SIMILAR PATTERNS OF AMINO ACIDS FOR 2OAX_E_SNLE5001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jmc SPECTRIN ALPHA
CHAIN, BRAIN AND P41
PEPTIDE CHIMERA

(Gallus gallus) 		PF00018
(SH3_1) 		4 LEU A  46
TRP A  27
LEU A  18
MET A  10
 None
 1.34A 2oaxE-2jmcA:
0.0		 2oaxE-2jmcA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 504
TRP A 498
LEU A 445
MET A 837
 None
 1.44A 2oaxE-2y8nA:
0.0		 2oaxE-2y8nA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 LEU A 112
TRP A 265
LEU A 271
MET A  65
 None
 1.34A 2oaxE-3bxpA:
0.0		 2oaxE-3bxpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		4 LEU A 323
TRP A 292
LEU A 299
MET A 353
 None
 1.40A 2oaxE-3gt5A:
0.0		 2oaxE-3gt5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 473
TRP A  72
LEU A  73
MET A 428
 None
 1.41A 2oaxE-3zo9A:
0.0		 2oaxE-3zo9A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exn INTERLEUKIN-34

(Mus musculus) 		PF15036
(IL34) 		4 LEU A  37
TRP A  94
LEU A 126
MET A 134
 None
 1.38A 2oaxE-4exnA:
0.0		 2oaxE-4exnA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		4 LEU A 337
TRP A 319
LEU A 358
MET A 368
 None
 1.34A 2oaxE-4ld7A:
0.0		 2oaxE-4ld7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		4 LEU A  79
TRP A 169
LEU A 203
MET A  16
 LFA  A 306 ( 4.9A)
LYR  A 200 ( 3.6A)
None
LYR  A 200 ( 4.0A)
 0.99A 2oaxE-5jsiA:
1.0		 2oaxE-5jsiA:
23.27