SIMILAR PATTERNS OF AMINO ACIDS FOR 2OMN_B_IPHB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3r FV ANTIBODY FRAGMENT

(Rattus
norvegicus) 		PF07686
(V-set) 		4 PRO B 182
HIS B  39
PRO B  45
TYR B  94
 None
 0.93A 2omnA-1f3rB:
5.9
2omnB-1f3rB:
5.9		 2omnA-1f3rB:
26.05
2omnB-1f3rB:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 PRO A 351
HIS A 327
PRO A 326
TYR A 329
 None
 1.01A 2omnA-1wdtA:
0.0
2omnB-1wdtA:
0.0		 2omnA-1wdtA:
15.53
2omnB-1wdtA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q49 PROBABLE
N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Arabidopsis
thaliana) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 PRO A 347
HIS A  41
PRO A  40
TYR A 346
 None
 1.42A 2omnA-2q49A:
0.3
2omnB-2q49A:
1.0		 2omnA-2q49A:
20.90
2omnB-2q49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 PRO A 326
HIS A 330
PRO A 313
TYR A 425
 None
 1.50A 2omnA-4p22A:
0.6
2omnB-4p22A:
0.0		 2omnA-4p22A:
18.61
2omnB-4p22A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnb UBIQUITIN-CONJUGATIN
G ENZYME E2 S

(Homo sapiens) 		PF00179
(UQ_con) 		4 PRO A  54
HIS A  85
PRO A 123
TYR A 144
 None
 1.47A 2omnA-5bnbA:
0.0
2omnB-5bnbA:
0.0		 2omnA-5bnbA:
22.73
2omnB-5bnbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 PRO A 137
HIS A 128
PRO A 869
TYR A 142
 None
 1.32A 2omnA-5nz7A:
1.0
2omnB-5nz7A:
1.4		 2omnA-5nz7A:
11.58
2omnB-5nz7A:
11.58