SIMILAR PATTERNS OF AMINO ACIDS FOR 2OMB_D_IPHD2002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  36
HIS B  39
PRO B  45
TYR B  91
 None
 0.73A 2ombC-1fn4A:
17.6
2ombD-1fn4A:
19.7		 2ombC-1fn4A:
42.79
2ombD-1fn4A:
42.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1isc IRON(III) SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  27
HIS A  73
HIS A  30
TYR A  34
 None
AZI  A 195 (-2.7A)
AZI  A 195 (-4.6A)
AZI  A 195 (-4.2A)
 1.30A 2ombC-1iscA:
undetectable
2ombD-1iscA:
undetectable		 2ombC-1iscA:
24.03
2ombD-1iscA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		4 HIS A 274
TYR A 306
PRO A 304
TYR A 307
 None
 1.26A 2ombC-1k8qA:
undetectable
2ombD-1k8qA:
undetectable		 2ombC-1k8qA:
19.09
2ombD-1k8qA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 TYR A 489
PRO A 488
PRO A 502
TYR A 425
 None
None
FUC  A 614 ( 3.8A)
NAG  A 616 (-4.8A)
 1.20A 2ombC-1lq2A:
undetectable
2ombD-1lq2A:
undetectable		 2ombC-1lq2A:
16.61
2ombD-1lq2A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		4 HIS A  66
TYR A  74
HIS A  43
PRO A  44
 HEM  A 560 (-3.3A)
None
HEM  A 560 (-3.3A)
HEM  A 560 (-4.3A)
 1.12A 2ombC-1ltdA:
undetectable
2ombD-1ltdA:
undetectable		 2ombC-1ltdA:
17.49
2ombD-1ltdA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF00173
(Cyt-b5)
PF01070
(FMN_dh) 		4 TYR A  74
HIS A  43
PRO A  44
HIS A  66
 None
HEM  A 560 (-3.3A)
HEM  A 560 (-4.3A)
HEM  A 560 (-3.3A)
 1.09A 2ombC-1ltdA:
undetectable
2ombD-1ltdA:
undetectable		 2ombC-1ltdA:
17.49
2ombD-1ltdA:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mi5 TCR ALPHA CHAIN
TCR BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR E  35
TYR D  35
PRO D  43
TYR D  89
 None
 1.14A 2ombC-1mi5E:
19.9
2ombD-1mi5E:
15.0		 2ombC-1mi5E:
33.85
2ombD-1mi5E:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mim CHIMERIC SDZ CHI621

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PRO L  43
TYR L  86
HIS L  88
TYR L  35
 None
 1.24A 2ombC-1mimL:
17.3
2ombD-1mimL:
20.1		 2ombC-1mimL:
42.98
2ombD-1mimL:
42.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		4 TYR A  38
HIS A  36
PRO A  44
TYR A  41
 None
 1.24A 2ombC-1uuoA:
undetectable
2ombD-1uuoA:
undetectable		 2ombC-1uuoA:
22.69
2ombD-1uuoA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlg FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF07559
(FlaE) 		4 TYR A 210
HIS A 212
PRO A 222
TYR A 198
 None
 1.05A 2ombC-1wlgA:
undetectable
2ombD-1wlgA:
undetectable		 2ombC-1wlgA:
22.19
2ombD-1wlgA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.59A 2ombC-2adfL:
18.5
2ombD-2adfL:
20.4		 2ombC-2adfL:
42.34
2ombD-2adfL:
42.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeg HYPOTHETICAL PROTEIN
AGR_PAT_140

(Agrobacterium
fabrum) 		PF02586
(SRAP) 		4 TYR A 179
HIS A  53
PRO A 121
TYR A  30
 None
 1.16A 2ombC-2aegA:
undetectable
2ombD-2aegA:
undetectable		 2ombC-2aegA:
23.30
2ombD-2aegA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw3 IRON SUPEROXIDE
DISMUTASE

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  32
HIS A  81
HIS A  35
TYR A  39
 None
FE  A 524 (-3.1A)
None
None
 1.22A 2ombC-2cw3A:
undetectable
2ombD-2cw3A:
undetectable		 2ombC-2cw3A:
22.59
2ombD-2cw3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR H  95
 None
 1.23A 2ombC-2d7tL:
17.6
2ombD-2d7tL:
17.5		 2ombC-2d7tL:
27.06
2ombD-2d7tL:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt8 DEGV FAMILY PROTEIN

(Thermus
thermophilus) 		PF02645
(DegV) 		4 TYR A 278
HIS A 153
TYR A 228
TYR A 276
 None
GOL  A 601 (-3.5A)
None
PLM  A 701 (-4.6A)
 1.10A 2ombC-2dt8A:
undetectable
2ombD-2dt8A:
undetectable		 2ombC-2dt8A:
21.99
2ombD-2dt8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.65A 2ombC-2e27L:
18.4
2ombD-2e27L:
18.1		 2ombC-2e27L:
25.34
2ombD-2e27L:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.99A 2ombC-2e27L:
18.4
2ombD-2e27L:
18.1		 2ombC-2e27L:
25.34
2ombD-2e27L:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		4 PRO A  44
TYR A  74
HIS A  75
PRO A  76
 None
 1.18A 2ombC-2espA:
undetectable
2ombD-2espA:
undetectable		 2ombC-2espA:
19.74
2ombD-2espA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2

(Homo sapiens) 		PF00179
(UQ_con) 		4 TYR A  74
HIS A  75
PRO A  76
PRO A  44
 None
 1.09A 2ombC-2espA:
undetectable
2ombD-2espA:
undetectable		 2ombC-2espA:
19.74
2ombD-2espA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpc IRON SUPEROXIDE
DISMUTASE

(Trypanosoma
cruzi) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  28
HIS A  75
HIS A  31
TYR A  35
 None
FE2  A 195 (-3.2A)
None
None
 1.30A 2ombC-2gpcA:
undetectable
2ombD-2gpcA:
undetectable		 2ombC-2gpcA:
23.71
2ombD-2gpcA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		4 TYR A 127
PRO A  95
HIS A  92
TYR A  39
 None
 1.18A 2ombC-2higA:
undetectable
2ombD-2higA:
undetectable		 2ombC-2higA:
18.24
2ombD-2higA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 HIS A 244
TYR A 133
HIS A 135
PRO A 134
 None
 1.28A 2ombC-2punA:
undetectable
2ombD-2punA:
undetectable		 2ombC-2punA:
18.52
2ombD-2punA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  87
TYR A 198
HIS A 171
TYR A 173
 None
 1.25A 2ombC-2rsvA:
undetectable
2ombD-2rsvA:
undetectable		 2ombC-2rsvA:
19.90
2ombD-2rsvA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		4 TYR A 260
HIS A 262
PRO A 199
TYR A 258
 None
 1.21A 2ombC-2vp3A:
undetectable
2ombD-2vp3A:
undetectable		 2ombC-2vp3A:
19.76
2ombD-2vp3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN

(Bordetella
bronchiseptica) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 TYR A 511
HIS A 449
HIS A 162
PRO A 163
 None
ATP  A1607 (-3.6A)
ATP  A1607 (-4.4A)
None
 1.16A 2ombC-2x0qA:
undetectable
2ombD-2x0qA:
undetectable		 2ombC-2x0qA:
16.42
2ombD-2x0qA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a69 FLAGELLAR HOOK
PROTEIN FLGE

(Salmonella
enterica) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07559
(FlaE) 		4 TYR A 210
HIS A 212
PRO A 222
TYR A 198
 None
 1.05A 2ombC-3a69A:
undetectable
2ombD-3a69A:
undetectable		 2ombC-3a69A:
21.13
2ombD-3a69A:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  37
HIS A  39
PRO A  45
TYR A  88
 None
 0.60A 2ombC-3bjlA:
24.4
2ombD-3bjlA:
20.3		 2ombC-3bjlA:
77.88
2ombD-3bjlA:
77.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c60 TCR YAE62 ALPHA
CHAIN
TCR YAE62 BETA CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  33
TYR A  35
PRO A  43
TYR A  88
 None
 1.28A 2ombC-3c60B:
19.2
2ombD-3c60B:
14.7		 2ombC-3c60B:
32.08
2ombD-3c60B:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do9 UPF0302 PROTEIN
BA_1542/GBAA1542/BAS
1430

(Bacillus
anthracis) 		PF08858
(IDEAL)
PF08864
(UPF0302) 		4 HIS A 125
PRO A 123
HIS A  50
TYR A  53
 None
 1.17A 2ombC-3do9A:
undetectable
2ombD-3do9A:
undetectable		 2ombC-3do9A:
20.34
2ombD-3do9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esf IRON-CONTAINING
SUPEROXIDE DISMUTASE
B2

(Trypanosoma
brucei) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  29
HIS A  76
HIS A  32
TYR A  36
 None
FE  A 198 (-3.3A)
None
None
 1.29A 2ombC-3esfA:
undetectable
2ombD-3esfA:
undetectable		 2ombC-3esfA:
23.01
2ombD-3esfA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 441
TYR A 423
PRO A 342
TYR A 382
 None
 1.31A 2ombC-3fhhA:
undetectable
2ombD-3fhhA:
undetectable		 2ombC-3fhhA:
16.43
2ombD-3fhhA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A 155
PRO A 156
TYR A 177
HIS A 176
 None
 1.26A 2ombC-3gbdA:
undetectable
2ombD-3gbdA:
undetectable		 2ombC-3gbdA:
15.96
2ombD-3gbdA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 4 TYR B 179
HIS B 181
PRO B 187
TYR B  95
 None
 0.67A 2ombC-3juyB:
13.9
2ombD-3juyB:
14.2		 2ombC-3juyB:
25.75
2ombD-3juyB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 4 TYR B 179
HIS B 181
PRO B 187
TYR B 230
 None
 0.32A 2ombC-3juyB:
13.9
2ombD-3juyB:
14.2		 2ombC-3juyB:
25.75
2ombD-3juyB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4z GLYCOSIDE HYDROLASE
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF02018
(CBM_4_9)
PF02927
(CelD_N) 		4 TYR A 259
HIS A 273
PRO A 274
TYR A 271
 None
 1.01A 2ombC-3k4zA:
5.6
2ombD-3k4zA:
5.4		 2ombC-3k4zA:
24.73
2ombD-3k4zA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		4 TYR A1010
HIS A1012
PRO A1011
TYR A1036
 None
ZN  A2402 (-4.1A)
ZN  A2402 (-4.2A)
None
 1.15A 2ombC-3l9xA:
undetectable
2ombD-3l9xA:
undetectable		 2ombC-3l9xA:
20.98
2ombD-3l9xA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		4 TYR A1036
TYR A1010
HIS A1012
PRO A1011
 None
None
ZN  A2402 (-4.1A)
ZN  A2402 (-4.2A)
 1.23A 2ombC-3l9xA:
undetectable
2ombD-3l9xA:
undetectable		 2ombC-3l9xA:
20.98
2ombD-3l9xA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 PRO A 196
HIS A 107
PRO A 106
TYR A 194
 None
 1.27A 2ombC-3lggA:
undetectable
2ombD-3lggA:
undetectable		 2ombC-3lggA:
19.26
2ombD-3lggA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omz HUMAN VDELTA1 GAMMA
DELTA T CELL
RECEPTOR DELTA1A/B-3

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A  37
HIS A  39
PRO A  45
TYR A  95
 None
 0.60A 2ombC-3omzA:
11.6
2ombD-3omzA:
11.6		 2ombC-3omzA:
26.36
2ombD-3omzA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbt GLUTATHIONE
TRANSFERASE O1

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 HIS A  33
PRO A 175
TYR A  31
HIS A  25
 None
 1.28A 2ombC-3rbtA:
undetectable
2ombD-3rbtA:
undetectable		 2ombC-3rbtA:
17.93
2ombD-3rbtA:
17.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ru8 ANTIBODY B12, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  37
HIS L  39
PRO L  45
TYR L  88
 None
 0.34A 2ombC-3ru8L:
18.1
2ombD-3ru8L:
20.2		 2ombC-3ru8L:
44.93
2ombD-3ru8L:
44.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hf5 FAB 8F8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H 100
TYR H 100
HIS H 100
TYR H 100
 None
 1.11A 2ombC-4hf5H:
11.5
2ombD-4hf5H:
11.8		 2ombC-4hf5H:
31.95
2ombD-4hf5H:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhe QUINOLINATE SYNTHASE
A

(Pyrococcus
furiosus) 		PF02445
(NadA) 		4 HIS A  97
PRO A 169
HIS A 173
TYR A 175
 None
 1.28A 2ombC-4hheA:
undetectable
2ombD-4hheA:
undetectable		 2ombC-4hheA:
19.28
2ombD-4hheA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 TYR A 284
HIS A 285
HIS A 282
TYR A 273
 None
 1.20A 2ombC-4i9cA:
undetectable
2ombD-4i9cA:
undetectable		 2ombC-4i9cA:
18.65
2ombD-4i9cA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		4 PRO C  44
TYR C  74
HIS C  75
PRO C  76
 None
 1.13A 2ombC-4ii2C:
undetectable
2ombD-4ii2C:
undetectable		 2ombC-4ii2C:
22.12
2ombD-4ii2C:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		4 TYR C  74
HIS C  75
PRO C  76
PRO C  44
 None
 1.01A 2ombC-4ii2C:
undetectable
2ombD-4ii2C:
undetectable		 2ombC-4ii2C:
22.12
2ombD-4ii2C:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6r LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.53A 2ombC-4j6rL:
17.8
2ombD-4j6rL:
20.1		 2ombC-4j6rL:
43.36
2ombD-4j6rL:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy4 PGT121 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  36
HIS A  38
PRO A  44
TYR A  87
 None
 0.35A 2ombC-4jy4A:
18.3
2ombD-4jy4A:
19.2		 2ombC-4jy4A:
74.09
2ombD-4jy4A:
74.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  36
HIS A  38
PRO A  44
TYR B  91
 None
 0.74A 2ombC-4jy4A:
18.3
2ombD-4jy4A:
19.2		 2ombC-4jy4A:
74.09
2ombD-4jy4A:
74.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TYR D  40
TYR G  39
HIS G  41
PRO G  47
TYR G  97
 None
 1.05A 2ombC-4lhuD:
7.6
2ombD-4lhuD:
13.6		 2ombC-4lhuD:
31.20
2ombD-4lhuD:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR DELTA CHAIN
9C2 TCR GAMMA CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR G  39
HIS G  41
PRO G  47
TYR D  40
 None
 1.21A 2ombC-4lhuG:
11.0
2ombD-4lhuG:
13.6		 2ombC-4lhuG:
29.64
2ombD-4lhuG:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mng TRA@ PROTEIN,TRA@
PROTEIN, TI ANTIGEN
CD3-ASSOCIATED
PROTEIN GAMMA CHAIN
V-J-C REGION

(Homo sapiens) 		PF07686
(V-set) 		4 TYR E  37
HIS E 177
PRO E 183
TYR E 233
 None
 0.89A 2ombC-4mngE:
13.4
2ombD-4mngE:
13.5		 2ombC-4mngE:
24.16
2ombD-4mngE:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mng TRA@ PROTEIN,TRA@
PROTEIN, TI ANTIGEN
CD3-ASSOCIATED
PROTEIN GAMMA CHAIN
V-J-C REGION

(Homo sapiens) 		PF07686
(V-set) 		4 TYR E 175
HIS E 177
PRO E 183
TYR E 233
 None
 0.57A 2ombC-4mngE:
13.4
2ombD-4mngE:
13.5		 2ombC-4mngE:
24.16
2ombD-4mngE:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mnh T-CELL RECEPTOR
GAMMA CHAIN V REGION
PT-GAMMA-1/2, HUMAN
NKT TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  36
HIS A  38
PRO A  44
TYR A  94
 None
 0.53A 2ombC-4mnhA:
18.4
2ombD-4mnhA:
14.2		 2ombC-4mnhA:
32.02
2ombD-4mnhA:
32.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ndm T-CELL GAMMA
PROTEIN,T-CELL
RECEPTOR BETA-2
CHAIN C REGION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  37
HIS A  39
PRO A  45
TYR A  95
 None
 0.51A 2ombC-4ndmA:
19.6
2ombD-4ndmA:
12.8		 2ombC-4ndmA:
32.02
2ombD-4ndmA:
32.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 HIS A  80
PRO A  81
TYR A  76
TYR A  90
 SO4  A 507 (-3.5A)
None
None
None
 1.19A 2ombC-4pz7A:
undetectable
2ombD-4pz7A:
undetectable		 2ombC-4pz7A:
21.28
2ombD-4pz7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 131
HIS A  77
PRO A  76
TYR A 277
 None
 1.13A 2ombC-4redA:
undetectable
2ombD-4redA:
undetectable		 2ombC-4redA:
19.72
2ombD-4redA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzc FV M6P-1 HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 PRO L  44
TYR L  87
HIS L  89
TYR L  36
 None
 1.15A 2ombC-4rzcL:
18.6
2ombD-4rzcL:
18.3		 2ombC-4rzcL:
22.94
2ombD-4rzcL:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 TYR E 176
HIS E 178
PRO E 184
TYR E 227
 None
 0.40A 2ombC-4v1dE:
19.7
2ombD-4v1dE:
19.9		 2ombC-4v1dE:
33.19
2ombD-4v1dE:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR E 176
HIS E 178
PRO E 184
TYR D  95
 None
 0.78A 2ombC-4v1dE:
19.7
2ombD-4v1dE:
19.9		 2ombC-4v1dE:
33.19
2ombD-4v1dE:
33.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yet SUPEROXIDE DISMUTASE

(Babesia bovis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 TYR A  28
HIS A  74
HIS A  31
TYR A  35
 None
FE  A 300 (-3.3A)
None
None
 1.28A 2ombC-4yetA:
undetectable
2ombD-4yetA:
undetectable		 2ombC-4yetA:
22.27
2ombD-4yetA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqx JES6-1 VH DOMAIN
JES6-1 VL DOMAIN

(Rattus
norvegicus;
Rattus
norvegicus) 		PF07686
(V-set)
PF07686
(V-set) 		4 HIS H  42
TYR L  45
PRO L  53
TYR L  96
 None
 1.20A 2ombC-4yqxH:
14.6
2ombD-4yqxH:
14.8		 2ombC-4yqxH:
20.80
2ombD-4yqxH:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 TYR A 306
HIS A 125
TYR A 300
HIS A 302
 None
ZN  A 401 (-3.2A)
None
ZN  A 402 (-3.5A)
 1.28A 2ombC-4zyoA:
undetectable
2ombD-4zyoA:
undetectable		 2ombC-4zyoA:
19.38
2ombD-4zyoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		4 PRO D  45
TYR D 234
PRO D 242
TYR D 285
 None
 0.88A 2ombC-5d9qD:
undetectable
2ombD-5d9qD:
undetectable		 2ombC-5d9qD:
23.05
2ombD-5d9qD:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 TYR A 182
HIS A 183
PRO A 184
TYR A 253
 None
 1.00A 2ombC-5eufA:
undetectable
2ombD-5eufA:
undetectable		 2ombC-5eufA:
19.67
2ombD-5eufA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 TYR A  98
PRO A 109
TYR A 254
HIS A 238
 None
 0.78A 2ombC-5ev7A:
undetectable
2ombD-5ev7A:
undetectable		 2ombC-5ev7A:
17.56
2ombD-5ev7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 TYR A 130
PRO A  71
PRO A 109
TYR A 254
 None
 1.10A 2ombC-5ev7A:
undetectable
2ombD-5ev7A:
undetectable		 2ombC-5ev7A:
17.56
2ombD-5ev7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		5 TYR A 254
HIS A 238
TYR A  98
PRO A 109
TYR A 130
 None
 0.95A 2ombC-5ev7A:
undetectable
2ombD-5ev7A:
undetectable		 2ombC-5ev7A:
17.56
2ombD-5ev7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A1055
HIS A1052
PRO A1049
TYR A1054
 None
 1.30A 2ombC-5f1zA:
undetectable
2ombD-5f1zA:
undetectable		 2ombC-5f1zA:
20.85
2ombD-5f1zA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grv HOMO-SPECIFIC
DIABODY LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 PRO K 168
TYR K 211
HIS K 213
TYR K 160
 None
 1.21A 2ombC-5grvK:
17.9
2ombD-5grvK:
17.9		 2ombC-5grvK:
29.19
2ombD-5grvK:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 DIABODY

(Homo sapiens) 		PF07686
(V-set) 		4 PRO C 168
TYR C 211
HIS C 213
TYR C 160
 None
 1.15A 2ombC-5gs1C:
13.7
2ombD-5gs1C:
14.0		 2ombC-5gs1C:
27.08
2ombD-5gs1C:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs1 LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 PRO A  45
TYR A  88
HIS A  90
TYR A  37
 None
 1.18A 2ombC-5gs1A:
17.8
2ombD-5gs1A:
17.8		 2ombC-5gs1A:
26.67
2ombD-5gs1A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 HIS A  75
PRO A  74
TYR A 283
TYR A 275
 None
 0.98A 2ombC-5isoA:
undetectable
2ombD-5isoA:
undetectable		 2ombC-5isoA:
18.56
2ombD-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 TYR A 129
HIS A  75
TYR A 283
TYR A 275
 None
 1.30A 2ombC-5isoA:
undetectable
2ombD-5isoA:
undetectable		 2ombC-5isoA:
18.56
2ombD-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 TYR A 283
TYR A 129
HIS A  75
PRO A  74
 None
 1.15A 2ombC-5isoA:
undetectable
2ombD-5isoA:
undetectable		 2ombC-5isoA:
18.56
2ombD-5isoA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		4 TYR A  14
HIS A  16
PRO A  15
TYR A  82
 None
 1.16A 2ombC-5jigA:
undetectable
2ombD-5jigA:
undetectable		 2ombC-5jigA:
20.00
2ombD-5jigA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 414
HIS A 415
PRO A 416
HIS A 468
 None
 1.08A 2ombC-5jtaA:
undetectable
2ombD-5jtaA:
undetectable		 2ombC-5jtaA:
14.54
2ombD-5jtaA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kja APOCAROTENOID-15,15'
-OXYGENASE

(Synechocystis
sp. PCC 6803) 		PF03055
(RPE65) 		4 TYR A  24
HIS A 478
PRO A 480
TYR A 448
 None
 1.10A 2ombC-5kjaA:
undetectable
2ombD-5kjaA:
undetectable		 2ombC-5kjaA:
18.11
2ombD-5kjaA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 HIS B 356
PRO B 361
TYR B 370
TYR B 425
 None
 1.26A 2ombC-5kyuB:
3.1
2ombD-5kyuB:
3.0		 2ombC-5kyuB:
13.58
2ombD-5kyuB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf2 LAMININ SUBUNIT
BETA-2

(Rattus
norvegicus) 		PF00053
(Laminin_EGF) 		4 HIS A 569
PRO A 565
PRO A 725
TYR A 780
 CL  A1002 ( 4.7A)
None
None
None
 1.31A 2ombC-5lf2A:
undetectable
2ombD-5lf2A:
undetectable		 2ombC-5lf2A:
23.58
2ombD-5lf2A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m4a NEUTRAL TREHALASE

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 414
HIS A 415
PRO A 416
HIS A 468
 None
 1.01A 2ombC-5m4aA:
undetectable
2ombD-5m4aA:
undetectable		 2ombC-5m4aA:
17.01
2ombD-5m4aA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nns GLYCOSYL HYDROLASE
FAMILY 61, 2 PROTEIN

(Heterobasidion
irregulare) 		no annotation 4 TYR A  36
HIS A  80
PRO A  79
TYR A 167
 None
CU  A 303 ( 3.3A)
None
None
 0.89A 2ombC-5nnsA:
4.2
2ombD-5nnsA:
4.3		 2ombC-5nnsA:
undetectable
2ombD-5nnsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5te6 LIGHT CHAIN OF N6

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.68A 2ombC-5te6L:
16.9
2ombD-5te6L:
19.3		 2ombC-5te6L:
42.48
2ombD-5te6L:
42.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5te6 HEAVY CHAIN OF N6
LIGHT CHAIN OF N6

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.85A 2ombC-5te6L:
16.9
2ombD-5te6L:
19.3		 2ombC-5te6L:
42.48
2ombD-5te6L:
42.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0u DH270.1 SINGLE-CHAIN
VARIABLE FRAGMENT

(Homo sapiens) 		no annotation 4 PRO G  45
TYR G 177
PRO G 185
TYR G 228
 None
 1.11A 2ombC-5u0uG:
21.2
2ombD-5u0uG:
21.2		 2ombC-5u0uG:
26.36
2ombD-5u0uG:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3k DH511.2 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.40A 2ombC-5u3kL:
18.2
2ombD-5u3kL:
20.0		 2ombC-5u3kL:
41.96
2ombD-5u3kL:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3n DH511.12P FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.36A 2ombC-5u3nL:
20.9
2ombD-5u3nL:
19.1		 2ombC-5u3nL:
43.69
2ombD-5u3nL:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3n DH511.12P FAB HEAVY
CHAIN
DH511.12P FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.71A 2ombC-5u3nL:
20.9
2ombD-5u3nL:
19.1		 2ombC-5u3nL:
43.69
2ombD-5u3nL:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3p DH511.4 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.33A 2ombC-5u3pL:
20.9
2ombD-5u3pL:
19.8		 2ombC-5u3pL:
41.07
2ombD-5u3pL:
41.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.73A 2ombC-5u3pL:
20.9
2ombD-5u3pL:
19.8		 2ombC-5u3pL:
41.07
2ombD-5u3pL:
41.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.54A 2ombC-5uy3L:
17.6
2ombD-5uy3L:
20.2		 2ombC-5uy3L:
40.44
2ombD-5uy3L:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
ANTIBODY PGT144 FAB
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.96A 2ombC-5uy3L:
17.6
2ombD-5uy3L:
20.2		 2ombC-5uy3L:
40.44
2ombD-5uy3L:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN
BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 PRO D  45
TYR E  34
PRO E  42
TYR E  85
 None
 0.70A 2ombC-5wduD:
14.0
2ombD-5wduD:
14.1		 2ombC-5wduD:
undetectable
2ombD-5wduD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 HIS A 607
PRO A 614
TYR A 582
PRO A 583
 SO4  A 701 (-4.1A)
None
None
None
 1.27A 2ombC-5xpgA:
undetectable
2ombD-5xpgA:
undetectable		 2ombC-5xpgA:
undetectable
2ombD-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 TYR A 582
PRO A 583
HIS A 607
PRO A 614
 None
None
SO4  A 701 (-4.1A)
None
 1.27A 2ombC-5xpgA:
undetectable
2ombD-5xpgA:
undetectable		 2ombC-5xpgA:
undetectable
2ombD-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 4 HIS A 342
PRO A 343
TYR A 403
PRO A 425
 None
 1.28A 2ombC-5ze8A:
4.3
2ombD-5ze8A:
4.2		 2ombC-5ze8A:
undetectable
2ombD-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bck N49P7 FAB HEAVY
CHAIN OF N29P7 IGG
N49P7 FAB LIGHT
CHAIN FROM N49P7 IGG

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 HIS L  38
PRO L  44
PRO H  45
TYR H  91
 None
 0.65A 2ombC-6bckL:
24.7
2ombD-6bckL:
18.3		 2ombC-6bckL:
undetectable
2ombD-6bckL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp2 -

(-) 		no annotation 4 PRO B  45
TYR B  75
HIS B  76
PRO B  77
 None
 0.91A 2ombC-6cp2B:
undetectable
2ombD-6cp2B:
undetectable		 2ombC-6cp2B:
undetectable
2ombD-6cp2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp2 -

(-) 		no annotation 4 TYR B  75
HIS B  76
PRO B  77
PRO B  45
 None
 0.79A 2ombC-6cp2B:
undetectable
2ombD-6cp2B:
undetectable		 2ombC-6cp2B:
undetectable
2ombD-6cp2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp2 -

(-) 		no annotation 4 TYR B  75
PRO B  77
PRO B  45
TYR B 129
 None
 1.24A 2ombC-6cp2B:
undetectable
2ombD-6cp2B:
undetectable		 2ombC-6cp2B:
undetectable
2ombD-6cp2B:
undetectable