SIMILAR PATTERNS OF AMINO ACIDS FOR 2OC8_A_HU5A999
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bjn | PHOSPHOSERINEAMINOTRANSFERASE (Escherichiacoli) |
PF00266(Aminotran_5) | 5 | ARG A 58ILE A 179GLY A 201SER A 249PHE A 253 | None | 1.00A | 2oc8A-1bjnA:0.0 | 2oc8A-1bjnA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxn | PROTEIN (RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN) (Cupriavidusnecator) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | HIS A 294ILE A 384LEU A 402GLY A 174ALA A 380 | None | 0.99A | 2oc8A-1bxnA:0.0 | 2oc8A-1bxnA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 11 | GLN A 41HIS A 57ARG A 123LEU A 135GLY A 137SER A 139PHE A 154ARG A 155ALA A 156ALA A 157VAL A 158 | None | 0.76A | 2oc8A-1cu1A:31.2 | 2oc8A-1cu1A:29.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dnv | GALLERIA MELLONELLADENSOVIRUS CAPSIDPROTEIN (Lepidopteranambidensovirus1) |
PF02336(Denso_VP4) | 5 | GLN A 79ILE A 251GLY A 351ALA A 74ALA A 354 | None | 0.96A | 2oc8A-1dnvA:undetectable | 2oc8A-1dnvA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1es6 | MATRIX PROTEIN VP40 (Ebola virus sp.) |
PF07447(VP40) | 5 | ILE A 142LEU A 150GLY A 153ARG A 52ALA A 114 | None | 0.94A | 2oc8A-1es6A:undetectable | 2oc8A-1es6A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gq1 | CYTOCHROME CD1NITRITE REDUCTASE (Paracoccuspantotrophus) |
PF02239(Cytochrom_D1)PF13442(Cytochrome_CBB3) | 5 | LEU A 438GLY A 440SER A 442ALA A 471VAL A 472 | None | 0.81A | 2oc8A-1gq1A:0.4 | 2oc8A-1gq1A:16.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gqj | ALPHA-D-GLUCURONIDASE (Cellvibriojaponicus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 5 | ILE A 84GLY A 90ALA A 118ALA A 117VAL A 116 | None | 0.99A | 2oc8A-1gqjA:undetectable | 2oc8A-1gqjA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwa | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Galdieriapartita) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | HIS A 292ILE A 382LEU A 400GLY A 171ALA A 378 | None | 0.97A | 2oc8A-1iwaA:undetectable | 2oc8A-1iwaA:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kc8 | RIBOSOMAL PROTEINL14 (Haloarculamarismortui) |
PF00238(Ribosomal_L14) | 6 | ILE L 53GLY L 11ARG L 75ALA L 94ALA L 95VAL L 96 | None G A1743 ( 3.0A)NoneNoneNoneNone | 1.50A | 2oc8A-1kc8L:undetectable | 2oc8A-1kc8L:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kvk | MEVALONATE KINASE (Rattusnorvegicus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | HIS A 197LEU A 137GLY A 140ALA A 147ALA A 148 | MG A 536 ( 4.3A)NoneATP A 535 (-2.8A) MG A 536 (-3.9A)None | 1.00A | 2oc8A-1kvkA:undetectable | 2oc8A-1kvkA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mo2 | ERYTHRONOLIDESYNTHASE, MODULES 5AND 6 (Saccharopolysporaerythraea) |
PF00975(Thioesterase) | 5 | ARG A 202LEU A 38GLY A 40SER A 42ALA A 205 | None | 0.81A | 2oc8A-1mo2A:undetectable | 2oc8A-1mo2A:21.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 9 | GLN A 41ARG A 123LEU A 135GLY A 137SER A 139PHE A 154ALA A 156ALA A 157VAL A 158 | None | 0.80A | 2oc8A-1ns3A:31.5 | 2oc8A-1ns3A:81.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 9 | GLN A 41HIS A 57LEU A 135GLY A 137SER A 139PHE A 154ALA A 156ALA A 157VAL A 158 | None | 0.61A | 2oc8A-1ns3A:31.5 | 2oc8A-1ns3A:81.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 7 | LEU A 135GLY A 137SER A 139PHE A 154ARG A 155ALA A 156ALA A 157 | None | 0.78A | 2oc8A-1ns3A:31.5 | 2oc8A-1ns3A:81.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNITQUINOLINE2-OXIDOREDUCTASESMALL SUBUNIT (Pseudomonasputida) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 5 | GLN A 106ILE B 670GLY B 509ALA B 550VAL B 551 | MCN B4921 ( 3.7A)MCN B4921 (-3.5A)MCN B4921 ( 4.3A)MCN B4921 (-3.1A)None | 1.00A | 2oc8A-1t3qA:undetectable | 2oc8A-1t3qA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tyg | THIAZOLEBIOSYNTHESIS PROTEINTHIG (Bacillussubtilis) |
PF05690(ThiG) | 5 | ARG A 183ILE A 197LEU A 222GLY A 226ALA A 185 | None | 0.87A | 2oc8A-1tygA:undetectable | 2oc8A-1tygA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wqa | PHOSPHO-SUGAR MUTASE (Pyrococcushorikoshii) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | LEU A 338GLY A 117ARG A 340ALA A 313VAL A 312 | LEU A 338 ( 0.6A)GLY A 117 ( 0.0A)ARG A 340 ( 0.6A)ALA A 313 ( 0.0A)VAL A 312 ( 0.6A) | 0.99A | 2oc8A-1wqaA:undetectable | 2oc8A-1wqaA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yg8 | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Escherichiacoli) |
PF00574(CLP_protease) | 5 | ARG A 118ILE A 63LEU A 103ALA A 96ALA A 95 | None | 1.01A | 2oc8A-1yg8A:undetectable | 2oc8A-1yg8A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3q | THAUMATIN-LIKEPROTEIN (Musa acuminata) |
PF00314(Thaumatin) | 5 | ILE A 33ARG A 47ALA A 16ALA A 17VAL A 18 | None | 0.90A | 2oc8A-1z3qA:undetectable | 2oc8A-1z3qA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d62 | MULTIPLESUGAR-BINDINGTRANSPORTATP-BINDING PROTEIN (Pyrococcushorikoshii) |
PF00005(ABC_tran)PF08402(TOBE_2) | 5 | ARG A 182ILE A 243GLY A 225ALA A 206VAL A 204 | None | 1.01A | 2oc8A-2d62A:undetectable | 2oc8A-2d62A:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e6e | 5'-NUCLEOTIDASE SURE (Thermusthermophilus) |
PF01975(SurE) | 6 | ILE A 3LEU A 92GLY A 94ARG A 142ALA A 22ALA A 23 | None | 1.44A | 2oc8A-2e6eA:undetectable | 2oc8A-2e6eA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewc | CONSERVEDHYPOTHETICAL PROTEIN (Streptococcuspyogenes) |
no annotation | 5 | HIS A 122LEU A 53GLY A 57ALA A 118VAL A 117 | None | 0.95A | 2oc8A-2ewcA:undetectable | 2oc8A-2ewcA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fn9 | RIBOSE ABCTRANSPORTER,PERIPLASMICRIBOSE-BINDINGPROTEIN (Thermotogamaritima) |
PF13407(Peripla_BP_4) | 5 | ILE A 194LEU A 136GLY A 197ARG A 174ALA A 205 | None | 0.89A | 2oc8A-2fn9A:undetectable | 2oc8A-2fn9A:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g28 | PYRUVATEDEHYDROGENASE E1COMPONENT (Escherichiacoli) |
PF00456(Transketolase_N) | 5 | GLN A 204LEU A 196GLY A 200ALA A 614ALA A 613 | None | 0.96A | 2oc8A-2g28A:undetectable | 2oc8A-2g28A:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsm | GLUTAMYL-TRNASYNTHETASE,CYTOPLASMIC (Saccharomycescerevisiae) |
no annotation | 6 | ILE A 129LEU A 130GLY A 132ALA A 137ALA A 138VAL A 97 | None | 1.26A | 2oc8A-2hsmA:undetectable | 2oc8A-2hsmA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m4k | DNA-DIRECTED RNAPOLYMERASE SUBUNITDELTA (Bacillussubtilis) |
PF05066(HARE-HTH) | 5 | ILE A 40LEU A 36PHE A 24ALA A 20VAL A 17 | None | 0.98A | 2oc8A-2m4kA:undetectable | 2oc8A-2m4kA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pro | ALPHA-LYTIC PROTEASE (Lysobacterenzymogenes) |
PF02983(Pro_Al_protease) | 6 | ARG A 82ILE A 40GLY A 45ALA A 66ALA A 65VAL A 64 | None | 1.06A | 2oc8A-2proA:undetectable | 2oc8A-2proA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r7a | BACTERIAL HEMEBINDING PROTEIN (Shigelladysenteriae) |
PF01497(Peripla_BP_2) | 5 | GLN A 272ILE A 186LEU A 189ARG A 146ALA A 264 | None | 1.00A | 2oc8A-2r7aA:undetectable | 2oc8A-2r7aA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsq | SURFACTIN SYNTHETASESUBUNIT 3 (Bacillussubtilis) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 5 | ILE A 790LEU A 806GLY A 843ALA A 857ALA A 846 | None | 0.90A | 2oc8A-2vsqA:undetectable | 2oc8A-2vsqA:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yd3 | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE S (Homo sapiens) |
PF07679(I-set) | 5 | ARG A 92LEU A 122PHE A 52ALA A 50VAL A 49 | None | 1.00A | 2oc8A-2yd3A:undetectable | 2oc8A-2yd3A:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yd7 | PTPRD PROTEIN (Homo sapiens) |
PF07679(I-set) | 5 | ARG A 83LEU A 113PHE A 43ALA A 41VAL A 40 | None | 0.92A | 2oc8A-2yd7A:undetectable | 2oc8A-2yd7A:25.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zb3 | PROSTAGLANDINREDUCTASE 2 (Mus musculus) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 5 | LEU A 196GLY A 201ALA A 204ALA A 205VAL A 206 | None | 0.87A | 2oc8A-2zb3A:undetectable | 2oc8A-2zb3A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zcv | UNCHARACTERIZEDOXIDOREDUCTASE YTFG (Escherichiacoli) |
PF05368(NmrA) | 5 | ARG A 49ILE A 16GLY A 9ALA A 30VAL A 29 | NoneNoneNDP A 400 (-2.9A)NoneNone | 0.95A | 2oc8A-2zcvA:undetectable | 2oc8A-2zcvA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fys | PROTEIN DEGV (Bacillussubtilis) |
PF02645(DegV) | 5 | ILE A 232LEU A 121PHE A 125ALA A 229ALA A 230 | PLM A 501 (-4.0A)NoneNoneNoneNone | 0.96A | 2oc8A-3fysA:undetectable | 2oc8A-3fysA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvp | ADENOSYLHOMOCYSTEINASE 3 (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | ILE A 293LEU A 314GLY A 311ALA A 257ALA A 256 | None | 1.00A | 2oc8A-3gvpA:undetectable | 2oc8A-3gvpA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h1l | MITOCHONDRIALUBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEXCORE PROTEIN 2 (Gallus gallus) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C) | 5 | ILE B 35LEU B 29GLY B 32ALA B 220VAL B 219 | None | 0.98A | 2oc8A-3h1lB:undetectable | 2oc8A-3h1lB:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i09 | PERIPLASMICBRANCHED-CHAIN AMINOACID-BINDING PROTEIN (Burkholderiamallei) |
PF13458(Peripla_BP_6) | 5 | HIS A 200LEU A 253GLY A 228PHE A 175ALA A 225 | NoneNoneEDO A 8 ( 4.0A)AAE A 501 (-3.6A)None | 1.00A | 2oc8A-3i09A:undetectable | 2oc8A-3i09A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3izy | TRANSLATIONINITIATION FACTORIF-2, MITOCHONDRIAL (Bos taurus) |
PF00009(GTP_EFTU)PF11987(IF-2) | 6 | GLN P 215ILE P 376LEU P 424GLY P 404ALA P 374VAL P 359 | None | 1.20A | 2oc8A-3izyP:undetectable | 2oc8A-3izyP:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv7 | ADH-A (Rhodococcusruber) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | LEU A 168GLY A 170SER A 173ALA A 175ALA A 242VAL A 243 | None | 1.35A | 2oc8A-3jv7A:undetectable | 2oc8A-3jv7A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3md0 | ARGININE/ORNITHINETRANSPORT SYSTEMATPASE (Mycobacteriumtuberculosis) |
PF03308(ArgK) | 5 | ILE A 154LEU A 146GLY A 150ALA A 90VAL A 91 | None | 0.97A | 2oc8A-3md0A:undetectable | 2oc8A-3md0A:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxs | LAO/AO TRANSPORTSYSTEM ATPASE (Mycolicibacteriumsmegmatis) |
PF03308(ArgK) | 5 | ILE A 150LEU A 142GLY A 146ALA A 117ALA A 86 | None | 0.99A | 2oc8A-3nxsA:undetectable | 2oc8A-3nxsA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqb | OXIDOREDUCTASE (Bradyrhizobiumdiazoefficiens) |
PF01408(GFO_IDH_MocA) | 5 | ILE A 152LEU A 155GLY A 159ALA A 286VAL A 287 | None | 0.85A | 2oc8A-3oqbA:undetectable | 2oc8A-3oqbA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4s | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | ILE A 32GLY A 16ARG A 404ALA A 22ALA A 23 | None | 0.99A | 2oc8A-3p4sA:undetectable | 2oc8A-3p4sA:15.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pen | TRANSLATIONINITIATION FACTOR 2SUBUNIT GAMMA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | ILE A 315LEU A 256GLY A 258ALA A 387VAL A 388 | None | 0.95A | 2oc8A-3penA:undetectable | 2oc8A-3penA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sil | SIALIDASE (Salmonellaenterica) |
PF13859(BNR_3) | 5 | GLN A 281ILE A 235ALA A 296ALA A 295VAL A 294 | None | 0.98A | 2oc8A-3silA:undetectable | 2oc8A-3silA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stj | PROTEASE DEGQ (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 6 | ILE A 182GLY A 185SER A 66ALA A 190ALA A 143VAL A 142 | None | 1.44A | 2oc8A-3stjA:13.9 | 2oc8A-3stjA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti7 | BASIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE BPRV (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 5 | ILE A 44LEU A 50GLY A 52ALA A 110VAL A 109 | None | 0.94A | 2oc8A-3ti7A:undetectable | 2oc8A-3ti7A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk1 | MEMBRANEATPASE/PROTEINKINASE (Mycolicibacteriumthermoresistibile) |
PF03308(ArgK) | 5 | ARG A 108LEU A 140GLY A 144ALA A 84VAL A 85 | None | 0.99A | 2oc8A-3tk1A:undetectable | 2oc8A-3tk1A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tlk | FERRIENTEROBACTIN-BINDING PERIPLASMICPROTEIN (Escherichiacoli) |
PF01497(Peripla_BP_2) | 5 | GLN A 192LEU A 257GLY A 259ALA A 196VAL A 198 | NoneNoneNoneNoneEB4 A 328 (-4.0A) | 1.00A | 2oc8A-3tlkA:undetectable | 2oc8A-3tlkA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbb | DIAMINOPIMELATEDEHYDROGENASE (Symbiobacteriumthermophilum) |
PF01408(GFO_IDH_MocA)PF16654(DAPDH_C) | 5 | ILE A 55LEU A 58GLY A 60ALA A 7VAL A 8 | None | 0.79A | 2oc8A-3wbbA:undetectable | 2oc8A-3wbbA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ILE A 828GLY A 608ALA A 676ALA A 675VAL A 674 | None | 0.92A | 2oc8A-3zyvA:undetectable | 2oc8A-3zyvA:9.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4axj | ETHANOLAMINECARBOXYSOMESTRUCTURAL PROTEIN (Clostridioidesdifficile) |
PF00936(BMC) | 5 | ILE A 10LEU A 72GLY A 70ALA A 64ALA A 63 | None | 0.99A | 2oc8A-4axjA:undetectable | 2oc8A-4axjA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c9m | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | GLY A 39PHE A 267ALA A 406ALA A 405VAL A 404 | NoneNoneNoneNoneGOL A1419 (-3.5A) | 0.83A | 2oc8A-4c9mA:undetectable | 2oc8A-4c9mA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cuk | D-LACTATEDEHYDROGENASE (Salmonellaenterica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ILE A 110LEU A 163GLY A 165ALA A 158ALA A 159 | None | 1.01A | 2oc8A-4cukA:undetectable | 2oc8A-4cukA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dxy | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | GLY A 37PHE A 265ALA A 404ALA A 403VAL A 402 | None | 0.97A | 2oc8A-4dxyA:undetectable | 2oc8A-4dxyA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fn5 | ELONGATION FACTOR G1 (Pseudomonasaeruginosa) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 5 | ARG A 521ILE A 560LEU A 577GLY A 536ALA A 579 | None | 0.86A | 2oc8A-4fn5A:undetectable | 2oc8A-4fn5A:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2r | ACCD6,CARBOXYLTRANSFERASEBETA-SUBUNIT OFACYL-COA CARBOXYLASE (Mycobacteriumtuberculosis) |
PF01039(Carboxyl_trans) | 6 | LEU A 22SER A 30PHE A 26ARG A 53ALA A 46ALA A 45 | None | 1.44A | 2oc8A-4g2rA:undetectable | 2oc8A-4g2rA:17.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2t | SSFS6 (Streptomycessp. SF2575) |
PF00201(UDPGT)PF06722(DUF1205) | 5 | ILE A 282LEU A 279GLY A 197ALA A 255VAL A 254 | NoneTYD A 401 (-3.8A)NoneTYD A 401 (-3.3A)None | 1.01A | 2oc8A-4g2tA:undetectable | 2oc8A-4g2tA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gw9 | BACTERIOPHYTOCHROME (Rhodopseudomonaspalustris) |
PF00360(PHY)PF00989(PAS)PF01590(GAF)PF08446(PAS_2) | 5 | LEU A 389GLY A 430ALA A 423ALA A 422VAL A 421 | None | 0.94A | 2oc8A-4gw9A:undetectable | 2oc8A-4gw9A:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hea | NADH-QUINONEOXIDOREDUCTASESUBUNIT 14 (Thermusthermophilus) |
PF00361(Proton_antipo_M) | 5 | ARG N 354LEU N 361GLY N 359ALA N 355ALA N 352 | None | 0.89A | 2oc8A-4heaN:undetectable | 2oc8A-4heaN:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kv7 | PROBABLELEUCINE/ISOLEUCINE/VALINE-BINDINGPROTEIN (Rhodopirellulabaltica) |
PF13458(Peripla_BP_6) | 5 | ILE A 192LEU A 182GLY A 186ALA A 252VAL A 253 | None | 1.01A | 2oc8A-4kv7A:undetectable | 2oc8A-4kv7A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l2j | OSMOTIN: ANTIFUNGALLATICIFER PROTEIN (Calotropisprocera) |
PF00314(Thaumatin) | 5 | ILE A 34ARG A 48ALA A 17ALA A 18VAL A 19 | None | 0.86A | 2oc8A-4l2jA:undetectable | 2oc8A-4l2jA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld8 | MATRIX PROTEIN VP40 (Sudanebolavirus) |
PF07447(VP40) | 5 | ILE A 142LEU A 150GLY A 153ARG A 52ALA A 114 | None | 0.95A | 2oc8A-4ld8A:undetectable | 2oc8A-4ld8A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lut | ALANINE RACEMASE (Clostridioidesdifficile) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | ARG A 223ILE A 24LEU A 228GLY A 230ALA A 224 | DCS A 401 (-4.1A)NoneNoneNoneNone | 0.96A | 2oc8A-4lutA:undetectable | 2oc8A-4lutA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mkv | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Pisum sativum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | HIS A 292ILE A 382LEU A 400GLY A 171ALA A 378 | None | 1.00A | 2oc8A-4mkvA:undetectable | 2oc8A-4mkvA:16.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 8 | ARG A 123ILE A 132LEU A 135GLY A 137PHE A 154ALA A 156ALA A 157VAL A 158 | None2R8 A 301 (-4.3A)2R8 A 301 (-4.4A)GOL A 305 ( 3.2A)2R8 A 301 (-3.7A)2R8 A 301 (-3.1A)2R8 A 301 (-3.8A)2R8 A 301 ( 4.4A) | 0.73A | 2oc8A-4nwkA:29.9 | 2oc8A-4nwkA:81.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 8 | GLN A 41HIS A 57ILE A 132LEU A 135GLY A 137ALA A 156ALA A 157VAL A 158 | 2R8 A 301 ( 3.5A)2R8 A 301 (-3.3A)2R8 A 301 (-4.3A)2R8 A 301 (-4.4A)GOL A 305 ( 3.2A)2R8 A 301 (-3.1A)2R8 A 301 (-3.8A)2R8 A 301 ( 4.4A) | 0.71A | 2oc8A-4nwkA:29.9 | 2oc8A-4nwkA:81.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 9 | HIS A 57ILE A 132LEU A 135GLY A 137SER A 139PHE A 154ALA A 156ALA A 157VAL A 158 | 2R8 A 301 (-3.3A)2R8 A 301 (-4.3A)2R8 A 301 (-4.4A)GOL A 305 ( 3.2A)2R8 A 301 (-2.6A)2R8 A 301 (-3.7A)2R8 A 301 (-3.1A)2R8 A 301 (-3.8A)2R8 A 301 ( 4.4A) | 0.73A | 2oc8A-4nwkA:29.9 | 2oc8A-4nwkA:81.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 6 | LEU A 135GLY A 137PHE A 154ARG A 155ALA A 157VAL A 158 | 2R8 A 301 (-4.4A)GOL A 305 ( 3.2A)2R8 A 301 (-3.7A)2R8 A 301 (-3.6A)2R8 A 301 (-3.8A)2R8 A 301 ( 4.4A) | 1.01A | 2oc8A-4nwkA:29.9 | 2oc8A-4nwkA:81.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o99 | ACETYL-COAACETYLTRANSFERASE (Cupriavidusnecator) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ILE A 358LEU A 359GLY A 91ALA A 387ALA A 376 | None | 0.97A | 2oc8A-4o99A:undetectable | 2oc8A-4o99A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe5 | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 6 | ILE A 248LEU A 249GLY A 217ARG A 171ALA A 132ALA A 131 | None | 1.28A | 2oc8A-4oe5A:undetectable | 2oc8A-4oe5A:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe5 | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF00171(Aldedh) | 6 | ILE A 248LEU A 249PHE A 170ARG A 171ALA A 132ALA A 131 | None | 1.45A | 2oc8A-4oe5A:undetectable | 2oc8A-4oe5A:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pbv | PROTEIN-TYROSINEPHOSPHATASECRYPALPHA1 ISOFORM (Gallus gallus) |
PF07679(I-set)PF13927(Ig_3) | 5 | ARG C 91LEU C 121PHE C 51ALA C 49VAL C 48 | None | 0.90A | 2oc8A-4pbvC:undetectable | 2oc8A-4pbvC:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pwv | P450 MONOOXYGENASE (Streptomycessp. Acta 2897) |
PF00067(p450) | 5 | ILE A 312LEU A 307GLY A 309ARG A 39VAL A 55 | None | 0.97A | 2oc8A-4pwvA:undetectable | 2oc8A-4pwvA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r70 | BACTERIOPHYTOCHROME(LIGHT-REGULATEDSIGNAL TRANSDUCTIONHISTIDINE KINASE),PHYB2 (Rhodopseudomonaspalustris) |
PF00360(PHY)PF01590(GAF)PF08446(PAS_2) | 5 | GLY A 360SER A 362PHE A 388ALA A 386VAL A 385 | None | 0.66A | 2oc8A-4r70A:undetectable | 2oc8A-4r70A:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rcn | LONG-CHAIN ACYL-COACARBOXYLASE (Mycobacteriumavium) |
PF00289(Biotin_carb_N)PF01039(Carboxyl_trans)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ILE A 18LEU A 15GLY A 11SER A 39ALA A 44 | None | 0.96A | 2oc8A-4rcnA:undetectable | 2oc8A-4rcnA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbt | PROBABLEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Sinorhizobiummeliloti) |
PF00155(Aminotran_1_2) | 5 | ARG A 220ILE A 94LEU A 97GLY A 99ALA A 221 | PEG A 404 ( 4.0A)PLP A 401 (-3.6A)NoneNoneNone | 1.01A | 2oc8A-4wbtA:undetectable | 2oc8A-4wbtA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wyr | ACETYL-COAACETYLTRANSFERASE (Clostridiumacetobutylicum) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ILE A 357LEU A 358GLY A 91ALA A 386ALA A 375 | None | 0.97A | 2oc8A-4wyrA:undetectable | 2oc8A-4wyrA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y61 | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE DELTA (Mus musculus) |
PF00041(fn3)PF07679(I-set)PF13927(Ig_3) | 5 | ARG A 90LEU A 120PHE A 50ALA A 48VAL A 47 | None | 0.94A | 2oc8A-4y61A:undetectable | 2oc8A-4y61A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zrx | F5/8 TYPE C DOMAINPROTEIN (Bacteroidesovatus) |
PF00754(F5_F8_type_C)PF01120(Alpha_L_fucos) | 5 | LEU A 299ARG A 419ALA A 47ALA A 46VAL A 43 | None | 0.98A | 2oc8A-4zrxA:undetectable | 2oc8A-4zrxA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5t | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT E (Oryctolaguscuniculus) |
PF01399(PCI)PF09440(eIF3_N) | 5 | ILE E 177LEU E 173GLY E 171ALA E 184ALA E 185 | None | 1.00A | 2oc8A-5a5tE:undetectable | 2oc8A-5a5tE:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkp | ATP-DEPENDENT CLPPROTEASE PROTEOLYTICSUBUNIT (Neisseriameningitidis) |
PF00574(CLP_protease) | 5 | ARG A 123ILE A 68LEU A 108ALA A 101ALA A 100 | None | 0.93A | 2oc8A-5dkpA:undetectable | 2oc8A-5dkpA:22.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eqq | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 7 | ARG A1123LEU A1135GLY A1137PHE A1154ARG A1155ALA A1157VAL A1158 | 5RS A1203 ( 3.3A)5RS A1203 (-4.2A)5RS A1203 (-3.2A)5RS A1203 (-3.3A)5RS A1203 (-4.8A)5RS A1203 (-3.5A)5RS A1203 ( 3.6A) | 1.12A | 2oc8A-5eqqA:29.9 | 2oc8A-5eqqA:86.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eqq | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 10 | GLN A1041HIS A1057ARG A1123ILE A1132LEU A1135GLY A1137PHE A1154ALA A1156ALA A1157VAL A1158 | 5RS A1203 (-2.9A)5RS A1203 (-2.5A)5RS A1203 ( 3.3A)5RS A1203 ( 4.1A)5RS A1203 (-4.2A)5RS A1203 (-3.2A)5RS A1203 (-3.3A)5RS A1203 (-2.9A)5RS A1203 (-3.5A)5RS A1203 ( 3.6A) | 0.77A | 2oc8A-5eqqA:29.9 | 2oc8A-5eqqA:86.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f38 | ACETYL-COAACETYLTRANSFERASE (Escherichiacoli) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ILE B 358LEU B 359GLY B 91ALA B 387ALA B 376 | None | 0.99A | 2oc8A-5f38B:undetectable | 2oc8A-5f38B:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m3q | EUKARYOTICTRANSLATIONINITIATION FACTOR 6 (Chaetomiumthermophilum) |
PF01912(eIF-6) | 5 | ILE A 218GLY A 158SER A 155ALA A 204VAL A 205 | None | 0.94A | 2oc8A-5m3qA:undetectable | 2oc8A-5m3qA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mhj | MAJOR VIRALTRANSCRIPTION FACTORICP4 (Humanalphaherpesvirus1) |
PF03584(Herpes_ICP4_N) | 5 | GLN A 372GLY A 367ARG A 351ALA A 348ALA A 345 | None | 0.99A | 2oc8A-5mhjA:undetectable | 2oc8A-5mhjA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mhk | RS1 (Humanalphaherpesvirus1) |
PF03584(Herpes_ICP4_N) | 5 | GLN A 372GLY A 367ARG A 351ALA A 348ALA A 345 | None | 0.98A | 2oc8A-5mhkA:undetectable | 2oc8A-5mhkA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4c | PROLYLOLIGOPEPTIDASE (Galerinamarginata) |
no annotation | 5 | ILE A 587GLY A 593ALA A 597ALA A 598VAL A 599 | None | 0.98A | 2oc8A-5n4cA:undetectable | 2oc8A-5n4cA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nop | ATTACHMENTGLYCOPROTEIN (Mojianghenipavirus) |
PF00423(HN) | 5 | LEU A 361GLY A 358ALA A 289ALA A 288VAL A 287 | None | 0.87A | 2oc8A-5nopA:undetectable | 2oc8A-5nopA:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv3 | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Rhodobactersphaeroides) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | HIS A 293ILE A 383LEU A 401GLY A 173ALA A 379 | KCX A 203 ( 4.8A)NoneNoneNoneNone | 0.99A | 2oc8A-5nv3A:undetectable | 2oc8A-5nv3A:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5trw | PYRIDOXAL KINASEPDXY (Paraburkholderiaxenovorans) |
PF08543(Phos_pyr_kin) | 6 | ARG A 168ILE A 157LEU A 149GLY A 154ALA A 166VAL A 164 | None | 1.34A | 2oc8A-5trwA:undetectable | 2oc8A-5trwA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7q | 50S RIBOSOMALPROTEIN L14 (Mycobacteriumtuberculosis) |
PF00238(Ribosomal_L14) | 5 | ILE K 19ARG K 64ALA K 83ALA K 84VAL K 85 | None | 0.99A | 2oc8A-5v7qK:undetectable | 2oc8A-5v7qK:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vad | BIFUNCTIONALGLUTAMATE/PROLINE--TRNA LIGASE (Homo sapiens) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF09180(ProRS-C_1) | 5 | ILE A1404LEU A1401PHE A1379ALA A1381VAL A1382 | None | 0.98A | 2oc8A-5vadA:undetectable | 2oc8A-5vadA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vm1 | XYLULOKINASE (Brucella ovis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ILE A 388LEU A 381GLY A 385ALA A 264ALA A 263 | None | 0.81A | 2oc8A-5vm1A:undetectable | 2oc8A-5vm1A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 10 | HIS A 57ARG A 123ILE A 132LEU A 135GLY A 137PHE A 154ARG A 155ALA A 156ALA A 157VAL A 158 | None | 0.60A | 2oc8A-5wdxA:25.5 | 2oc8A-5wdxA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 8 | HIS A 57ARG A 123LEU A 135GLY A 137SER A 139PHE A 154ARG A 155ALA A 156 | None | 0.73A | 2oc8A-5wdxA:25.5 | 2oc8A-5wdxA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xnp | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE DELTA (Homo sapiens) |
no annotation | 5 | ARG D 83LEU D 113PHE D 43ALA D 41VAL D 40 | None | 0.98A | 2oc8A-5xnpD:undetectable | 2oc8A-5xnpD:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH-UBIQUINONEOXIDOREDUCTASE 75KDA SUBUNIT,MITOCHONDRIAL (Homo sapiens) |
PF00384(Molybdopterin)PF09326(NADH_dhqG_C)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 5 | GLN M 522ILE M 537ALA M 340ALA M 339VAL M 338 | None | 1.00A | 2oc8A-5xtbM:undetectable | 2oc8A-5xtbM:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk6 | HENDRA VIRUS MATRIXPROTEIN (Hendrahenipavirus) |
no annotation | 5 | ILE A 259ARG A 322ALA A 324ALA A 325VAL A 326 | CME A 255 ( 4.0A)NoneNoneNoneNone | 0.94A | 2oc8A-6bk6A:undetectable | 2oc8A-6bk6A:15.84 |