SIMILAR PATTERNS OF AMINO ACIDS FOR 2OTH_A_NIMA300
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a6c | TOBACCO RINGSPOTVIRUS CAPSID PROTEIN (Tobaccoringspot virus) |
PF03391(Nepo_coat)PF03688(Nepo_coat_C)PF03689(Nepo_coat_N) | 4 | LEU A 185ALA A 190ILE A 191SER A 230 | None | 1.09A | 2othA-1a6cA:0.0 | 2othA-1a6cA:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g0v | PROTEASE A INHIBITOR3PROTEINASE A (Saccharomycescerevisiae) |
PF00026(Asp)PF10466(Inhibitor_I34) | 4 | LEU A 220ILE A 286SER A 284LYS B 16 | None | 1.16A | 2othA-1g0vA:0.0 | 2othA-1g0vA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i74 | PROBABLEMANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusmutans) |
PF01368(DHH)PF02833(DHHA2) | 4 | LEU A 38ALA A 15ILE A 16SER A 19 | None MN A 401 ( 4.1A)NoneNone | 0.86A | 2othA-1i74A:undetectable | 2othA-1i74A:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 4 | LEU A 141ALA A 381ILE A 389SER A 378 | None | 1.13A | 2othA-1iyxA:undetectable | 2othA-1iyxA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5t | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Thermotogamaritima) |
PF00218(IGPS) | 4 | LEU A 59ALA A 29ILE A 36LYS A 86 | None | 0.96A | 2othA-1j5tA:undetectable | 2othA-1j5tA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcm | INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00218(IGPS) | 4 | LEU P 87ALA P 57ILE P 64LYS P 114 | NoneNoneNone137 P 400 (-2.4A) | 1.00A | 2othA-1jcmP:undetectable | 2othA-1jcmP:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jjo | NEUROSERPIN (Mus musculus) |
PF00079(Serpin) | 4 | LEU E 383ALA C 347ILE C 338SER C 345 | None | 1.17A | 2othA-1jjoE:undetectable | 2othA-1jjoE:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k20 | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusgordonii) |
PF01368(DHH)PF02833(DHHA2) | 4 | LEU A 40ALA A 16ILE A 17SER A 20 | None MN A 701 ( 4.0A)NoneNone | 0.98A | 2othA-1k20A:undetectable | 2othA-1k20A:17.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q6v | PHOSPHOLIPASE A2VRV-PL-VIIIA (Daboia russelii) |
PF00068(Phospholip_A2_1) | 4 | LEU A 2ALA A 18ILE A 19SER A 23 | None | 0.80A | 2othA-1q6vA:24.9 | 2othA-1q6vA:95.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdb | CYTOCHROME C NITRITEREDUCTASE (Sulfurospirillumdeleyianum) |
PF02335(Cytochrom_C552) | 4 | LEU A 76ALA A 85ILE A 84SER A 87 | None | 1.12A | 2othA-1qdbA:undetectable | 2othA-1qdbA:12.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1s8h | PHOSPHOLIPASE A2HOMOLOG (Agkistrodoncontortrix) |
PF00068(Phospholip_A2_1) | 4 | LEU A 2ALA A 18ILE A 19LYS A 69 | None | 0.30A | 2othA-1s8hA:21.0 | 2othA-1s8hA:64.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spx | SHORT-CHAINREDUCTASE FAMILYMEMBER (5L265) (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 4 | ALA A 165ILE A 164SER A 163LYS A 109 | None | 1.10A | 2othA-1spxA:undetectable | 2othA-1spxA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 40 KDASUBUNIT (Saccharomycescerevisiae) |
PF13177(DNA_pol3_delta2) | 4 | LEU E 219ALA E 223ILE E 198SER E 233 | None | 1.11A | 2othA-1sxjE:undetectable | 2othA-1sxjE:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5f | CELL DIVISIONPROTEIN FTSZ (Thermotogamaritima) |
PF00091(Tubulin)PF12327(FtsZ_C) | 4 | LEU A 171ALA A 128ILE A 111SER A 124 | None | 1.10A | 2othA-1w5fA:undetectable | 2othA-1w5fA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1whv | POLY(A)-SPECIFICRIBONUCLEASE (Mus musculus) |
PF08675(RNA_bind) | 4 | LEU A 457ALA A 487ILE A 499SER A 491 | None | 1.01A | 2othA-1whvA:undetectable | 2othA-1whvA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xer | FERREDOXIN (Sulfurisphaeratokodaii) |
PF13187(Fer4_9) | 4 | LEU A 44ALA A 70ILE A 46LYS A 1 | NoneNoneF3S A 104 (-4.6A)None | 1.14A | 2othA-1xerA:undetectable | 2othA-1xerA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykg | SULFITE REDUCTASE[NADPH] FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00258(Flavodoxin_1) | 4 | LEU A 110ALA A 203SER A 206LYS A 109 | None | 1.15A | 2othA-1ykgA:1.9 | 2othA-1ykgA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvp | 60-KDA SS-A/RORIBONUCLEOPROTEIN (Xenopus laevis) |
PF05731(TROVE) | 4 | LEU A 278ALA A 356ILE A 324SER A 360 | A G 10 ( 4.3A)NoneNoneNone | 1.16A | 2othA-1yvpA:undetectable | 2othA-1yvpA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq7 | HYPOTHETICAL PROTEINMM0484 (Methanosarcinamazei) |
PF01871(AMMECR1) | 4 | LEU A 22ALA A 78ILE A 79SER A 80 | None | 1.13A | 2othA-1zq7A:undetectable | 2othA-1zq7A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a1x | PHYTANOYL-COADIOXYGENASE (Homo sapiens) |
PF05721(PhyH) | 4 | LEU A 206ALA A 277ILE A 159SER A 279 | NoneAKG A 451 ( 4.5A)AKG A 451 (-3.5A)None | 1.13A | 2othA-2a1xA:undetectable | 2othA-2a1xA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0g | WINDBEUTEL PROTEIN (Drosophilamelanogaster) |
PF07749(ERp29)PF07912(ERp29_N) | 4 | LEU A1076ALA A1072ILE A1144SER A1068 | None | 1.10A | 2othA-2c0gA:undetectable | 2othA-2c0gA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ch6 | N-ACETYL-D-GLUCOSAMINE KINASE (Homo sapiens) |
PF01869(BcrAD_BadFG) | 4 | LEU A 19ALA A 316SER A 70LYS A 57 | None | 0.74A | 2othA-2ch6A:undetectable | 2othA-2ch6A:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkd | PHOSPHOACETYLGLUCOSAMINE MUTASE (Candidaalbicans) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I) | 4 | LEU A 315ALA A 441ILE A 428SER A 437 | None | 0.97A | 2othA-2dkdA:undetectable | 2othA-2dkdA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2enx | MANGANESE-DEPENDENTINORGANICPYROPHOSPHATASE (Streptococcusagalactiae) |
PF01368(DHH)PF02833(DHHA2) | 4 | LEU A 40ALA A 16ILE A 17SER A 20 | None MN A 401 ( 3.9A)NoneNone | 0.93A | 2othA-2enxA:undetectable | 2othA-2enxA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f2a | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Staphylococcusaureus) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 4 | LEU B 375ALA B 386ILE B 385SER B 382 | None | 1.16A | 2othA-2f2aB:undetectable | 2othA-2f2aB:11.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gnx | HYPOTHETICAL PROTEIN (Mus musculus) |
PF09404(DUF2003) | 4 | LEU A 266ALA A 200ILE A 204SER A 212 | None | 0.92A | 2othA-2gnxA:undetectable | 2othA-2gnxA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hg4 | 6-DEOXYERYTHRONOLIDEB SYNTHASE (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08990(Docking)PF16197(KAsynt_C_assoc) | 4 | LEU A 571ALA A 579ILE A 582SER A 623 | None | 1.10A | 2othA-2hg4A:2.4 | 2othA-2hg4A:7.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg7 | ANTIQUITIN (Acanthopagrusschlegelii) |
PF00171(Aldedh) | 4 | LEU A 18ALA A 49ILE A 48SER A 39 | None | 1.08A | 2othA-2jg7A:undetectable | 2othA-2jg7A:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k7h | STRESS-INDUCEDPROTEIN SAM22 (Glycine max) |
PF00407(Bet_v_1) | 4 | LEU A 142ALA A 33ILE A 30LYS A 138 | None | 1.07A | 2othA-2k7hA:undetectable | 2othA-2k7hA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kij | COPPER-TRANSPORTINGATPASE 1 (Homo sapiens) |
PF00122(E1-E2_ATPase) | 4 | LEU A 7ALA A 86ILE A 85SER A 88 | None | 0.98A | 2othA-2kijA:undetectable | 2othA-2kijA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kqk | NIFU-LIKE PROTEIN (Escherichiacoli) |
PF01592(NifU_N) | 4 | LEU A 99ALA A 68ILE A 67SER A 70 | None | 0.95A | 2othA-2kqkA:undetectable | 2othA-2kqkA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0w | HISTONEACETYLTRANSFERASETYPE B CATALYTICSUBUNIT (Homo sapiens) |
PF10394(Hat1_N) | 4 | LEU A 215ALA A 80ILE A 79SER A 82 | None | 1.08A | 2othA-2p0wA:undetectable | 2othA-2p0wA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q14 | PHOSPHOHYDROLASE (Bacteroidesthetaiotaomicron) |
PF01966(HD) | 4 | LEU A 151ALA A 69ILE A 70LYS A 148 | None | 1.16A | 2othA-2q14A:undetectable | 2othA-2q14A:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qk2 | LP04448P (Drosophilamelanogaster) |
PF12348(CLASP_N) | 4 | LEU A 347ALA A 387ILE A 388SER A 391 | None | 1.01A | 2othA-2qk2A:undetectable | 2othA-2qk2A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | LEU A 577ALA A 585ILE A 588SER A 632 | None | 1.06A | 2othA-2qo3A:1.5 | 2othA-2qo3A:7.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2taa | TAKA-AMYLASE A (Aspergillusoryzae) |
PF00128(Alpha-amylase)PF09260(DUF1966) | 4 | LEU A 462ALA A 394ILE A 407SER A 409 | None | 1.14A | 2othA-2taaA:undetectable | 2othA-2taaA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v95 | CORTICOSTEROID-BINDING GLOBULIN (Rattusnorvegicus) |
PF00079(Serpin) | 4 | LEU A 320ALA A 318ILE A 171SER A 39 | None | 0.88A | 2othA-2v95A:undetectable | 2othA-2v95A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xua | 3-OXOADIPATEENOL-LACTONASE (Paraburkholderiaxenovorans) |
PF12146(Hydrolase_4) | 4 | LEU A 228ALA A 220ILE A 129SER A 100 | None | 1.08A | 2othA-2xuaA:undetectable | 2othA-2xuaA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yhg | CELLULOSE-BINDINGPROTEIN (Saccharophagusdegradans) |
PF07632(DUF1593) | 4 | LEU A 912ALA A 895ILE A 887SER A 890 | None | 1.11A | 2othA-2yhgA:undetectable | 2othA-2yhgA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ys1 | DYNAMIN-2 (Homo sapiens) |
PF00169(PH) | 4 | LEU A 38ALA A 111ILE A 9SER A 107 | None | 1.10A | 2othA-2ys1A:undetectable | 2othA-2ys1A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyv | TYROSINE-ESTERSULFOTRANSFERASE (Mus musculus) |
PF00685(Sulfotransfer_1) | 4 | LEU X 12ALA X 25ILE X 24SER X 23 | None | 1.15A | 2othA-2zyvX:undetectable | 2othA-2zyvX:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 4 | ALA A 465ILE A 468SER A 150LYS A 293 | None | 1.13A | 2othA-3af5A:undetectable | 2othA-3af5A:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c17 | L-ASPARAGINASEPRECURSOR (Escherichiacoli) |
PF01112(Asparaginase_2) | 4 | LEU A 185ALA A 226SER A 224LYS A 3 | None | 1.12A | 2othA-3c17A:undetectable | 2othA-3c17A:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d45 | POLY(A)-SPECIFICRIBONUCLEASE PARN (Mus musculus) |
PF01424(R3H)PF04857(CAF1)PF08675(RNA_bind) | 4 | LEU A 457ALA A 487ILE A 499SER A 491 | None | 0.89A | 2othA-3d45A:undetectable | 2othA-3d45A:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fid | PUTATIVE OUTERMEMBRANE PROTEIN(LPXR) (Salmonellaenterica) |
PF09982(DUF2219) | 4 | LEU A 239ALA A 78ILE A 137SER A 80 | None | 1.13A | 2othA-3fidA:undetectable | 2othA-3fidA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1t | TYPE I SITE-SPECIFICRESTRICTION-MODIFICATION SYSTEM, R(RESTRICTION)SUBUNIT (Vibriovulnificus) |
PF00271(Helicase_C)PF04851(ResIII)PF13588(HSDR_N_2) | 4 | ALA A 280ILE A 281SER A 284LYS A 322 | None | 1.06A | 2othA-3h1tA:undetectable | 2othA-3h1tA:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ha4 | MIX1 (Leishmaniamajor) |
no annotation | 4 | LEU A 143ALA A 173ILE A 170SER A 171 | None | 1.16A | 2othA-3ha4A:undetectable | 2othA-3ha4A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3im9 | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Staphylococcusaureus) |
PF00698(Acyl_transf_1) | 4 | LEU A 22ALA A 75ILE A 32SER A 71 | None | 1.16A | 2othA-3im9A:undetectable | 2othA-3im9A:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3krm | INSULIN-LIKE GROWTHFACTOR 2MRNA-BINDING PROTEIN1 (Homo sapiens) |
PF00013(KH_1) | 4 | LEU A 513ALA A 519ILE A 539SER A 546 | None | 1.15A | 2othA-3krmA:undetectable | 2othA-3krmA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lma | STAGE V SPORULATIONPROTEIN AD (SPOVAD) (Bacilluslicheniformis) |
PF07451(SpoVAD) | 4 | LEU A 81ALA A 118ILE A 117SER A 121 | None | 1.10A | 2othA-3lmaA:undetectable | 2othA-3lmaA:15.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n4p | TERMINASE SUBUNITUL89 PROTEIN (Humanbetaherpesvirus5) |
PF02499(DNA_pack_C) | 4 | LEU A 548ALA A 507ILE A 508SER A 504 | None | 1.15A | 2othA-3n4pA:undetectable | 2othA-3n4pA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc8 | TOXIN COREGULATEDPILUS BIOSYNTHESISPROTEIN F (Vibrio cholerae) |
PF06340(TcpF) | 4 | LEU A 201ALA A 209ILE A 208SER A 272 | NoneNoneNoneGOL A 502 ( 4.5A) | 1.16A | 2othA-3oc8A:undetectable | 2othA-3oc8A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3om9 | LACTATEDEHYDROGENASE (Toxoplasmagondii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | LEU A 51ALA A 24ILE A 26LYS A 62 | None | 1.13A | 2othA-3om9A:undetectable | 2othA-3om9A:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3on6 | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF06824(Glyco_hydro_125) | 4 | LEU A 257ALA A 281ILE A 179SER A 277 | None | 0.99A | 2othA-3on6A:undetectable | 2othA-3on6A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p2c | PUTATIVE GLYCOSYLHYDROLASE (Bacteroidesovatus) |
PF06824(Glyco_hydro_125) | 4 | LEU A 263ALA A 287ILE A 186SER A 283 | None | 1.01A | 2othA-3p2cA:undetectable | 2othA-3p2cA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pe8 | ENOYL-COA HYDRATASE (Mycolicibacteriumsmegmatis) |
PF00378(ECH_1) | 4 | LEU A 169ALA A 115ILE A 95LYS A 143 | None | 1.03A | 2othA-3pe8A:undetectable | 2othA-3pe8A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qyr | ECHA16_2 (Mycobacteriumavium) |
PF00378(ECH_1) | 4 | LEU A 168ALA A 114ILE A 94LYS A 142 | None | 0.99A | 2othA-3qyrA:undetectable | 2othA-3qyrA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r44 | FATTY ACYL COASYNTHETASE FADD13(FATTY-ACYL-COASYNTHETASE) (Mycobacteriumtuberculosis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | LEU A 493ALA A 477ILE A 475LYS A 490 | None | 0.95A | 2othA-3r44A:undetectable | 2othA-3r44A:13.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT ANADH-QUINONEOXIDOREDUCTASESUBUNIT J (Escherichiacoli) |
PF00507(Oxidored_q4)no annotation | 4 | LEU A 20ALA J 53ILE J 56SER J 40 | None | 0.85A | 2othA-3rkoA:2.2 | 2othA-3rkoA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5k | FALCILYSIN (Plasmodiumfalciparum) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 4 | LEU A 422ALA A 505ILE A 781SER A 501 | None | 0.95A | 2othA-3s5kA:undetectable | 2othA-3s5kA:6.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sun | DNA POLYMERASE (Escherichiavirus RB69) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ALA A 780ILE A 779SER A 778LYS A 859 | None | 1.08A | 2othA-3sunA:2.0 | 2othA-3sunA:8.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsm | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Brucellaabortus) |
PF00218(IGPS) | 4 | LEU A 95ALA A 64ILE A 71LYS A 122 | None | 1.06A | 2othA-3tsmA:undetectable | 2othA-3tsmA:15.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0b | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 4 | LEU A 366ALA A 383ILE A 364SER A 342 | None | 1.01A | 2othA-3u0bA:undetectable | 2othA-3u0bA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up8 | PUTATIVE2,5-DIKETO-D-GLUCONIC ACID REDUCTASE B (Sinorhizobiummeliloti) |
PF00248(Aldo_ket_red) | 4 | LEU A 104ALA A 145ILE A 153SER A 149 | None | 0.95A | 2othA-3up8A:undetectable | 2othA-3up8A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vti | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | LEU C 284ALA C 196ILE C 210SER C 199 | None | 1.01A | 2othA-3vtiC:undetectable | 2othA-3vtiC:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3woy | CLIP-ASSOCIATINGPROTEIN 2 (Homo sapiens) |
PF12348(CLASP_N) | 4 | LEU A 88ALA A 122ILE A 80SER A 118 | None | 1.11A | 2othA-3woyA:undetectable | 2othA-3woyA:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4apm | APICAL MEMBRANEANTIGEN 1 (Babesiadivergens) |
PF02430(AMA-1) | 4 | ALA A 312ILE A 313SER A 429LYS A 491 | NoneNoneNoneACT A1513 (-2.7A) | 1.11A | 2othA-4apmA:undetectable | 2othA-4apmA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwr | PROTEINCORRESPONDING TOLOCUS C5321 FROMCFT073 E.COLI STRAIN (Escherichiacoli) |
PF08238(Sel1) | 4 | LEU A 197ALA A 234ILE A 233SER A 232 | NoneNoneNoneEDO A1493 ( 3.7A) | 0.99A | 2othA-4bwrA:undetectable | 2othA-4bwrA:14.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h0s | BASIC PHOSPHOLIPASEA2 HOMOLOG CTS-R6 (Trimeresurusstejnegeri) |
PF00068(Phospholip_A2_1) | 4 | LEU A 2ILE A 19SER A 23LYS A 69 | None | 1.13A | 2othA-4h0sA:20.4 | 2othA-4h0sA:50.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jjt | ENOYL-COA HYDRATASE (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 4 | LEU A 168ALA A 114ILE A 94LYS A 142 | None | 1.00A | 2othA-4jjtA:undetectable | 2othA-4jjtA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lqk | PROTEIN A46 (Vaccinia virus) |
no annotation | 4 | LEU C 95ALA C 185ILE C 188SER C 165 | None | 1.08A | 2othA-4lqkC:undetectable | 2othA-4lqkC:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lub | PUTATIVE PREPHENATEDEHYDRATASE (Streptococcusmutans) |
PF00800(PDT) | 4 | LEU A 71ALA A 200ILE A 243SER A 198 | None | 0.87A | 2othA-4lubA:undetectable | 2othA-4lubA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nar | PUTATIVE URONATEISOMERASE (Thermotogamaritima) |
PF09861(DUF2088) | 4 | LEU A 33ALA A 216ILE A 214SER A 218 | None | 1.06A | 2othA-4narA:undetectable | 2othA-4narA:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o6m | AF2299, ACDP-ALCOHOLPHOSPHOTRANSFERASE (Archaeoglobusfulgidus) |
PF01066(CDP-OH_P_transf) | 4 | LEU A 72ALA A 115ILE A 59LYS A 70 | None | 0.99A | 2othA-4o6mA:undetectable | 2othA-4o6mA:14.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p52 | HOMOSERINE KINASE (Cytophagahutchinsonii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | LEU A 250ALA A 268ILE A 279SER A 270 | None | 1.08A | 2othA-4p52A:undetectable | 2othA-4p52A:16.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 4 | LEU A 518ALA A 335ILE A 332SER A 333 | None | 1.14A | 2othA-4q0cA:undetectable | 2othA-4q0cA:10.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q88 | UNCHARACTERIZEDPROTEIN (Bacteroidesvulgatus) |
PF07470(Glyco_hydro_88) | 4 | LEU A 305ALA A 262ILE A 261SER A 260 | None | 1.11A | 2othA-4q88A:undetectable | 2othA-4q88A:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rt6 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 4 | LEU A 358ALA A 363ILE A 383SER A 391 | None | 1.14A | 2othA-4rt6A:undetectable | 2othA-4rt6A:8.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkr | THIAMINE TRANSPORTERTHIA (Listeriamonocytogenes) |
PF09515(Thia_YuaJ) | 4 | LEU A 104ALA A 116ILE A 113SER A 173 | NoneNoneBGL A 305 ( 4.8A)BGL A 305 ( 3.9A) | 0.96A | 2othA-4tkrA:undetectable | 2othA-4tkrA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpd | N-TERMINALACETYLTRANSFERASE ACOMPLEX SUBUNIT NAT1 (Saccharomycescerevisiae) |
PF12569(NARP1) | 4 | LEU A 553ALA A 671ILE A 488LYS A 549 | None | 0.79A | 2othA-4xpdA:undetectable | 2othA-4xpdA:8.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y7i | MYOTUBULARIN-RELATEDPROTEIN 8 (Homo sapiens) |
PF06602(Myotub-related) | 4 | LEU A 335ALA A 201ILE A 202SER A 192 | None | 1.04A | 2othA-4y7iA:undetectable | 2othA-4y7iA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypl | LON PROTEASE (Meiothermustaiwanensis) |
PF00004(AAA)PF05362(Lon_C) | 4 | LEU A 420ALA A 369ILE A 368SER A 367 | None | 0.87A | 2othA-4yplA:undetectable | 2othA-4yplA:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yw5 | NEURAMINIDASE C (Streptococcuspneumoniae) |
PF02012(BNR)PF02973(Sialidase)PF13088(BNR_2) | 4 | LEU A 219ALA A 194SER A 196LYS A 167 | None | 1.15A | 2othA-4yw5A:undetectable | 2othA-4yw5A:10.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zi5 | P91 (metagenome) |
PF01738(DLH) | 4 | LEU A 231ALA A 113ILE A 137SER A 157 | None | 1.06A | 2othA-4zi5A:undetectable | 2othA-4zi5A:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5l | D-FRUCTOSE1,6-BISPHOSPHATASECLASS2/SEDOHEPTULOSE1,7-BISPHOSPHATASE (Thermosynechococcuselongatus) |
PF03320(FBPase_glpX) | 4 | LEU A 217ALA A 206SER A 202LYS A 134 | NoneNoneNoneVTB A1339 (-3.6A) | 1.11A | 2othA-5a5lA:1.3 | 2othA-5a5lA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5auo | ATPASE INVOLVED INCHROMOSOMEPARTITIONING,PARA/MIND FAMILY,MRP HOMOLOG (Thermococcuskodakarensis) |
PF10609(ParA) | 4 | LEU B 56ALA B 113ILE B 110SER B 111 | None | 1.15A | 2othA-5auoB:undetectable | 2othA-5auoB:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bjx | WLAL PROTEIN (Campylobacterjejuni) |
no annotation | 4 | LEU A 299ALA A 279ILE A 312SER A 285 | None | 1.08A | 2othA-5bjxA:undetectable | 2othA-5bjxA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ed1 | DOUBLE-STRANDEDRNA-SPECIFIC EDITASE1 (Homo sapiens) |
PF02137(A_deamin) | 4 | LEU A 547ALA A 324ILE A 584SER A 328 | None | 1.10A | 2othA-5ed1A:undetectable | 2othA-5ed1A:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iao | BIFUNCTIONAL PROTEINPYRR (Mycobacteriumtuberculosis) |
PF00156(Pribosyltran) | 4 | LEU A 117ALA A 134ILE A 85SER A 130 | None | 1.12A | 2othA-5iaoA:undetectable | 2othA-5iaoA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iao | BIFUNCTIONAL PROTEINPYRR (Mycobacteriumtuberculosis) |
PF00156(Pribosyltran) | 4 | LEU A 146ALA A 131ILE A 55SER A 127 | None | 1.09A | 2othA-5iaoA:undetectable | 2othA-5iaoA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnx | ACYL-COADEHYDROGENASE (Bacillussubtilis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | LEU A 69ALA A 246ILE A 71SER A 75 | None | 1.12A | 2othA-5lnxA:undetectable | 2othA-5lnxA:13.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nil | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Escherichiacoli) |
PF00005(ABC_tran)PF02687(FtsX)PF12704(MacB_PCD) | 4 | LEU J 134ALA J 156ILE J 155SER J 154 | None | 0.92A | 2othA-5nilJ:undetectable | 2othA-5nilJ:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfk | UNCHARACTERIZEDPROTEIN (Sulfolobussolfataricus) |
no annotation | 4 | LEU A 111ALA A 90SER A 92LYS A 110 | None | 1.05A | 2othA-5vfkA:undetectable | 2othA-5vfkA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ws4 | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Acinetobacterbaumannii) |
no annotation | 4 | LEU A 136ALA A 158ILE A 157SER A 156 | None | 0.98A | 2othA-5ws4A:0.9 | 2othA-5ws4A:11.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x3h | URACIL-DNAGLYCOSYLASE (Nitratifractorsalsuginis) |
no annotation | 4 | LEU A 148ALA A 123ILE A 120LYS A 145 | None | 1.11A | 2othA-5x3hA:undetectable | 2othA-5x3hA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yay | KN MOTIF AND ANKYRINREPEAT DOMAINS 1 (Mus musculus) |
no annotation | 4 | LEU A1279ALA A1316ILE A1315SER A1314 | None | 1.09A | 2othA-5yayA:undetectable | 2othA-5yayA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bma | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Campylobacterjejuni) |
no annotation | 4 | LEU A 91ALA A 60ILE A 67LYS A 118 | None | 1.04A | 2othA-6bmaA:undetectable | 2othA-6bmaA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eu6 | AMMONIUM TRANSPORTER (CandidatusKueneniastuttgartiensis) |
no annotation | 4 | LEU A 254ALA A 272ILE A 304SER A 268 | None | 1.01A | 2othA-6eu6A:undetectable | 2othA-6eu6A:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ezm | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Saccharomycescerevisiae) |
no annotation | 4 | LEU U 100ALA U 170ILE U 98SER U 166 | None | 1.09A | 2othA-6ezmU:undetectable | 2othA-6ezmU:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f4f | GLUTATHIONETRANSFERASE (Trametesversicolor) |
no annotation | 4 | LEU A 40ALA A 12ILE A 56SER A 15 | GDN A 301 (-3.8A)NoneGDN A 301 (-4.3A)GDN A 301 ( 3.7A) | 1.01A | 2othA-6f4fA:undetectable | 2othA-6f4fA:18.18 |