SIMILAR PATTERNS OF AMINO ACIDS FOR 2OAX_D_SNLD4001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		4 LEU A 209
LEU A 206
MET A 122
THR A 249
 None
 1.30A 2oaxD-1amkA:
undetectable		 2oaxD-1amkA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		4 LEU A 158
LEU A 114
MET A 126
THR A 199
 None
 1.41A 2oaxD-1axnA:
0.0		 2oaxD-1axnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 242
LEU O 259
CYH O 153
THR O 150
 None
None
None
SO4  O 339 ( 4.5A)
 1.29A 2oaxD-1dbvO:
0.0		 2oaxD-1dbvO:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 LEU A 140
LEU A 191
CYH A 355
THR A 380
 SF4  A 582 ( 4.9A)
SF4  A 582 (-4.3A)
SF4  A 581 ( 2.3A)
None
 1.22A 2oaxD-1fehA:
undetectable		 2oaxD-1fehA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 246
LEU O 263
CYH O 158
THR O 155
 None
None
None
SO4  O 342 ( 4.4A)
 1.31A 2oaxD-1obfO:
0.0		 2oaxD-1obfO:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 402
MET A 440
CYH A 418
THR A 334
 None
 1.30A 2oaxD-1pduA:
21.3		 2oaxD-1pduA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5t VPS36P
DEFECTIVE IN
VACUOLAR PROTEIN
SORTING

(Saccharomyces
cerevisiae) 		PF04157
(EAP30) 		4 LEU B 440
LEU B 420
MET B 448
THR B 528
 None
 1.43A 2oaxD-1u5tB:
0.0		 2oaxD-1u5tB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE

(Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A 172
LEU A  62
MET A 212
THR A 325
 None
 1.43A 2oaxD-1wqlA:
0.0		 2oaxD-1wqlA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A  70
LEU A 118
MET A 222
THR A 105
 None
 1.29A 2oaxD-1x1qA:
0.0		 2oaxD-1x1qA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 344
LEU A 319
CYH A  37
THR A  41
 None
None
ZN  A1000 ( 2.3A)
None
 1.17A 2oaxD-1y9aA:
undetectable		 2oaxD-1y9aA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN

(Thermus
thermophilus) 		PF00890
(FAD_binding_2)
PF07992
(Pyr_redox_2) 		4 LEU A 102
LEU A 166
CYH A 105
THR A 106
 None
None
None
FAD  A2304 (-4.3A)
 1.39A 2oaxD-2cvjA:
undetectable		 2oaxD-2cvjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 LEU A   8
LEU A  32
MET A   4
THR A 185
 None
 1.40A 2oaxD-2e1bA:
undetectable		 2oaxD-2e1bA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 LEU A 400
LEU A 407
MET A 384
THR A 177
 None
 1.41A 2oaxD-2gwcA:
undetectable		 2oaxD-2gwcA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		4 LEU A 106
LEU A  86
MET A  95
THR A  76
 None
 1.24A 2oaxD-2gzsA:
undetectable		 2oaxD-2gzsA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltk MONO-CYSTEINE
GLUTAREDOXIN

(Trypanosoma
brucei) 		PF00462
(Glutaredoxin) 		4 LEU A 114
LEU A 165
CYH A 181
THR A 180
 None
 1.43A 2oaxD-2ltkA:
undetectable		 2oaxD-2ltkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 LEU A 328
LEU A 277
MET A 304
THR A 316
 None
 1.35A 2oaxD-2nlzA:
undetectable		 2oaxD-2nlzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuj THIOESTERASE
SUPERFAMILY

(Jannaschia) 		PF13279
(4HBT_2) 		4 LEU A 117
LEU A  15
CYH A 123
THR A 124
 None
 1.44A 2oaxD-2nujA:
undetectable		 2oaxD-2nujA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o52 RAS-RELATED PROTEIN
RAB-4B

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A 148
LEU A  24
CYH A 165
THR A 168
 None
 1.21A 2oaxD-2o52A:
undetectable		 2oaxD-2o52A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o96 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 7

(Homo sapiens) 		PF01398
(JAB) 		4 LEU A  48
LEU A  40
MET A 112
THR A 135
 None
 1.40A 2oaxD-2o96A:
undetectable		 2oaxD-2o96A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 LEU A 312
LEU A 286
MET A 159
CYH A 293
 None
 1.23A 2oaxD-2q4aA:
undetectable		 2oaxD-2q4aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5f PROLYL 4-HYDROXYLASE
SUBUNIT ALPHA-1

(Homo sapiens) 		PF07719
(TPR_2) 		4 LEU A 177
LEU A 194
CYH A 150
THR A 146
 None
 1.39A 2oaxD-2v5fA:
undetectable		 2oaxD-2v5fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 LEU A 192
LEU A 236
CYH A 202
THR A 185
 None
 1.43A 2oaxD-2vc6A:
undetectable		 2oaxD-2vc6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 145
LEU A 113
CYH A 194
THR A 131
 None
 1.42A 2oaxD-2wyaA:
undetectable		 2oaxD-2wyaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 259
LEU A 276
CYH A 169
THR A 166
 None
None
None
SO4  A 360 ( 4.7A)
 1.30A 2oaxD-2x0nA:
undetectable		 2oaxD-2x0nA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00121
(TIM) 		4 LEU A 209
LEU A 206
MET A 122
THR A 249
 None
 1.42A 2oaxD-2x2gA:
undetectable		 2oaxD-2x2gA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		4 LEU A 206
LEU A 229
CYH A 276
THR A 277
 None
None
None
NAP  A 501 (-4.3A)
 1.27A 2oaxD-2xlrA:
undetectable		 2oaxD-2xlrA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		4 LEU A 277
LEU A 185
CYH A 266
THR A 267
 None
 1.34A 2oaxD-2xwgA:
undetectable		 2oaxD-2xwgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 410
LEU A 427
MET A 433
THR A 450
 None
 1.37A 2oaxD-2y8nA:
undetectable		 2oaxD-2y8nA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 455
LEU A 410
MET A 472
THR A 826
 None
 1.28A 2oaxD-2y8nA:
undetectable		 2oaxD-2y8nA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znv AMSH-LIKE PROTEASE

(Homo sapiens) 		PF01398
(JAB) 		4 LEU A 282
LEU A 435
CYH A 294
THR A 348
 None
 1.42A 2oaxD-2znvA:
undetectable		 2oaxD-2znvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)

(Synechococcus
elongatus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 247
LEU A 264
CYH A 159
THR A 156
 None
None
None
SO4  A1339 (-3.7A)
 1.35A 2oaxD-3b20A:
undetectable		 2oaxD-3b20A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LEU A 550
LEU A 546
CYH A 997
THR A 996
 None
 1.39A 2oaxD-3bgaA:
undetectable		 2oaxD-3bgaA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhn THIJ/PFPI DOMAIN
PROTEIN

(Shewanella
loihica) 		PF01965
(DJ-1_PfpI) 		4 LEU A 157
LEU A  19
CYH A 100
THR A 119
 None
 1.41A 2oaxD-3bhnA:
1.8		 2oaxD-3bhnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 LEU A 138
LEU A 148
CYH A  12
THR A  11
 None
 1.42A 2oaxD-3d4jA:
undetectable		 2oaxD-3d4jA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 LEU A 138
LEU A 148
CYH A  12
THR A  11
 None
 1.30A 2oaxD-3f0nA:
undetectable		 2oaxD-3f0nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g69 SORTASE C

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 LEU A 232
LEU A 140
CYH A 221
THR A 222
 None
 1.39A 2oaxD-3g69A:
undetectable		 2oaxD-3g69A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 245
LEU A 263
CYH A 157
THR A 154
 None
None
None
SO4  A 336 (-3.3A)
 1.35A 2oaxD-3hjaA:
undetectable		 2oaxD-3hjaA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG

(Homo sapiens) 		PF09817
(Zwilch) 		4 LEU B 467
LEU B 504
CYH B 495
THR B 492
 None
 1.16A 2oaxD-3if8B:
undetectable		 2oaxD-3if8B:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A 147
LEU A  38
MET A  53
THR A  82
 None
 1.33A 2oaxD-3ifeA:
undetectable		 2oaxD-3ifeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		4 LEU R 108
LEU R 126
MET R 147
CYH R 113
 A  N  78 ( 4.5A)
None
None
None
 1.34A 2oaxD-3jb9R:
undetectable		 2oaxD-3jb9R:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsz GLUTATHIONE
S-TRANSFERASE

(Rhodobacter
sphaeroides) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LEU A  55
LEU A  47
CYH A  65
THR A  74
 None
None
None
TRS  A 301 (-3.2A)
 1.43A 2oaxD-3lszA:
undetectable		 2oaxD-3lszA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0p SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 LEU A 230
LEU A 138
CYH A 219
THR A 220
 None
 1.36A 2oaxD-3o0pA:
undetectable		 2oaxD-3o0pA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oa2 WBPB

(Pseudomonas
aeruginosa) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 LEU A 193
LEU A 131
CYH A 287
THR A 290
 None
 1.37A 2oaxD-3oa2A:
undetectable		 2oaxD-3oa2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 104
LEU A  96
CYH A 131
THR A  34
 None
 1.42A 2oaxD-3p4eA:
undetectable		 2oaxD-3p4eA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		4 LEU A   9
LEU A  18
MET A   1
THR A 207
 None
 1.30A 2oaxD-3pl0A:
undetectable		 2oaxD-3pl0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf0 EXOPOLYPHOSPHATASE

(Yersinia pestis) 		no annotation 4 LEU A 132
LEU A  62
MET A  74
THR A  32
 None
 1.40A 2oaxD-3rf0A:
3.2		 2oaxD-3rf0A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LEU A  76
LEU A 115
CYH A  60
THR A  61
 None
 1.28A 2oaxD-3rzaA:
undetectable		 2oaxD-3rzaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		4 LEU A 389
LEU A 426
MET A 447
THR A 460
 None
 1.42A 2oaxD-3zxlA:
undetectable		 2oaxD-3zxlA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 184
LEU A 256
CYH A 263
THR A 177
 None
 1.35A 2oaxD-4af3A:
undetectable		 2oaxD-4af3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 LEU A 218
LEU A 273
CYH A 256
THR A 286
 None
 1.27A 2oaxD-4d47A:
undetectable		 2oaxD-4d47A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7w SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 LEU A 222
LEU A 130
CYH A 211
THR A 212
 None
 1.42A 2oaxD-4d7wA:
undetectable		 2oaxD-4d7wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1h SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 LEU A 229
LEU A 137
CYH A 218
THR A 219
 None
 1.35A 2oaxD-4g1hA:
undetectable		 2oaxD-4g1hA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1j SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		4 LEU A 236
LEU A 144
CYH A 225
THR A 226
 None
 1.39A 2oaxD-4g1jA:
undetectable		 2oaxD-4g1jA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		4 LEU A 210
LEU A 207
MET A 123
THR A 250
 None
 1.38A 2oaxD-4gnjA:
undetectable		 2oaxD-4gnjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 LEU A 498
MET A 445
CYH A 494
THR A 518
 None
 1.34A 2oaxD-4hlnA:
undetectable		 2oaxD-4hlnA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 LEU B 345
LEU B 245
MET B 349
THR B 192
 None
 1.31A 2oaxD-4lwoB:
undetectable		 2oaxD-4lwoB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E

(Vibrio cholerae) 		PF02508
(Rnf-Nqr) 		4 LEU D  26
LEU E  29
CYH E 120
THR D 110
 None
None
FE  D 301 (-2.2A)
None
 1.41A 2oaxD-4p6vD:
undetectable		 2oaxD-4p6vD:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9j RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		no annotation 4 LEU C1211
LEU C1204
CYH C1151
THR C1163
 None
 1.20A 2oaxD-4p9jC:
undetectable		 2oaxD-4p9jC:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 LEU A 565
LEU A 599
CYH A 606
THR A 609
 None
 1.08A 2oaxD-4ppmA:
undetectable		 2oaxD-4ppmA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 LEU A 230
LEU A 105
CYH A 112
THR A  61
 None
 1.08A 2oaxD-4q65A:
undetectable		 2oaxD-4q65A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		4 LEU A 507
LEU A 805
MET A 823
THR A 485
 None
 1.05A 2oaxD-4q8gA:
undetectable		 2oaxD-4q8gA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Bacillus
subtilis) 		PF11638
(DnaA_N) 		4 LEU B  41
LEU B  59
MET B  28
THR B  70
 None
 0.87A 2oaxD-4tpsB:
undetectable		 2oaxD-4tpsB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5
COG7

(Kluyveromyces
lactis) 		PF10392
(COG5)
no annotation 		4 LEU A  39
LEU B 187
CYH A  46
THR A  44
 None
 1.41A 2oaxD-4u6uA:
undetectable		 2oaxD-4u6uA:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 769
LEU A 810
CYH A 942
THR A 945
 CV7  A1987 (-4.1A)
CV7  A1987 (-4.0A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
 0.47A 2oaxD-4udbA:
36.8		 2oaxD-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN UL2M, MRPL2

(Sus scrofa) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 LEU D 229
LEU D 218
CYH D 214
THR D 213
 G  A 849 ( 4.1A)
None
None
A  A 860 ( 3.8A)
 0.90A 2oaxD-4v19D:
undetectable		 2oaxD-4v19D:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 699
LEU A 562
MET A 531
THR A 604
 None
 1.17A 2oaxD-4wrnA:
undetectable		 2oaxD-4wrnA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx6 PROTEASE

(Human
mastadenovirus
D) 		PF00770
(Peptidase_C5) 		4 LEU A 178
LEU A 130
MET A 147
THR A 196
 None
 1.43A 2oaxD-4wx6A:
undetectable		 2oaxD-4wx6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 878
LEU A 856
MET A 861
THR A 913
 None
 1.24A 2oaxD-4wz9A:
undetectable		 2oaxD-4wz9A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 LEU A1956
LEU A1877
CYH A1971
THR A1972
 None
 1.40A 2oaxD-4yknA:
undetectable		 2oaxD-4yknA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 LEU A  74
LEU A  89
CYH A  77
THR A  48
 None
 1.14A 2oaxD-4ylrA:
undetectable		 2oaxD-4ylrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 416
LEU A 432
MET A 399
THR A 381
 None
 1.19A 2oaxD-4ywoA:
undetectable		 2oaxD-4ywoA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP1
VP2
VP4

(Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF08935
(VP4_2) 		4 LEU 2 142
LEU 4  71
CYH 1 192
THR 1  70
 None
 1.26A 2oaxD-5aca2:
undetectable		 2oaxD-5aca2:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 4 LEU A 167
LEU A 160
CYH A 208
THR A 211
 None
 1.24A 2oaxD-5affA:
undetectable		 2oaxD-5affA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahv ANTH DOMAIN OF
ENDOCYTIC ADAPTOR
SLA2

(Saccharomyces
cerevisiae) 		PF07651
(ANTH) 		4 LEU F 105
LEU F  64
CYH F 182
THR F 180
 None
 1.26A 2oaxD-5ahvF:
undetectable		 2oaxD-5ahvF:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Dictyostelium
discoideum) 		PF01912
(eIF-6) 		4 LEU I 104
LEU I  70
CYH I  76
THR I  75
 None
 1.17A 2oaxD-5anbI:
undetectable		 2oaxD-5anbI:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 506
LEU A 537
CYH A 544
THR A 545
 None
 1.23A 2oaxD-5b7iA:
undetectable		 2oaxD-5b7iA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1)
PF00603
(Flu_PA) 		4 LEU A 691
LEU A 678
CYH A 643
THR B  21
 None
 1.36A 2oaxD-5d9aA:
undetectable		 2oaxD-5d9aA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 452
LEU A 380
CYH A 520
THR A 518
 None
 1.18A 2oaxD-5e8yA:
undetectable		 2oaxD-5e8yA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 MYOSIN LIGHT CHAIN
1/3, SKELETAL MUSCLE
ISOFORM
SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N)
PF13405
(EF-hand_6) 		4 LEU C  80
LEU C  77
MET A 801
THR C  85
 None
 1.24A 2oaxD-5h53C:
undetectable		 2oaxD-5h53C:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		4 LEU A 682
LEU A 481
MET A 469
THR A 492
 None
 1.40A 2oaxD-5hb3A:
undetectable		 2oaxD-5hb3A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Klebsiella
pneumoniae) 		PF04390
(LptE) 		4 LEU B  77
LEU B 109
MET B  36
THR B 120
 None
 1.34A 2oaxD-5iv9B:
undetectable		 2oaxD-5iv9B:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE

(Plasmodium
falciparum) 		PF07992
(Pyr_redox_2) 		4 LEU A 181
LEU A 304
CYH A 187
THR A 188
 None
None
None
ACT  A 611 ( 4.4A)
 1.30A 2oaxD-5jwbA:
undetectable		 2oaxD-5jwbA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3)
PF06444
(NADH_dehy_S2_C) 		4 LEU N  27
LEU N  70
MET K  37
THR J 157
 None
 1.42A 2oaxD-5lc5N:
undetectable		 2oaxD-5lc5N:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnq 3-KETOACYL-COA
THIOLASE-LIKE
PROTEIN

(Leishmania
mexicana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 165
LEU A 185
MET A 426
CYH A 258
 CAA  A 501 (-3.4A)
None
CAA  A 501 (-4.8A)
CAA  A 501 (-3.8A)
 1.10A 2oaxD-5lnqA:
undetectable		 2oaxD-5lnqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		4 LEU A 397
LEU A 411
CYH A 378
THR A 426
 None
 1.26A 2oaxD-5lqdA:
undetectable		 2oaxD-5lqdA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 4 LEU A 769
MET A 852
CYH A 942
THR A 945
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.7A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
 0.80A 2oaxD-5mwpA:
38.6		 2oaxD-5mwpA:
73.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 4 LEU B 191
LEU B 193
CYH B 200
THR B 147
 None
 1.08A 2oaxD-5nzpB:
undetectable		 2oaxD-5nzpB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 4 LEU A 193
LEU A 112
MET A  94
CYH A 108
 None
 1.18A 2oaxD-5o96A:
undetectable		 2oaxD-5o96A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 165
LEU A 496
CYH A  77
THR A  76
 None
None
AYE  A 602 (-1.7A)
None
 1.41A 2oaxD-5ohkA:
undetectable		 2oaxD-5ohkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 LEU B 847
MET B 939
CYH B 388
THR B 391
 None
 1.42A 2oaxD-5vniB:
undetectable		 2oaxD-5vniB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvs GDP/UDP-N,N'-DIACETY
LBACILLOSAMINE
2-EPIMERASE
(HYDROLYZING)

(Acinetobacter
baumannii) 		no annotation 4 LEU A 124
LEU A  16
MET A  21
THR A 111
 None
 1.14A 2oaxD-5xvsA:
undetectable		 2oaxD-5xvsA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y50 PROTEIN
DETOXIFICATION 14

(Arabidopsis
thaliana) 		no annotation 4 LEU A 179
LEU A 163
MET A 227
THR A 312
 None
 1.38A 2oaxD-5y50A:
undetectable		 2oaxD-5y50A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Homo sapiens) 		no annotation 4 LEU C 254
LEU C 234
CYH C 244
THR C 243
 None
 1.43A 2oaxD-5zcsC:
undetectable		 2oaxD-5zcsC:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 4 LEU A 401
LEU A 110
CYH A  87
THR A  42
 None
 1.31A 2oaxD-6avhA:
undetectable		 2oaxD-6avhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 LEU A2117
LEU A2110
CYH A2167
THR A2171
 None
 1.43A 2oaxD-6b3rA:
undetectable		 2oaxD-6b3rA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 LEU A2117
LEU A2110
CYH A2167
THR A2171
 None
 1.38A 2oaxD-6bpzA:
undetectable		 2oaxD-6bpzA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esx THIOREDOXIN 1

(Caulobacter
vibrioides) 		no annotation 4 LEU A  23
LEU A  99
MET A  93
THR A  86
 None
 1.43A 2oaxD-6esxA:
undetectable		 2oaxD-6esxA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewz GTP
PYROPHOSPHOKINASE

(Staphylococcus
aureus) 		no annotation 4 LEU A 154
LEU A 128
CYH A 115
THR A 179
 None
 1.19A 2oaxD-6ewzA:
undetectable		 2oaxD-6ewzA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 4 LEU B 314
LEU B 320
MET B 344
THR B 294
 None
 1.39A 2oaxD-6ez8B:
undetectable		 2oaxD-6ez8B:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f36 MITOCHONDRIAL ATP
SYNTHASE SUBUNIT 6
MITOCHONDRIAL ATP
SYNTHASE SUBUNIT
ASA6

(Polytomella sp.
Pringsheim
198.80) 		no annotation 4 LEU M 259
LEU N 105
CYH M 278
THR M 274
 None
 1.42A 2oaxD-6f36M:
undetectable		 2oaxD-6f36M:
15.64