SIMILAR PATTERNS OF AMINO ACIDS FOR 2OPX_A_DXCA1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 455
PHE A 400
ILE A 342
GLU A 446
 None
 0.89A 2opxA-1ibjA:
2.1		 2opxA-1ibjA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jif BLEOMYCIN-BINDING
PROTEIN

(Streptomyces
verticillus) 		no annotation 4 LEU A  48
PHE A  22
PHE A  29
ILE A  66
 None
 0.87A 2opxA-1jifA:
undetectable		 2opxA-1jifA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A 205
PHE A 191
ILE A 169
PHE A 273
 10A  A1901 (-3.9A)
None
10A  A1901 ( 4.7A)
None
 0.90A 2opxA-1kphA:
4.4		 2opxA-1kphA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3a P24: PLANT
TRANSCRIPTIONAL
REGULATOR PBF-2

(Solanum
tuberosum) 		PF08536
(Whirly) 		4 LEU A 153
PHE A 172
ILE A 161
PHE A 203
 None
 0.84A 2opxA-1l3aA:
undetectable		 2opxA-1l3aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4t PUTATIVE OXALATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		4 LEU A  52
PHE A  79
PHE A 114
GLU A  68
 None
None
None
MN  A 300 ( 2.7A)
 0.94A 2opxA-1o4tA:
undetectable		 2opxA-1o4tA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgs PEPTIDE-N(4)-(N-ACET
YL-BETA-D-GLUCOSAMIN
YL)ASPARAGINE
AMIDASE F

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 LEU A 107
PHE A  31
PHE A 131
ILE A  78
 None
 0.77A 2opxA-1pgsA:
undetectable		 2opxA-1pgsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 LEU A 496
PHE A 473
ILE A 307
PHE A 481
 None
 0.82A 2opxA-1q15A:
2.9		 2opxA-1q15A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qye ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 249
ILE A 247
ASN A 107
PHE A 199
 None
None
CDY  A 338 (-4.1A)
None
 0.95A 2opxA-1qyeA:
undetectable		 2opxA-1qyeA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu2 MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 LEU A  17
PHE A 307
PHE A 294
ILE A  21
 None
 0.89A 2opxA-1wu2A:
2.2		 2opxA-1wu2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		5 LEU A  85
PHE A 295
PHE A 198
ILE A  90
PHE A 258
 None
 1.43A 2opxA-1xr5A:
undetectable		 2opxA-1xr5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		4 LEU A  56
PHE A  50
ILE A 295
PHE A  43
 None
 0.96A 2opxA-1yy3A:
undetectable		 2opxA-1yy3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 LEU A  66
PHE A  86
PHE A  91
ILE A  59
 None
 0.83A 2opxA-2aqwA:
undetectable		 2opxA-2aqwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 LEU A 325
PHE A 260
ILE A 327
PHE A 357
 None
 0.97A 2opxA-2awaA:
undetectable		 2opxA-2awaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0t NADP ISOCITRATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF03971
(IDH) 		5 LEU A 234
PHE A 273
ILE A 372
ASN A 336
PHE A 248
 None
 1.48A 2opxA-2b0tA:
undetectable		 2opxA-2b0tA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LEU A 412
PHE A 377
PHE A 325
ILE A 408
 None
 0.70A 2opxA-2bf4A:
3.8		 2opxA-2bf4A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 476
PHE A 474
ILE A 330
ASN A 293
 None
 0.93A 2opxA-2c9kA:
undetectable		 2opxA-2c9kA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ct8 METHIONYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 LEU A 275
PHE A 110
PHE A 235
PHE A 164
 None
 0.97A 2opxA-2ct8A:
2.5		 2opxA-2ct8A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 LEU A 332
PHE A 295
ILE A 311
PHE A 322
 None
 0.88A 2opxA-2g39A:
undetectable		 2opxA-2g39A:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		6 LEU A 100
PHE A 107
PHE A 154
ILE A 279
ASN A 286
GLU A 443
 None
 0.83A 2opxA-2iluA:
62.7		 2opxA-2iluA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		5 LEU A 100
PHE A 157
ILE A 279
ASN A 286
GLU A 443
 None
 1.26A 2opxA-2iluA:
62.7		 2opxA-2iluA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 178
ILE A 176
ASN A  38
PHE A 127
 None
None
ADP  A1001 (-3.9A)
None
 0.89A 2opxA-2iopA:
undetectable		 2opxA-2iopA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ior CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 LEU A 178
ILE A 176
ASN A  38
PHE A 127
 None
None
MG  A2000 ( 2.6A)
None
 0.83A 2opxA-2iorA:
undetectable		 2opxA-2iorA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbx PARVALBUMIN BETA

(Gadus morhua) 		PF13499
(EF-hand_7) 		4 LEU A  64
PHE A  71
PHE A  86
ILE A  98
 None
 0.94A 2opxA-2mbxA:
undetectable		 2opxA-2mbxA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1v ENDOPLASMIN

(Canis lupus) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 249
ILE A 247
ASN A 107
PHE A 199
 None
None
MG  A 755 ( 2.7A)
None
 0.88A 2opxA-2o1vA:
undetectable		 2opxA-2o1vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 4 LEU A  96
PHE A  68
ILE A 331
PHE A  87
 None
 0.80A 2opxA-2vowA:
undetectable		 2opxA-2vowA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A) 		no annotation 4 LEU A 389
PHE A 424
ILE A 387
PHE A 514
 None
 0.93A 2opxA-2wbvA:
undetectable		 2opxA-2wbvA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 169
PHE A 247
ILE A 224
PHE A 213
 None
 0.93A 2opxA-3b70A:
3.4		 2opxA-3b70A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LEU A 240
PHE A 154
ILE A 199
ASN A 181
 None
 0.96A 2opxA-3bgaA:
undetectable		 2opxA-3bgaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		4 LEU A  36
PHE A  62
PHE A  32
ILE A 119
 None
 0.93A 2opxA-3dmcA:
undetectable		 2opxA-3dmcA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP3

(Rhinovirus A) 		PF00073
(Rhv) 		4 LEU C  94
PHE C 211
PHE C 115
ILE C  85
 None
 0.97A 2opxA-3dprC:
undetectable		 2opxA-3dprC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 426
PHE A 320
ILE A 296
PHE A 437
 None
 0.96A 2opxA-3e9yA:
undetectable		 2opxA-3e9yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		4 LEU A 389
PHE A 329
ILE A 274
ASN A 279
 None
 0.73A 2opxA-3eq2A:
3.4		 2opxA-3eq2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		4 LEU A 150
PHE A 176
ILE A 154
PHE A 184
 None
 0.87A 2opxA-3h2yA:
2.1		 2opxA-3h2yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ied HEAT SHOCK PROTEIN

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 LEU A 303
ILE A 301
ASN A 133
PHE A 248
 None
None
AN2  A 401 (-3.0A)
None
 0.88A 2opxA-3iedA:
undetectable		 2opxA-3iedA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j6n COXSACKIE AND
ADENOVIRUS RECEPTOR

(Homo sapiens) 		PF00047
(ig)
PF07686
(V-set) 		4 LEU K  53
PHE K  43
ILE K  55
PHE K  93
 None
 0.92A 2opxA-3j6nK:
undetectable		 2opxA-3j6nK:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens) 		PF00829
(Ribosomal_L21p) 		4 LEU s 332
PHE s 299
ASN s 427
PHE s 424
 None
 0.95A 2opxA-3j7ys:
undetectable		 2opxA-3j7ys:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k60 HEAT SHOCK PROTEIN
86

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 175
ILE A 173
ASN A  37
PHE A 124
 None
None
ADP  A 400 (-2.7A)
None
 0.92A 2opxA-3k60A:
undetectable		 2opxA-3k60A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p PROTEIN TRANSPORT
PROTEIN SEC39

(Saccharomyces
cerevisiae) 		PF08314
(Sec39) 		4 LEU D 385
PHE D 359
ILE D 406
PHE D 367
 None
 0.97A 2opxA-3k8pD:
undetectable		 2opxA-3k8pD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 LEU A  83
PHE A 116
PHE A  55
ILE A  73
 None
 0.88A 2opxA-3lv4A:
undetectable		 2opxA-3lv4A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 LEU A 400
PHE A 351
ILE A 399
ASN A 390
 None
 0.90A 2opxA-3nixA:
undetectable		 2opxA-3nixA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6o HEAT SHOCK PROTEIN
83

(Trypanosoma
brucei) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 173
ILE A 171
ASN A  36
PHE A 123
 None
None
94M  A 214 (-4.1A)
94M  A 214 (-3.7A)
 0.87A 2opxA-3o6oA:
undetectable		 2opxA-3o6oA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 LEU A 382
PHE A  90
ILE A 341
PHE A 339
 None
 0.94A 2opxA-3ogrA:
undetectable		 2opxA-3ogrA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3peh ENDOPLASMIN HOMOLOG

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 245
ILE A 243
ASN A 106
PHE A 194
 None
None
IBD  A1001 ( 4.0A)
IBD  A1001 ( 4.3A)
 0.94A 2opxA-3pehA:
undetectable		 2opxA-3pehA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppe VASCULAR ENDOTHELIAL
CADHERIN

(Gallus gallus) 		PF00028
(Cadherin) 		4 LEU A  61
PHE A  58
PHE A  46
ILE A   9
 None
 0.88A 2opxA-3ppeA:
undetectable		 2opxA-3ppeA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1297
PHE A1299
ILE A1367
PHE A1351
 None
 0.76A 2opxA-3pvlA:
undetectable		 2opxA-3pvlA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		4 LEU A 287
PHE A  78
PHE A 317
ILE A 291
 None
 0.88A 2opxA-3qqzA:
undetectable		 2opxA-3qqzA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 LEU B 133
ILE B 137
PHE B  54
GLU B  51
 None
 0.97A 2opxA-3sqgB:
undetectable		 2opxA-3sqgB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6o SULFATE
TRANSPORTER/ANTISIGM
A-FACTOR ANTAGONIST
STAS

(Planctopirus
limnophila) 		no annotation 4 LEU A  52
PHE A  21
PHE A  62
ILE A  50
 None
 0.56A 2opxA-3t6oA:
undetectable		 2opxA-3t6oA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7i REGULATOR OF TY1
TRANSPOSITION
PROTEIN 107

(Saccharomyces
cerevisiae) 		PF16770
(RTT107_BRCT_5)
PF16771
(RTT107_BRCT_6) 		4 LEU A 857
PHE A 849
ILE A 906
PHE A 878
 None
 0.96A 2opxA-3t7iA:
undetectable		 2opxA-3t7iA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		4 LEU A 152
PHE A 205
ILE A 148
ASN A 172
 None
 0.94A 2opxA-3tkaA:
4.3		 2opxA-3tkaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u67 HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 173
ILE A 171
ASN A  36
PHE A 123
 None
None
MG  A 215 ( 2.5A)
None
 0.92A 2opxA-3u67A:
undetectable		 2opxA-3u67A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 LEU A 159
PHE A 125
ILE A 175
PHE A 137
 None
 0.88A 2opxA-3v6aA:
undetectable		 2opxA-3v6aA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 LEU A 761
PHE A 648
PHE A 669
ASN A 734
 None
C  B  23 ( 4.5A)
None
A  B  24 ( 3.2A)
 0.78A 2opxA-4arcA:
undetectable		 2opxA-4arcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckn SAS-6

(Leishmania
major) 		PF16531
(SAS-6_N) 		4 LEU A 205
PHE A 209
PHE A 199
ILE A 263
 None
 0.82A 2opxA-4cknA:
undetectable		 2opxA-4cknA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		4 LEU A 324
ILE A 322
ASN A 339
PHE A 313
 None
 0.91A 2opxA-4cp6A:
undetectable		 2opxA-4cp6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im4 ENDOGLUCANASE E

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 LEU A 238
ILE A 144
ASN A  69
PHE A 347
 None
 0.90A 2opxA-4im4A:
undetectable		 2opxA-4im4A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 LEU A 270
ILE A 268
ASN A 134
PHE A 220
 None
None
MG  A 802 ( 2.5A)
None
 0.87A 2opxA-4ipeA:
undetectable		 2opxA-4ipeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k81 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		4 LEU A 258
PHE A 279
ILE A 337
PHE A 308
 None
 0.87A 2opxA-4k81A:
undetectable		 2opxA-4k81A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		4 LEU A 264
PHE A 273
ILE A 278
PHE A 181
 None
 0.95A 2opxA-4lfeA:
undetectable		 2opxA-4lfeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT

(Homo sapiens) 		PF01896
(DNA_primase_S) 		4 LEU A 189
PHE A 108
ILE A 185
PHE A 152
 None
 0.93A 2opxA-4likA:
undetectable		 2opxA-4likA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 4 LEU A 219
PHE A 197
ILE A 176
PHE A 166
 None
 0.96A 2opxA-4lr4A:
undetectable		 2opxA-4lr4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		4 LEU A  28
PHE A 273
ILE A 102
PHE A 265
 None
 0.67A 2opxA-4lxiA:
2.5		 2opxA-4lxiA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 413
PHE A 428
ILE A 400
PHE A 443
 None
 0.85A 2opxA-4mn8A:
undetectable		 2opxA-4mn8A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 413
PHE A 428
ILE A 400
PHE A 443
 None
 0.94A 2opxA-4mnaA:
undetectable		 2opxA-4mnaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 106
PHE A 155
PHE A 150
ILE A 121
 None
 0.95A 2opxA-4n5aA:
undetectable		 2opxA-4n5aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfd PAIRED
IMMUNOGLOBULIN-LIKE
TYPE 2 RECEPTOR BETA

(Homo sapiens) 		PF07686
(V-set) 		4 LEU A  80
PHE A  94
PHE A  51
ILE A  82
 None
 0.98A 2opxA-4nfdA:
undetectable		 2opxA-4nfdA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU B 307
PHE B 345
ILE B 310
PHE B 365
 None
 0.96A 2opxA-4ol0B:
undetectable		 2opxA-4ol0B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A  65
PHE A  58
PHE A 829
ILE A 810
 None
 0.96A 2opxA-4q0wA:
3.0		 2opxA-4q0wA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		5 LEU A 270
PHE A  78
PHE A 276
ILE A 268
PHE A  56
 None
 1.17A 2opxA-4qx8A:
undetectable		 2opxA-4qx8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rca SLIT AND NTRK-LIKE
PROTEIN 1

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU B 111
PHE B 102
ILE B 113
PHE B 121
 None
 0.94A 2opxA-4rcaB:
undetectable		 2opxA-4rcaB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4j PUTATIVE OXYGENASE

(Amycolatopsis
orientalis) 		PF01494
(FAD_binding_3) 		4 LEU A 180
PHE A 176
PHE A 229
ILE A 244
 None
 0.92A 2opxA-4x4jA:
undetectable		 2opxA-4x4jA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xko HEAT SHOCK COGNATE
90 KDA PROTEIN

(Dictyostelium
discoideum) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 178
ILE A 176
ASN A  40
PHE A 128
 None
None
PEG  A 301 (-4.1A)
PEG  A 301 ( 4.5A)
 0.93A 2opxA-4xkoA:
undetectable		 2opxA-4xkoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 LEU A 184
PHE A 104
ILE A 186
ASN A 287
 None
 0.89A 2opxA-4ypvA:
3.8		 2opxA-4ypvA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbt ACETOACETATE
DECARBOXYLASE

(Streptomyces
bingchenggensis) 		PF06314
(ADC) 		4 LEU A 234
PHE A  85
ILE A  87
PHE A  33
 None
 0.92A 2opxA-4zbtA:
undetectable		 2opxA-4zbtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a15 BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD16

(Homo sapiens) 		PF02214
(BTB_2) 		4 LEU A  29
PHE A  55
ILE A  75
PHE A 113
 None
 0.80A 2opxA-5a15A:
undetectable		 2opxA-5a15A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 233
PHE A 241
PHE A 271
ILE A 228
ASN A 258
 None
 0.98A 2opxA-5a7mA:
3.3		 2opxA-5a7mA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eft P9-1

(Southern rice
black-streaked
dwarf virus) 		PF06043
(Reo_P9) 		4 LEU B  56
PHE B 121
ILE B  52
PHE B 199
 None
 0.81A 2opxA-5eftB:
undetectable		 2opxA-5eftB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fld FIBER PROTEIN

(Raptor
siadenovirus A) 		no annotation 4 LEU A 357
PHE A 413
ILE A 342
PHE A 363
 None
 0.83A 2opxA-5fldA:
undetectable		 2opxA-5fldA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 LEU A 345
PHE A 275
ILE A 101
PHE A 117
 None
 0.92A 2opxA-5g0aA:
undetectable		 2opxA-5g0aA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5
COMPLEMENT C5

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 LEU B 575
PHE A 788
ILE A 799
GLU A 776
 None
 0.94A 2opxA-5hccB:
undetectable		 2opxA-5hccB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1t STAGE II SPORULATION
PROTEIN D

(Clostridioides
difficile) 		PF08486
(SpoIID) 		4 LEU A 279
PHE A 241
ILE A 289
PHE A 300
 None
 0.96A 2opxA-5i1tA:
undetectable		 2opxA-5i1tA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 LEU A 101
PHE A  62
ILE A  70
GLU A 226
 None
 0.95A 2opxA-5i33A:
undetectable		 2opxA-5i33A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 LEU A 770
PHE A 675
ILE A 765
PHE A 703
 None
 0.86A 2opxA-5ijlA:
undetectable		 2opxA-5ijlA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu9 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 173
PHE A 151
ILE A 115
PHE A 125
 None
 0.92A 2opxA-5iu9A:
undetectable		 2opxA-5iu9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 291
PHE A 354
ILE A 274
GLU A 393
 None
 0.87A 2opxA-5ja1A:
3.3		 2opxA-5ja1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 LEU A 264
PHE A 284
ILE A 312
GLU A 318
 None
 0.88A 2opxA-5jpnA:
undetectable		 2opxA-5jpnA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		4 LEU C 378
PHE C  17
ILE C 546
GLU C  21
 None
 0.81A 2opxA-5k1cC:
undetectable		 2opxA-5k1cC:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7e COLH PROTEIN

(Hathewaya
histolytica) 		no annotation 4 LEU A 633
PHE A 696
PHE A 713
PHE A 673
 None
 0.94A 2opxA-5o7eA:
undetectable		 2opxA-5o7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 LEU A 803
PHE A 766
PHE A 769
ILE A 753
 None
 0.96A 2opxA-5okoA:
undetectable		 2opxA-5okoA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Streptococcus
pyogenes;
Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 LEU A 270
ILE A 268
ASN A 134
PHE A 220
 None
None
MG  A 903 ( 2.6A)
None
 0.87A 2opxA-5tthA:
undetectable		 2opxA-5tthA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Homo sapiens) 		PF13191
(AAA_16)
PF14629
(ORC4_C) 		4 LEU C 136
PHE C 177
ILE C 114
PHE C 156
 None
 0.89A 2opxA-5uj7C:
2.5		 2opxA-5uj7C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 4 LEU A 414
PHE A 406
ILE A 380
PHE A 392
 None
 0.96A 2opxA-5w4zA:
undetectable		 2opxA-5w4zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 LEU A1498
PHE A1468
PHE A1488
ILE A1501
 None
 0.96A 2opxA-5xsyA:
undetectable		 2opxA-5xsyA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 LEU A2262
PHE A2321
ILE A2293
PHE A2296
 None
 0.94A 2opxA-5yz0A:
undetectable		 2opxA-5yz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbq NEUROPEPTIDE Y
RECEPTOR TYPE 1,T4
LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		no annotation 4 LEU A 323
ILE A 261
ASN A  73
GLU A  70
 None
 0.92A 2opxA-5zbqA:
undetectable		 2opxA-5zbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 4 LEU A 286
PHE A 262
ILE A 345
PHE A 271
 None
 0.78A 2opxA-6cddA:
undetectable		 2opxA-6cddA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 4 PHE A 155
ILE A 197
PHE A  93
GLU A  97
 None
None
None
MN  A 401 ( 2.6A)
 0.97A 2opxA-6cwoA:
undetectable		 2opxA-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 4 LEU A 270
ILE A 268
ASN A 134
PHE A 220
 None
None
ANP  A 801 (-2.7A)
None
 0.88A 2opxA-6d14A:
undetectable		 2opxA-6d14A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 365
PHE A 390
ILE A 292
PHE A 387
 None
 0.92A 2opxA-6eojA:
undetectable		 2opxA-6eojA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARE

(Acetobacterium
woodii) 		no annotation 4 LEU A 298
PHE A 278
PHE A 337
ILE A 387
 None
 0.97A 2opxA-6fahA:
undetectable		 2opxA-6fahA:
undetectable