 1.4A)None0GJ A 1 (-3.5A)0GJ A 1 ( 4.3A) | 0.29A | 2otvA-1bqyA:35.8 | 2otvA-1bqyA:42.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bru | ELASTASE (Sus scrofa) |
PF00089(Trypsin) | 4 | SER P 190SER P 195VAL P 213GLY P 216 | 1NB P 1 (-3.5A)1NB P 1 ( 1.2A)None1NB P 1 ( 4.4A) | 0.45A | 2otvA-1bruP:16.7 | 2otvA-1bruP:40.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cte | CATHEPSIN B (Rattusnorvegicus) |
PF00112(Peptidase_C1) | 5 | SER A 90SER A 39VAL A 52GLY A 92GLY A 99 | None | 1.13A | 2otvA-1cteA:undetectable | 2otvA-1cteA:20.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dlk | THROMBIN HEAVY CHAIN (Bos taurus) |
PF00089(Trypsin) | 5 | SER B 190SER B 195VAL B 213GLY B 216GLY B 226 | None | 0.50A | 2otvA-1dlkB:36.7 | 2otvA-1dlkB:43.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ekb | ENTEROPEPTIDASE (Bos taurus) |
PF00089(Trypsin) | 5 | ASP B 189SER B 190SER B 195GLY B 216GLY B 226 | None | 0.27A | 2otvA-1ekbB:36.6 | 2otvA-1ekbB:36.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1elv | COMPLEMENT C1SCOMPONENT (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 6 | ASP A 611SER A 612SER A 617VAL A 638GLY A 641GLY A 648 | NoneNoneSO4 A2001 ( 2.7A)NoneNoneNone | 0.23A | 2otvA-1elvA:11.0 | 2otvA-1elvA:30.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ept | PORCINE E-TRYPSIN (Sus scrofa) |
PF00089(Trypsin) | 6 | ASP C 189SER C 190SER C 195VAL C 213GLY C 216GLY C 226 | None | 0.24A | 2otvA-1eptC:16.2 | 2otvA-1eptC:81.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1euf | DUODENASE (Bos taurus) |
PF00089(Trypsin) | 4 | SER A 190SER A 195VAL A 213GLY A 216 | None | 0.27A | 2otvA-1eufA:36.0 | 2otvA-1eufA:38.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fi8 | NATURAL KILLER CELLPROTEASE 1 (Rattusnorvegicus) |
PF00089(Trypsin) | 4 | SER A 190SER A 195VAL A 213GLY A 216 | None | 0.39A | 2otvA-1fi8A:36.1 | 2otvA-1fi8A:38.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fiw | BETA-ACROSIN HEAVYCHAIN (Ovis aries) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | PBZ A 305 (-2.7A)PBZ A 305 (-2.9A)PBZ A 305 (-3.4A)PBZ A 305 (-3.3A) | 0.23A | 2otvA-1fiwA:16.4 | 2otvA-1fiwA:34.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fiz | BETA-ACROSIN HEAVYCHAIN (Sus scrofa) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | PBZ A 308 (-2.9A)PBZ A 308 (-3.2A)PBZ A 308 (-3.6A)PBZ A 308 ( 3.7A) | 0.36A | 2otvA-1fizA:17.1 | 2otvA-1fizA:37.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fq3 | GRANZYME B (Homo sapiens) |
PF00089(Trypsin) | 4 | SER A 190SER A 195VAL A 213GLY A 216 | NoneSO4 A 800 (-2.4A)NoneNone | 0.68A | 2otvA-1fq3A:11.6 | 2otvA-1fq3A:36.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1fxy | COAGULATION FACTORXA-TRYPSIN CHIMERA (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | 0G6 A 1 (-2.8A)0G6 A 1 (-2.8A)0G6 A 1 (-1.4A)None0G6 A 1 (-3.9A)0G6 A 1 (-3.3A) | 0.25A | 2otvA-1fxyA:38.2 | 2otvA-1fxyA:55.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gk2 | HISTIDINEAMMONIA-LYASE (Pseudomonasputida) |
PF00221(Lyase_aromatic) | 5 | ASP A 145SER A 200VAL A 334GLY A 329GLY A 141 | None | 1.08A | 2otvA-1gk2A:undetectable | 2otvA-1gk2A:17.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1gvl | KALLIKREIN 6 (Homo sapiens) |
PF00089(Trypsin) | 4 | SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.69A | 2otvA-1gvlA:28.3 | 2otvA-1gvlA:44.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h4w | TRYPSIN IVA (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | BEN A 250 (-2.9A)BEN A 250 (-2.9A)BEN A 250 (-3.6A)NoneBEN A 250 (-3.9A)BEN A 250 (-3.3A) | 0.18A | 2otvA-1h4wA:43.4 | 2otvA-1h4wA:72.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1h9h | TRYPSIN (Sus scrofa) |
PF00089(Trypsin) | 6 | ASP E 189SER E 190SER E 195VAL E 213GLY E 216GLY E 226 | None | 0.25A | 2otvA-1h9hE:43.0 | 2otvA-1h9hE:82.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1id5 | THROMBIN (Bos taurus) |
PF00089(Trypsin) | 5 | ASP H 189SER H 195VAL H 213GLY H 216GLY H 226 | None | 0.41A | 2otvA-1id5H:34.4 | 2otvA-1id5H:37.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1j17 | TRYPSIN II, ANIONIC (Rattusnorvegicus) |
PF00089(Trypsin) | 5 | ASP T 189SER T 195VAL T 213GLY T 216GLY T 226 | ZEN T 1 ( 3.8A)SO4 T 600 ( 2.6A)ZEN T 1 (-4.1A)ZEN T 1 (-3.7A)ZEN T 1 (-3.7A) | 0.13A | 2otvA-1j17T:43.0 | 2otvA-1j17T:71.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kig | FACTOR XA (Bos taurus) |
PF00089(Trypsin) | 5 | ASP H 189SER H 195VAL H 213GLY H 216GLY H 226 | None | 0.36A | 2otvA-1kigH:34.5 | 2otvA-1kigH:40.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mbq | TRYPSIN (Oncorhynchusketa) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | BEN A1222 (-2.9A)BEN A1222 (-2.9A)BEN A1222 (-3.5A)NoneBEN A1222 (-3.9A)BEN A1222 (-3.4A) | 0.23A | 2otvA-1mbqA:41.1 | 2otvA-1mbqA:65.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1npm | NEUROPSIN (Mus musculus) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | None | 0.27A | 2otvA-1npmA:37.8 | 2otvA-1npmA:45.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1o5f | SERINE PROTEASEHEPSIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP H 189SER H 195VAL H 213GLY H 216GLY H 226 | CR9 H 256 (-2.4A)CR9 H 256 (-1.5A)CR9 H 256 (-4.3A)CR9 H 256 ( 3.8A)CR9 H 256 (-3.0A) | 0.18A | 2otvA-1o5fH:19.2 | 2otvA-1o5fH:41.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1op2 | VENOM SERINEPROTEINASE (Deinagkistrodonacutus) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.33A | 2otvA-1op2A:34.8 | 2otvA-1op2A:41.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1orf | GRANZYME A (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP A 189SER A 190SER A 195GLY A 216GLY A 226 | 0G6 A 1 (-2.9A)0G6 A 1 (-2.9A)0G6 A 1 (-1.3A)0G6 A 1 (-3.3A)0G6 A 1 (-3.5A) | 0.22A | 2otvA-1orfA:12.8 | 2otvA-1orfA:35.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pfx | FACTOR IXA (Sus scrofa) |
PF00089(Trypsin) | 5 | ASP C 189SER C 190SER C 195GLY C 216GLY C 226 | 0G6 C 301 (-3.0A)0G6 C 301 (-2.6A)0G6 C 301 (-1.4A)0G6 C 301 (-3.2A)0G6 C 301 ( 3.5A) | 0.38A | 2otvA-1pfxC:34.9 | 2otvA-1pfxC:43.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pq5 | TRYPSIN (Fusariumoxysporum) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 210GLY A 213GLY A 223 | ARG A 703 (-2.0A)ARG A 703 (-2.5A)ARG A 703 (-2.3A)ARG A 703 (-4.5A)ARG A 703 ( 3.7A)ARG A 703 (-2.6A) | 0.25A | 2otvA-1pq5A:34.0 | 2otvA-1pq5A:44.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3x | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 6 | ASP A 627SER A 628SER A 633VAL A 653GLY A 656GLY A 667 | NA A 800 ( 4.6A)GOL A 701 (-3.4A)GOL A 701 (-3.0A)GOL A 701 (-4.9A)GOL A 701 ( 4.1A)GOL A 701 ( 4.0A) | 0.39A | 2otvA-1q3xA:34.1 | 2otvA-1q3xA:29.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1sgf | NERVE GROWTH FACTOR (Mus musculus) |
PF00089(Trypsin) | 4 | ASP G 189SER G 195GLY G 216GLY G 226 | None | 0.33A | 2otvA-1sgfG:36.8 | 2otvA-1sgfG:41.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ym0 | FIBRINOTIC ENZYMECOMPONENT B (Eisenia fetida) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.24A | 2otvA-1ym0A:36.2 | 2otvA-1ym0A:39.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zca | G ALPHA I/12 (Mus musculus) |
PF00503(G-alpha) | 4 | SER A 66SER A 69GLY A 228GLY A 62 | GDP A 382 (-2.9A) MG A 383 ( 2.1A)ALF A 384 (-3.3A)None | 0.73A | 2otvA-1zcaA:undetectable | 2otvA-1zcaA:18.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zlr | COAGULATION FACTORXI (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | 368 A 901 (-2.8A)368 A 901 (-1.4A)368 A 901 (-3.6A)368 A 901 (-3.5A) | 0.28A | 2otvA-1zlrA:33.9 | 2otvA-1zlrA:39.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2aip | PROTEIN C ACTIVATOR (Agkistrodoncontortrix) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | NoneSO4 A 301 (-2.8A)NoneNone | 0.49A | 2otvA-2aipA:34.0 | 2otvA-2aipA:39.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b5n | DAMAGE-SPECIFIC DNABINDING PROTEIN 1 (Homo sapiens) |
PF10433(MMS1_N) | 4 | ASP A 654SER A 653GLY A 609GLY A 632 | None | 0.78A | 2otvA-2b5nA:undetectable | 2otvA-2b5nA:21.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2eek | TRYPSIN-1 (Gadus morhua) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | BEN A 301 (-2.7A)BEN A 301 (-2.8A)BEN A 301 (-3.4A)NoneBEN A 301 ( 3.8A)BEN A 301 (-3.2A) | 0.21A | 2otvA-2eekA:40.2 | 2otvA-2eekA:62.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ei8 | COAGULATION FACTORX, HEAVY CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 213GLY A 216GLY A 226 | DT8 A 700 (-3.5A)DT8 A 700 ( 3.9A)DT8 A 700 ( 4.1A)DT8 A 700 (-3.5A)DT8 A 700 (-3.5A) | 0.28A | 2otvA-2ei8A:35.8 | 2otvA-2ei8A:38.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f91 | HEPATOPANCREASTRYPSIN (Astacusleptodactylus) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 227 | None | 0.26A | 2otvA-2f91A:36.8 | 2otvA-2f91A:44.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iou | MAJOR TROPISMDETERMINANT P1 (Bordetellavirus BPP1) |
no annotation | 4 | SER A 271VAL A 276GLY A 285GLY A 273 | None | 0.76A | 2otvA-2iouA:undetectable | 2otvA-2iouA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipp | CATHEPSIN BCATHEPSIN B (Homo sapiens;Homo sapiens) |
PF00112(Peptidase_C1)PF00112(Peptidase_C1) | 5 | ASP B 143SER A 39VAL B 52GLY B 91GLY B 99 | None | 1.39A | 2otvA-2ippB:undetectable | 2otvA-2ippB:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jet | CHYMOTRYPSINOGEN BCHAIN C (Rattusnorvegicus) |
PF00089(Trypsin) | 4 | SER C 195VAL C 213GLY C 216GLY C 226 | None | 0.65A | 2otvA-2jetC:9.6 | 2otvA-2jetC:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mna | SINGLE-STRANDED DNABINDING PROTEIN(SSB) (Sulfolobussolfataricus) |
PF01336(tRNA_anti-codon) | 4 | ASP A 46VAL A 51GLY A 6GLY A 49 | None | 0.78A | 2otvA-2mnaA:undetectable | 2otvA-2mnaA:17.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oq5 | TRANSMEMBRANEPROTEASE, SERINE 11E (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 213GLY A 216GLY A 226 | BEN A 245 (-3.0A)BEN A 245 (-3.3A)NoneBEN A 245 ( 3.8A)BEN A 245 (-3.4A) | 0.19A | 2otvA-2oq5A:14.5 | 2otvA-2oq5A:37.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2owm | RELATED TOKINESIN-LIKE PROTEINKIF1C (Neurosporacrassa) |
PF00225(Kinesin) | 4 | SER A 148SER A 151GLY A 302GLY A 144 | ADP A1002 (-3.4A) MG A1001 ( 1.9A)NoneNone | 0.76A | 2otvA-2owmA:undetectable | 2otvA-2owmA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pks | THROMBIN HEAVY CHAINFRAGMENT (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP C 229SER C 235VAL C 255GLY C 258GLY C 268 | G44 C 101 (-2.6A)G44 C 101 (-3.5A)NoneG44 C 101 (-3.3A)G44 C 101 (-3.0A) | 0.24A | 2otvA-2pksC:12.4 | 2otvA-2pksC:21.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psy | KALLIKREIN-5 (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.26A | 2otvA-2psyA:38.8 | 2otvA-2psyA:47.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3f | RAS-RELATEDGTP-BINDING PROTEIND (Homo sapiens) |
PF04670(Gtr1_RagA) | 4 | SER A 54SER A 57GLY A 101GLY A 50 | GNP A 401 (-3.5A) MG A 301 ( 2.1A)GNP A 401 (-3.2A)None | 0.76A | 2otvA-2q3fA:undetectable | 2otvA-2q3fA:21.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qy0 | COMPLEMENT C1RSUBCOMPONENT (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP B 631SER B 637VAL B 657GLY B 660GLY B 668 | None | 0.43A | 2otvA-2qy0B:32.1 | 2otvA-2qy0B:32.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r0l | HEPATOCYTE GROWTHFACTOR ACTIVATOR (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | None | 0.34A | 2otvA-2r0lA:18.5 | 2otvA-2r0lA:37.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2w | PLASMINOGENACTIVATOR, UROKINASE (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP U 189SER U 190VAL U 213GLY U 216GLY U 226 | 4PG U 300 (-2.8A)4PG U 300 (-2.7A)None4PG U 300 (-3.3A)4PG U 300 (-3.2A) | 0.42A | 2otvA-2r2wU:15.5 | 2otvA-2r2wU:39.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wpm | COAGULATION FACTORIXA HEAVY CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP S 189SER S 190SER S 195GLY S 216GLY S 226 | None | 0.19A | 2otvA-2wpmS:36.2 | 2otvA-2wpmS:41.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xtz | GUANINENUCLEOTIDE-BINDINGPROTEIN ALPHA-1SUBUNIT (Arabidopsisthaliana) |
PF00503(G-alpha) | 4 | SER A 49SER A 52GLY A 221GLY A 45 | GSP A1382 (-3.4A) MG A1381 ( 2.0A)GSP A1382 (-3.4A)None | 0.73A | 2otvA-2xtzA:undetectable | 2otvA-2xtzA:20.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zec | TRYPTASE BETA 2 (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 203SER A 204SER A 209VAL A 227GLY A 230GLY A 240 | 11N A 1 (-2.6A)11N A 1 (-3.5A)11N A 1 (-3.3A)None11N A 1 (-3.9A)11N A 1 (-3.6A) | 0.36A | 2otvA-2zecA:32.9 | 2otvA-2zecA:40.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 4 | SER A 634VAL A 601GLY A 704GLY A 708 | None | 0.72A | 2otvA-3aqpA:undetectable | 2otvA-3aqpA:14.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3beu | TRYPSIN (Streptomycesgriseus) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 213GLY A 216GLY A 226 | BEN A 247 (-3.0A)SO4 A 246 ( 2.5A)NoneBEN A 247 (-3.7A)BEN A 247 (-3.5A) | 0.16A | 2otvA-3beuA:32.3 | 2otvA-3beuA:36.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bu1 | LIPOCALIN (Argasmonolakensis) |
PF02098(His_binding) | 5 | ASP A 94SER A 88SER A 8VAL A 7GLY A 15 | HSM A 301 (-2.9A)NoneNoneNoneNone | 1.43A | 2otvA-3bu1A:undetectable | 2otvA-3bu1A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cx6 | GUANINENUCLEOTIDE-BINDINGPROTEIN ALPHA-13SUBUNIT (Mus musculus) |
PF00503(G-alpha) | 4 | SER A 59SER A 62GLY A 225GLY A 55 | GDP A 775 (-3.4A) MG A 675 ( 2.7A)NoneNone | 0.74A | 2otvA-3cx6A:undetectable | 2otvA-3cx6A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cx6 | GUANINENUCLEOTIDE-BINDINGPROTEIN ALPHA-13SUBUNIT (Mus musculus) |
PF00503(G-alpha) | 5 | SER A 268SER A 248VAL A 247GLY A 57GLY A 55 | NoneNoneNoneGDP A 775 ( 4.2A)None | 1.18A | 2otvA-3cx6A:undetectable | 2otvA-3cx6A:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmy | PROTEIN FDRA (Escherichiacoli) |
PF00549(Ligase_CoA)PF02629(CoA_binding) | 5 | ASP A 230SER A 239VAL A 170GLY A 225GLY A 227 | None | 1.49A | 2otvA-3dmyA:undetectable | 2otvA-3dmyA:17.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3f6u | VITAMIN K-DEPENDENTPROTEIN C HEAVYCHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP H 189SER H 195VAL H 213GLY H 216GLY H 226 | 0G6 H 1 (-2.8A)0G6 H 1 (-1.8A)None0G6 H 1 (-3.8A)0G6 H 1 ( 3.9A) | 0.30A | 2otvA-3f6uH:35.4 | 2otvA-3f6uH:36.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gaf | 7-ALPHA-HYDROXYSTEROID DEHYDROGENASE (Brucellaabortus) |
PF13561(adh_short_C2) | 4 | SER A 145VAL A 166GLY A 160GLY A 149 | None | 0.74A | 2otvA-3gafA:undetectable | 2otvA-3gafA:21.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gov | MASP-1 (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP B 640SER B 646VAL B 666GLY B 669GLY B 679 | None | 0.43A | 2otvA-3govB:35.5 | 2otvA-3govB:35.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gym | PROSTASIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.25A | 2otvA-3gymA:34.9 | 2otvA-3gymA:40.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6z | PUTATIVEIMMUNOGLOBULIN A1PROTEASE (Bacteroidesovatus) |
no annotation | 4 | SER A 290SER A 224GLY A 239GLY A 270 | None | 0.78A | 2otvA-3n6zA:undetectable | 2otvA-3n6zA:22.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3r3g | THROMBIN HEAVY CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP B 189SER B 195VAL B 213GLY B 216GLY B 226 | None | 0.33A | 2otvA-3r3gB:34.2 | 2otvA-3r3gB:37.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r7w | GTP-BINDING PROTEINGTR1 (Saccharomycescerevisiae) |
PF04670(Gtr1_RagA) | 4 | SER A 17SER A 20GLY A 64GLY A 13 | GNP A 500 (-3.6A) MG A 600 ( 2.0A)GNP A 500 (-3.8A)None | 0.79A | 2otvA-3r7wA:undetectable | 2otvA-3r7wA:18.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s69 | THROMBIN-LIKE ENZYMEDEFIBRASE (Gloydiussaxatilis) |
PF00089(Trypsin) | 5 | ASP A 189SER A 195VAL A 209GLY A 212GLY A 223 | None | 0.43A | 2otvA-3s69A:35.2 | 2otvA-3s69A:44.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s9b | VIPERA RUSSELLIPROTEINASE RVV-VGAMMA (Daboiasiamensis) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195VAL A 213GLY A 216 | None | 0.53A | 2otvA-3s9bA:13.1 | 2otvA-3s9bA:41.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3w94 | ENTEROPEPTIDASE-1 (Oryzias latipes) |
PF00089(Trypsin) | 5 | ASP A 973SER A 974SER A 979GLY A1000GLY A1010 | None | 0.22A | 2otvA-3w94A:37.0 | 2otvA-3w94A:35.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zjc | GTPASE IMAP FAMILYMEMBER 7 (Homo sapiens) |
PF04548(AIG1) | 4 | SER A 19SER A 22GLY A 66GLY A 15 | GNP A1297 (-3.9A) MG A1296 ( 2.4A)GNP A1297 ( 4.3A)None | 0.71A | 2otvA-3zjcA:undetectable | 2otvA-3zjcA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxw | FACTOR XA (Pseudonajatextilis) |
PF00089(Trypsin)PF14670(FXa_inhibition) | 5 | ASP A 356SER A 362VAL A 380GLY A 383GLY A 393 | 0GJ A1411 (-2.7A)0GJ A1411 (-1.4A)None0GJ A1411 (-3.7A)0GJ A1411 (-3.3A) | 0.21A | 2otvA-4bxwA:33.0 | 2otvA-4bxwA:23.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4d9r | COMPLEMENT FACTOR D (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP A 189SER A 190SER A 195VAL A 213GLY A 226 | None | 0.53A | 2otvA-4d9rA:16.5 | 2otvA-4d9rA:37.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dgj | ENTEROPEPTIDASECATALYTIC LIGHTCHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP A 181SER A 182GLY A 208GLY A 218 | None | 0.16A | 2otvA-4dgjA:37.0 | 2otvA-4dgjA:37.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fxg | MANNAN-BINDINGLECTIN SERINEPROTEASE 2 B CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP H 627SER H 628VAL H 653GLY H 656GLY H 667 | None | 0.33A | 2otvA-4fxgH:33.5 | 2otvA-4fxgH:36.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gso | THROMBIN-LIKE ENZYMEBJUSSUSP-1 (Bothropsjararacussu) |
PF00089(Trypsin) | 5 | ASP A 172SER A 178VAL A 192GLY A 195GLY A 206 | None | 0.46A | 2otvA-4gsoA:undetectable | 2otvA-4gsoA:44.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu9 | NITRITE EXTRUSIONPROTEIN 2 (Escherichiacoli) |
no annotation | 4 | SER B 272VAL B 176GLY B 299GLY B 295 | None | 0.76A | 2otvA-4iu9B:undetectable | 2otvA-4iu9B:17.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4iw4 | MANNAN-BINDINGLECTIN SERINEPROTEASE 3 (Homo sapiens) |
PF00089(Trypsin) | 5 | ASP E 639SER E 645VAL E 665GLY E 668GLY E 680 | None | 0.50A | 2otvA-4iw4E:33.7 | 2otvA-4iw4E:34.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k8y | KALLIKREIN-4 (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.39A | 2otvA-4k8yA:37.0 | 2otvA-4k8yA:40.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7g | TRYPSIN-LIKEPROTEASE (Saccharopolysporaerythraea) |
PF00089(Trypsin) | 4 | ASP A 173SER A 179GLY A 196GLY A 206 | None | 0.31A | 2otvA-4m7gA:33.8 | 2otvA-4m7gA:40.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q4y | COXSACKIEVIRUSCAPSID PROTEIN VP1COXSACKIEVIRUSCAPSID PROTEIN VP2 (Enterovirus C;Enterovirus C) |
PF00073(Rhv)PF00073(Rhv) | 5 | ASP 1 287SER 2 141VAL 1 234GLY 1 283GLY 1 285 | NoneNoneHEZ 15003 ( 4.7A)NoneNone | 1.20A | 2otvA-4q4y1:undetectable | 2otvA-4q4y1:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qed | ELXO (Staphylococcusepidermidis) |
PF13561(adh_short_C2) | 4 | SER A 139VAL A 160GLY A 154GLY A 143 | None | 0.78A | 2otvA-4qedA:undetectable | 2otvA-4qedA:21.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r0i | SUPPRESSOR OFTUMORIGENICITY 14PROTEIN (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | 3KM A 900 (-2.9A)3KM A 900 (-2.9A)3KM A 900 (-3.6A)None3KM A 900 (-3.4A)3KM A 900 (-3.2A) | 0.15A | 2otvA-4r0iA:37.6 | 2otvA-4r0iA:40.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wwy | TRYPSIN-1 (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP A 189SER A 190SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.22A | 2otvA-4wwyA:42.0 | 2otvA-4wwyA:74.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ylq | COAGULATION FACTORVII (Homo sapiens) |
PF00089(Trypsin) | 6 | ASP H 189SER H 190SER H 195VAL H 213GLY H 216GLY H 226 | 0Z7 H 501 (-2.3A)0Z7 H 501 (-2.3A)0Z7 H 501 (-1.4A)0Z7 H 501 ( 4.7A)0Z7 H 501 (-3.4A)0Z7 H 501 (-3.0A) | 0.21A | 2otvA-4ylqH:35.6 | 2otvA-4ylqH:40.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f8z | PLASMA KALLIKREINLIGHT CHAIN (Homo sapiens) |
PF00089(Trypsin) | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | None | 0.53A | 2otvA-5f8zA:34.5 | 2otvA-5f8zA:41.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkx | UNCHARACTERIZEDPROTEIN (Thermococcusonnurineus) |
PF14336(DUF4392) | 5 | ASP A 61SER A 196VAL A 155GLY A 65GLY A 62 | None | 1.37A | 2otvA-5gkxA:undetectable | 2otvA-5gkxA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gvt | PLASMA KALLIKREIN (Mus musculus) |
no annotation | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | None | 0.49A | 2otvA-5gvtA:33.4 | 2otvA-5gvtA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lcx | (-)-ISOPIPERITENONEREDUCTASE (Mentha xpiperita) |
PF00106(adh_short) | 4 | SER A 241VAL A 151GLY A 98GLY A 146 | None | 0.73A | 2otvA-5lcxA:undetectable | 2otvA-5lcxA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mg3 | PROTEIN TRANSLOCASESUBUNIT SECF (Escherichiacoli) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 4 | ASP F 213SER F 214VAL F 173GLY F 284 | None | 0.60A | 2otvA-5mg3F:undetectable | 2otvA-5mg3F:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ms3 | KALLIKREIN-8 (Homo sapiens) |
no annotation | 4 | ASP A 189SER A 195GLY A 216GLY A 226 | None | 0.24A | 2otvA-5ms3A:38.3 | 2otvA-5ms3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oyn | DEHYDRATASE,ILVD/EDD FAMILY (Caulobactervibrioides) |
no annotation | 4 | ASP A 486SER A 505GLY A 457GLY A 452 | None | 0.77A | 2otvA-5oynA:undetectable | 2otvA-5oynA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5to3 | PROTHROMBIN,THROMBOMODULIN (Homo sapiens) |
PF00089(Trypsin)PF09064(Tme5_EGF_like) | 5 | ASP B 214SER B 220VAL B 240GLY B 243GLY B 253 | 0G6 B 501 (-2.9A)0G6 B 501 (-1.3A)None0G6 B 501 (-3.7A)0G6 B 501 (-3.6A) | 0.20A | 2otvA-5to3B:34.8 | 2otvA-5to3B:27.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | SER A 327VAL A 325GLY A 456GLY A 454 | NoneNone83M A 801 (-4.8A)None | 0.76A | 2otvA-5ubkA:undetectable | 2otvA-5ubkA:16.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ubm | COMPLEMENT C1SSUBCOMPONENT (Homo sapiens) |
no annotation | 6 | ASP A 626SER A 627SER A 632VAL A 653GLY A 656GLY A 663 | None | 0.46A | 2otvA-5ubmA:11.7 | 2otvA-5ubmA:34.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xrf | SNAKE VENOM SERINEPROTEASE DA-36 (Deinagkistrodonacutus) |
no annotation | 5 | ASP A 200SER A 206VAL A 220GLY A 223GLY A 234 | None | 0.63A | 2otvA-5xrfA:13.5 | 2otvA-5xrfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zfh | KALLIKREIN-7 (Mus musculus) |
no annotation | 4 | SER A 195VAL A 213GLY A 216GLY A 226 | None | 0.37A | 2otvA-5zfhA:37.8 | 2otvA-5zfhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6au6 | GUANINENUCLEOTIDE-BINDINGPROTEIN G(S) SUBUNITALPHA ISOFORMS SHORT (Homo sapiens) |
no annotation | 4 | SER A 51SER A 54GLY A 226GLY A 47 | GDP A 401 (-3.4A) MG A 402 ( 2.1A)NoneNone | 0.71A | 2otvA-6au6A:undetectable | 2otvA-6au6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b74 | COAGULATION FACTORXII (Homo sapiens) |
no annotation | 4 | ASP B 189SER B 195GLY B 216GLY B 226 | BEN B 301 (-2.7A)SO4 B 304 ( 2.5A)BEN B 301 (-3.3A)BEN B 301 (-3.1A) | 0.22A | 2otvA-6b74B:13.7 | 2otvA-6b74B:undetectable |