SIMILAR PATTERNS OF AMINO ACIDS FOR 2OLD_B_IPHB2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 HIS B  39
PRO B  45
TYR B  91
TYR A  36
PRO A  44
 None
 1.19A 2oldA-1fn4B:
18.1
2oldB-1fn4B:
12.8		 2oldA-1fn4B:
31.36
2oldB-1fn4B:
31.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
FLUORESCEIN-SCFV
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR H 105
TYR L  44
PRO L  52
TYR L 105
 None
 0.71A 2oldA-2a9mH:
13.8
2oldB-2a9mH:
13.8		 2oldA-2a9mH:
23.50
2oldB-2a9mH:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a9m FLUORESCEIN-SCFV
HEAVY CHAIN
FLUORESCEIN-SCFV
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  44
PRO L  52
TYR L 105
TYR H 105
 None
 0.66A 2oldA-2a9mL:
21.1
2oldB-2a9mL:
21.2		 2oldA-2a9mL:
64.86
2oldB-2a9mL:
64.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.54A 2oldA-2adfL:
15.8
2oldB-2adfL:
20.5		 2oldA-2adfL:
42.34
2oldB-2adfL:
42.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		5 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.75A 2oldA-2e27L:
18.6
2oldB-2e27L:
18.1		 2oldA-2e27L:
25.34
2oldB-2e27L:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghw ANTI-SARS SCFV
ANTIBODY, 80R

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B 168
PRO B 176
TYR B 219
TYR B  95
 None
 0.72A 2oldA-2ghwB:
17.5
2oldB-2ghwB:
17.4		 2oldA-2ghwB:
27.34
2oldB-2ghwB:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h32 IMMUNOGLOBULIN IOTA
CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  38
PRO A  46
TYR A  95
TYR H  95
 None
 0.70A 2oldA-2h32A:
12.4
2oldB-2h32A:
12.5		 2oldA-2h32A:
24.66
2oldB-2h32A:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h32 IMMUNOGLOBULIN IOTA
CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  95
TYR A  38
PRO A  46
TYR A  95
 None
 0.74A 2oldA-2h32H:
11.6
2oldB-2h32H:
16.5		 2oldA-2h32H:
34.27
2oldB-2h32H:
34.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjl LOC - LAMBDA 1 TYPE
LIGHT-CHAIN DIMER

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  37
HIS A  39
PRO A  45
TYR A  88
 None
 0.51A 2oldA-3bjlA:
18.9
2oldB-3bjlA:
18.9		 2oldA-3bjlA:
77.88
2oldB-3bjlA:
77.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.74A 2oldA-3go1L:
19.7
2oldB-3go1L:
23.8		 2oldA-3go1L:
75.12
2oldB-3go1L:
75.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		5 PRO C 179
TYR C 229
TYR C  42
PRO C  50
TYR C  93
 None
 0.97A 2oldA-3h3bC:
16.9
2oldB-3h3bC:
16.8		 2oldA-3h3bC:
33.21
2oldB-3h3bC:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		5 TYR C  42
PRO C  50
TYR C  93
PRO C 179
TYR C 229
 None
 0.92A 2oldA-3h3bC:
16.9
2oldB-3h3bC:
16.8		 2oldA-3h3bC:
33.21
2oldB-3h3bC:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 4 TYR B  95
TYR B 179
PRO B 187
TYR B 230
 None
 0.45A 2oldA-3juyB:
6.3
2oldB-3juyB:
18.3		 2oldA-3juyB:
25.75
2oldB-3juyB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 5 TYR B 179
HIS B 181
PRO B 187
TYR B 230
TYR B  95
 None
 0.39A 2oldA-3juyB:
6.3
2oldB-3juyB:
18.3		 2oldA-3juyB:
25.75
2oldB-3juyB:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omz HUMAN VDELTA1 GAMMA
DELTA T CELL
RECEPTOR DELTA1A/B-3

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A  37
HIS A  39
PRO A  45
TYR A  95
 None
 0.59A 2oldA-3omzA:
11.7
2oldB-3omzA:
11.7		 2oldA-3omzA:
26.36
2oldB-3omzA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p30 1281 FAB HEAVY CHAIN
1281 FAB LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 PRO H  45
TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.90A 2oldA-3p30H:
14.3
2oldB-3p30H:
17.8		 2oldA-3p30H:
31.20
2oldB-3p30H:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p30 1281 FAB HEAVY CHAIN
1281 FAB LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L  36
PRO L  44
TYR L  87
PRO H  45
TYR H  91
 None
 0.88A 2oldA-3p30L:
26.8
2oldB-3p30L:
20.9		 2oldA-3p30L:
80.37
2oldB-3p30L:
80.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q6g HEAVY CHAIN OF FAB
OF RHESUS MAB 2.5B
LIGHT CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta;
Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.73A 2oldA-3q6gH:
19.3
2oldB-3q6gH:
14.2		 2oldA-3q6gH:
31.56
2oldB-3q6gH:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q6g HEAVY CHAIN OF FAB
OF RHESUS MAB 2.5B
LIGHT CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta;
Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.69A 2oldA-3q6gL:
19.5
2oldB-3q6gL:
23.8		 2oldA-3q6gL:
71.83
2oldB-3q6gL:
71.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ru8 ANTIBODY B12, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  37
HIS L  39
PRO L  45
TYR L  88
 None
 0.34A 2oldA-3ru8L:
16.1
2oldB-3ru8L:
15.9		 2oldA-3ru8L:
44.93
2oldB-3ru8L:
44.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ux9 SCFV ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B  39
PRO B  47
TYR B  90
TYR B 229
 None
 0.73A 2oldA-3ux9B:
21.2
2oldB-3ux9B:
21.3		 2oldA-3ux9B:
38.26
2oldB-3ux9B:
38.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4glr ANTI-PTAU HEAVY
CHAIN
ANTI-PTAU LIGHT
CHAIN

(Gallus gallus;
Gallus gallus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
TYR I  36
PRO I  44
TYR I  87
 None
 0.63A 2oldA-4glrH:
18.5
2oldB-4glrH:
16.3		 2oldA-4glrH:
31.40
2oldB-4glrH:
31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4glr ANTI-PTAU HEAVY
CHAIN
ANTI-PTAU LIGHT
CHAIN

(Gallus gallus;
Gallus gallus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR I  36
PRO I  44
TYR I  87
TYR H  91
 None
 0.56A 2oldA-4glrI:
19.9
2oldB-4glrI:
23.3		 2oldA-4glrI:
75.58
2oldB-4glrI:
75.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR H  95
TYR L  35
PRO L  43
TYR L  86
 None
 0.75A 2oldA-4imlH:
15.7
2oldB-4imlH:
19.0		 2oldA-4imlH:
34.29
2oldB-4imlH:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR L  35
PRO L  43
TYR L  86
TYR H  95
 None
 0.70A 2oldA-4imlL:
20.1
2oldB-4imlL:
19.7		 2oldA-4imlL:
43.38
2oldB-4imlL:
43.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6r LIGHT CHAIN OF
ANTIBODY VRC23

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.42A 2oldA-4j6rL:
16.2
2oldB-4j6rL:
19.9		 2oldA-4j6rL:
43.36
2oldB-4j6rL:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TYR A  36
HIS A  38
PRO A  44
TYR A  87
TYR B  91
 None
 0.37A 2oldA-4jy4A:
19.1
2oldB-4jy4A:
18.4		 2oldA-4jy4A:
74.09
2oldB-4jy4A:
74.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  91
TYR A  36
PRO A  44
TYR A  87
 None
 0.42A 2oldA-4jy4B:
13.1
2oldB-4jy4B:
16.4		 2oldA-4jy4B:
32.38
2oldB-4jy4B:
32.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  95
TYR B  35
PRO B  43
TYR B  86
 None
 0.71A 2oldA-4jznA:
20.2
2oldB-4jznA:
15.4		 2oldA-4jznA:
29.67
2oldB-4jznA:
29.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  35
PRO B  43
TYR B  86
TYR A  95
 None
 0.66A 2oldA-4jznB:
16.1
2oldB-4jznB:
21.5		 2oldA-4jznB:
46.64
2oldB-4jznB:
46.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR G  39
HIS G  41
PRO G  47
TYR G  97
 None
 0.53A 2oldA-4lhuG:
17.7
2oldB-4lhuG:
13.8		 2oldA-4lhuG:
29.64
2oldB-4lhuG:
29.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mng TRA@ PROTEIN,TRA@
PROTEIN, TI ANTIGEN
CD3-ASSOCIATED
PROTEIN GAMMA CHAIN
V-J-C REGION

(Homo sapiens) 		PF07686
(V-set) 		4 TYR E 175
HIS E 177
PRO E 183
TYR E 233
 None
 0.60A 2oldA-4mngE:
13.7
2oldB-4mngE:
13.6		 2oldA-4mngE:
24.16
2oldB-4mngE:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mnh T-CELL RECEPTOR
GAMMA CHAIN V REGION
PT-GAMMA-1/2, HUMAN
NKT TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  36
HIS A  38
PRO A  44
TYR A  94
 None
 0.57A 2oldA-4mnhA:
14.6
2oldB-4mnhA:
14.6		 2oldA-4mnhA:
32.02
2oldB-4mnhA:
32.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ndm T-CELL GAMMA
PROTEIN,T-CELL
RECEPTOR BETA-2
CHAIN C REGION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  37
HIS A  39
PRO A  45
TYR A  95
 None
 0.55A 2oldA-4ndmA:
20.0
2oldB-4ndmA:
14.5		 2oldA-4ndmA:
32.02
2oldB-4ndmA:
32.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B  97
TYR B 172
PRO B 180
TYR B 223
 None
 0.69A 2oldA-4nikB:
13.8
2oldB-4nikB:
14.0		 2oldA-4nikB:
28.37
2oldB-4nikB:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		4 TYR B 172
PRO B 180
TYR B 223
TYR B  97
 None
 0.62A 2oldA-4nikB:
13.8
2oldB-4nikB:
14.0		 2oldA-4nikB:
28.37
2oldB-4nikB:
28.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 TYR A  36
PRO A  45
TYR A  88
TYR A 223
 None
 0.58A 2oldA-4p48A:
16.3
2oldB-4p48A:
16.2		 2oldA-4p48A:
35.61
2oldB-4p48A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p48 ANTIBODY SCFV 180

(Gallus gallus) 		PF07686
(V-set) 		4 TYR A 223
TYR A  36
PRO A  45
TYR A  88
 None
 0.64A 2oldA-4p48A:
16.3
2oldB-4p48A:
16.2		 2oldA-4p48A:
35.61
2oldB-4p48A:
35.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p49 ANTIBODY SCFV B8

(Gallus gallus) 		PF07686
(V-set) 		4 TYR A  30
PRO A  39
TYR A  82
TYR A 216
 None
 0.71A 2oldA-4p49A:
17.8
2oldB-4p49A:
17.8		 2oldA-4p49A:
35.74
2oldB-4p49A:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR A  95
TYR B 165
PRO B 173
TYR B 216
 None
 0.56A 2oldA-4ravA:
13.8
2oldB-4ravA:
13.8		 2oldA-4ravA:
23.50
2oldB-4ravA:
23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rav SINGLE-CHAIN FV, VH
SINGLE-CHAIN FV, VL

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR B 165
PRO B 173
TYR B 216
TYR A  95
 None
 0.50A 2oldA-4ravB:
22.3
2oldB-4ravB:
21.9		 2oldA-4ravB:
41.74
2oldB-4ravB:
41.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.67A 2oldA-4ut7H:
12.6
2oldB-4ut7H:
12.5		 2oldA-4ut7H:
22.94
2oldB-4ut7H:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ut7 BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11
BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE2
A11

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.62A 2oldA-4ut7L:
18.7
2oldB-4ut7L:
18.8		 2oldA-4ut7L:
45.75
2oldB-4ut7L:
45.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR D  95
TYR E 176
PRO E 184
TYR E 227
 None
 0.47A 2oldA-4v1dD:
13.6
2oldB-4v1dD:
13.8		 2oldA-4v1dD:
19.28
2oldB-4v1dD:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		5 TYR E 176
HIS E 178
PRO E 184
TYR E 227
TYR D  95
 None
 0.49A 2oldA-4v1dE:
20.0
2oldB-4v1dE:
20.2		 2oldA-4v1dE:
33.19
2oldB-4v1dE:
33.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR A  95
TYR B  36
PRO B  44
TYR B  87
 None
 0.70A 2oldA-4x4yA:
14.3
2oldB-4x4yA:
14.5		 2oldA-4x4yA:
25.68
2oldB-4x4yA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR B  36
PRO B  44
TYR B  87
TYR A  95
 None
 0.65A 2oldA-4x4yB:
18.3
2oldB-4x4yB:
18.3		 2oldA-4x4yB:
26.67
2oldB-4x4yB:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5x DIABODY 310 VL
DOMAIN
DIABODY 310 VH
DOMAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR A  95
TYR B  37
PRO B  45
TYR B  88
 None
 0.48A 2oldA-4y5xA:
13.0
2oldB-4y5xA:
13.1		 2oldA-4y5xA:
25.57
2oldB-4y5xA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y5x DIABODY 310 VL
DOMAIN
DIABODY 310 VH
DOMAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR B  37
PRO B  45
TYR B  88
TYR A  95
 None
 0.43A 2oldA-4y5xB:
20.7
2oldB-4y5xB:
20.9		 2oldA-4y5xB:
35.29
2oldB-4y5xB:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydv HIV ANTIBODY 7B2
HEAVY CHAIN,IGG H
CHAIN
HIV ANTIBODY 7B2
LIGHT CHAIN,IG KAPPA
CHAIN C REGION

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.73A 2oldA-4ydvL:
15.6
2oldB-4ydvL:
19.9		 2oldA-4ydvL:
39.48
2oldB-4ydvL:
39.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 HIS A 366
TYR A 449
TYR A 436
PRO A 450
TYR A 435
 None
None
None
GOL  A 506 (-4.3A)
None
 1.32A 2oldA-4yt9A:
7.1
2oldB-4yt9A:
6.0		 2oldA-4yt9A:
18.12
2oldB-4yt9A:
18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR A  35
PRO A  43
TYR A  86
TYR B 120
 None
 0.66A 2oldA-4z0xA:
19.1
2oldB-4z0xA:
19.0		 2oldA-4z0xA:
57.66
2oldB-4z0xA:
57.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR B 120
TYR A  35
PRO A  43
TYR A  86
 None
 0.72A 2oldA-4z0xB:
11.9
2oldB-4z0xB:
11.9		 2oldA-4z0xB:
21.66
2oldB-4z0xB:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN
LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama;
Lama glama) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  38
PRO L  46
TYR L  89
TYR H  96
 None
 0.74A 2oldA-4zs7L:
7.6
2oldB-4zs7L:
24.5		 2oldA-4zs7L:
82.03
2oldB-4zs7L:
82.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR A  40
PRO A  48
TYR A  91
TYR B  95
 None
 0.67A 2oldA-5b8cA:
17.7
2oldB-5b8cA:
17.6		 2oldA-5b8cA:
32.29
2oldB-5b8cA:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR B  95
TYR A  40
PRO A  48
TYR A  91
 None
 0.72A 2oldA-5b8cB:
14.8
2oldB-5b8cB:
14.8		 2oldA-5b8cB:
19.82
2oldB-5b8cB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6w PROTEIN
IGHV1-69-2,IG LAMBDA
CHAIN V-II REGION
NIG-84

(Homo sapiens) 		PF07686
(V-set) 		4 TYR H  95
TYR H1038
PRO H1046
TYR H1089
 None
 0.65A 2oldA-5c6wH:
14.2
2oldB-5c6wH:
14.1		 2oldA-5c6wH:
28.96
2oldB-5c6wH:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6w PROTEIN
IGHV1-69-2,IG LAMBDA
CHAIN V-II REGION
NIG-84

(Homo sapiens) 		PF07686
(V-set) 		4 TYR H1038
PRO H1046
TYR H1089
TYR H  95
 None
 0.60A 2oldA-5c6wH:
14.2
2oldB-5c6wH:
14.1		 2oldA-5c6wH:
28.96
2oldB-5c6wH:
28.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta;
Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.42A 2oldA-5dd5H:
13.0
2oldB-5dd5H:
16.9		 2oldA-5dd5H:
31.65
2oldB-5dd5H:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN

(Macaca mulatta;
Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.39A 2oldA-5dd5L:
16.1
2oldB-5dd5L:
20.0		 2oldA-5dd5L:
42.11
2oldB-5dd5L:
42.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  35
PRO B  43
TYR B  86
TYR A  95
 None
 0.74A 2oldA-5esaB:
16.4
2oldB-5esaB:
21.4		 2oldA-5esaB:
46.85
2oldB-5esaB:
46.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f89 CAP248-2B HEAVY
CHAIN
CAP248-2B LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.74A 2oldA-5f89L:
6.1
2oldB-5f89L:
24.8		 2oldA-5f89L:
84.89
2oldB-5f89L:
84.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  35
PRO B  43
TYR B  86
TYR E  95
 None
 0.64A 2oldA-5fgcB:
16.1
2oldB-5fgcB:
21.3		 2oldA-5fgcB:
48.43
2oldB-5fgcB:
48.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR E  95
TYR B  35
PRO B  43
TYR B  86
 None
 0.69A 2oldA-5fgcE:
18.6
2oldB-5fgcE:
15.1		 2oldA-5fgcE:
29.08
2oldB-5fgcE:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR H  95
TYR L  38
PRO L  46
TYR L  89
 None
 0.67A 2oldA-5grjH:
13.5
2oldB-5grjH:
13.6		 2oldA-5grjH:
27.65
2oldB-5grjH:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grj AVELUMAB H CHAIN
AVELUMAB L CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  38
PRO L  46
TYR L  89
TYR H  95
 None
 0.61A 2oldA-5grjL:
21.7
2oldB-5grjL:
21.6		 2oldA-5grjL:
84.68
2oldB-5grjL:
84.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs0 LIGHT CHAIN
(ANTI-TLR3)
HEAVY CHAIN
(ANTI-TLR3)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR C  35
PRO C  43
TYR C  86
TYR D  98
 None
 0.67A 2oldA-5gs0C:
19.3
2oldB-5gs0C:
19.2		 2oldA-5gs0C:
59.13
2oldB-5gs0C:
59.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 LIGHT CHAIN
(ANTI-TLR3)
HEAVY CHAIN
(ANTI-TLR3)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR D  98
TYR C  35
PRO C  43
TYR C  86
 None
 0.71A 2oldA-5gs0D:
13.5
2oldB-5gs0D:
13.5		 2oldA-5gs0D:
23.58
2oldB-5gs0D:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 TYR A 129
HIS A  75
PRO A  74
TYR A 283
TYR A 275
 None
 1.23A 2oldA-5isoA:
undetectable
2oldB-5isoA:
undetectable		 2oldA-5isoA:
18.56
2oldB-5isoA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  38
PRO B  46
TYR B  89
TYR C  98
 None
 0.72A 2oldA-5j13B:
26.8
2oldB-5j13B:
18.7		 2oldA-5j13B:
66.94
2oldB-5j13B:
66.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR C  91
TYR D  36
PRO D  44
TYR D  87
 None
 0.68A 2oldA-5jz7C:
14.3
2oldB-5jz7C:
14.3		 2oldA-5jz7C:
21.65
2oldB-5jz7C:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR D  36
PRO D  44
TYR D  87
TYR C  91
 None
 0.65A 2oldA-5jz7D:
20.6
2oldB-5jz7D:
20.4		 2oldA-5jz7D:
39.27
2oldB-5jz7D:
39.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kve ZV-48 ANTIBODY SCFV
HEAVY CHAIN
ZV-48 ANTIBODY SCFV
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 PRO H  45
TYR H  91
TYR L  36
TYR L  87
 None
 0.72A 2oldA-5kveH:
15.5
2oldB-5kveH:
15.6		 2oldA-5kveH:
22.52
2oldB-5kveH:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kve ZV-48 ANTIBODY SCFV
HEAVY CHAIN
ZV-48 ANTIBODY SCFV
LIGHT CHAIN

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  36
TYR L  87
PRO H  45
TYR H  91
 None
 0.67A 2oldA-5kveL:
17.2
2oldB-5kveL:
17.1		 2oldA-5kveL:
26.79
2oldB-5kveL:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR H  95
TYR L  38
PRO L  46
TYR L  89
 None
 0.71A 2oldA-5ngvH:
15.3
2oldB-5ngvH:
15.3		 2oldA-5ngvH:
19.74
2oldB-5ngvH:
19.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR L  38
PRO L  46
TYR L  89
TYR H  95
 None
 0.66A 2oldA-5ngvL:
20.7
2oldB-5ngvL:
20.7		 2oldA-5ngvL:
45.93
2oldB-5ngvL:
45.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR A  95
TYR B  36
PRO B  44
TYR B  87
 None
 0.72A 2oldA-5odbA:
13.0
2oldB-5odbA:
17.5		 2oldA-5odbA:
undetectable
2oldB-5odbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odb D10 FAB FRAGMENT -
HEAVY CHAIN
D10 FAB FRAGMENT -
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR B  36
PRO B  44
TYR B  87
TYR A  95
 None
 0.67A 2oldA-5odbB:
26.1
2oldB-5odbB:
19.8		 2oldA-5odbB:
undetectable
2oldB-5odbB:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5te6 HEAVY CHAIN OF N6
LIGHT CHAIN OF N6

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.67A 2oldA-5te6H:
16.9
2oldB-5te6H:
17.4		 2oldA-5te6H:
31.30
2oldB-5te6H:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5te6 HEAVY CHAIN OF N6
LIGHT CHAIN OF N6

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.64A 2oldA-5te6L:
15.9
2oldB-5te6L:
19.5		 2oldA-5te6L:
42.48
2oldB-5te6L:
42.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3k DH511.2 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 4 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.40A 2oldA-5u3kL:
16.2
2oldB-5u3kL:
20.3		 2oldA-5u3kL:
41.96
2oldB-5u3kL:
41.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3n DH511.12P FAB HEAVY
CHAIN
DH511.12P FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.51A 2oldA-5u3nH:
14.2
2oldB-5u3nH:
17.0		 2oldA-5u3nH:
31.56
2oldB-5u3nH:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3n DH511.12P FAB HEAVY
CHAIN
DH511.12P FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.45A 2oldA-5u3nL:
21.5
2oldB-5u3nL:
19.3		 2oldA-5u3nL:
43.69
2oldB-5u3nL:
43.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.49A 2oldA-5u3pH:
11.6
2oldB-5u3pH:
17.1		 2oldA-5u3pH:
32.20
2oldB-5u3pH:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		5 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.42A 2oldA-5u3pL:
21.5
2oldB-5u3pL:
20.1		 2oldA-5u3pL:
41.07
2oldB-5u3pL:
41.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u68 MPE8

(Homo sapiens) 		PF07686
(V-set) 		4 TYR E 201
PRO E 209
TYR E 252
TYR E 114
 None
 0.70A 2oldA-5u68E:
18.9
2oldB-5u68E:
18.8		 2oldA-5u68E:
24.09
2oldB-5u68E:
24.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
ANTIBODY PGT144 FAB
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		5 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.75A 2oldA-5uy3L:
16.0
2oldB-5uy3L:
20.2		 2oldA-5uy3L:
40.44
2oldB-5uy3L:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
HEAVY CHAIN
BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR E  34
PRO E  42
TYR E  85
PRO D  45
 None
 0.73A 2oldA-5wduE:
17.1
2oldB-5wduE:
17.0		 2oldA-5wduE:
undetectable
2oldB-5wduE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR A  95
TYR B  37
PRO B  45
TYR B  88
 None
 0.73A 2oldA-5xj3A:
14.0
2oldB-5xj3A:
14.0		 2oldA-5xj3A:
undetectable
2oldB-5xj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 TYR B  37
PRO B  45
TYR B  88
TYR A  95
 None
 0.67A 2oldA-5xj3B:
18.2
2oldB-5xj3B:
18.1		 2oldA-5xj3B:
undetectable
2oldB-5xj3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR H 103
TYR L  42
PRO L  50
TYR L 103
 None
 0.71A 2oldA-5xs7H:
12.9
2oldB-5xs7H:
13.0		 2oldA-5xs7H:
20.18
2oldB-5xs7H:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 TYR L  42
PRO L  50
TYR L 103
TYR H 103
 None
 0.64A 2oldA-5xs7L:
17.4
2oldB-5xs7L:
17.2		 2oldA-5xs7L:
27.18
2oldB-5xs7L:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5


(;
) 		no annotation
no annotation 		4 TYR C  91
TYR D  37
PRO D  45
TYR D  88
 None
 0.60A 2oldA-5yy5C:
13.2
2oldB-5yy5C:
13.3		 2oldA-5yy5C:
undetectable
2oldB-5yy5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy5


(;
) 		no annotation
no annotation 		4 TYR D  37
PRO D  45
TYR D  88
TYR C  91
 None
 0.54A 2oldA-5yy5D:
19.3
2oldB-5yy5D:
19.4		 2oldA-5yy5D:
undetectable
2oldB-5yy5D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bck N49P7 FAB HEAVY
CHAIN OF N29P7 IGG
N49P7 FAB LIGHT
CHAIN FROM N49P7 IGG

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 HIS L  38
PRO L  44
PRO H  45
TYR H  91
 None
 0.66A 2oldA-6bckL:
25.3
2oldB-6bckL:
18.3		 2oldA-6bckL:
undetectable
2oldB-6bckL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 TYR F  41
PRO F  49
TYR F  92
TYR G  96
 None
 0.64A 2oldA-6cnkF:
15.7
2oldB-6cnkF:
18.9		 2oldA-6cnkF:
undetectable
2oldB-6cnkF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnk IGG1 KAPPA LIGHT
CHAIN
IGG1 HEAVY CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 TYR G  96
TYR F  41
PRO F  49
TYR F  92
 None
 0.68A 2oldA-6cnkG:
12.0
2oldB-6cnkG:
15.4		 2oldA-6cnkG:
undetectable
2oldB-6cnkG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehy SCFV ANTIBODY
FRAGMENT

(Homo sapiens) 		no annotation 4 TYR A 174
PRO A 182
TYR A 225
TYR A  95
 None
 0.74A 2oldA-6ehyA:
14.8
2oldB-6ehyA:
14.7		 2oldA-6ehyA:
24.90
2oldB-6ehyA:
24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR A  35
PRO A  43
TYR A  86
TYR B  95
 None
 0.70A 2oldA-8fabA:
26.6
2oldB-8fabA:
20.8		 2oldA-8fabA:
76.04
2oldB-8fabA:
76.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR B  95
TYR A  35
PRO A  43
TYR A  86
 None
 0.74A 2oldA-8fabB:
13.6
2oldB-8fabB:
17.2		 2oldA-8fabB:
32.03
2oldB-8fabB:
32.03