SIMILAR PATTERNS OF AMINO ACIDS FOR 2OQE_C_CUC801_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 456
HIS A 458
HIS A 624
 CU  A   1 (-3.3A)
CU  A   1 (-3.2A)
CU  A   1 (-3.1A)
 0.14A 2oqeC-1a2vA:
66.2		 2oqeC-1a2vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 147
HIS A 132
HIS A 130
 ZN  A  28 (-3.1A)
None
None
 0.57A 2oqeC-1do5A:
undetectable		 2oqeC-1do5A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 HIS A 282
HIS A 283
HIS A 233
 HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
CU  A 803 (-3.1A)
 0.58A 2oqeC-1ehkA:
undetectable		 2oqeC-1ehkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 501 ( 3.2A)
CU  A 502 (-3.2A)
CU  A 502 (-3.3A)
 0.47A 2oqeC-1eqwA:
undetectable		 2oqeC-1eqwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 149 ( 3.2A)
CU  A 150 ( 3.3A)
CU  A 150 ( 3.2A)
 0.45A 2oqeC-1esoA:
undetectable		 2oqeC-1esoA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfu LACCASE 1

(Coprinopsis
cinerea) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 399
HIS A 451
HIS A 453
 CU  A 702 ( 3.7A)
CU  A 702 (-3.2A)
CU  A 703 (-3.3A)
 0.68A 2oqeC-1hfuA:
undetectable		 2oqeC-1hfuA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A2702
HIS A2671
HIS A2571
 CUO  A 888 (-3.3A)
CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
 0.70A 2oqeC-1js8A:
undetectable		 2oqeC-1js8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksi COPPER AMINE OXIDASE

(Pisum sativum) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 442
HIS A 444
HIS A 603
 CU  A 650 ( 3.3A)
CU  A 650 ( 3.3A)
CU  A 650 ( 3.2A)
 0.07A 2oqeC-1ksiA:
52.9		 2oqeC-1ksiA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 364
HIS A 324
HIS A 204
 CU  A 630 (-3.0A)
CU  A 630 (-3.3A)
CU  A 629 (-3.1A)
 0.69A 2oqeC-1llaA:
undetectable		 2oqeC-1llaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 212
HIS A 181
HIS A  70
 CU  A5012 (-3.1A)
CU  A5012 (-3.4A)
CU  A5001 ( 3.1A)
 0.63A 2oqeC-1lnlA:
undetectable		 2oqeC-1lnlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 541
HIS A 361
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.3A)
FE2  A 840 (-3.3A)
 0.63A 2oqeC-1loxA:
undetectable		 2oqeC-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 541
HIS A 366
HIS A 545
 FE2  A 840 ( 3.4A)
FE2  A 840 (-3.4A)
FE2  A 840 (-3.3A)
 0.69A 2oqeC-1loxA:
undetectable		 2oqeC-1loxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzg SUFE PROTEIN

(Escherichia
coli) 		PF02657
(SufE) 		3 HIS A 144
HIS A 145
HIS A 142
 None
 0.51A 2oqeC-1mzgA:
undetectable		 2oqeC-1mzgA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oal SUPEROXIDE DISMUTASE

(Photobacterium
leiognathi) 		PF00080
(Sod_Cu) 		3 HIS A  70
HIS A  47
HIS A  45
 ZN  A 152 ( 3.1A)
CU  A 153 (-3.1A)
CU  A 153 (-3.0A)
 0.42A 2oqeC-1oalA:
undetectable		 2oqeC-1oalA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 HIS A  17
HIS A  21
HIS A  18
 None
 0.72A 2oqeC-1odoA:
undetectable		 2oqeC-1odoA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1v SUPEROXIDE DISMUTASE
[CU-ZN]

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 202 (-3.1A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.1A)
 0.55A 2oqeC-1p1vA:
2.8		 2oqeC-1p1vA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		3 HIS A  75
HIS A  49
HIS A  47
 CU  A 172 (-4.1A)
CU  A 172 (-3.2A)
CU  A 172 (-3.1A)
 0.41A 2oqeC-1pzsA:
undetectable		 2oqeC-1pzsA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 HIS A 524
HIS A 526
HIS A 689
 CU  A 801 (-3.4A)
CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
 0.17A 2oqeC-1qafA:
47.2		 2oqeC-1qafA:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		3 HIS A 325
HIS A 326
HIS A 276
 CU  A 603 ( 3.4A)
CU  A 603 ( 3.3A)
CU  A 603 (-3.2A)
 0.72A 2oqeC-1qleA:
undetectable		 2oqeC-1qleA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		3 HIS A 195
HIS A 225
HIS A 236
 None
 0.72A 2oqeC-1r5lA:
undetectable		 2oqeC-1r5lA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1srd COPPER,ZINC
SUPEROXIDE DISMUTASE

(Spinacia
oleracea) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 CU  A 155 ( 3.2A)
CU  A 155 (-3.2A)
CU  A 155 (-3.0A)
 0.51A 2oqeC-1srdA:
undetectable		 2oqeC-1srdA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxz PROTEIN (CU-ZN
SUPEROXIDE
DISMUTASE)

(Bos taurus) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 153 ( 3.1A)
CU  A 152 (-3.4A)
CU  A 152 ( 3.1A)
 0.50A 2oqeC-1sxzA:
undetectable		 2oqeC-1sxzA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 HIS A 177
HIS A 205
HIS A 206
 None
 0.71A 2oqeC-1tffA:
undetectable		 2oqeC-1tffA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to5 SUPEROXIDE DISMUTASE

(Schistosoma
mansoni) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A 711 ( 3.1A)
CU  A 712 (-3.4A)
CU  A 712 (-3.3A)
 0.41A 2oqeC-1to5A:
undetectable		 2oqeC-1to5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		3 HIS A 528
HIS A 530
HIS A 694
 CU  A 801 (-3.2A)
CU  A 801 (-3.2A)
CU  A 801 (-3.1A)
 0.15A 2oqeC-1w7cA:
40.0		 2oqeC-1w7cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xso COPPER,ZINC
SUPEROXIDE DISMUTASE

(Xenopus laevis) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 152 (-3.1A)
CU  A   1 ( 3.4A)
CU  A   1 ( 3.0A)
 0.43A 2oqeC-1xsoA:
undetectable		 2oqeC-1xsoA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9n SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A  95
HIS A  72
HIS A  70
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.2A)
CU  A 200 (-3.1A)
 0.38A 2oqeC-1z9nA:
undetectable		 2oqeC-1z9nA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9p SUPEROXIDE DISMUTASE
[CU-ZN]

([Haemophilus]
ducreyi) 		PF00080
(Sod_Cu) 		3 HIS A  95
HIS A  72
HIS A  70
 ZN  A 201 ( 3.1A)
CU  A 200 (-3.2A)
CU  A 200 (-3.1A)
 0.36A 2oqeC-1z9pA:
undetectable		 2oqeC-1z9pA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		3 HIS A  -1
HIS A   0
HIS A  -3
 None
ZN  A 405 (-3.2A)
ZN  A 405 (-3.1A)
 0.51A 2oqeC-2a5vA:
undetectable		 2oqeC-2a5vA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aps PROTEIN (CU,ZN
SUPEROXIDE
DISMUTASE)

(Actinobacillus
pleuropneumoniae) 		PF00080
(Sod_Cu) 		3 HIS A  85
HIS A  62
HIS A  60
 ZN  A 400 (-3.2A)
CU  A 402 ( 3.4A)
CU  A 402 ( 3.3A)
 0.43A 2oqeC-2apsA:
undetectable		 2oqeC-2apsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqt SUPEROXIDE DISMUTASE
[CU-ZN]

(Neisseria
meningitidis) 		no annotation 3 HIS C 104
HIS C  81
HIS C  79
 ZN  C 201 ( 3.1A)
CU1  C 200 (-3.3A)
CU1  C 200 (-3.1A)
 0.43A 2oqeC-2aqtC:
undetectable		 2oqeC-2aqtC:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 520
HIS A 522
HIS A 684
 CU  A1737 (-3.4A)
CU  A1737 (-3.1A)
CU  A1737 (-3.1A)
 0.20A 2oqeC-2c11A:
42.3		 2oqeC-2c11A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs7 PNEUMOCOCCAL
HISTIDINE TRIAD A
PROTEIN

(Streptococcus
pneumoniae) 		PF04270
(Strep_his_triad) 		3 HIS A  31
HIS A  33
HIS A  28
 ZN  A 201 (-3.2A)
ZN  A 201 (-3.2A)
ZN  A 201 (-3.1A)
 0.46A 2oqeC-2cs7A:
undetectable		 2oqeC-2cs7A:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e47 TIME INTERVAL
MEASURING ENZYME
TIME

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  67
HIS A  52
HIS A  50
 ZN  A 172 ( 3.1A)
CU  A 171 (-3.2A)
CU  A 171 (-3.1A)
 0.45A 2oqeC-2e47A:
undetectable		 2oqeC-2e47A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		3 HIS A 290
HIS A 291
HIS A 240
 CU  A 517 ( 3.2A)
CU  A 517 ( 3.1A)
CU  A 517 (-3.1A)
 0.52A 2oqeC-2eijA:
undetectable		 2oqeC-2eijA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h39 PROBABLE
GALACTOSE-1-PHOSPHAT
E URIDYL TRANSFERASE

(Arabidopsis
thaliana) 		PF01087
(GalP_UDP_transf)
PF02744
(GalP_UDP_tr_C) 		3 HIS A 260
HIS A 261
HIS A 258
 CL  A 402 (-4.3A)
None
None
 0.66A 2oqeC-2h39A:
undetectable		 2oqeC-2h39A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 HIS A  85
HIS A 151
HIS A 155
 None
 0.63A 2oqeC-2inpA:
undetectable		 2oqeC-2inpA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		3 HIS A 113
HIS A  98
HIS A  96
 ZN  A 226 ( 3.1A)
CU  A 225 (-3.2A)
CU  A 225 (-3.2A)
 0.43A 2oqeC-2jlpA:
undetectable		 2oqeC-2jlpA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A  78
HIS A  76
HIS A 137
 ZN  A 493 (-3.2A)
ZN  A 493 (-3.5A)
None
 0.60A 2oqeC-2pajA:
undetectable		 2oqeC-2pajA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 519
HIS A 521
HIS A 683
 CU  A 804 (-3.3A)
CU  A 804 ( 3.3A)
CU  A 804 (-3.2A)
 0.18A 2oqeC-2pncA:
37.0		 2oqeC-2pncA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2l SUPEROXIDE DISMUTASE

(Potentilla
atrosanguinea) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A1001 (-3.1A)
None
None
 0.50A 2oqeC-2q2lA:
undetectable		 2oqeC-2q2lA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w57 FERRIC UPTAKE
REGULATION PROTEIN

(Vibrio cholerae) 		PF01475
(FUR) 		3 HIS A  90
HIS A  33
HIS A  71
 ZN  A 202 (-3.5A)
ZN  A 202 (-3.3A)
ZN  A 202 ( 4.9A)
 0.68A 2oqeC-2w57A:
undetectable		 2oqeC-2w57A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wwo SUPEROXIDE DISMUTASE
[CU-ZN]

(Yersinia
pseudotuberculosis) 		PF00080
(Sod_Cu) 		3 HIS A  79
HIS A  56
HIS A  54
 ZN  A1162 ( 3.2A)
ZN  A1165 (-3.4A)
ZN  A1165 (-3.3A)
 0.39A 2oqeC-2wwoA:
undetectable		 2oqeC-2wwoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A 296
HIS A 259
HIS A  94
 CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
CU  A 400 (-3.2A)
 0.65A 2oqeC-2y9xA:
undetectable		 2oqeC-2y9xA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		3 HIS A 299
HIS A 300
HIS A 250
 CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
CU  A1017 (-3.2A)
 0.63A 2oqeC-2yevA:
undetectable		 2oqeC-2yevA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 HIS A  97
HIS A  99
HIS A 204
 ZN  A 647 (-3.4A)
GOL  A 656 ( 4.7A)
ZN  A 647 (-3.3A)
 0.71A 2oqeC-2zwsA:
undetectable		 2oqeC-2zwsA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE

(Vibrio
parahaemolyticus) 		PF14583
(Pectate_lyase22) 		3 HIS A 287
HIS A 355
HIS A 353
 MN  A 401 (-3.1A)
MN  A 401 (-3.3A)
MN  A 401 (-3.3A)
 0.72A 2oqeC-3c5mA:
3.6		 2oqeC-3c5mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		3 HIS A  67
HIS A  52
HIS A  50
 ZN  A 202 ( 3.1A)
CU  A 201 (-3.2A)
CU  A 201 (-3.6A)
 0.41A 2oqeC-3ce1A:
undetectable		 2oqeC-3ce1A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		3 HIS A 243
HIS A 106
HIS A  60
 None
 0.66A 2oqeC-3dclA:
undetectable		 2oqeC-3dclA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7l COPPER,ZINC
SUPEROXIDE DISMUTASE

(Alvinella
pompejana) 		PF00080
(Sod_Cu) 		3 HIS A  61
HIS A  46
HIS A  44
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.1A)
CU  A 202 ( 2.9A)
 0.45A 2oqeC-3f7lA:
undetectable		 2oqeC-3f7lA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 762
HIS A 757
HIS A 943
 FE2  A1500 (-3.2A)
FE2  A1500 (-3.3A)
FE2  A1500 (-3.2A)
 0.73A 2oqeC-3fg4A:
undetectable		 2oqeC-3fg4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 155 (-3.2A)
None
None
 0.56A 2oqeC-3gttA:
undetectable		 2oqeC-3gttA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 HIS A 879
HIS A 861
HIS A 859
 None
 0.71A 2oqeC-3h09A:
undetectable		 2oqeC-3h09A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 510
HIS A 512
HIS A 675
 CU  A 801 (-3.3A)
CU  A 801 (-3.2A)
CU  A 801 (-3.0A)
 0.15A 2oqeC-3higA:
41.6		 2oqeC-3higA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 HIS A  95
HIS A  93
HIS A 153
 ZN  A 480 (-3.3A)
ZN  A 480 (-3.3A)
None
 0.42A 2oqeC-3hpaA:
undetectable		 2oqeC-3hpaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km2 SUPEROXIDE DISMUTASE
[CU-ZN],
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 155 (-3.2A)
None
None
 0.51A 2oqeC-3km2A:
undetectable		 2oqeC-3km2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kog PUTATIVE
PORE-FORMING TOXIN

(Bacteroides
vulgatus) 		PF12985
(DUF3869) 		3 HIS A 204
HIS A 256
HIS A 258
 None
 0.60A 2oqeC-3kogA:
undetectable		 2oqeC-3kogA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9y SUPEROXIDE DISMUTASE
[CU-ZN]

(Bombyx mori) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A 155 ( 3.1A)
CU  A 156 (-3.2A)
CU  A 156 (-3.2A)
 0.46A 2oqeC-3l9yA:
undetectable		 2oqeC-3l9yA:
13.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 HIS A 436
HIS A 438
HIS A 597
 CU  A 635 (-3.2A)
CU  A 635 (-3.2A)
CU  A 635 (-3.0A)
 0.09A 2oqeC-3loyA:
51.6		 2oqeC-3loyA:
35.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnd SUPEROXIDE DISMUTASE
[CU-ZN]

(Taenia solium) 		PF00080
(Sod_Cu) 		3 HIS A  60
HIS A  45
HIS A  43
 ZN  A 153 ( 3.1A)
CU  A 155 (-3.5A)
CU  A 155 (-3.1A)
 0.44A 2oqeC-3mndA:
undetectable		 2oqeC-3mndA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		3 HIS A 333
HIS A 334
HIS A 284
 HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
CU1  A   5 ( 3.2A)
 0.66A 2oqeC-3omnA:
undetectable		 2oqeC-3omnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 HIS A 238
HIS A 202
HIS A 200
 None
 0.66A 2oqeC-3p77A:
undetectable		 2oqeC-3p77A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		3 HIS A 552
HIS A 554
HIS A 718
 CU  A 901 (-3.2A)
CU  A 901 (-3.2A)
CU  A 901 (-3.1A)
 0.12A 2oqeC-3pgbA:
38.1		 2oqeC-3pgbA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 HIS A 330
HIS A 328
HIS A 156
 GOL  A 513 (-4.1A)
GOL  A 512 (-4.6A)
ZN  A 999 ( 3.3A)
 0.67A 2oqeC-3ramA:
undetectable		 2oqeC-3ramA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 HIS A 355
HIS A 351
HIS A 354
 None
 0.72A 2oqeC-3rcnA:
undetectable		 2oqeC-3rcnA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 HIS A 541
HIS A 361
HIS A 545
 FE2  A   1 (-3.3A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.63A 2oqeC-3rdeA:
undetectable		 2oqeC-3rdeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		3 HIS A 541
HIS A 366
HIS A 545
 FE2  A   1 (-3.3A)
FE2  A   1 ( 3.4A)
FE2  A   1 (-3.3A)
 0.61A 2oqeC-3rdeA:
undetectable		 2oqeC-3rdeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A  90
HIS A 144
HIS A 146
 None
 0.67A 2oqeC-3t9wA:
undetectable		 2oqeC-3t9wA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 378
HIS A 373
HIS A 556
 FE2  A 701 (-3.3A)
FE2  A 701 (-3.4A)
FE2  A 701 (-3.3A)
 0.71A 2oqeC-3vf1A:
undetectable		 2oqeC-3vf1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 HIS A 372
HIS A 328
HIS A 103
 None
 0.72A 2oqeC-3w6qA:
undetectable		 2oqeC-3w6qA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 431
HIS A 433
HIS A 592
 CU  A 701 (-3.2A)
CU  A 701 (-3.2A)
CU  A 701 (-3.0A)
 0.11A 2oqeC-3x3yA:
49.8		 2oqeC-3x3yA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfj PNEUMOCOCCAL
HISTIDINE TRIAD
PROTEIN D

(Streptococcus
pneumoniae) 		no annotation 3 HIS A  83
HIS A  86
HIS A  88
 ZN  A1159 (-3.2A)
ZN  A1159 (-3.2A)
ZN  A1159 (-3.1A)
 0.54A 2oqeC-3zfjA:
undetectable		 2oqeC-3zfjA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 210
HIS A 179
HIS A  69
 CUO  A9001 (-3.3A)
CUO  A9001 (-3.4A)
CUO  A9001 (-3.1A)
 0.71A 2oqeC-4bedA:
undetectable		 2oqeC-4bedA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A1455
HIS A1424
HIS A1320
 CUO  A9004 (-3.3A)
CUO  A9004 (-3.0A)
CUO  A9004 (-3.5A)
 0.72A 2oqeC-4bedA:
undetectable		 2oqeC-4bedA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B1878
HIS B1847
HIS B1734
 CUO  B9005 (-3.3A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.4A)
 0.69A 2oqeC-4bedB:
undetectable		 2oqeC-4bedB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2291
HIS B2260
HIS B2150
 CUO  B9006 (-3.5A)
CUO  B9006 (-3.2A)
CUO  B9006 (-3.3A)
 0.72A 2oqeC-4bedB:
undetectable		 2oqeC-4bedB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2701
HIS B2670
HIS B2570
 CUO  B9007 (-3.1A)
CUO  B9007 (-3.4A)
CUO  B9007 (-3.3A)
 0.72A 2oqeC-4bedB:
undetectable		 2oqeC-4bedB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]

(Brucella
abortus) 		PF00080
(Sod_Cu) 		3 HIS A  73
HIS A  50
HIS A  48
 ZN  A 203 (-3.1A)
CU1  A 201 ( 3.2A)
CU1  A 201 ( 3.1A)
 0.42A 2oqeC-4l05A:
undetectable		 2oqeC-4l05A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4low ACRAF

(Thiomonas
intermedia) 		PF01329
(Pterin_4a) 		3 HIS A   7
HIS A   8
HIS A   5
 NI  A 107 (-4.1A)
NI  A 107 ( 4.2A)
NI  A 106 (-3.3A)
 0.58A 2oqeC-4lowA:
undetectable		 2oqeC-4lowA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn7 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0848

(Thermoplasma
acidophilum) 		PF13185
(GAF_2) 		3 HIS A 146
HIS A 147
HIS A 144
 None
 0.68A 2oqeC-4mn7A:
undetectable		 2oqeC-4mn7A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 378
HIS A 373
HIS A 553
 C8E  A 702 ( 2.6A)
C8E  A 702 ( 3.5A)
FE2  A 701 (-3.4A)
 0.73A 2oqeC-4nreA:
undetectable		 2oqeC-4nreA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oja SUPEROXIDE DISMUTASE
[CU-ZN]

(Hydra vulgaris) 		PF00080
(Sod_Cu) 		3 HIS A  62
HIS A  47
HIS A  45
 ZN  A 202 ( 3.2A)
CU  A 201 (-3.3A)
CU  A 201 (-3.4A)
 0.53A 2oqeC-4ojaA:
undetectable		 2oqeC-4ojaA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS B 283
HIS B 251
HIS B  91
 CU1  B 602 (-3.0A)
CU1  B 602 (-3.2A)
CU1  B 601 (-3.2A)
 0.64A 2oqeC-4ouaB:
undetectable		 2oqeC-4ouaB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A 283
HIS A 251
HIS A  91
 CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
CU1  A 401 (-3.3A)
 0.72A 2oqeC-4ouaA:
undetectable		 2oqeC-4ouaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvp SUPEROXIDE DISMUTASE

(Sedum alfredii) 		PF00080
(Sod_Cu) 		3 HIS A  75
HIS A  60
HIS A  58
 ZN  A 201 (-3.2A)
None
None
 0.56A 2oqeC-4rvpA:
undetectable		 2oqeC-4rvpA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4i CU/ZN SUPEROXIDE
DISMUTASE

(Megavirus
chiliensis) 		PF00080
(Sod_Cu) 		3 HIS A  71
HIS A  56
HIS A  54
 None
 0.65A 2oqeC-4u4iA:
undetectable		 2oqeC-4u4iA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		3 HIS A 194
HIS A 196
HIS A 303
 ZN  A 801 ( 3.3A)
PO4  A 810 (-4.0A)
ZN  A 801 ( 3.2A)
 0.68A 2oqeC-4wgkA:
undetectable		 2oqeC-4wgkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		3 HIS B 145
HIS B 146
HIS B 143
 None
 0.68A 2oqeC-4ydoB:
undetectable		 2oqeC-4ydoB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 419
HIS A 379
HIS A 252
 CU  A 802 (-3.1A)
CU  A 802 (-3.2A)
CU  A 801 (-3.2A)
 0.70A 2oqeC-4yzwA:
undetectable		 2oqeC-4yzwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.4A)
 0.71A 2oqeC-4zr0A:
undetectable		 2oqeC-4zr0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 345
HIS A 330
HIS A 326
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.5A)
 0.72A 2oqeC-4zr1A:
undetectable		 2oqeC-4zr1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		3 HIS A 257
HIS A 258
HIS A 207
 CU  A 503 ( 3.1A)
CU  A 503 (-3.1A)
CU  A 503 ( 3.0A)
 0.70A 2oqeC-5djqA:
undetectable		 2oqeC-5djqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ek8 LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 HIS A 364
HIS A 359
HIS A 570
 FE2  A 701 (-3.6A)
FE2  A 701 (-3.5A)
FE2  A 701 (-3.6A)
 0.73A 2oqeC-5ek8A:
undetectable		 2oqeC-5ek8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		3 HIS A 289
HIS A 284
HIS A 469
 MN  A 606 (-3.4A)
MN  A 606 (-3.7A)
MN  A 606 (-3.3A)
 0.71A 2oqeC-5fnoA:
undetectable		 2oqeC-5fnoA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]

(Onchocerca
volvulus) 		PF00080
(Sod_Cu) 		3 HIS A  63
HIS A  48
HIS A  46
 ZN  A 202 (-3.1A)
CU  A 203 ( 3.2A)
CU  A 203 ( 3.1A)
 0.47A 2oqeC-5in2A:
undetectable		 2oqeC-5in2A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbm CELL SURFACE CU-ONLY
SUPEROXIDE DISMUTASE
5

(Candida
albicans) 		PF00080
(Sod_Cu) 		3 HIS A  93
HIS A  77
HIS A  75
 CU1  A 201 (-4.2A)
CU1  A 201 (-3.1A)
CU1  A 201 (-3.0A)
 0.46A 2oqeC-5kbmA:
undetectable		 2oqeC-5kbmA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		3 HIS A 183
HIS A 304
HIS A 238
 FE2  A 502 (-4.0A)
FE2  A 502 (-3.8A)
FE2  A 502 (-4.5A)
 0.61A 2oqeC-5kjaA:
undetectable		 2oqeC-5kjaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		3 HIS A 382
HIS A 377
HIS A 555
 FE2  A 701 ( 3.5A)
FE2  A 701 ( 3.5A)
FE2  A 701 (-3.4A)
 0.71A 2oqeC-5lc8A:
undetectable		 2oqeC-5lc8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5med ARACHIDONATE
15-LIPOXYGENASE

(Cyanothece sp.
PCC 8801) 		PF00305
(Lipoxygenase) 		3 HIS A 262
HIS A 257
HIS A 449
 FE  A1001 ( 3.4A)
FE  A1001 (-3.5A)
FE  A1001 (-3.4A)
 0.69A 2oqeC-5medA:
undetectable		 2oqeC-5medA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6csl HISTIDINE TRIAD
PROTEIN D

(Streptococcus
pneumoniae) 		no annotation 3 HIS A 317
HIS A 319
HIS A 314
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.2A)
ZN  A 401 (-3.0A)
 0.40A 2oqeC-6cslA:
undetectable		 2oqeC-6cslA:
undetectable