SIMILAR PATTERNS OF AMINO ACIDS FOR 2OIQ_A_STIA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 101
VAL A  91
LEU A  84
ARG A 273
 None
 1.10A 2oiqA-1a2vA:
undetectable		 2oiqA-1a2vA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 150
VAL A  95
LEU A 120
ARG A 131
 None
 0.92A 2oiqA-1cs1A:
undetectable		 2oiqA-1cs1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7o GLUTAREDOXIN 2

(Escherichia
coli) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  28
VAL A 185
LEU A 182
MET A  17
 None
 0.98A 2oiqA-1g7oA:
undetectable		 2oiqA-1g7oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
VAL A  58
LEU A   8
MET A  95
 None
 0.95A 2oiqA-1iovA:
undetectable		 2oiqA-1iovA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 229
VAL A 364
LEU A 368
ARG A 380
 None
 0.90A 2oiqA-1jhdA:
undetectable		 2oiqA-1jhdA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 239
LEU A 243
MET A 269
ARG A 313
 None
 0.97A 2oiqA-1k9aA:
30.9		 2oiqA-1k9aA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 232
VAL A 108
LEU A  38
ARG A  11
 None
 1.11A 2oiqA-1qvrA:
undetectable		 2oiqA-1qvrA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 409
LEU A 413
MET A 438
ARG A 481
 None
 0.83A 2oiqA-1snxA:
22.4		 2oiqA-1snxA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 643
LEU A 647
ARG A 791
 STI  A   3 ( 3.8A)
None
None
None
 0.96A 2oiqA-1t46A:
26.2		 2oiqA-1t46A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		4 LEU A   6
VAL A  27
LEU A  36
ARG A  13
 None
 0.87A 2oiqA-1txoA:
undetectable		 2oiqA-1txoA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 397
VAL A 262
LEU A 266
ARG A 380
 None
 1.09A 2oiqA-1uqwA:
undetectable		 2oiqA-1uqwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		4 LEU A 156
VAL A  24
LEU A  96
ARG A 359
 None
 1.06A 2oiqA-1v4vA:
undetectable		 2oiqA-1v4vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		4 LEU A 211
VAL A  43
LEU A 101
ARG A 122
 None
 1.09A 2oiqA-1vd6A:
undetectable		 2oiqA-1vd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 LEU A 327
VAL A 313
LEU A 240
ARG A 279
 LEU  A 327 ( 0.5A)
VAL  A 313 ( 0.6A)
LEU  A 240 ( 0.6A)
ARG  A 279 ( 0.6A)
 1.10A 2oiqA-1vhoA:
undetectable		 2oiqA-1vhoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		4 LEU A 139
VAL A  14
LEU A 179
ARG A 194
 None
 1.11A 2oiqA-1vzyA:
undetectable		 2oiqA-1vzyA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A 311
VAL A 345
LEU A 276
ARG A 224
 None
 0.98A 2oiqA-1x1qA:
undetectable		 2oiqA-1x1qA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep) 		4 LEU E 313
VAL A 396
LEU A 400
MET E 307
 None
 0.95A 2oiqA-1xlsE:
undetectable		 2oiqA-1xlsE:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zub REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 LEU A 645
VAL A 614
LEU A 616
ARG A 665
 None
 1.06A 2oiqA-1zubA:
undetectable		 2oiqA-1zubA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 LEU A  39
VAL A 205
LEU A 198
ARG A  58
 None
 1.12A 2oiqA-2bi3A:
undetectable		 2oiqA-2bi3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 401
VAL A 392
LEU A 477
ARG A 467
 None
 1.12A 2oiqA-2d1cA:
undetectable		 2oiqA-2d1cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9q GRANULOCYTE
COLONY-STIMULATING
FACTOR RECEPTOR

(Homo sapiens) 		PF06328
(Lep_receptor_Ig) 		4 LEU B 245
VAL B 202
LEU B 112
MET B 208
 None
 0.99A 2oiqA-2d9qB:
undetectable		 2oiqA-2d9qB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 403
VAL A 160
LEU A 361
MET A 256
ARG A 126
 None
None
HEM  A 430 (-4.7A)
None
None
 1.46A 2oiqA-2dkkA:
undetectable		 2oiqA-2dkkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 327
VAL A 283
LEU A  89
ARG A 269
 None
 0.98A 2oiqA-2elcA:
undetectable		 2oiqA-2elcA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 746
VAL A 371
LEU A 398
ARG A 384
 None
 0.96A 2oiqA-2f3oA:
undetectable		 2oiqA-2f3oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 VAL A 356
LEU A 360
MET A 468
ARG A 322
 None
 1.09A 2oiqA-2gq0A:
undetectable		 2oiqA-2gq0A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LEU A 317
MET A 341
ARG A 385
 H8H  A 534 (-3.8A)
None
None
None
 0.75A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 291
LEU A 295
MET A 319
 1BM  A 499 ( 3.7A)
None
None
None
 0.71A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
LEU A 295
MET A 319
ARG A 363
 None
 0.89A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
VAL A 289
MET A 318
ARG A 362
 GIN  A 600 ( 4.6A)
None
None
None
 0.87A 2oiqA-2hz0A:
32.1		 2oiqA-2hz0A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 LEU A  70
VAL A 160
LEU A  90
ARG A 143
 None
 1.11A 2oiqA-2id3A:
undetectable		 2oiqA-2id3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
MET B 195
ARG B 235
 None
 1.06A 2oiqA-2ippB:
undetectable		 2oiqA-2ippB:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LEU A 295
MET A 319
ARG A 363
 None
1N8  A 501 ( 3.9A)
1N8  A 501 ( 4.4A)
None
 0.73A 2oiqA-2og8A:
29.3		 2oiqA-2og8A:
67.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 VAL A  91
LEU A  95
MET A 156
ARG A  63
 None
 1.02A 2oiqA-2ohhA:
undetectable		 2oiqA-2ohhA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbh PROCATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.11A 2oiqA-2pbhA:
undetectable		 2oiqA-2pbhA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 LEU A 752
VAL A 541
LEU A 539
ARG A 492
 None
 0.91A 2oiqA-2r6fA:
undetectable		 2oiqA-2r6fA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 LEU A 119
VAL A  27
LEU A  85
ARG A  34
 D12  A1008 ( 4.6A)
None
None
None
 1.09A 2oiqA-2ynkA:
undetectable		 2oiqA-2ynkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 195
LEU A 206
MET A 266
ARG A 238
 None
 0.91A 2oiqA-3a31A:
undetectable		 2oiqA-3a31A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 LEU A 373
VAL A 155
MET A 273
ARG A 139
 None
 1.09A 2oiqA-3b1bA:
undetectable		 2oiqA-3b1bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 LEU A  34
VAL A 153
LEU A 155
ARG A 145
 None
None
None
CIT  A 302 (-4.3A)
 1.06A 2oiqA-3cswA:
undetectable		 2oiqA-3cswA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 239
LEU A 243
MET A 269
ARG A 313
 None
 0.97A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 LEU A  81
VAL A 352
LEU A 348
ARG A 390
 None
 1.11A 2oiqA-3do6A:
undetectable		 2oiqA-3do6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 LEU D 442
VAL A 396
LEU A 400
ARG A 371
 None
 1.10A 2oiqA-3dzuD:
undetectable		 2oiqA-3dzuD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum) 		PF02645
(DegV) 		4 LEU A 229
VAL A  17
LEU A  13
ARG A 112
 None
None
None
MLY  A 115 ( 4.4A)
 1.05A 2oiqA-3eglA:
undetectable		 2oiqA-3eglA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A 225
VAL A 173
LEU A 180
ARG A 282
 None
 1.12A 2oiqA-3f7wA:
7.6		 2oiqA-3f7wA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		4 LEU A 236
VAL A 361
LEU A 382
ARG A 376
 None
 1.10A 2oiqA-3gg0A:
undetectable		 2oiqA-3gg0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu0 TRIGGER FACTOR

(Thermotoga
maritima) 		PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 LEU A 384
VAL A 397
LEU A 398
ARG A 338
 None
 1.06A 2oiqA-3gu0A:
2.1		 2oiqA-3gu0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A 344
VAL A  48
LEU A  17
MET A 136
 None
 0.99A 2oiqA-3hfwA:
undetectable		 2oiqA-3hfwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir4 GLUTAREDOXIN 2

(Salmonella
enterica) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  28
VAL A 185
LEU A 182
MET A  17
 None
 1.05A 2oiqA-3ir4A:
undetectable		 2oiqA-3ir4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		4 LEU P 200
VAL P 281
LEU P 345
ARG P 245
 None
 0.91A 2oiqA-3izyP:
undetectable		 2oiqA-3izyP:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3p D-ALANINE--D-ALANINE
LIGASE

(Streptococcus
mutans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 280
VAL A  89
LEU A   9
MET A 126
 None
 0.91A 2oiqA-3k3pA:
undetectable		 2oiqA-3k3pA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.08A 2oiqA-3k9mA:
undetectable		 2oiqA-3k9mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9b PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF16450
(Prot_ATP_ID_OB) 		4 LEU A 192
VAL A 149
LEU A 143
ARG A 123
 None
 1.06A 2oiqA-3m9bA:
undetectable		 2oiqA-3m9bA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		4 LEU A 250
VAL A 263
LEU A 264
ARG A 236
 None
None
None
UNX  A 339 ( 3.6A)
 1.06A 2oiqA-3md0A:
undetectable		 2oiqA-3md0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		4 LEU A 246
VAL A 259
LEU A 260
ARG A 232
 None
 0.90A 2oiqA-3nxsA:
undetectable		 2oiqA-3nxsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pru PHYCOBILISOME 32.1
KDA LINKER
POLYPEPTIDE,
PHYCOCYANIN-ASSOCIAT
ED, ROD 1

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU C  29
VAL C  43
LEU C  44
ARG C  74
 None
 1.08A 2oiqA-3pruC:
undetectable		 2oiqA-3pruC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		4 LEU A 175
VAL A 220
LEU A 223
ARG A 164
 None
 1.02A 2oiqA-3re1A:
undetectable		 2oiqA-3re1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  32
LEU A 213
MET A  39
ARG A 192
 None
 1.11A 2oiqA-3stpA:
undetectable		 2oiqA-3stpA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		4 LEU A 162
VAL A  44
LEU A  46
ARG A  65
 None
 1.10A 2oiqA-3tevA:
undetectable		 2oiqA-3tevA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		4 LEU A 132
VAL A 173
LEU A 181
ARG A  38
 None
AMP  A 280 (-3.9A)
AMP  A 280 (-4.4A)
None
 1.08A 2oiqA-3uk2A:
undetectable		 2oiqA-3uk2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 LEU A 233
VAL A 219
LEU A 221
ARG A 149
 None
 0.84A 2oiqA-3wy7A:
undetectable		 2oiqA-3wy7A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		4 LEU A 156
VAL A 458
LEU A 413
MET A 151
 None
 1.10A 2oiqA-3zmrA:
undetectable		 2oiqA-3zmrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 229
VAL A 364
LEU A 368
ARG A 206
 None
 1.09A 2oiqA-4dnxA:
undetectable		 2oiqA-4dnxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 229
VAL A 364
LEU A 368
ARG A 380
 None
 0.93A 2oiqA-4dnxA:
undetectable		 2oiqA-4dnxA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
VAL A 423
LEU A 427
ARG A 493
 0SB  A 701 ( 3.9A)
None
None
SO4  A 702 (-3.0A)
 0.80A 2oiqA-4f4pA:
30.4		 2oiqA-4f4pA:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE

(Salmonella
enterica) 		no annotation 4 LEU D 194
VAL D  51
LEU D  47
MET D 197
 None
 1.03A 2oiqA-4g81D:
undetectable		 2oiqA-4g81D:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		4 LEU A 180
VAL A 114
LEU A 187
ARG A 137
 None
 1.07A 2oiqA-4guzA:
undetectable		 2oiqA-4guzA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		4 LEU A   7
VAL A 420
LEU A 422
ARG A 442
 None
 1.07A 2oiqA-4gysA:
undetectable		 2oiqA-4gysA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		4 LEU A 894
VAL A 675
LEU A 707
ARG A 634
 None
 1.06A 2oiqA-4i15A:
undetectable		 2oiqA-4i15A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		4 LEU A  15
VAL A 133
LEU A 126
ARG A 279
 None
 1.01A 2oiqA-4k2xA:
undetectable		 2oiqA-4k2xA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 313
LEU A 317
MET A 341
ARG A 385
 VGG  A 601 (-3.2A)
None
None
None
None
 1.22A 2oiqA-4lggA:
29.6		 2oiqA-4lggA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		4 VAL A 329
LEU A 318
MET A 125
ARG A 363
 None
 1.03A 2oiqA-4o8oA:
undetectable		 2oiqA-4o8oA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqy (S)-IMINE REDUCTASE

(Streptomyces
sp. GF3546) 		PF03446
(NAD_binding_2) 		4 LEU A  42
VAL A  88
LEU A 115
MET A  14
 None
None
None
NDP  A1000 (-4.9A)
 0.78A 2oiqA-4oqyA:
undetectable		 2oiqA-4oqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		4 LEU A 180
VAL A 139
LEU A 140
ARG A 116
 None
 1.07A 2oiqA-4pl7A:
undetectable		 2oiqA-4pl7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A   5
VAL A 150
LEU A 148
ARG A  98
 None
 1.09A 2oiqA-4q0mA:
undetectable		 2oiqA-4q0mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhp UBIQUINONE
BIOSYNTHESIS PROTEIN
COQ9, MITOCHONDRIAL

(Homo sapiens) 		PF08511
(COQ9) 		4 LEU A 147
VAL A 160
LEU A 161
ARG A 191
 None
 1.12A 2oiqA-4rhpA:
undetectable		 2oiqA-4rhpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		4 LEU A  17
VAL A 111
LEU A 119
ARG A  72
 NDP  A 400 (-4.0A)
None
None
None
 1.12A 2oiqA-4tqgA:
undetectable		 2oiqA-4tqgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 VAL A  10
LEU A  14
MET A 101
ARG A 149
 None
 0.79A 2oiqA-4u2mA:
undetectable		 2oiqA-4u2mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 VAL A 141
LEU A 145
MET A 237
ARG A  18
 None
 0.68A 2oiqA-4u2mA:
undetectable		 2oiqA-4u2mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A  85
VAL A 145
LEU A 139
ARG A  47
 None
MG  A1250 (-4.7A)
None
None
 1.11A 2oiqA-4unfA:
undetectable		 2oiqA-4unfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		4 LEU A1321
VAL A1470
LEU A1289
MET A1125
 None
 1.06A 2oiqA-4w4tA:
undetectable		 2oiqA-4w4tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 173
LEU A 105
MET A 158
ARG A 112
 None
 1.03A 2oiqA-4wumA:
undetectable		 2oiqA-4wumA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 LEU A  51
VAL A  78
LEU A  82
ARG A 212
 None
 1.10A 2oiqA-4yfmA:
undetectable		 2oiqA-4yfmA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A   5
VAL A 150
LEU A 148
ARG A  98
 None
 1.04A 2oiqA-5b5uA:
undetectable		 2oiqA-5b5uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 156
VAL A 354
LEU A 358
ARG A 180
 None
 1.02A 2oiqA-5e6kA:
undetectable		 2oiqA-5e6kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 156
VAL A 354
LEU A 358
ARG A 180
 None
 1.03A 2oiqA-5enyA:
undetectable		 2oiqA-5enyA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin)
PF01798
(Nop) 		4 LEU A 122
VAL E 152
LEU E 150
ARG E 135
 None
None
None
SAH  E 301 ( 4.8A)
 1.08A 2oiqA-5ginA:
undetectable		 2oiqA-5ginA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		4 LEU A 153
VAL A 238
LEU A 202
ARG A  23
 None
 1.08A 2oiqA-5hj5A:
undetectable		 2oiqA-5hj5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 325
VAL A1438
LEU A1439
ARG A 351
 None
 0.98A 2oiqA-5iy9A:
3.0		 2oiqA-5iy9A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		4 LEU A  24
VAL A 103
LEU A 114
ARG A  41
 None
 1.09A 2oiqA-5jigA:
undetectable		 2oiqA-5jigA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 LEU A  80
VAL A 116
LEU A 120
ARG A 168
 None
 1.06A 2oiqA-5ko3A:
undetectable		 2oiqA-5ko3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 4 LEU A  62
VAL A 120
LEU A 124
MET A  53
 None
 1.00A 2oiqA-5nzbA:
undetectable		 2oiqA-5nzbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Streptosporangium
roseum) 		no annotation 4 LEU A  42
VAL A  88
LEU A 115
MET A  14
 None
None
None
NAP  A 301 (-4.9A)
 1.04A 2oiqA-5ocmA:
undetectable		 2oiqA-5ocmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 4 LEU A 236
VAL A 246
LEU A 215
MET A 194
 None
 0.88A 2oiqA-5oevA:
undetectable		 2oiqA-5oevA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 354
VAL A 330
LEU A 334
ARG A 316
 None
 0.85A 2oiqA-5w70A:
undetectable		 2oiqA-5w70A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3r LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		no annotation 4 LEU A 103
VAL A  64
LEU A  63
ARG A  36
 None
 1.12A 2oiqA-5x3rA:
undetectable		 2oiqA-5x3rA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 207
VAL A 273
LEU A 276
ARG A  64
 None
 1.06A 2oiqA-5xnwA:
undetectable		 2oiqA-5xnwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		4 LEU A 102
VAL A 199
LEU A 190
ARG A 183
 None
 1.09A 2oiqA-6ao1A:
undetectable		 2oiqA-6ao1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 4 LEU A 602
VAL A 519
LEU A 533
ARG A 882
 None
 1.08A 2oiqA-6brsA:
undetectable		 2oiqA-6brsA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 LEU A1237
VAL A1253
LEU A 201
ARG A1249
 None
 1.12A 2oiqA-6byoA:
3.0		 2oiqA-6byoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1
IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 LEU A 540
VAL B  23
LEU B  88
ARG B 109
 None
 1.10A 2oiqA-6faeA:
undetectable		 2oiqA-6faeA:
13.24