SIMILAR PATTERNS OF AMINO ACIDS FOR 2OC8_A_HU5A999_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE


(Escherichia
coli)
PF00266
(Aminotran_5)
5 ARG A  58
ILE A 179
GLY A 201
SER A 249
PHE A 253
None
1.00A 2oc8A-1bjnA:
0.0
2oc8A-1bjnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)


(Cupriavidus
necator)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 HIS A 294
ILE A 384
LEU A 402
GLY A 174
ALA A 380
None
0.99A 2oc8A-1bxnA:
0.0
2oc8A-1bxnA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)


(Hepacivirus C)
PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD)
11 GLN A  41
HIS A  57
ARG A 123
LEU A 135
GLY A 137
SER A 139
PHE A 154
ARG A 155
ALA A 156
ALA A 157
VAL A 158
None
0.76A 2oc8A-1cu1A:
31.2
2oc8A-1cu1A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN


(Lepidopteran
ambidensovirus
1)
PF02336
(Denso_VP4)
5 GLN A  79
ILE A 251
GLY A 351
ALA A  74
ALA A 354
None
0.96A 2oc8A-1dnvA:
undetectable
2oc8A-1dnvA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1es6 MATRIX PROTEIN VP40

(Ebola virus sp.)
PF07447
(VP40)
5 ILE A 142
LEU A 150
GLY A 153
ARG A  52
ALA A 114
None
0.94A 2oc8A-1es6A:
undetectable
2oc8A-1es6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE


(Paracoccus
pantotrophus)
PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3)
5 LEU A 438
GLY A 440
SER A 442
ALA A 471
VAL A 472
None
0.81A 2oc8A-1gq1A:
0.4
2oc8A-1gq1A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E


(Cellvibrio
japonicus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
5 ILE A  84
GLY A  90
ALA A 118
ALA A 117
VAL A 116
None
0.99A 2oc8A-1gqjA:
undetectable
2oc8A-1gqjA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Galdieria
partita)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 HIS A 292
ILE A 382
LEU A 400
GLY A 171
ALA A 378
None
0.97A 2oc8A-1iwaA:
undetectable
2oc8A-1iwaA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kc8 RIBOSOMAL PROTEIN
L14


(Haloarcula
marismortui)
PF00238
(Ribosomal_L14)
6 ILE L  53
GLY L  11
ARG L  75
ALA L  94
ALA L  95
VAL L  96
None
G  A1743 ( 3.0A)
None
None
None
None
1.50A 2oc8A-1kc8L:
undetectable
2oc8A-1kc8L:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 HIS A 197
LEU A 137
GLY A 140
ALA A 147
ALA A 148
MG  A 536 ( 4.3A)
None
ATP  A 535 (-2.8A)
MG  A 536 (-3.9A)
None
1.00A 2oc8A-1kvkA:
undetectable
2oc8A-1kvkA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo2 ERYTHRONOLIDE
SYNTHASE, MODULES 5
AND 6


(Saccharopolyspora
erythraea)
PF00975
(Thioesterase)
5 ARG A 202
LEU A  38
GLY A  40
SER A  42
ALA A 205
None
0.81A 2oc8A-1mo2A:
undetectable
2oc8A-1mo2A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
9 GLN A  41
ARG A 123
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
None
0.80A 2oc8A-1ns3A:
31.5
2oc8A-1ns3A:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
9 GLN A  41
HIS A  57
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
None
0.61A 2oc8A-1ns3A:
31.5
2oc8A-1ns3A:
81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
7 LEU A 135
GLY A 137
SER A 139
PHE A 154
ARG A 155
ALA A 156
ALA A 157
None
0.78A 2oc8A-1ns3A:
31.5
2oc8A-1ns3A:
81.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT


(Pseudomonas
putida)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 GLN A 106
ILE B 670
GLY B 509
ALA B 550
VAL B 551
MCN  B4921 ( 3.7A)
MCN  B4921 (-3.5A)
MCN  B4921 ( 4.3A)
MCN  B4921 (-3.1A)
None
1.00A 2oc8A-1t3qA:
undetectable
2oc8A-1t3qA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg THIAZOLE
BIOSYNTHESIS PROTEIN
THIG


(Bacillus
subtilis)
PF05690
(ThiG)
5 ARG A 183
ILE A 197
LEU A 222
GLY A 226
ALA A 185
None
0.87A 2oc8A-1tygA:
undetectable
2oc8A-1tygA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 LEU A 338
GLY A 117
ARG A 340
ALA A 313
VAL A 312
LEU  A 338 ( 0.6A)
GLY  A 117 ( 0.0A)
ARG  A 340 ( 0.6A)
ALA  A 313 ( 0.0A)
VAL  A 312 ( 0.6A)
0.99A 2oc8A-1wqaA:
undetectable
2oc8A-1wqaA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yg8 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Escherichia
coli)
PF00574
(CLP_protease)
5 ARG A 118
ILE A  63
LEU A 103
ALA A  96
ALA A  95
None
1.01A 2oc8A-1yg8A:
undetectable
2oc8A-1yg8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3q THAUMATIN-LIKE
PROTEIN


(Musa acuminata)
PF00314
(Thaumatin)
5 ILE A  33
ARG A  47
ALA A  16
ALA A  17
VAL A  18
None
0.90A 2oc8A-1z3qA:
undetectable
2oc8A-1z3qA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN


(Pyrococcus
horikoshii)
PF00005
(ABC_tran)
PF08402
(TOBE_2)
5 ARG A 182
ILE A 243
GLY A 225
ALA A 206
VAL A 204
None
1.01A 2oc8A-2d62A:
undetectable
2oc8A-2d62A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus)
PF01975
(SurE)
6 ILE A   3
LEU A  92
GLY A  94
ARG A 142
ALA A  22
ALA A  23
None
1.44A 2oc8A-2e6eA:
undetectable
2oc8A-2e6eA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewc CONSERVED
HYPOTHETICAL PROTEIN


(Streptococcus
pyogenes)
no annotation 5 HIS A 122
LEU A  53
GLY A  57
ALA A 118
VAL A 117
None
0.95A 2oc8A-2ewcA:
undetectable
2oc8A-2ewcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN


(Thermotoga
maritima)
PF13407
(Peripla_BP_4)
5 ILE A 194
LEU A 136
GLY A 197
ARG A 174
ALA A 205
None
0.89A 2oc8A-2fn9A:
undetectable
2oc8A-2fn9A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT


(Escherichia
coli)
PF00456
(Transketolase_N)
5 GLN A 204
LEU A 196
GLY A 200
ALA A 614
ALA A 613
None
0.96A 2oc8A-2g28A:
undetectable
2oc8A-2g28A:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Saccharomyces
cerevisiae)
no annotation 6 ILE A 129
LEU A 130
GLY A 132
ALA A 137
ALA A 138
VAL A  97
None
1.26A 2oc8A-2hsmA:
undetectable
2oc8A-2hsmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4k DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DELTA


(Bacillus
subtilis)
PF05066
(HARE-HTH)
5 ILE A  40
LEU A  36
PHE A  24
ALA A  20
VAL A  17
None
0.98A 2oc8A-2m4kA:
undetectable
2oc8A-2m4kA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pro ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes)
PF02983
(Pro_Al_protease)
6 ARG A  82
ILE A  40
GLY A  45
ALA A  66
ALA A  65
VAL A  64
None
1.06A 2oc8A-2proA:
undetectable
2oc8A-2proA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN


(Shigella
dysenteriae)
PF01497
(Peripla_BP_2)
5 GLN A 272
ILE A 186
LEU A 189
ARG A 146
ALA A 264
None
1.00A 2oc8A-2r7aA:
undetectable
2oc8A-2r7aA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 ILE A 790
LEU A 806
GLY A 843
ALA A 857
ALA A 846
None
0.90A 2oc8A-2vsqA:
undetectable
2oc8A-2vsqA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S


(Homo sapiens)
PF07679
(I-set)
5 ARG A  92
LEU A 122
PHE A  52
ALA A  50
VAL A  49
None
1.00A 2oc8A-2yd3A:
undetectable
2oc8A-2yd3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd7 PTPRD PROTEIN

(Homo sapiens)
PF07679
(I-set)
5 ARG A  83
LEU A 113
PHE A  43
ALA A  41
VAL A  40
None
0.92A 2oc8A-2yd7A:
undetectable
2oc8A-2yd7A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2


(Mus musculus)
PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2)
5 LEU A 196
GLY A 201
ALA A 204
ALA A 205
VAL A 206
None
0.87A 2oc8A-2zb3A:
undetectable
2oc8A-2zb3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG


(Escherichia
coli)
PF05368
(NmrA)
5 ARG A  49
ILE A  16
GLY A   9
ALA A  30
VAL A  29
None
None
NDP  A 400 (-2.9A)
None
None
0.95A 2oc8A-2zcvA:
undetectable
2oc8A-2zcvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis)
PF02645
(DegV)
5 ILE A 232
LEU A 121
PHE A 125
ALA A 229
ALA A 230
PLM  A 501 (-4.0A)
None
None
None
None
0.96A 2oc8A-3fysA:
undetectable
2oc8A-3fysA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
5 ILE A 293
LEU A 314
GLY A 311
ALA A 257
ALA A 256
None
1.00A 2oc8A-3gvpA:
undetectable
2oc8A-3gvpA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN 2


(Gallus gallus)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 ILE B  35
LEU B  29
GLY B  32
ALA B 220
VAL B 219
None
0.98A 2oc8A-3h1lB:
undetectable
2oc8A-3h1lB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN


(Burkholderia
mallei)
PF13458
(Peripla_BP_6)
5 HIS A 200
LEU A 253
GLY A 228
PHE A 175
ALA A 225
None
None
EDO  A   8 ( 4.0A)
AAE  A 501 (-3.6A)
None
1.00A 2oc8A-3i09A:
undetectable
2oc8A-3i09A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL


(Bos taurus)
PF00009
(GTP_EFTU)
PF11987
(IF-2)
6 GLN P 215
ILE P 376
LEU P 424
GLY P 404
ALA P 374
VAL P 359
None
1.20A 2oc8A-3izyP:
undetectable
2oc8A-3izyP:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
6 LEU A 168
GLY A 170
SER A 173
ALA A 175
ALA A 242
VAL A 243
None
1.35A 2oc8A-3jv7A:
undetectable
2oc8A-3jv7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3md0 ARGININE/ORNITHINE
TRANSPORT SYSTEM
ATPASE


(Mycobacterium
tuberculosis)
PF03308
(ArgK)
5 ILE A 154
LEU A 146
GLY A 150
ALA A  90
VAL A  91
None
0.97A 2oc8A-3md0A:
undetectable
2oc8A-3md0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxs LAO/AO TRANSPORT
SYSTEM ATPASE


(Mycolicibacterium
smegmatis)
PF03308
(ArgK)
5 ILE A 150
LEU A 142
GLY A 146
ALA A 117
ALA A  86
None
0.99A 2oc8A-3nxsA:
undetectable
2oc8A-3nxsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens)
PF01408
(GFO_IDH_MocA)
5 ILE A 152
LEU A 155
GLY A 159
ALA A 286
VAL A 287
None
0.85A 2oc8A-3oqbA:
undetectable
2oc8A-3oqbA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Escherichia
coli)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 ILE A  32
GLY A  16
ARG A 404
ALA A  22
ALA A  23
None
0.99A 2oc8A-3p4sA:
undetectable
2oc8A-3p4sA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pen TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA


(Sulfolobus
solfataricus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
5 ILE A 315
LEU A 256
GLY A 258
ALA A 387
VAL A 388
None
0.95A 2oc8A-3penA:
undetectable
2oc8A-3penA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sil SIALIDASE

(Salmonella
enterica)
PF13859
(BNR_3)
5 GLN A 281
ILE A 235
ALA A 296
ALA A 295
VAL A 294
None
0.98A 2oc8A-3silA:
undetectable
2oc8A-3silA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
6 ILE A 182
GLY A 185
SER A  66
ALA A 190
ALA A 143
VAL A 142
None
1.44A 2oc8A-3stjA:
13.9
2oc8A-3stjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
5 ILE A  44
LEU A  50
GLY A  52
ALA A 110
VAL A 109
None
0.94A 2oc8A-3ti7A:
undetectable
2oc8A-3ti7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE


(Mycolicibacterium
thermoresistibile)
PF03308
(ArgK)
5 ARG A 108
LEU A 140
GLY A 144
ALA A  84
VAL A  85
None
0.99A 2oc8A-3tk1A:
undetectable
2oc8A-3tk1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN


(Escherichia
coli)
PF01497
(Peripla_BP_2)
5 GLN A 192
LEU A 257
GLY A 259
ALA A 196
VAL A 198
None
None
None
None
EB4  A 328 (-4.0A)
1.00A 2oc8A-3tlkA:
undetectable
2oc8A-3tlkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE


(Symbiobacterium
thermophilum)
PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C)
5 ILE A  55
LEU A  58
GLY A  60
ALA A   7
VAL A   8
None
0.79A 2oc8A-3wbbA:
undetectable
2oc8A-3wbbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 ILE A 828
GLY A 608
ALA A 676
ALA A 675
VAL A 674
None
0.92A 2oc8A-3zyvA:
undetectable
2oc8A-3zyvA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axj ETHANOLAMINE
CARBOXYSOME
STRUCTURAL PROTEIN


(Clostridioides
difficile)
PF00936
(BMC)
5 ILE A  10
LEU A  72
GLY A  70
ALA A  64
ALA A  63
None
0.99A 2oc8A-4axjA:
undetectable
2oc8A-4axjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 GLY A  39
PHE A 267
ALA A 406
ALA A 405
VAL A 404
None
None
None
None
GOL  A1419 (-3.5A)
0.83A 2oc8A-4c9mA:
undetectable
2oc8A-4c9mA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE


(Salmonella
enterica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ILE A 110
LEU A 163
GLY A 165
ALA A 158
ALA A 159
None
1.01A 2oc8A-4cukA:
undetectable
2oc8A-4cukA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans)
PF00067
(p450)
5 GLY A  37
PHE A 265
ALA A 404
ALA A 403
VAL A 402
None
0.97A 2oc8A-4dxyA:
undetectable
2oc8A-4dxyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1


(Pseudomonas
aeruginosa)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II)
5 ARG A 521
ILE A 560
LEU A 577
GLY A 536
ALA A 579
None
0.86A 2oc8A-4fn5A:
undetectable
2oc8A-4fn5A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE


(Mycobacterium
tuberculosis)
PF01039
(Carboxyl_trans)
6 LEU A  22
SER A  30
PHE A  26
ARG A  53
ALA A  46
ALA A  45
None
1.44A 2oc8A-4g2rA:
undetectable
2oc8A-4g2rA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575)
PF00201
(UDPGT)
PF06722
(DUF1205)
5 ILE A 282
LEU A 279
GLY A 197
ALA A 255
VAL A 254
None
TYD  A 401 (-3.8A)
None
TYD  A 401 (-3.3A)
None
1.01A 2oc8A-4g2tA:
undetectable
2oc8A-4g2tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gw9 BACTERIOPHYTOCHROME

(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF00989
(PAS)
PF01590
(GAF)
PF08446
(PAS_2)
5 LEU A 389
GLY A 430
ALA A 423
ALA A 422
VAL A 421
None
0.94A 2oc8A-4gw9A:
undetectable
2oc8A-4gw9A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14


(Thermus
thermophilus)
PF00361
(Proton_antipo_M)
5 ARG N 354
LEU N 361
GLY N 359
ALA N 355
ALA N 352
None
0.89A 2oc8A-4heaN:
undetectable
2oc8A-4heaN:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN


(Rhodopirellula
baltica)
PF13458
(Peripla_BP_6)
5 ILE A 192
LEU A 182
GLY A 186
ALA A 252
VAL A 253
None
1.01A 2oc8A-4kv7A:
undetectable
2oc8A-4kv7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN


(Calotropis
procera)
PF00314
(Thaumatin)
5 ILE A  34
ARG A  48
ALA A  17
ALA A  18
VAL A  19
None
0.86A 2oc8A-4l2jA:
undetectable
2oc8A-4l2jA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus)
PF07447
(VP40)
5 ILE A 142
LEU A 150
GLY A 153
ARG A  52
ALA A 114
None
0.95A 2oc8A-4ld8A:
undetectable
2oc8A-4ld8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 ARG A 223
ILE A  24
LEU A 228
GLY A 230
ALA A 224
DCS  A 401 (-4.1A)
None
None
None
None
0.96A 2oc8A-4lutA:
undetectable
2oc8A-4lutA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN


(Pisum sativum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 HIS A 292
ILE A 382
LEU A 400
GLY A 171
ALA A 378
None
1.00A 2oc8A-4mkvA:
undetectable
2oc8A-4mkvA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
8 ARG A 123
ILE A 132
LEU A 135
GLY A 137
PHE A 154
ALA A 156
ALA A 157
VAL A 158
None
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
0.73A 2oc8A-4nwkA:
29.9
2oc8A-4nwkA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
8 GLN A  41
HIS A  57
ILE A 132
LEU A 135
GLY A 137
ALA A 156
ALA A 157
VAL A 158
2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
0.71A 2oc8A-4nwkA:
29.9
2oc8A-4nwkA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
9 HIS A  57
ILE A 132
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
2R8  A 301 (-3.3A)
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
0.73A 2oc8A-4nwkA:
29.9
2oc8A-4nwkA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
6 LEU A 135
GLY A 137
PHE A 154
ARG A 155
ALA A 157
VAL A 158
2R8  A 301 (-4.4A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.6A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
1.01A 2oc8A-4nwkA:
29.9
2oc8A-4nwkA:
81.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE


(Cupriavidus
necator)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ILE A 358
LEU A 359
GLY A  91
ALA A 387
ALA A 376
None
0.97A 2oc8A-4o99A:
undetectable
2oc8A-4o99A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
6 ILE A 248
LEU A 249
GLY A 217
ARG A 171
ALA A 132
ALA A 131
None
1.28A 2oc8A-4oe5A:
undetectable
2oc8A-4oe5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
6 ILE A 248
LEU A 249
PHE A 170
ARG A 171
ALA A 132
ALA A 131
None
1.45A 2oc8A-4oe5A:
undetectable
2oc8A-4oe5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv PROTEIN-TYROSINE
PHOSPHATASE
CRYPALPHA1 ISOFORM


(Gallus gallus)
PF07679
(I-set)
PF13927
(Ig_3)
5 ARG C  91
LEU C 121
PHE C  51
ALA C  49
VAL C  48
None
0.90A 2oc8A-4pbvC:
undetectable
2oc8A-4pbvC:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897)
PF00067
(p450)
5 ILE A 312
LEU A 307
GLY A 309
ARG A  39
VAL A  55
None
0.97A 2oc8A-4pwvA:
undetectable
2oc8A-4pwvA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2


(Rhodopseudomonas
palustris)
PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2)
5 GLY A 360
SER A 362
PHE A 388
ALA A 386
VAL A 385
None
0.66A 2oc8A-4r70A:
undetectable
2oc8A-4r70A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE


(Mycobacterium
avium)
PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 ILE A  18
LEU A  15
GLY A  11
SER A  39
ALA A  44
None
0.96A 2oc8A-4rcnA:
undetectable
2oc8A-4rcnA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Sinorhizobium
meliloti)
PF00155
(Aminotran_1_2)
5 ARG A 220
ILE A  94
LEU A  97
GLY A  99
ALA A 221
PEG  A 404 ( 4.0A)
PLP  A 401 (-3.6A)
None
None
None
1.01A 2oc8A-4wbtA:
undetectable
2oc8A-4wbtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE


(Clostridium
acetobutylicum)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ILE A 357
LEU A 358
GLY A  91
ALA A 386
ALA A 375
None
0.97A 2oc8A-4wyrA:
undetectable
2oc8A-4wyrA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA


(Mus musculus)
PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3)
5 ARG A  90
LEU A 120
PHE A  50
ALA A  48
VAL A  47
None
0.94A 2oc8A-4y61A:
undetectable
2oc8A-4y61A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrx F5/8 TYPE C DOMAIN
PROTEIN


(Bacteroides
ovatus)
PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos)
5 LEU A 299
ARG A 419
ALA A  47
ALA A  46
VAL A  43
None
0.98A 2oc8A-4zrxA:
undetectable
2oc8A-4zrxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT E


(Oryctolagus
cuniculus)
PF01399
(PCI)
PF09440
(eIF3_N)
5 ILE E 177
LEU E 173
GLY E 171
ALA E 184
ALA E 185
None
1.00A 2oc8A-5a5tE:
undetectable
2oc8A-5a5tE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT


(Neisseria
meningitidis)
PF00574
(CLP_protease)
5 ARG A 123
ILE A  68
LEU A 108
ALA A 101
ALA A 100
None
0.93A 2oc8A-5dkpA:
undetectable
2oc8A-5dkpA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
7 ARG A1123
LEU A1135
GLY A1137
PHE A1154
ARG A1155
ALA A1157
VAL A1158
5RS  A1203 ( 3.3A)
5RS  A1203 (-4.2A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
1.12A 2oc8A-5eqqA:
29.9
2oc8A-5eqqA:
86.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
10 GLN A1041
HIS A1057
ARG A1123
ILE A1132
LEU A1135
GLY A1137
PHE A1154
ALA A1156
ALA A1157
VAL A1158
5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
0.77A 2oc8A-5eqqA:
29.9
2oc8A-5eqqA:
86.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE


(Escherichia
coli)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ILE B 358
LEU B 359
GLY B  91
ALA B 387
ALA B 376
None
0.99A 2oc8A-5f38B:
undetectable
2oc8A-5f38B:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6


(Chaetomium
thermophilum)
PF01912
(eIF-6)
5 ILE A 218
GLY A 158
SER A 155
ALA A 204
VAL A 205
None
0.94A 2oc8A-5m3qA:
undetectable
2oc8A-5m3qA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhj MAJOR VIRAL
TRANSCRIPTION FACTOR
ICP4


(Human
alphaherpesvirus
1)
PF03584
(Herpes_ICP4_N)
5 GLN A 372
GLY A 367
ARG A 351
ALA A 348
ALA A 345
None
0.99A 2oc8A-5mhjA:
undetectable
2oc8A-5mhjA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhk RS1

(Human
alphaherpesvirus
1)
PF03584
(Herpes_ICP4_N)
5 GLN A 372
GLY A 367
ARG A 351
ALA A 348
ALA A 345
None
0.98A 2oc8A-5mhkA:
undetectable
2oc8A-5mhkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4c PROLYL
OLIGOPEPTIDASE


(Galerina
marginata)
no annotation 5 ILE A 587
GLY A 593
ALA A 597
ALA A 598
VAL A 599
None
0.98A 2oc8A-5n4cA:
undetectable
2oc8A-5n4cA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nop ATTACHMENT
GLYCOPROTEIN


(Mojiang
henipavirus)
PF00423
(HN)
5 LEU A 361
GLY A 358
ALA A 289
ALA A 288
VAL A 287
None
0.87A 2oc8A-5nopA:
undetectable
2oc8A-5nopA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN


(Rhodobacter
sphaeroides)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 HIS A 293
ILE A 383
LEU A 401
GLY A 173
ALA A 379
KCX  A 203 ( 4.8A)
None
None
None
None
0.99A 2oc8A-5nv3A:
undetectable
2oc8A-5nv3A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY


(Paraburkholderia
xenovorans)
PF08543
(Phos_pyr_kin)
6 ARG A 168
ILE A 157
LEU A 149
GLY A 154
ALA A 166
VAL A 164
None
1.34A 2oc8A-5trwA:
undetectable
2oc8A-5trwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7q 50S RIBOSOMAL
PROTEIN L14


(Mycobacterium
tuberculosis)
PF00238
(Ribosomal_L14)
5 ILE K  19
ARG K  64
ALA K  83
ALA K  84
VAL K  85
None
0.99A 2oc8A-5v7qK:
undetectable
2oc8A-5v7qK:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
5 ILE A1404
LEU A1401
PHE A1379
ALA A1381
VAL A1382
None
0.98A 2oc8A-5vadA:
undetectable
2oc8A-5vadA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ILE A 388
LEU A 381
GLY A 385
ALA A 264
ALA A 263
None
0.81A 2oc8A-5vm1A:
undetectable
2oc8A-5vm1A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C)
no annotation 10 HIS A  57
ARG A 123
ILE A 132
LEU A 135
GLY A 137
PHE A 154
ARG A 155
ALA A 156
ALA A 157
VAL A 158
None
0.60A 2oc8A-5wdxA:
25.5
2oc8A-5wdxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C)
no annotation 8 HIS A  57
ARG A 123
LEU A 135
GLY A 137
SER A 139
PHE A 154
ARG A 155
ALA A 156
None
0.73A 2oc8A-5wdxA:
25.5
2oc8A-5wdxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA


(Homo sapiens)
no annotation 5 ARG D  83
LEU D 113
PHE D  43
ALA D  41
VAL D  40
None
0.98A 2oc8A-5xnpD:
undetectable
2oc8A-5xnpD:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 GLN M 522
ILE M 537
ALA M 340
ALA M 339
VAL M 338
None
1.00A 2oc8A-5xtbM:
undetectable
2oc8A-5xtbM:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN


(Hendra
henipavirus)
no annotation 5 ILE A 259
ARG A 322
ALA A 324
ALA A 325
VAL A 326
CME  A 255 ( 4.0A)
None
None
None
None
0.94A 2oc8A-6bk6A:
undetectable
2oc8A-6bk6A:
15.84