SIMILAR PATTERNS OF AMINO ACIDS FOR 2OTH_A_IMNA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		3 ASP A  49
TYR A  52
LYS A  64
 NA  A 121 (-2.6A)
None
None
 0.67A 2othA-1bunA:
17.3		 2othA-1bunA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ASP A 497
TYR A 500
LYS A 153
 None
 1.13A 2othA-1g8kA:
undetectable		 2othA-1g8kA:
9.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		3 ASP A  48
TYR A  51
LYS A  60
 None
 0.64A 2othA-1gmzA:
20.4		 2othA-1gmzA:
64.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iiz LYSOZYME

(Antheraea
mylitta) 		PF00062
(Lys) 		3 ASP A  50
TYR A  51
LYS A  64
 None
 1.08A 2othA-1iizA:
undetectable		 2othA-1iizA:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		3 ASP A  48
TYR A  51
LYS A  60
 CA  A 203 (-2.6A)
None
None
 0.76A 2othA-1ijlA:
20.7		 2othA-1ijlA:
52.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jia PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		3 ASP A  49
TYR A  52
LYS A  69
 CA  A 134 (-2.4A)
None
None
 0.96A 2othA-1jiaA:
21.7		 2othA-1jiaA:
61.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		3 ASP A  25
TYR A  26
LYS A  79
 None
 1.21A 2othA-1m2pA:
undetectable		 2othA-1m2pA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		3 ASP A 226
TYR A 223
LYS A 187
 None
 1.19A 2othA-1ofmA:
undetectable		 2othA-1ofmA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi1 SCML2 PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		3 ASP A 200
TYR A 219
LYS A 166
 None
 1.14A 2othA-1oi1A:
undetectable		 2othA-1oi1A:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		3 ASP A  49
TYR A  52
LYS A  69
 CA  A 134 (-2.6A)
None
None
 0.72A 2othA-1oz6A:
20.5		 2othA-1oz6A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		3 ASP A 408
TYR A 390
LYS A 393
 None
 1.19A 2othA-1ph5A:
undetectable		 2othA-1ph5A:
12.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 3 ASP R  49
TYR R  52
LYS R  69
 None
 0.88A 2othA-1pp2R:
21.4		 2othA-1pp2R:
54.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qot CHITIN BINDING
LECTIN, UEA-II

(Ulex europaeus) 		PF00139
(Lectin_legB) 		3 ASP A 128
TYR A 130
LYS A 133
 CA  A 302 ( 2.3A)
GAL  A 502 (-3.6A)
None
 1.18A 2othA-1qotA:
undetectable		 2othA-1qotA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sny SNIFFER CG10964-PA

(Drosophila
melanogaster) 		PF00106
(adh_short) 		3 ASP A  66
TYR A  68
LYS A 124
 None
 1.12A 2othA-1snyA:
undetectable		 2othA-1snyA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tw9 GLUTATHIONE
S-TRANSFERASE 2

(Heligmosomoides
polygyrus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ASP A  57
TYR A   4
LYS A  28
 None
 1.01A 2othA-1tw9A:
undetectable		 2othA-1tw9A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		3 ASP A 416
TYR A 417
LYS A  88
 None
 0.61A 2othA-1yw1A:
undetectable		 2othA-1yw1A:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		3 ASP A  48
TYR A  51
LYS A  60
 CA  A1001 ( 2.3A)
None
None
 0.64A 2othA-1zl7A:
19.2		 2othA-1zl7A:
53.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		3 ASP A 118
TYR A  99
LYS A  93
 None
 1.22A 2othA-2bugA:
undetectable		 2othA-2bugA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		3 ASP H 100
TYR L  49
LYS L  55
 None
AB0  H6001 (-4.6A)
None
 1.22A 2othA-2e27H:
undetectable		 2othA-2e27H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eey MOLYBDOPTERIN
BIOSYNTHESIS

(Geobacillus
kaustophilus) 		PF01967
(MoaC) 		3 ASP A 130
TYR A 129
LYS A 137
 None
 0.98A 2othA-2eeyA:
undetectable		 2othA-2eeyA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 3 ASP A 268
TYR A 270
LYS A 239
 None
 0.87A 2othA-2f9rA:
undetectable		 2othA-2f9rA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		3 ASP A 140
TYR A 139
LYS A 258
 None
 1.17A 2othA-2gq3A:
undetectable		 2othA-2gq3A:
9.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-III

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		3 ASP A  49
TYR A  52
LYS A  69
 None
 0.75A 2othA-2h4cA:
20.1		 2othA-2h4cA:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khr PROTEIN MBTH

(Mycobacterium
tuberculosis) 		PF03621
(MbtH) 		3 ASP A  53
TYR A  54
LYS A  65
 None
 1.07A 2othA-2khrA:
undetectable		 2othA-2khrA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1w ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		3 ASP A 257
TYR A 258
LYS A  97
 None
 1.18A 2othA-2o1wA:
undetectable		 2othA-2o1wA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o55 PUTATIVE
GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Galdieria
sulphuraria) 		PF03009
(GDPD) 		3 ASP A 147
TYR A 148
LYS A 160
 None
 1.13A 2othA-2o55A:
undetectable		 2othA-2o55A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p12 HYPOTHETICAL PROTEIN
DUF402

(Rhodococcus
jostii) 		PF04167
(DUF402) 		3 ASP A 119
TYR A 104
LYS A  12
 None
 1.05A 2othA-2p12A:
undetectable		 2othA-2p12A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E

(Bacillus
subtilis) 		PF04439
(Adenyl_transf) 		3 ASP A 139
TYR A 142
LYS A 213
 None
 1.02A 2othA-2pbeA:
undetectable		 2othA-2pbeA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		3 ASP A 424
TYR A 423
LYS A 321
 None
 1.18A 2othA-2qgqA:
undetectable		 2othA-2qgqA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		3 ASP G1344
TYR G1412
LYS G1349
 None
 0.90A 2othA-2uv8G:
undetectable		 2othA-2uv8G:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		3 ASP A 102
TYR A 107
LYS A 162
 ADP  A1789 (-4.5A)
None
None
 1.22A 2othA-2v26A:
undetectable		 2othA-2v26A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpi GMP SYNTHASE

(Homo sapiens) 		PF00117
(GATase) 		3 ASP A 155
TYR A 105
LYS A  86
 None
 1.22A 2othA-2vpiA:
undetectable		 2othA-2vpiA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9x CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 ASP A 241
TYR A 222
LYS A 443
 None
 1.03A 2othA-2x9xA:
undetectable		 2othA-2x9xA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xp1 SPT6

(Antonospora
locustae) 		PF14633
(SH2_2) 		3 ASP A 933
TYR A 865
LYS A 853
 None
 0.76A 2othA-2xp1A:
undetectable		 2othA-2xp1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		3 ASP A 388
TYR A 387
LYS A 348
 None
 0.98A 2othA-2y6iA:
undetectable		 2othA-2y6iA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE SMALL
SUBUNIT

(Hydrogenovibrio
marinus) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 ASP B 149
TYR B 148
LYS B 106
 None
 0.95A 2othA-3ayxB:
undetectable		 2othA-3ayxB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans) 		PF00296
(Bac_luciferase) 		3 ASP A 406
TYR A 407
LYS A  97
 None
 0.88A 2othA-3b9nA:
undetectable		 2othA-3b9nA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c17 L-ASPARAGINASE
PRECURSOR

(Escherichia
coli) 		PF01112
(Asparaginase_2) 		3 ASP A 304
TYR A 301
LYS A   2
 None
 1.11A 2othA-3c17A:
undetectable		 2othA-3c17A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3caz BAR PROTEIN

(Galdieria
sulphuraria) 		no annotation 3 ASP A  84
TYR A  87
LYS A  92
 None
 1.18A 2othA-3cazA:
undetectable		 2othA-3cazA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmi PEROXIREDOXIN HYR1

(Saccharomyces
cerevisiae) 		PF00255
(GSHPx) 		3 ASP A  20
TYR A   5
LYS A  25
 None
 1.21A 2othA-3cmiA:
undetectable		 2othA-3cmiA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		3 ASP A 264
TYR A 268
LYS A 293
 None
 1.18A 2othA-3d8xA:
undetectable		 2othA-3d8xA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		3 ASP A  24
TYR A  25
LYS A 182
 None
 0.75A 2othA-3dqpA:
undetectable		 2othA-3dqpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP X  26
TYR X  27
LYS X  80
 None
 1.19A 2othA-3e3bX:
undetectable		 2othA-3e3bX:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9a 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Vibrio cholerae) 		PF00793
(DAHP_synth_1) 		3 ASP A  46
TYR A  52
LYS A  91
 None
 1.22A 2othA-3e9aA:
undetectable		 2othA-3e9aA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		3 ASP A  24
TYR A  58
LYS A 126
 None
None
NA  A   1 ( 4.2A)
 1.08A 2othA-3f83A:
undetectable		 2othA-3f83A:
14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		3 ASP A  48
TYR A  51
LYS A  60
 None
 0.76A 2othA-3g8gA:
22.2		 2othA-3g8gA:
80.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 240
TYR A 241
LYS A 212
 None
 1.22A 2othA-3hpfA:
undetectable		 2othA-3hpfA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		3 ASP A 171
TYR A 170
LYS A  92
 None
 0.77A 2othA-3k30A:
undetectable		 2othA-3k30A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ASP B 120
TYR B 126
LYS B 316
 None
 0.73A 2othA-3mm5B:
undetectable		 2othA-3mm5B:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 ASP B 231
TYR B 230
LYS B 251
 None
 1.01A 2othA-3n3bB:
undetectable		 2othA-3n3bB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		3 ASP A 220
TYR A 221
LYS A 199
 None
 0.97A 2othA-3nvsA:
undetectable		 2othA-3nvsA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		3 ASP A 482
TYR A 481
LYS A 465
 None
 1.16A 2othA-3odmA:
undetectable		 2othA-3odmA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		3 ASP A 325
TYR A 324
LYS A  77
 None
 1.04A 2othA-3ohtA:
undetectable		 2othA-3ohtA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pct CLASS C ACID
PHOSPHATASE

(Pasteurella
multocida) 		PF03767
(Acid_phosphat_B) 		3 ASP A 222
TYR A 190
LYS A 160
 None
 0.99A 2othA-3pctA:
undetectable		 2othA-3pctA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qoy 50S RIBOSOMAL
PROTEIN L1

(Aquifex
aeolicus) 		PF00687
(Ribosomal_L1) 		3 ASP A 191
TYR A 194
LYS A 240
 None
 0.88A 2othA-3qoyA:
undetectable		 2othA-3qoyA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06824
(Glyco_hydro_125) 		3 ASP A 424
TYR A 422
LYS A 374
 None
 0.90A 2othA-3qpfA:
undetectable		 2othA-3qpfA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF13185
(GAF_2) 		3 ASP A 141
TYR A 142
LYS A   6
 None
 1.03A 2othA-3rfbA:
undetectable		 2othA-3rfbA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		3 ASP A  33
TYR A  36
LYS A  17
 None
 1.13A 2othA-3tfyA:
undetectable		 2othA-3tfyA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9m PHOSPHOLIPASE A2
ISOZYME PA-11

(Pseudechis
australis) 		PF00068
(Phospholip_A2_1) 		3 ASP A  49
TYR A  52
LYS A  63
 CA  A 205 (-2.2A)
EDO  A 201 ( 4.8A)
PEG  A 206 (-2.2A)
 0.53A 2othA-3v9mA:
17.7		 2othA-3v9mA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vac CFA/I FIMBRIAL
SUBUNIT E

(Escherichia
coli) 		PF07434
(CblD) 		3 ASP A  24
TYR A  58
LYS A 126
 None
 1.13A 2othA-3vacA:
undetectable		 2othA-3vacA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP A  77
TYR A  76
LYS A  45
 None
 1.17A 2othA-3wa1A:
undetectable		 2othA-3wa1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASP A 107
TYR A 106
LYS A 153
 None
 0.96A 2othA-3wdjA:
undetectable		 2othA-3wdjA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbj TRAO PROTEIN

(Escherichia
coli) 		PF03524
(CagX) 		3 ASP A  10
TYR A  11
LYS A  99
 None
 1.07A 2othA-3zbjA:
undetectable		 2othA-3zbjA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zys DYNAMIN-1

(Homo sapiens) 		PF00169
(PH) 		3 ASP C  91
TYR C  89
LYS C  54
 None
 1.21A 2othA-3zysC:
undetectable		 2othA-3zysC:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		3 ASP A 250
TYR A 249
LYS A 178
 None
PEG  A 302 (-4.5A)
PEG  A 309 (-3.1A)
 1.08A 2othA-4eiuA:
undetectable		 2othA-4eiuA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkm SIMILAR TO FERRIC
HYDROXAMATE RECEPTOR
1

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		3 ASP A 282
TYR A 284
LYS A  83
 None
MLY  A  84 ( 3.9A)
MLY  A  84 ( 1.3A)
 1.19A 2othA-4fkmA:
undetectable		 2othA-4fkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN
MGC81050 PROTEIN

(Xenopus laevis) 		PF00400
(WD40)
PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		3 ASP A 160
TYR B 153
LYS B 140
 None
 1.14A 2othA-4g56A:
undetectable		 2othA-4g56A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ied CLASS D
BETA-LACTAMASE

(Fusobacterium
nucleatum) 		PF00905
(Transpeptidase) 		3 ASP A  96
TYR A  81
LYS A 113
 EDO  A 305 (-3.2A)
None
None
 1.18A 2othA-4iedA:
undetectable		 2othA-4iedA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ios LLAMA NANOBODY 11

(Lama glama) 		PF07686
(V-set) 		3 ASP D 111
TYR D 110
LYS D 104
 None
 0.94A 2othA-4iosD:
undetectable		 2othA-4iosD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myb 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Francisella
tularensis) 		PF01128
(IspD) 		3 ASP A  49
TYR A   5
LYS A  97
 None
 1.19A 2othA-4mybA:
undetectable		 2othA-4mybA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		3 ASP A  90
TYR A 311
LYS A 464
 FE  A 602 ( 3.4A)
None
None
 1.08A 2othA-4orbA:
undetectable		 2othA-4orbA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		3 ASP A 546
TYR A 548
LYS A 296
 None
 1.19A 2othA-4qi7A:
undetectable		 2othA-4qi7A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		3 ASP A 394
TYR A 397
LYS A 402
 None
 1.12A 2othA-4y1kA:
undetectable		 2othA-4y1kA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF09295
(ChAPs) 		3 ASP B 352
TYR B 353
LYS B 384
 None
 1.19A 2othA-4yg8B:
undetectable		 2othA-4yg8B:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA
METHYL-COENZYME M
REDUCTASE II,
SUBUNIT BETA

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		3 ASP B   6
TYR B   4
LYS C 260
 None
 0.82A 2othA-5a8rB:
undetectable		 2othA-5a8rB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		3 ASP A 338
TYR A 337
LYS A  73
 None
 1.04A 2othA-5awmA:
undetectable		 2othA-5awmA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		3 ASP A 341
TYR A 345
LYS A 246
 None
 1.15A 2othA-5ebbA:
undetectable		 2othA-5ebbA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		3 ASP A  97
TYR A  98
LYS A 113
 None
 0.94A 2othA-5f8vA:
undetectable		 2othA-5f8vA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		3 ASP A 198
TYR A 220
LYS A 218
 None
 1.13A 2othA-5fllA:
undetectable		 2othA-5fllA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		3 ASP B  77
TYR B  76
LYS B  45
 None
 1.21A 2othA-5fozB:
undetectable		 2othA-5fozB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm3 ENDOGLUCANASE-1

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		3 ASP A 107
TYR A 193
LYS A  72
 None
 0.88A 2othA-5gm3A:
undetectable		 2othA-5gm3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hde TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 12

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASP A  87
TYR A  88
LYS A  55
 None
 1.15A 2othA-5hdeA:
undetectable		 2othA-5hdeA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 3 ASP B 837
TYR B 836
LYS B 993
 None
 1.20A 2othA-5kdjB:
undetectable		 2othA-5kdjB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5low RABPHILIN-3A

(Rattus
norvegicus) 		PF00168
(C2) 		3 ASP A 577
TYR A 632
LYS A 636
 CA  A 702 (-3.7A)
None
CA  A 703 ( 3.8A)
 1.08A 2othA-5lowA:
undetectable		 2othA-5lowA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 ASP A 586
TYR A 365
LYS A 176
 None
 1.21A 2othA-5mqsA:
undetectable		 2othA-5mqsA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz8 ALDEHYDE
DEHYDROGENASE 21

(Physcomitrella
patens) 		PF00171
(Aldedh) 		3 ASP A 468
TYR A 422
LYS A 394
 EDO  A 510 (-3.8A)
None
None
 0.93A 2othA-5mz8A:
undetectable		 2othA-5mz8A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9e PUTATIVE U3 SMALL
NUCLEOLAR
RIBONUCLEOPROTEIN

(Chaetomium
thermophilum) 		PF04427
(Brix) 		3 ASP A  75
TYR A  77
LYS A 209
 None
 1.19A 2othA-5o9eA:
undetectable		 2othA-5o9eA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 3 ASP A  47
TYR A  50
LYS A  61
 CA  A 201 ( 2.2A)
AYZ  A 202 ( 4.9A)
None
 0.56A 2othA-5owcA:
19.4		 2othA-5owcA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		3 ASP A  49
TYR A  52
LYS A  69
 None
 0.82A 2othA-5tfvA:
21.0		 2othA-5tfvA:
68.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubv ATPASE DOMAIN OF
I-AAA PROTEASE

(Thermothelomyces
thermophila) 		no annotation 3 ASP A 118
TYR A 121
LYS A  80
 None
 1.10A 2othA-5ubvA:
undetectable		 2othA-5ubvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vp3 MNEMIOPSIN 1

(Mnemiopsis
leidyi) 		no annotation 3 ASP A   4
TYR A  11
LYS A  22
 None
 1.20A 2othA-5vp3A:
undetectable		 2othA-5vp3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrb TRANSKETOLASE

(Neisseria
gonorrhoeae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ASP A 104
TYR A  77
LYS A 294
 None
 1.18A 2othA-5vrbA:
undetectable		 2othA-5vrbA:
12.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 3 ASP A  47
TYR A  50
LYS A  61
 CA  A 210 (-2.2A)
None
CL  A 201 (-4.0A)
 0.99A 2othA-5wzmA:
19.9		 2othA-5wzmA:
34.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ASP C 220
TYR C 221
LYS A 570
 None
 1.18A 2othA-5xogC:
undetectable		 2othA-5xogC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-) 		no annotation 3 ASP B 221
TYR B   4
LYS B 176
 None
 1.21A 2othA-5y35B:
undetectable		 2othA-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		3 ASP A  88
TYR A  89
LYS A  71
 None
 1.18A 2othA-6apeA:
undetectable		 2othA-6apeA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 3 ASP A 117
TYR A 118
LYS A 348
 None
 0.75A 2othA-6bqhA:
undetectable		 2othA-6bqhA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ce2 -

(-) 		no annotation 3 ASP A  76
TYR A  75
LYS A 100
 None
 1.01A 2othA-6ce2A:
21.3		 2othA-6ce2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 ASP A 341
TYR A 344
LYS A 360
 None
 1.03A 2othA-6czxA:
undetectable		 2othA-6czxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE
HOLOENZYME TEB2
SUBUNIT
TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 3 ASP A 147
TYR A 150
LYS E 104
 None
 0.97A 2othA-6d6vA:
undetectable		 2othA-6d6vA:
19.66