SIMILAR PATTERNS OF AMINO ACIDS FOR 2OPX_A_DXCA1002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 GLY A 580
ARG A 586
TYR A 182
 None
 0.84A 2opxA-1bf2A:
undetectable		 2opxA-1bf2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eke RIBONUCLEASE HII

(Methanocaldococcus
jannaschii) 		PF01351
(RNase_HII) 		3 GLY A  12
ARG A  11
TYR A 184
 None
 0.87A 2opxA-1ekeA:
undetectable		 2opxA-1ekeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 GLY A  17
ARG A  23
TYR A  92
 None
 0.81A 2opxA-1fuiA:
2.5		 2opxA-1fuiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 GLY A 106
ARG A 209
TYR A 108
 None
 0.77A 2opxA-1g0dA:
undetectable		 2opxA-1g0dA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		3 GLY A 124
ARG A 127
TYR A 122
 None
 0.75A 2opxA-1g59A:
2.8		 2opxA-1g59A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		3 GLY A 168
ARG A  39
TYR A 109
 None
 0.77A 2opxA-1q2eA:
undetectable		 2opxA-1q2eA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		3 GLY A 165
ARG A  39
TYR A 106
 None
 0.80A 2opxA-1q9hA:
undetectable		 2opxA-1q9hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 3 GLY A  88
ARG A  89
TYR A 194
 None
 0.83A 2opxA-1qniA:
undetectable		 2opxA-1qniA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5f CHOLERA ENTEROTOXIN,
A CHAIN

(Vibrio cholerae) 		PF01375
(Enterotoxin_a) 		3 GLY A 144
ARG A 143
TYR A 121
 None
 0.77A 2opxA-1s5fA:
undetectable		 2opxA-1s5fA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xju LYSOZYME

(Escherichia
virus P1) 		PF00959
(Phage_lysozyme) 		3 GLY A 166
ARG A 165
TYR A  49
 None
 0.66A 2opxA-1xjuA:
undetectable		 2opxA-1xjuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzw GFP-LIKE
NON-FLUORESCENT
CHROMOPROTEIN

(Heteractis
crispa) 		PF01353
(GFP) 		3 GLY A 157
ARG A 158
TYR A 178
 None
 0.84A 2opxA-1yzwA:
undetectable		 2opxA-1yzwA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		3 GLY A 165
ARG A  39
TYR A 106
 None
 0.81A 2opxA-1z3vA:
undetectable		 2opxA-1z3vA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLY A 299
ARG A 131
TYR A 125
 None
 0.71A 2opxA-1zh8A:
3.0		 2opxA-1zh8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLY A 285
ARG A 292
TYR A 176
 None
 0.84A 2opxA-2cgjA:
undetectable		 2opxA-2cgjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dl2 PROTEIN (MHC CLASS I
NK CELL RECEPTOR
PRECURSOR (P58
NATURAL KILLER CELL
RECEPTOR CLONE
CL-43))

(Homo sapiens) 		PF00047
(ig) 		3 GLY A  75
ARG A  41
TYR A 186
 None
 0.83A 2opxA-2dl2A:
undetectable		 2opxA-2dl2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 GLY A 259
ARG A 286
TYR A 257
 None
 0.87A 2opxA-2dw6A:
undetectable		 2opxA-2dw6A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyp LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 2

(Homo sapiens) 		PF13895
(Ig_2) 		3 GLY D  71
ARG D  39
TYR D 182
 None
 0.71A 2opxA-2dypD:
undetectable		 2opxA-2dypD:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		3 GLY X 338
ARG X 270
TYR X 273
 None
 0.86A 2opxA-2f5tX:
undetectable		 2opxA-2f5tX:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		3 GLY A 119
ARG A 120
TYR A 136
 None
 0.81A 2opxA-2gtiA:
undetectable		 2opxA-2gtiA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		3 GLY A 315
ARG A 320
TYR A 364
 None
 0.54A 2opxA-2iluA:
62.7		 2opxA-2iluA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLY A 547
ARG A 479
TYR A 372
 None
None
TPP  A3001 (-4.4A)
 0.80A 2opxA-2q27A:
undetectable		 2opxA-2q27A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		3 GLY A 275
ARG A 131
TYR A 274
 None
 0.85A 2opxA-2qvlA:
4.1		 2opxA-2qvlA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5d O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 GLY A 494
ARG A 484
TYR A 397
 None
 0.58A 2opxA-2v5dA:
undetectable		 2opxA-2v5dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		3 GLY A 542
ARG A 548
TYR A 177
 None
 0.87A 2opxA-2vr5A:
undetectable		 2opxA-2vr5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 GLY A 778
ARG A 784
TYR A 436
 None
 0.77A 2opxA-2wanA:
undetectable		 2opxA-2wanA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 GLY A 373
ARG A 372
TYR A 356
 None
 0.65A 2opxA-2wc7A:
undetectable		 2opxA-2wc7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi7 RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF15518
(L_protein_N) 		3 GLY A  38
ARG A  39
TYR A  93
 None
 0.81A 2opxA-2xi7A:
undetectable		 2opxA-2xi7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 GLY A 170
ARG A  39
TYR A 110
 None
 0.78A 2opxA-2yg1A:
undetectable		 2opxA-2yg1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		3 GLY A 181
ARG A  55
TYR A 122
 None
 0.82A 2opxA-2yokA:
undetectable		 2opxA-2yokA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 GLY A  22
ARG A  28
TYR A  97
 None
 0.77A 2opxA-3a9sA:
2.4		 2opxA-3a9sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		3 GLY B 228
ARG B 232
TYR B 216
 None
 0.88A 2opxA-3aqcB:
undetectable		 2opxA-3aqcB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 GLY X 177
ARG X 119
TYR X 308
 None
 0.79A 2opxA-3b8aX:
undetectable		 2opxA-3b8aX:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		3 GLY A  64
ARG A  65
TYR A  70
 None
EDO  A 300 (-4.0A)
None
 0.81A 2opxA-3bwxA:
3.2		 2opxA-3bwxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 GLY A 156
ARG A 157
TYR A 178
 None
 0.82A 2opxA-3bxaA:
undetectable		 2opxA-3bxaA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED

(Myxococcus
xanthus) 		PF00204
(DNA_gyraseB) 		3 GLY A 129
ARG A  15
TYR A 111
 None
 0.83A 2opxA-3cwvA:
undetectable		 2opxA-3cwvA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2
POLIOVIRUS RECEPTOR

(Enterovirus C;
Homo sapiens) 		PF00073
(Rhv)
PF07686
(V-set)
PF08205
(C2-set_2) 		3 GLY R 100
ARG R  98
TYR 2 141
 None
 0.77A 2opxA-3epdR:
undetectable		 2opxA-3epdR:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gle PILIN

(Streptococcus
pyogenes) 		PF12892
(FctA) 		3 GLY A 186
ARG A 188
TYR A 266
 GLY  A 186 ( 0.0A)
ARG  A 188 ( 0.6A)
TYR  A 266 ( 1.3A)
 0.69A 2opxA-3gleA:
undetectable		 2opxA-3gleA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpu DNA GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		3 GLY A 115
ARG A  76
TYR A 108
 None
 0.86A 2opxA-3gpuA:
undetectable		 2opxA-3gpuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		3 GLY A 213
ARG A 215
TYR A 251
 None
 0.61A 2opxA-3gq9A:
undetectable		 2opxA-3gq9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni;
Comamonas
testosteroni) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		3 GLY A 112
ARG B  62
TYR A  73
 None
 0.85A 2opxA-3gzyA:
undetectable		 2opxA-3gzyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 GLY A 726
ARG A 442
TYR A 722
 None
 0.87A 2opxA-3hmjA:
4.3		 2opxA-3hmjA:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		3 GLY A 106
ARG A 105
TYR A 293
 None
None
7NA  A 402 ( 4.5A)
 0.78A 2opxA-3i58A:
4.5		 2opxA-3i58A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		3 GLY A 239
ARG A 185
TYR A 233
 None
 0.70A 2opxA-3k31A:
4.2		 2opxA-3k31A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		3 GLY B 501
ARG A  37
TYR B 513
 None
 0.81A 2opxA-3ml0B:
undetectable		 2opxA-3ml0B:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpp BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		3 GLY G1097
ARG G 940
TYR G1227
 None
 0.81A 2opxA-3mppG:
undetectable		 2opxA-3mppG:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsz STAR-RELATED LIPID
TRANSFER PROTEIN

(Xanthomonas
citri) 		PF01852
(START) 		3 GLY A 112
ARG A 145
TYR A 114
 None
 0.78A 2opxA-3qszA:
undetectable		 2opxA-3qszA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		3 GLY L 589
ARG K  99
TYR L 594
 None
 0.87A 2opxA-3rkoL:
undetectable		 2opxA-3rkoL:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 GLY A 226
ARG A 227
TYR A  11
 None
 0.82A 2opxA-3rwaA:
undetectable		 2opxA-3rwaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		3 GLY A 167
ARG A 168
TYR A 165
 None
 0.80A 2opxA-3s6oA:
undetectable		 2opxA-3s6oA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6v AC-ASP-7

(Ancylostoma
caninum) 		no annotation 3 GLY A  49
ARG A  30
TYR A 176
 None
 0.88A 2opxA-3s6vA:
undetectable		 2opxA-3s6vA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skv SSFX3

(Streptomyces
sp. SF2575) 		PF13472
(Lipase_GDSL_2) 		3 GLY A 269
ARG A 231
TYR A 312
 None
 0.88A 2opxA-3skvA:
2.7		 2opxA-3skvA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		3 GLY A 213
ARG A 215
TYR A 251
 None
 0.51A 2opxA-3sucA:
undetectable		 2opxA-3sucA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		3 GLY A 311
ARG A 300
TYR A 339
 None
 0.83A 2opxA-3tzeA:
2.4		 2opxA-3tzeA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		3 GLY A 274
ARG A 109
TYR A 276
 None
 0.79A 2opxA-3wbbA:
2.6		 2opxA-3wbbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 3 GLY A 111
ARG A 164
TYR A 184
 None
 0.64A 2opxA-3wlaA:
undetectable		 2opxA-3wlaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		3 GLY A 193
ARG A 273
TYR A 231
 None
 0.78A 2opxA-3wrfA:
undetectable		 2opxA-3wrfA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 3 GLY A 127
ARG A 180
TYR A 200
 None
 0.70A 2opxA-3wweA:
undetectable		 2opxA-3wweA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		3 GLY A 617
ARG A 619
TYR A 686
 None
 0.69A 2opxA-4bugA:
undetectable		 2opxA-4bugA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 GLY A  15
ARG A  21
TYR A  90
 EDO  A1591 (-4.2A)
EDO  A1591 (-4.0A)
None
 0.85A 2opxA-4c22A:
undetectable		 2opxA-4c22A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		3 GLY A 169
ARG A  39
TYR A 110
 None
 0.76A 2opxA-4csiA:
undetectable		 2opxA-4csiA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc8 TRANSCRIPTION
PROTEIN RTR1

(Kluyveromyces
lactis) 		PF04181
(RPAP2_Rtr1) 		3 GLY A  74
ARG A  67
TYR A 110
 None
 0.82A 2opxA-4fc8A:
undetectable		 2opxA-4fc8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 11
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00420
(Oxidored_q2)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		3 GLY L 584
ARG K  94
TYR L 589
 None
 0.81A 2opxA-4heaL:
undetectable		 2opxA-4heaL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		PF00082
(Peptidase_S8) 		3 GLY B 194
ARG B 144
TYR B 202
 None
 0.74A 2opxA-4i0wB:
2.5		 2opxA-4i0wB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3o KLLA0F12672P

(Kluyveromyces
lactis) 		PF04181
(RPAP2_Rtr1) 		3 GLY A  74
ARG A  67
TYR A 110
 None
 0.78A 2opxA-4m3oA:
undetectable		 2opxA-4m3oA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfi SN-GLYCEROL-3-PHOSPH
ATE ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN USPB

(Mycobacterium
tuberculosis) 		PF13416
(SBP_bac_8) 		3 GLY A 173
ARG A 172
TYR A 159
 None
 0.77A 2opxA-4mfiA:
undetectable		 2opxA-4mfiA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5

(Brucella
melitensis) 		PF00496
(SBP_bac_5) 		3 GLY A  72
ARG A  71
TYR A 229
 None
 0.81A 2opxA-4onyA:
undetectable		 2opxA-4onyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		3 GLY A 198
ARG A 206
TYR A 107
 None
 0.65A 2opxA-4p05A:
undetectable		 2opxA-4p05A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 GLY A 446
ARG A 103
TYR A 444
 None
 0.75A 2opxA-4pj3A:
undetectable		 2opxA-4pj3A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 GLY A 428
ARG A 439
TYR A 275
 None
 0.85A 2opxA-4pj6A:
undetectable		 2opxA-4pj6A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		3 GLY A  24
ARG A  15
TYR A 300
 None
 0.73A 2opxA-4rhmA:
undetectable		 2opxA-4rhmA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		3 GLY A 168
ARG A  39
TYR A 109
 None
 0.83A 2opxA-4v20A:
undetectable		 2opxA-4v20A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		3 GLY A 165
ARG A  39
TYR A 106
 None
 0.78A 2opxA-4xebA:
undetectable		 2opxA-4xebA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygt UNCHARACTERIZED
PROTEIN YJGB

(Bacillus
subtilis) 		PF14172
(DUF4309) 		3 GLY A 126
ARG A 131
TYR A 124
 None
 0.85A 2opxA-4ygtA:
undetectable		 2opxA-4ygtA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh2 GLUTATHIONE S
TRANSFERASE E6

(Drosophila
melanogaster) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		3 GLY A 203
ARG A 207
TYR A 198
 None
 0.65A 2opxA-4yh2A:
undetectable		 2opxA-4yh2A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		3 GLY A 218
ARG A 164
TYR A 212
 None
 0.78A 2opxA-4yqzA:
4.6		 2opxA-4yqzA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 GLY A 494
ARG A 484
TYR A 397
 None
 0.54A 2opxA-4zxlA:
undetectable		 2opxA-4zxlA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		3 GLY O 433
ARG O 434
TYR O 618
 None
 0.77A 2opxA-5a31O:
undetectable		 2opxA-5a31O:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 GLY A 866
ARG A 867
TYR A 155
 None
 0.84A 2opxA-5agaA:
3.7		 2opxA-5agaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		3 GLY A 168
ARG A  39
TYR A 109
 None
 0.79A 2opxA-5ampA:
undetectable		 2opxA-5ampA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2y RNA POLYMERASE II
SUBUNIT B1 CTD
PHOSPHATASE RTR1

(Saccharomyces
cerevisiae) 		PF04181
(RPAP2_Rtr1) 		3 GLY A  74
ARG A  67
TYR A 111
 None
 0.86A 2opxA-5c2yA:
undetectable		 2opxA-5c2yA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		3 GLY A 105
ARG A 553
TYR A 107
 None
 0.47A 2opxA-5d0fA:
undetectable		 2opxA-5d0fA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 GLY A 370
ARG A 304
TYR A 307
 None
 0.83A 2opxA-5djwA:
undetectable		 2opxA-5djwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7v KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF00014
(Kunitz_BPTI)
PF00057
(Ldl_recept_a)
PF07502
(MANEC) 		3 GLY A 282
ARG A 365
TYR A 280
 None
 0.80A 2opxA-5h7vA:
undetectable		 2opxA-5h7vA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 GLY A 118
ARG A 120
TYR A1162
 None
 0.85A 2opxA-5hy7A:
undetectable		 2opxA-5hy7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6g ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 GLY A1913
ARG A1916
TYR A1824
 None
 0.51A 2opxA-5i6gA:
undetectable		 2opxA-5i6gA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 GLY A1913
ARG A1916
TYR A1824
 None
 0.56A 2opxA-5i6hA:
undetectable		 2opxA-5i6hA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 GLY A1913
ARG A1916
TYR A1824
 None
 0.59A 2opxA-5i6iA:
undetectable		 2opxA-5i6iA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		3 GLY A 806
ARG A 883
TYR A 963
 None
 0.87A 2opxA-5kdsA:
undetectable		 2opxA-5kdsA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		3 GLY A 315
ARG A 320
TYR A 442
 None
 0.74A 2opxA-5mogA:
2.4		 2opxA-5mogA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o34 ENOYL-COA HYDRATASE
CARB HOMOLOGUE

(Streptomyces
cattleya) 		no annotation 3 GLY A  98
ARG A 101
TYR A  96
 None
 0.74A 2opxA-5o34A:
undetectable		 2opxA-5o34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 3 GLY A 168
ARG A  39
TYR A 109
 None
 0.81A 2opxA-5o5dA:
undetectable		 2opxA-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 GLY Y 536
ARG Y 618
TYR Y 586
 None
 0.87A 2opxA-5svaY:
undetectable		 2opxA-5svaY:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		3 GLY A 341
ARG A 379
TYR A 288
 None
7A2  A 901 (-2.9A)
None
 0.81A 2opxA-5te1A:
2.0		 2opxA-5te1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uao TRYPTOPHANE-5-HALOGE
NASE

(Microbispora
sp. ATCC
PTA-5024) 		PF04820
(Trp_halogenase) 		3 GLY A 502
ARG A 153
TYR A 157
 None
 0.74A 2opxA-5uaoA:
2.7		 2opxA-5uaoA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 3 GLY A 167
ARG A  39
TYR A 110
 GLY  A 167 ( 0.0A)
ARG  A  39 ( 0.6A)
TYR  A 110 ( 1.3A)
 0.75A 2opxA-5w0aA:
undetectable		 2opxA-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 3 GLY A 169
ARG A  39
TYR A 110
 None
 0.73A 2opxA-5w11A:
undetectable		 2opxA-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		3 GLY A 251
ARG A 268
TYR A 249
 None
 0.86A 2opxA-5wgxA:
2.5		 2opxA-5wgxA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae) 		no annotation 3 GLY A 394
ARG A 331
TYR A  51
 None
 0.87A 2opxA-5xyhA:
undetectable		 2opxA-5xyhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 3 GLY A 227
ARG A 242
TYR A 203
 None
8LM  A 611 (-3.7A)
None
 0.87A 2opxA-6c0mA:
undetectable		 2opxA-6c0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 3 GLY A 167
ARG A 168
TYR A 213
 None
 0.84A 2opxA-6gh2A:
undetectable		 2opxA-6gh2A:
undetectable