SIMILAR PATTERNS OF AMINO ACIDS FOR 2OIQ_A_STIA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.72A 2oiqA-1k9aA:
30.9		 2oiqA-1k9aA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
 None
 0.61A 2oiqA-1k9aA:
30.9		 2oiqA-1k9aA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 588
ALA A 606
LYS A 608
TYR A 656
GLY A 660
LEU A 731
ALA A 741
ASP A 742
 None
 0.70A 2oiqA-1lufA:
28.0		 2oiqA-1lufA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 588
LYS A 608
MET A 629
TYR A 656
GLY A 660
LEU A 731
ALA A 741
ASP A 742
 None
 0.98A 2oiqA-1lufA:
28.0		 2oiqA-1lufA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 332
THR A 334
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.69A 2oiqA-1opkA:
31.7		 2oiqA-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.64A 2oiqA-1t46A:
26.2		 2oiqA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-3.9A)
 0.82A 2oiqA-1t46A:
26.2		 2oiqA-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.51A 2oiqA-1u59A:
30.7		 2oiqA-1u59A:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
LEU A 158
 None
 0.68A 2oiqA-1u5qA:
24.2		 2oiqA-1u5qA:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL X  25
ALA X  37
GLU X  54
MET X  58
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.66A 2oiqA-2dq7X:
35.8		 2oiqA-2dq7X:
84.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
ILE X  80
THR X  82
TYR X  84
GLY X  88
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.69A 2oiqA-2dq7X:
35.8		 2oiqA-2dq7X:
84.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 170
ALA A 184
LYS A 186
GLU A 201
ILE A 234
GLY A 240
LEU A 290
ALA A 319
 None
 1.11A 2oiqA-2eu9A:
22.0		 2oiqA-2eu9A:
25.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
TYR A 107
GLY A 110
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.55A 2oiqA-2gcdA:
25.2		 2oiqA-2gcdA:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
ILE A 336
THR A 338
TYR A 340
GLY A 344
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.75A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.65A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
GLU A 678
MET A 682
ILE A 705
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.69A 2oiqA-2henA:
27.2		 2oiqA-2henA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.96A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.42A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 269
GLU A 286
MET A 290
ILE A 313
THR A 315
GLY A 321
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.69A 2oiqA-2hz0A:
32.1		 2oiqA-2hz0A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 256
ALA A 269
GLU A 286
MET A 290
ILE A 313
THR A 315
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.62A 2oiqA-2hz0A:
32.1		 2oiqA-2hz0A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 2oiqA-2j0jA:
32.8		 2oiqA-2j0jA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.62A 2oiqA-2j0jA:
32.8		 2oiqA-2j0jA:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
MET A 475
ILE A 497
GLY A 505
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
None
None
BII  A1687 (-3.6A)
None
 0.75A 2oiqA-2jkmA:
32.2		 2oiqA-2jkmA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.62A 2oiqA-2jkmA:
32.2		 2oiqA-2jkmA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
TYR A 318
GLY A 322
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.47A 2oiqA-2og8A:
29.3		 2oiqA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
 0.74A 2oiqA-2og8A:
29.3		 2oiqA-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 614
GLU A 633
MET A 637
THR A 663
TYR A 665
GLY A 669
LEU A 785
ASP A 796
 None
 0.74A 2oiqA-2ogvA:
20.5		 2oiqA-2ogvA:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
MET A 637
THR A 663
TYR A 665
GLY A 669
LEU A 785
 None
 0.78A 2oiqA-2ogvA:
20.5		 2oiqA-2ogvA:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 838
ALA A 853
LYS A 855
TYR A 904
GLY A 908
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-3.8A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.59A 2oiqA-2p4iA:
24.0		 2oiqA-2p4iA:
33.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.71A 2oiqA-2psqA:
30.6		 2oiqA-2psqA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
LEU A 807
ASP A 818
 None
 0.85A 2oiqA-2r2pA:
32.8		 2oiqA-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.65A 2oiqA-2r2pA:
32.8		 2oiqA-2r2pA:
43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  85
ALA A  98
LYS A 100
GLU A 119
TYR A 150
LEU A 202
ALA A 212
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
 0.73A 2oiqA-2vd5A:
20.2		 2oiqA-2vd5A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 2oiqA-2xikA:
19.6		 2oiqA-2xikA:
29.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
TYR A 701
GLY A 705
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.61A 2oiqA-2xyuA:
27.9		 2oiqA-2xyuA:
43.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
TYR A 701
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
None
 0.63A 2oiqA-2xyuA:
27.9		 2oiqA-2xyuA:
43.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 313
ALA A 326
LYS A 328
GLU A 346
ILE A 374
TYR A 378
GLY A 382
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-4.6A)
770  A 901 (-3.9A)
None
770  A 901 (-4.2A)
770  A 901 (-3.4A)
 0.67A 2oiqA-2z2wA:
7.7		 2oiqA-2z2wA:
25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 261
ALA A 273
MET A 294
ILE A 317
THR A 319
GLY A 325
LEU A 374
ALA A 384
 None
 0.93A 2oiqA-2zv7A:
34.7		 2oiqA-2zv7A:
64.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.71A 2oiqA-3b2tA:
24.6		 2oiqA-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A1092
ALA A1108
GLU A1127
MET A1131
TYR A1159
GLY A1163
ALA A1221
ASP A1222
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 ( 4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.98A 2oiqA-3c1xA:
26.6		 2oiqA-3c1xA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.74A 2oiqA-3c4fA:
25.0		 2oiqA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.78A 2oiqA-3c4fA:
25.0		 2oiqA-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.72A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
ILE A 264
THR A 266
TYR A 268
 None
 0.62A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.70A 2oiqA-3dkoA:
32.9		 2oiqA-3dkoA:
41.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
LYS A 665
ILE A 709
GLY A 717
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.71A 2oiqA-3dkoA:
32.9		 2oiqA-3dkoA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
LYS A  38
GLU A  50
MET A  54
TYR A 119
LEU A 173
 None
DRK  A 384 (-3.5A)
None
None
None
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.75A 2oiqA-3eb0A:
21.8		 2oiqA-3eb0A:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
TYR A 911
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
None
 0.73A 2oiqA-3hngA:
31.0		 2oiqA-3hngA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		9 VAL A  67
ALA A  80
LYS A  82
MET A 104
TYR A 131
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 0.88A 2oiqA-3iecA:
22.4		 2oiqA-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 VAL A  67
LYS A  82
GLU A 100
MET A 104
GLY A 135
LEU A 182
ALA A 192
ASP A 193
 None
 1.06A 2oiqA-3iecA:
22.4		 2oiqA-3iecA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.65A 2oiqA-3kulA:
33.2		 2oiqA-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
GLY A 719
 None
None
None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
 0.76A 2oiqA-3kulA:
33.2		 2oiqA-3kulA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.61A 2oiqA-3mdyA:
24.3		 2oiqA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.62A 2oiqA-3mdyA:
24.3		 2oiqA-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
None
 0.72A 2oiqA-3my0A:
24.8		 2oiqA-3my0A:
27.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		10 VAL A 565
ALA A 576
LYS A 578
GLU A 596
MET A 600
ILE A 623
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.77A 2oiqA-3ppzA:
29.4		 2oiqA-3ppzA:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 368
GLU A 384
MET A 388
THR A 413
TYR A 415
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.96A 2oiqA-3s95A:
24.8		 2oiqA-3s95A:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 431
ALA A 443
MET A 464
ILE A 487
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.72A 2oiqA-3sxsA:
31.5		 2oiqA-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.71A 2oiqA-3tt0A:
30.5		 2oiqA-3tt0A:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
GLU A 125
TYR A 156
GLY A 160
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
None
 0.78A 2oiqA-4aw2A:
20.1		 2oiqA-4aw2A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
GLU A  81
ILE A 108
GLY A 116
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.66A 2oiqA-4bc6A:
21.5		 2oiqA-4bc6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.96A 2oiqA-4cfhA:
22.7		 2oiqA-4cfhA:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
TYR A 703
GLY A 707
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.78A 2oiqA-4ckrA:
31.1		 2oiqA-4ckrA:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
GLU A 705
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.77A 2oiqA-4crsA:
4.8		 2oiqA-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A 416
ALA A 429
LYS A 431
GLU A 442
ILE A 469
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.62A 2oiqA-4g3fA:
21.8		 2oiqA-4g3fA:
26.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
GLU A 871
TYR A 904
GLY A 908
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.62A 2oiqA-4hviA:
29.6		 2oiqA-4hviA:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 486
ALA A 506
GLU A 525
MET A 529
TYR A 557
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.91A 2oiqA-4k33A:
25.6		 2oiqA-4k33A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  50
ALA A  61
LYS A  63
GLU A  77
TYR A 106
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.73A 2oiqA-4l52A:
21.0		 2oiqA-4l52A:
31.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
ILE A 336
TYR A 340
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
 0.70A 2oiqA-4lggA:
16.4		 2oiqA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
MET A 314
ILE A 336
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.91A 2oiqA-4lggA:
16.4		 2oiqA-4lggA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.86A 2oiqA-4o27B:
19.0		 2oiqA-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL B  38
ALA B  51
GLU B  70
ILE B  97
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.77A 2oiqA-4o27B:
19.0		 2oiqA-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
MET A 667
ILE A 690
THR A 692
TYR A 694
ASP A 757
 None
 0.77A 2oiqA-4p2kA:
32.4		 2oiqA-4p2kA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.65A 2oiqA-4rt7A:
25.5		 2oiqA-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 VAL A  22
ALA A  35
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.87A 2oiqA-4ueuA:
34.2		 2oiqA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
TYR A  83
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
 0.67A 2oiqA-4ueuA:
34.2		 2oiqA-4ueuA:
62.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
MET A  56
ILE A  79
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.76A 2oiqA-4ueuA:
34.2		 2oiqA-4ueuA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
ILE A 124
GLY A 132
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.83A 2oiqA-4wsqA:
22.6		 2oiqA-4wsqA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
GLY A 556
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 2oiqA-4xcuA:
30.4		 2oiqA-4xcuA:
39.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
MET B 309
ILE B 332
THR B 334
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.59A 2oiqA-4xeyB:
32.6		 2oiqA-4xeyB:
36.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.65A 2oiqA-4xufA:
25.1		 2oiqA-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
LYS A 644
MET A 665
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.85A 2oiqA-4xufA:
25.1		 2oiqA-4xufA:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 VAL A 416
ALA A 428
ILE A 472
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.64A 2oiqA-4y93A:
30.9		 2oiqA-4y93A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 477
ALA A 488
LYS A 490
GLU A 509
ILE A 537
THR A 539
TYR A 541
GLY A 545
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.74A 2oiqA-4yffA:
20.1		 2oiqA-4yffA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.68A 2oiqA-5a46A:
31.0		 2oiqA-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 607
ALA A 625
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
GLY A 680
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.72A 2oiqA-5grnA:
26.3		 2oiqA-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
GLY A 680
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.8A)
 0.86A 2oiqA-5grnA:
26.3		 2oiqA-5grnA:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A  94
ALA A 105
ILE A 146
THR A 148
TYR A 150
GLY A 154
LEU A 215
 None
 0.51A 2oiqA-5gz8A:
18.8		 2oiqA-5gz8A:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  30
ALA A  43
LYS A  45
ILE A  80
THR A  82
TYR A  84
GLY A  88
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
032  A 401 (-4.2A)
032  A 401 ( 4.0A)
 0.52A 2oiqA-5hesA:
19.6		 2oiqA-5hesA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
ILE A 128
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.85A 2oiqA-5i3oA:
22.0		 2oiqA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  65
ALA A  77
LYS A  79
MET A  99
ILE A 128
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.72A 2oiqA-5i3oA:
22.0		 2oiqA-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
ILE A  88
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.74A 2oiqA-5j5tA:
21.6		 2oiqA-5j5tA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
GLU A 315
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.67A 2oiqA-5kbrA:
22.4		 2oiqA-5kbrA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
THR A 711
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
None
 0.65A 2oiqA-5l6oA:
32.7		 2oiqA-5l6oA:
41.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 106
ALA A 119
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 1.05A 2oiqA-5u7qA:
19.6		 2oiqA-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 8 ALA A  49
LYS A  51
GLU A  69
MET A  73
TYR A  98
GLY A 102
LEU A 150
ASP A 161
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.9A)
VX6  A 402 (-4.4A)
None
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 1.04A 2oiqA-5wnmA:
25.9		 2oiqA-5wnmA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 8 VAL A  36
ALA A  49
LYS A  51
GLU A  69
MET A  73
TYR A  98
GLY A 102
LEU A 150
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.9A)
VX6  A 402 (-4.4A)
None
VX6  A 402 (-4.3A)
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
 0.82A 2oiqA-5wnmA:
25.9		 2oiqA-5wnmA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.80A 2oiqA-5wnoA:
28.0		 2oiqA-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
LEU A 189
ALA A 199
 None
 1.02A 2oiqA-6c9dA:
21.7		 2oiqA-6c9dA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 VAL A  74
LYS A  89
GLU A 107
MET A 111
TYR A 138
GLY A 142
LEU A 189
ALA A 199
 None
 1.10A 2oiqA-6c9dA:
21.7		 2oiqA-6c9dA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 LEU A 101
VAL A  91
LEU A  84
ARG A 273
 None
 1.10A 2oiqA-1a2vA:
undetectable		 2oiqA-1a2vA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs1 PROTEIN
(CYSTATHIONINE
GAMMA-SYNTHASE)

(Escherichia
coli) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 150
VAL A  95
LEU A 120
ARG A 131
 None
 0.92A 2oiqA-1cs1A:
undetectable		 2oiqA-1cs1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7o GLUTAREDOXIN 2

(Escherichia
coli) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  28
VAL A 185
LEU A 182
MET A  17
 None
 0.98A 2oiqA-1g7oA:
undetectable		 2oiqA-1g7oA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 248
VAL A  58
LEU A   8
MET A  95
 None
 0.95A 2oiqA-1iovA:
undetectable		 2oiqA-1iovA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhd SULFATE
ADENYLYLTRANSFERASE

(Sulfur-oxidizing
endosymbiont of
Riftia
pachyptila) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 229
VAL A 364
LEU A 368
ARG A 380
 None
 0.90A 2oiqA-1jhdA:
undetectable		 2oiqA-1jhdA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 239
LEU A 243
MET A 269
ARG A 313
 None
 0.97A 2oiqA-1k9aA:
30.9		 2oiqA-1k9aA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 LEU A 232
VAL A 108
LEU A  38
ARG A  11
 None
 1.11A 2oiqA-1qvrA:
undetectable		 2oiqA-1qvrA:
16.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 409
LEU A 413
MET A 438
ARG A 481
 None
 0.83A 2oiqA-1snxA:
22.4		 2oiqA-1snxA:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 595
VAL A 643
LEU A 647
ARG A 791
 STI  A   3 ( 3.8A)
None
None
None
 0.96A 2oiqA-1t46A:
26.2		 2oiqA-1t46A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		4 LEU A   6
VAL A  27
LEU A  36
ARG A  13
 None
 0.87A 2oiqA-1txoA:
undetectable		 2oiqA-1txoA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 LEU A 397
VAL A 262
LEU A 266
ARG A 380
 None
 1.09A 2oiqA-1uqwA:
undetectable		 2oiqA-1uqwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		4 LEU A 156
VAL A  24
LEU A  96
ARG A 359
 None
 1.06A 2oiqA-1v4vA:
undetectable		 2oiqA-1v4vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		4 LEU A 211
VAL A  43
LEU A 101
ARG A 122
 None
 1.09A 2oiqA-1vd6A:
undetectable		 2oiqA-1vd6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 LEU A 327
VAL A 313
LEU A 240
ARG A 279
 LEU  A 327 ( 0.5A)
VAL  A 313 ( 0.6A)
LEU  A 240 ( 0.6A)
ARG  A 279 ( 0.6A)
 1.10A 2oiqA-1vhoA:
undetectable		 2oiqA-1vhoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		4 LEU A 139
VAL A  14
LEU A 179
ARG A 194
 None
 1.11A 2oiqA-1vzyA:
undetectable		 2oiqA-1vzyA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A 311
VAL A 345
LEU A 276
ARG A 224
 None
 0.98A 2oiqA-1x1qA:
undetectable		 2oiqA-1x1qA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens;
Mus musculus) 		PF00104
(Hormone_recep) 		4 LEU E 313
VAL A 396
LEU A 400
MET E 307
 None
 0.95A 2oiqA-1xlsE:
undetectable		 2oiqA-1xlsE:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zub REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 LEU A 645
VAL A 614
LEU A 616
ARG A 665
 None
 1.06A 2oiqA-1zubA:
undetectable		 2oiqA-1zubA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		4 LEU A  39
VAL A 205
LEU A 198
ARG A  58
 None
 1.12A 2oiqA-2bi3A:
undetectable		 2oiqA-2bi3A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 401
VAL A 392
LEU A 477
ARG A 467
 None
 1.12A 2oiqA-2d1cA:
undetectable		 2oiqA-2d1cA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9q GRANULOCYTE
COLONY-STIMULATING
FACTOR RECEPTOR

(Homo sapiens) 		PF06328
(Lep_receptor_Ig) 		4 LEU B 245
VAL B 202
LEU B 112
MET B 208
 None
 0.99A 2oiqA-2d9qB:
undetectable		 2oiqA-2d9qB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A 403
VAL A 160
LEU A 361
MET A 256
ARG A 126
 None
None
HEM  A 430 (-4.7A)
None
None
 1.46A 2oiqA-2dkkA:
undetectable		 2oiqA-2dkkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 LEU A 327
VAL A 283
LEU A  89
ARG A 269
 None
 0.98A 2oiqA-2elcA:
undetectable		 2oiqA-2elcA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 746
VAL A 371
LEU A 398
ARG A 384
 None
 0.96A 2oiqA-2f3oA:
undetectable		 2oiqA-2f3oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 VAL A 356
LEU A 360
MET A 468
ARG A 322
 None
 1.09A 2oiqA-2gq0A:
undetectable		 2oiqA-2gq0A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
LEU A 317
MET A 341
ARG A 385
 H8H  A 534 (-3.8A)
None
None
None
 0.75A 2oiqA-2h8hA:
33.8		 2oiqA-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 291
LEU A 295
MET A 319
 1BM  A 499 ( 3.7A)
None
None
None
 0.71A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
LEU A 295
MET A 319
ARG A 363
 None
 0.89A 2oiqA-2hk5A:
28.1		 2oiqA-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
VAL A 289
MET A 318
ARG A 362
 GIN  A 600 ( 4.6A)
None
None
None
 0.87A 2oiqA-2hz0A:
32.1		 2oiqA-2hz0A:
48.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 LEU A  70
VAL A 160
LEU A  90
ARG A 143
 None
 1.11A 2oiqA-2id3A:
undetectable		 2oiqA-2id3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipp CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU B 181
VAL B 246
MET B 195
ARG B 235
 None
 1.06A 2oiqA-2ippB:
undetectable		 2oiqA-2ippB:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
LEU A 295
MET A 319
ARG A 363
 None
1N8  A 501 ( 3.9A)
1N8  A 501 ( 4.4A)
None
 0.73A 2oiqA-2og8A:
29.3		 2oiqA-2og8A:
67.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 VAL A  91
LEU A  95
MET A 156
ARG A  63
 None
 1.02A 2oiqA-2ohhA:
undetectable		 2oiqA-2ohhA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbh PROCATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08127
(Propeptide_C1) 		4 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.11A 2oiqA-2pbhA:
undetectable		 2oiqA-2pbhA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 LEU A 752
VAL A 541
LEU A 539
ARG A 492
 None
 0.91A 2oiqA-2r6fA:
undetectable		 2oiqA-2r6fA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynk WZI

(Escherichia
coli) 		PF14052
(Caps_assemb_Wzi) 		4 LEU A 119
VAL A  27
LEU A  85
ARG A  34
 D12  A1008 ( 4.6A)
None
None
None
 1.09A 2oiqA-2ynkA:
undetectable		 2oiqA-2ynkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 LEU A 195
LEU A 206
MET A 266
ARG A 238
 None
 0.91A 2oiqA-3a31A:
undetectable		 2oiqA-3a31A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 LEU A 373
VAL A 155
MET A 273
ARG A 139
 None
 1.09A 2oiqA-3b1bA:
undetectable		 2oiqA-3b1bA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 LEU A  34
VAL A 153
LEU A 155
ARG A 145
 None
None
None
CIT  A 302 (-4.3A)
 1.06A 2oiqA-3cswA:
undetectable		 2oiqA-3cswA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 239
LEU A 243
MET A 269
ARG A 313
 None
 0.97A 2oiqA-3d7uA:
26.6		 2oiqA-3d7uA:
42.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 LEU A  81
VAL A 352
LEU A 348
ARG A 390
 None
 1.11A 2oiqA-3do6A:
undetectable		 2oiqA-3do6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 LEU D 442
VAL A 396
LEU A 400
ARG A 371
 None
 1.10A 2oiqA-3dzuD:
undetectable		 2oiqA-3dzuD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum) 		PF02645
(DegV) 		4 LEU A 229
VAL A  17
LEU A  13
ARG A 112
 None
None
None
MLY  A 115 ( 4.4A)
 1.05A 2oiqA-3eglA:
undetectable		 2oiqA-3eglA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 LEU A 225
VAL A 173
LEU A 180
ARG A 282
 None
 1.12A 2oiqA-3f7wA:
7.6		 2oiqA-3f7wA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		4 LEU A 236
VAL A 361
LEU A 382
ARG A 376
 None
 1.10A 2oiqA-3gg0A:
undetectable		 2oiqA-3gg0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gu0 TRIGGER FACTOR

(Thermotoga
maritima) 		PF05697
(Trigger_N)
PF05698
(Trigger_C) 		4 LEU A 384
VAL A 397
LEU A 398
ARG A 338
 None
 1.06A 2oiqA-3gu0A:
2.1		 2oiqA-3gu0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A 344
VAL A  48
LEU A  17
MET A 136
 None
 0.99A 2oiqA-3hfwA:
undetectable		 2oiqA-3hfwA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir4 GLUTAREDOXIN 2

(Salmonella
enterica) 		PF04399
(Glutaredoxin2_C)
PF13417
(GST_N_3) 		4 LEU A  28
VAL A 185
LEU A 182
MET A  17
 None
 1.05A 2oiqA-3ir4A:
undetectable		 2oiqA-3ir4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		4 LEU P 200
VAL P 281
LEU P 345
ARG P 245
 None
 0.91A 2oiqA-3izyP:
undetectable		 2oiqA-3izyP:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3p D-ALANINE--D-ALANINE
LIGASE

(Streptococcus
mutans) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 280
VAL A  89
LEU A   9
MET A 126
 None
 0.91A 2oiqA-3k3pA:
undetectable		 2oiqA-3k3pA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9m CATHEPSIN B

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 LEU A 181
VAL A 246
MET A 195
ARG A 235
 None
 1.08A 2oiqA-3k9mA:
undetectable		 2oiqA-3k9mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9b PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF16450
(Prot_ATP_ID_OB) 		4 LEU A 192
VAL A 149
LEU A 143
ARG A 123
 None
 1.06A 2oiqA-3m9bA:
undetectable		 2oiqA-3m9bA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE

(Mycobacterium
tuberculosis) 		PF03308
(ArgK) 		4 LEU A 250
VAL A 263
LEU A 264
ARG A 236
 None
None
None
UNX  A 339 ( 3.6A)
 1.06A 2oiqA-3md0A:
undetectable		 2oiqA-3md0A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE

(Mycolicibacterium
smegmatis) 		PF03308
(ArgK) 		4 LEU A 246
VAL A 259
LEU A 260
ARG A 232
 None
 0.90A 2oiqA-3nxsA:
undetectable		 2oiqA-3nxsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pru PHYCOBILISOME 32.1
KDA LINKER
POLYPEPTIDE,
PHYCOCYANIN-ASSOCIAT
ED, ROD 1

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU C  29
VAL C  43
LEU C  44
ARG C  74
 None
 1.08A 2oiqA-3pruC:
undetectable		 2oiqA-3pruC:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re1 UROPORPHYRINOGEN-III
SYNTHETASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02602
(HEM4) 		4 LEU A 175
VAL A 220
LEU A 223
ARG A 164
 None
 1.02A 2oiqA-3re1A:
undetectable		 2oiqA-3re1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  32
LEU A 213
MET A  39
ARG A 192
 None
 1.11A 2oiqA-3stpA:
undetectable		 2oiqA-3stpA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tev GLYCOSYL HYROLASE,
FAMILY 3

(Deinococcus
radiodurans) 		PF00933
(Glyco_hydro_3) 		4 LEU A 162
VAL A  44
LEU A  46
ARG A  65
 None
 1.10A 2oiqA-3tevA:
undetectable		 2oiqA-3tevA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		4 LEU A 132
VAL A 173
LEU A 181
ARG A  38
 None
AMP  A 280 (-3.9A)
AMP  A 280 (-4.4A)
None
 1.08A 2oiqA-3uk2A:
undetectable		 2oiqA-3uk2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 LEU A 233
VAL A 219
LEU A 221
ARG A 149
 None
 0.84A 2oiqA-3wy7A:
undetectable		 2oiqA-3wy7A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		4 LEU A 156
VAL A 458
LEU A 413
MET A 151
 None
 1.10A 2oiqA-3zmrA:
undetectable		 2oiqA-3zmrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 229
VAL A 364
LEU A 368
ARG A 206
 None
 1.09A 2oiqA-4dnxA:
undetectable		 2oiqA-4dnxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnx SULFATE
ADENYLYLTRANSFERASE

(Allochromatium
vinosum) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 229
VAL A 364
LEU A 368
ARG A 380
 None
 0.93A 2oiqA-4dnxA:
undetectable		 2oiqA-4dnxA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
VAL A 423
LEU A 427
ARG A 493
 0SB  A 701 ( 3.9A)
None
None
SO4  A 702 (-3.0A)
 0.80A 2oiqA-4f4pA:
30.4		 2oiqA-4f4pA:
37.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE

(Salmonella
enterica) 		no annotation 4 LEU D 194
VAL D  51
LEU D  47
MET D 197
 None
 1.03A 2oiqA-4g81D:
undetectable		 2oiqA-4g81D:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		4 LEU A 180
VAL A 114
LEU A 187
ARG A 137
 None
 1.07A 2oiqA-4guzA:
undetectable		 2oiqA-4guzA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		4 LEU A   7
VAL A 420
LEU A 422
ARG A 442
 None
 1.07A 2oiqA-4gysA:
undetectable		 2oiqA-4gysA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		4 LEU A 894
VAL A 675
LEU A 707
ARG A 634
 None
 1.06A 2oiqA-4i15A:
undetectable		 2oiqA-4i15A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		4 LEU A  15
VAL A 133
LEU A 126
ARG A 279
 None
 1.01A 2oiqA-4k2xA:
undetectable		 2oiqA-4k2xA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
VAL A 313
LEU A 317
MET A 341
ARG A 385
 VGG  A 601 (-3.2A)
None
None
None
None
 1.22A 2oiqA-4lggA:
29.6		 2oiqA-4lggA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		4 VAL A 329
LEU A 318
MET A 125
ARG A 363
 None
 1.03A 2oiqA-4o8oA:
undetectable		 2oiqA-4o8oA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqy (S)-IMINE REDUCTASE

(Streptomyces
sp. GF3546) 		PF03446
(NAD_binding_2) 		4 LEU A  42
VAL A  88
LEU A 115
MET A  14
 None
None
None
NDP  A1000 (-4.9A)
 0.78A 2oiqA-4oqyA:
undetectable		 2oiqA-4oqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl7 ACTIN,THYMOSIN
BETA-4

(Homo sapiens;
Komagataella
phaffii) 		PF00022
(Actin)
PF01290
(Thymosin) 		4 LEU A 180
VAL A 139
LEU A 140
ARG A 116
 None
 1.07A 2oiqA-4pl7A:
undetectable		 2oiqA-4pl7A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A   5
VAL A 150
LEU A 148
ARG A  98
 None
 1.09A 2oiqA-4q0mA:
undetectable		 2oiqA-4q0mA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhp UBIQUINONE
BIOSYNTHESIS PROTEIN
COQ9, MITOCHONDRIAL

(Homo sapiens) 		PF08511
(COQ9) 		4 LEU A 147
VAL A 160
LEU A 161
ARG A 191
 None
 1.12A 2oiqA-4rhpA:
undetectable		 2oiqA-4rhpA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE

(Megavirus
chiliensis) 		PF02719
(Polysacc_synt_2) 		4 LEU A  17
VAL A 111
LEU A 119
ARG A  72
 NDP  A 400 (-4.0A)
None
None
None
 1.12A 2oiqA-4tqgA:
undetectable		 2oiqA-4tqgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 VAL A  10
LEU A  14
MET A 101
ARG A 149
 None
 0.79A 2oiqA-4u2mA:
undetectable		 2oiqA-4u2mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 VAL A 141
LEU A 145
MET A 237
ARG A  18
 None
 0.68A 2oiqA-4u2mA:
undetectable		 2oiqA-4u2mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unf ENDONUCLEASE III-1

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		4 LEU A  85
VAL A 145
LEU A 139
ARG A  47
 None
MG  A1250 (-4.7A)
None
None
 1.11A 2oiqA-4unfA:
undetectable		 2oiqA-4unfA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4t MXAA

(Stigmatella
aurantiaca) 		PF07993
(NAD_binding_4) 		4 LEU A1321
VAL A1470
LEU A1289
MET A1125
 None
 1.06A 2oiqA-4w4tA:
undetectable		 2oiqA-4w4tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 173
LEU A 105
MET A 158
ARG A 112
 None
 1.03A 2oiqA-4wumA:
undetectable		 2oiqA-4wumA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfm BETA-LACTAMASE

(Mycobacteroides
abscessus) 		PF13354
(Beta-lactamase2) 		4 LEU A  51
VAL A  78
LEU A  82
ARG A 212
 None
 1.10A 2oiqA-4yfmA:
undetectable		 2oiqA-4yfmA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 LEU A   5
VAL A 150
LEU A 148
ARG A  98
 None
 1.04A 2oiqA-5b5uA:
undetectable		 2oiqA-5b5uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 156
VAL A 354
LEU A 358
ARG A 180
 None
 1.02A 2oiqA-5e6kA:
undetectable		 2oiqA-5e6kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 156
VAL A 354
LEU A 358
ARG A 180
 None
 1.03A 2oiqA-5enyA:
undetectable		 2oiqA-5enyA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin)
PF01798
(Nop) 		4 LEU A 122
VAL E 152
LEU E 150
ARG E 135
 None
None
None
SAH  E 301 ( 4.8A)
 1.08A 2oiqA-5ginA:
undetectable		 2oiqA-5ginA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		4 LEU A 153
VAL A 238
LEU A 202
ARG A  23
 None
 1.08A 2oiqA-5hj5A:
undetectable		 2oiqA-5hj5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A 325
VAL A1438
LEU A1439
ARG A 351
 None
 0.98A 2oiqA-5iy9A:
3.0		 2oiqA-5iy9A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		4 LEU A  24
VAL A 103
LEU A 114
ARG A  41
 None
 1.09A 2oiqA-5jigA:
undetectable		 2oiqA-5jigA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 LEU A  80
VAL A 116
LEU A 120
ARG A 168
 None
 1.06A 2oiqA-5ko3A:
undetectable		 2oiqA-5ko3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzb PROFILIN-2

(Betula pendula) 		no annotation 4 LEU A  62
VAL A 120
LEU A 124
MET A  53
 None
 1.00A 2oiqA-5nzbA:
undetectable		 2oiqA-5nzbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocm NAD_GLY3P_DH,
NAD-DEPENDENT
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Streptosporangium
roseum) 		no annotation 4 LEU A  42
VAL A  88
LEU A 115
MET A  14
 None
None
None
NAP  A 301 (-4.9A)
 1.04A 2oiqA-5ocmA:
undetectable		 2oiqA-5ocmA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 4 LEU A 236
VAL A 246
LEU A 215
MET A 194
 None
 0.88A 2oiqA-5oevA:
undetectable		 2oiqA-5oevA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 354
VAL A 330
LEU A 334
ARG A 316
 None
 0.85A 2oiqA-5w70A:
undetectable		 2oiqA-5w70A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3r LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		no annotation 4 LEU A 103
VAL A  64
LEU A  63
ARG A  36
 None
 1.12A 2oiqA-5x3rA:
undetectable		 2oiqA-5x3rA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 207
VAL A 273
LEU A 276
ARG A  64
 None
 1.06A 2oiqA-5xnwA:
undetectable		 2oiqA-5xnwA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		4 LEU A 102
VAL A 199
LEU A 190
ARG A 183
 None
 1.09A 2oiqA-6ao1A:
undetectable		 2oiqA-6ao1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 4 LEU A 602
VAL A 519
LEU A 533
ARG A 882
 None
 1.08A 2oiqA-6brsA:
undetectable		 2oiqA-6brsA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 4 LEU A1237
VAL A1253
LEU A 201
ARG A1249
 None
 1.12A 2oiqA-6byoA:
3.0		 2oiqA-6byoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae ADP-RIBOSYLATION
FACTOR 1
IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 LEU A 540
VAL B  23
LEU B  88
ARG B 109
 None
 1.10A 2oiqA-6faeA:
undetectable		 2oiqA-6faeA:
13.24