SIMILAR PATTERNS OF AMINO ACIDS FOR 2OAX_D_SNLD4001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 LEU A 238
ALA A 237
LEU A  79
LEU A  39
PHE A 204
 DCS  A 301 ( 4.6A)
DCS  A 301 (-3.5A)
None
None
None
 1.42A 2oaxD-1i2lA:
undetectable		 2oaxD-1i2lA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ASN A  32
LEU A  34
ALA A  35
LEU A 106
PHE A  26
 None
 1.27A 2oaxD-1imvA:
undetectable		 2oaxD-1imvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		5 LEU A 135
GLN A 140
LEU A 345
LEU A 151
PHE A 165
 None
 1.25A 2oaxD-1iuqA:
undetectable		 2oaxD-1iuqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		5 LEU A 170
LEU A 127
ALA A 103
ARG A  43
LEU A 209
 None
NAP  A 800 (-4.2A)
NAP  A 800 (-3.2A)
NAP  A 800 (-3.4A)
None
 1.42A 2oaxD-1oaaA:
undetectable		 2oaxD-1oaaA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 LEU A 164
GLN A 252
LEU A 260
ARG A 263
PHE A 237
 None
 1.38A 2oaxD-1p49A:
undetectable		 2oaxD-1p49A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 349
ALA A 350
TRP A 383
LEU A 391
ARG A 394
MET A 421
 EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
 0.70A 2oaxD-1pcgA:
26.6		 2oaxD-1pcgA:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrj HTLV-I CAPSID
PROTEIN

(Primate
T-lymphotropic
virus 1) 		PF00607
(Gag_p24) 		5 LEU A  43
ALA A  44
GLN A  47
MET A  15
PHE A 121
 None
 1.15A 2oaxD-1qrjA:
undetectable		 2oaxD-1qrjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU A  20
LEU A  14
ALA A  13
LEU A 115
LEU A  39
 None
 0.96A 2oaxD-1qvrA:
undetectable		 2oaxD-1qvrA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
LEU A 221
ALA A 222
LEU A 176
ARG A   3
 None
 1.19A 2oaxD-1r6mA:
undetectable		 2oaxD-1r6mA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
LEU A 220
ALA A 221
LEU A 175
ARG A   2
 None
 1.23A 2oaxD-1udqA:
undetectable		 2oaxD-1udqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjt TRANSCRIPTION
ELONGATION FACTOR
S-II PROTEIN 3

(Mus musculus) 		PF08711
(Med26) 		5 LEU A  15
LEU A  21
ALA A  58
LEU A  78
LEU A  50
 None
 1.06A 2oaxD-1wjtA:
undetectable		 2oaxD-1wjtA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1e 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 LEU A 125
LEU A 108
ALA A 109
TRP A 162
LEU A  71
 None
 1.30A 2oaxD-1x1eA:
undetectable		 2oaxD-1x1eA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkp CHAPERONE PROTEIN
SYCN

(Yersinia pestis) 		no annotation 5 LEU B  50
ALA B 109
GLN B 108
MET B  31
LEU B  15
 None
 1.35A 2oaxD-1xkpB:
undetectable		 2oaxD-1xkpB:
19.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 701
ASN A 705
LEU A 707
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
PHE A 891
 None
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
None
 0.72A 2oaxD-2ax9A:
35.3		 2oaxD-2ax9A:
51.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
ASN A 705
TRP A 741
MET A 742
MET A 780
LEU A 873
PHE A 891
 None
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
None
 1.22A 2oaxD-2ax9A:
35.3		 2oaxD-2ax9A:
51.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 LEU A 633
LEU A 510
ARG A 519
MET A 840
LEU A 753
 None
 1.42A 2oaxD-2bmbA:
undetectable		 2oaxD-2bmbA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 253
ASN A 271
LEU A 269
ALA A 298
ARG A  81
 None
 1.27A 2oaxD-2dpnA:
undetectable		 2oaxD-2dpnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASN A 505
LEU A 584
ALA A 555
LEU A 629
LEU A 700
 None
 1.18A 2oaxD-2f57A:
undetectable		 2oaxD-2f57A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 108
ALA A 269
GLN A 170
LEU A 237
ARG A 254
 None
ADP  A 902 (-4.4A)
ADP  A 902 (-3.6A)
None
None
 1.36A 2oaxD-2gksA:
undetectable		 2oaxD-2gksA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 265
LEU A 271
ALA A 272
TRP A 305
MET A 306
ARG A 316
 None
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
 0.59A 2oaxD-2gpvA:
25.5		 2oaxD-2gpvA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 271
LEU A 265
ALA A 264
LEU A 345
LEU A 324
 OHT  A 500 ( 4.4A)
None
None
OHT  A 500 (-4.3A)
None
 0.88A 2oaxD-2gpvA:
25.5		 2oaxD-2gpvA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A  25
ALA A 608
LEU A 285
MET A  44
LEU A  50
 None
 1.21A 2oaxD-2hpiA:
undetectable		 2oaxD-2hpiA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id3 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		5 LEU A 127
ALA A  74
LEU A  24
ARG A  20
LEU A 109
 None
 1.40A 2oaxD-2id3A:
undetectable		 2oaxD-2id3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k5e UNCHARACTERIZED
PROTEIN

(Methanocaldococcus
jannaschii) 		PF08984
(DUF1858) 		5 LEU A  58
ASN A  62
LEU A  64
ALA A  65
MET A   9
 None
 1.03A 2oaxD-2k5eA:
undetectable		 2oaxD-2k5eA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 LEU A 663
ASN A 233
ALA A 236
LEU A 356
LEU A 256
 None
 1.29A 2oaxD-2nyaA:
undetectable		 2oaxD-2nyaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 349
ALA A 350
LEU A 391
ARG A 394
MET A 421
 EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
 0.55A 2oaxD-2ocfA:
28.1		 2oaxD-2ocfA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 349
ALA A 350
TRP A 383
LEU A 391
ARG A 394
 EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
 0.49A 2oaxD-2ocfA:
28.1		 2oaxD-2ocfA:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
 1.23A 2oaxD-2q3yA:
37.4		 2oaxD-2q3yA:
72.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		12 LEU A  29
ASN A  33
LEU A  35
ALA A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 ( 4.4A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.5A)
 0.40A 2oaxD-2q3yA:
37.4		 2oaxD-2q3yA:
72.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A  52
LEU A 100
ALA A  99
ARG A 193
LEU A  12
 None
 1.33A 2oaxD-2qkxA:
undetectable		 2oaxD-2qkxA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 372
LEU A 378
ALA A 379
GLN A 382
LEU A 521
 None
 1.10A 2oaxD-2qveA:
undetectable		 2oaxD-2qveA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6l COBE

(Pseudomonas
aeruginosa) 		PF01890
(CbiG_C) 		5 LEU A 107
LEU A 132
ALA A 131
LEU A  28
LEU A  57
 None
 1.21A 2oaxD-2w6lA:
undetectable		 2oaxD-2w6lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 LEU A 313
LEU A 322
ALA A 323
LEU A 291
LEU A 194
 None
 1.11A 2oaxD-2ychA:
undetectable		 2oaxD-2ychA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		5 ASN A 178
ALA A 179
GLN A 183
ARG A 189
LEU A  90
 None
 1.42A 2oaxD-2z3tA:
undetectable		 2oaxD-2z3tA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG

(Escherichia
coli) 		PF05368
(NmrA) 		5 ASN A  89
LEU A  59
ALA A  90
LEU A  71
LEU A 125
 None
 1.40A 2oaxD-2zcvA:
undetectable		 2oaxD-2zcvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		5 LEU A 164
ALA A 168
LEU A 204
ARG A  26
MET A  90
 None
 1.38A 2oaxD-3dmpA:
undetectable		 2oaxD-3dmpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 ALA A 451
LEU A 315
ARG A 354
LEU A 308
PHE A 419
 None
 1.24A 2oaxD-3e1sA:
undetectable		 2oaxD-3e1sA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 ASN A 446
LEU A 448
ALA A 449
GLN A 452
PHE A 439
 None
 1.23A 2oaxD-3e2dA:
undetectable		 2oaxD-3e2dA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 LEU A 175
ASN A 166
LEU A  49
ALA A  48
LEU A  95
 None
 1.43A 2oaxD-3ifwA:
undetectable		 2oaxD-3ifwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 LEU A  55
ASN A  56
LEU A  91
ARG A 115
MET A  18
 None
None
None
ACT  A 500 (-3.3A)
None
 1.28A 2oaxD-3im8A:
undetectable		 2oaxD-3im8A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.36A 2oaxD-3irvA:
undetectable		 2oaxD-3irvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		5 LEU A  66
ALA A  89
TRP A  51
LEU A  81
ARG A 228
 None
None
None
None
SO4  A 558 (-4.7A)
 1.03A 2oaxD-3iteA:
undetectable		 2oaxD-3iteA:
17.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
LEU A 763
ARG A 766
LEU A 887
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
WOW  A   1 (-4.6A)
 0.61A 2oaxD-3kbaA:
35.2		 2oaxD-3kbaA:
54.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 715
ASN A 719
TRP A 755
MET A 756
LEU A 763
LEU A 887
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.0A)
WOW  A   1 (-4.6A)
 1.00A 2oaxD-3kbaA:
35.2		 2oaxD-3kbaA:
54.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 715
ASN A 719
TRP A 755
MET A 759
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
None
WOW  A   1 (-3.7A)
WOW  A   1 (-4.6A)
 1.37A 2oaxD-3kbaA:
35.2		 2oaxD-3kbaA:
54.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 LEU F  66
ALA F 168
GLN F 167
LEU F 163
LEU F 107
 None
 1.29A 2oaxD-3kfuF:
undetectable		 2oaxD-3kfuF:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 LEU A 802
LEU A 842
ALA A 838
MET A 745
LEU A 772
 None
 1.21A 2oaxD-3m62A:
undetectable		 2oaxD-3m62A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 LEU A 848
LEU A 661
GLN A 665
MET A1039
LEU A 969
 None
 1.25A 2oaxD-3nzuA:
undetectable		 2oaxD-3nzuA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oad RENIN

(Homo sapiens) 		PF00026
(Asp) 		5 LEU B 216
LEU B 222
ALA B 223
GLN B 202
PHE B 270
 None
 1.16A 2oaxD-3oadB:
undetectable		 2oaxD-3oadB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU B 315
LEU B 313
ALA B 312
ARG B 809
LEU B 699
 None
 1.39A 2oaxD-3ohmB:
undetectable		 2oaxD-3ohmB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz6 HPCH/HPAI ALDOLASE

(Desulfitobacterium
hafniense) 		PF03328
(HpcH_HpaI) 		5 LEU A 239
ALA A 238
TRP A 232
LEU A  18
LEU A  35
 None
 1.31A 2oaxD-3qz6A:
undetectable		 2oaxD-3qz6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		5 LEU A  22
LEU A 108
ALA A 109
MET A 101
LEU A 114
 None
 1.42A 2oaxD-3rmvA:
undetectable		 2oaxD-3rmvA:
25.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.30A 2oaxD-3ry9A:
37.0		 2oaxD-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		11 LEU A  29
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.3A)
 0.34A 2oaxD-3ry9A:
37.0		 2oaxD-3ry9A:
69.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 LEU A 934
LEU A 956
ALA A 957
MET A 913
PHE A 895
 None
 1.43A 2oaxD-3tadA:
undetectable		 2oaxD-3tadA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		5 LEU V 243
ASN V 233
LEU V 231
ALA V 234
LEU V 213
 None
 1.34A 2oaxD-4a2iV:
undetectable		 2oaxD-4a2iV:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A 272
LEU A 266
ALA A 265
LEU A 159
PHE A 182
 None
 1.05A 2oaxD-4bziA:
undetectable		 2oaxD-4bziA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezd UREA TRANSPORTER 1

(Bos taurus) 		PF03253
(UT) 		5 LEU A 339
LEU A 287
ALA A 288
LEU A 345
PHE A 313
 SPL  A 408 (-3.8A)
None
None
None
None
 1.30A 2oaxD-4ezdA:
undetectable		 2oaxD-4ezdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 324
LEU A 330
ALA A 331
GLN A 337
ARG A 341
 None
 1.18A 2oaxD-4fdhA:
undetectable		 2oaxD-4fdhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		5 ASN A 377
LEU A 456
ALA A 427
LEU A 501
LEU A 572
 None
 1.14A 2oaxD-4fieA:
undetectable		 2oaxD-4fieA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ASN A 463
LEU A 542
ALA A 513
LEU A 587
PHE A 462
 None
 1.28A 2oaxD-4ks8A:
undetectable		 2oaxD-4ks8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 ASN A 375
LEU A 276
LEU A 297
MET A 313
LEU A 356
 None
 1.35A 2oaxD-4lc3A:
undetectable		 2oaxD-4lc3A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		8 LEU A 280
LEU A 286
ALA A 287
TRP A 320
MET A 321
ARG A 331
MET A 358
PHE A 462
 None
 0.72A 2oaxD-4n1yA:
28.2		 2oaxD-4n1yA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51

(Mus musculus) 		PF03281
(Mab-21) 		5 LEU A 412
ALA A 411
TRP A 399
LEU A 139
LEU A 362
 None
 1.34A 2oaxD-4oahA:
undetectable		 2oaxD-4oahA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc8 RESTRICTION
ENDONUCLEASE ASPBHI

(Azoarcus sp.
BH72) 		PF04471
(Mrr_cat) 		5 LEU A 263
ALA A 304
LEU A 321
ARG A 324
LEU A 356
 None
 1.37A 2oaxD-4oc8A:
undetectable		 2oaxD-4oc8A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 ASN A 564
LEU A 566
GLN A 570
TRP A 600
MET A 601
LEU A 608
ARG A 611
LEU A 732
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-4.4A)
 0.48A 2oaxD-4p6wA:
34.1		 2oaxD-4p6wA:
56.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 LEU A 211
LEU A 204
ALA A 203
GLN A 200
LEU A 248
 None
 1.33A 2oaxD-4txaA:
undetectable		 2oaxD-4txaA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 766
ASN A 770
LEU A 772
ALA A 773
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
LEU A 938
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.7A)
 0.42A 2oaxD-4udbA:
36.8		 2oaxD-4udbA:
91.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 766
ASN A 770
LEU A 827
LEU A 938
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.7A)
 1.29A 2oaxD-4udbA:
36.8		 2oaxD-4udbA:
91.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 LEU A 301
ASN A 262
LEU A 260
ALA A 263
LEU A 215
 None
 1.42A 2oaxD-4w87A:
undetectable		 2oaxD-4w87A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxm TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF06490
(FleQ) 		5 LEU A   9
LEU A  53
ALA A  52
TRP A  76
LEU A  73
 None
 1.37A 2oaxD-4wxmA:
undetectable		 2oaxD-4wxmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		5 ASN A 377
LEU A 456
ALA A 427
LEU A 501
LEU A 572
 None
 1.14A 2oaxD-4xbrA:
undetectable		 2oaxD-4xbrA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 LEU A 505
LEU A 516
ALA A 502
LEU A 493
LEU A 465
 None
 1.28A 2oaxD-4z2aA:
undetectable		 2oaxD-4z2aA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlc ROQUIN-2

(Homo sapiens) 		no annotation 5 LEU A 208
LEU A 201
ALA A 200
GLN A 197
LEU A 245
 None
 1.35A 2oaxD-4zlcA:
undetectable		 2oaxD-4zlcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 508
LEU A 589
ALA A 588
MET A 542
LEU A 562
 None
 1.39A 2oaxD-4ztxA:
undetectable		 2oaxD-4ztxA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 LEU O 244
ASN A  36
LEU A  35
ALA A  34
LEU O 236
 None
 1.42A 2oaxD-5a31O:
undetectable		 2oaxD-5a31O:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 5 ASN A   8
LEU A  59
ALA A  60
LEU A 150
LEU A  34
 None
 1.19A 2oaxD-5b01A:
undetectable		 2oaxD-5b01A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Streptomyces
viridosporus;
Sulfolobus
solfataricus) 		no annotation 5 ASN A   8
LEU A  59
ALA A  60
LEU A 150
LEU A  34
 None
None
None
BNG  A 501 ( 4.0A)
BNG  A 501 (-3.8A)
 1.26A 2oaxD-5b0lA:
2.4		 2oaxD-5b0lA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 ALA A 822
GLN A 296
MET A 302
LEU A 830
PHE A 797
 None
 1.43A 2oaxD-5l3dA:
undetectable		 2oaxD-5l3dA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 LEU A 114
LEU A  66
ALA A  94
LEU A  80
LEU A 125
 None
 1.37A 2oaxD-5lfnA:
undetectable		 2oaxD-5lfnA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		5 LEU A 202
ALA A 200
MET A  39
LEU A  96
PHE A 161
 None
 1.15A 2oaxD-5m0tA:
undetectable		 2oaxD-5m0tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU E 263
ASN E 262
LEU E 246
ARG E   2
LEU E 322
 None
 1.42A 2oaxD-5mjsE:
undetectable		 2oaxD-5mjsE:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlq CDPS

(Nocardia
brasiliensis) 		no annotation 5 LEU A 116
ALA A 115
LEU A  68
ARG A  70
LEU A  32
 None
 1.32A 2oaxD-5mlqA:
undetectable		 2oaxD-5mlqA:
16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 12 LEU A 766
ASN A 770
LEU A 772
ALA A 773
GLN A 776
TRP A 806
MET A 807
LEU A 814
ARG A 817
MET A 845
LEU A 938
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 ( 4.7A)
 0.43A 2oaxD-5mwpA:
38.6		 2oaxD-5mwpA:
73.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ASN A 369
LEU A 367
ALA A 366
LEU A 292
MET A 222
 8R5  A 502 (-3.4A)
None
None
None
None
 1.27A 2oaxD-5nagA:
undetectable		 2oaxD-5nagA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nci LEUCINE HYDROXYLASE

(Streptomyces
muensis) 		PF05721
(PhyH) 		5 LEU A 223
ASN A  97
LEU A  58
ALA A  57
ARG A  64
 AKG  A 302 ( 4.8A)
AKG  A 302 (-3.3A)
None
None
None
 1.28A 2oaxD-5nciA:
undetectable		 2oaxD-5nciA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfg PROCARDOSIN-B,PROCAR
DOSIN-B

(Cynara
cardunculus) 		no annotation 5 ALA A 264
GLN A 242
ARG A 237
LEU A 346
PHE A 313
 None
 1.30A 2oaxD-5nfgA:
undetectable		 2oaxD-5nfgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 LEU A 166
ALA A 174
LEU A 275
LEU A 541
PHE A 190
 None
 1.40A 2oaxD-5opqA:
undetectable		 2oaxD-5opqA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 301
ALA A 302
TRP A 335
MET A 336
LEU A 343
ARG A 346
 EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
None
EST  A 601 ( 3.7A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
 0.47A 2oaxD-5toaA:
25.2		 2oaxD-5toaA:
29.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
LEU A 562
GLN A 566
LEU A 604
ARG A 607
MET A 635
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 4.7A)
 1.19A 2oaxD-5uc1A:
22.2		 2oaxD-5uc1A:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 ASN A 560
LEU A 562
GLN A 566
MET A 597
LEU A 604
ARG A 607
 486  A 801 (-4.2A)
486  A 801 ( 4.8A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.70A 2oaxD-5uc1A:
22.2		 2oaxD-5uc1A:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 562
GLN A 566
TRP A 596
MET A 597
LEU A 604
ARG A 607
 486  A 801 ( 4.8A)
486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.70A 2oaxD-5uc1A:
22.2		 2oaxD-5uc1A:
57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 ASN A  33
LEU A  35
GLN A  39
LEU A  77
ARG A  80
MET A 108
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-4.0A)
 1.10A 2oaxD-5ufsA:
35.8		 2oaxD-5ufsA:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
LEU A 201
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 ( 3.6A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-4.0A)
 0.48A 2oaxD-5ufsA:
35.8		 2oaxD-5ufsA:
62.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A 274
LEU A 268
ALA A 267
LEU A 166
PHE A 189
 None
 1.30A 2oaxD-5vniA:
undetectable		 2oaxD-5vniA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		5 LEU J 428
LEU J 468
ALA J 471
LEU J 501
LEU J 441
 None
 1.41A 2oaxD-5vzjJ:
undetectable		 2oaxD-5vzjJ:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C1601
LEU C1695
ALA C1692
LEU C1710
LEU C1684
 None
 1.30A 2oaxD-5y3rC:
undetectable		 2oaxD-5y3rC:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 5 LEU A1298
LEU A1566
ALA A1565
LEU A1365
LEU A1303
 None
 1.29A 2oaxD-5zalA:
undetectable		 2oaxD-5zalA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		5 LEU A 100
LEU A 173
ALA A  66
LEU A  36
LEU A  45
 None
 1.42A 2oaxD-6ao1A:
undetectable		 2oaxD-6ao1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 5 LEU A1214
ALA A1255
TRP A1298
MET A1193
PHE A1248
 None
 1.09A 2oaxD-6bq1A:
undetectable		 2oaxD-6bq1A:
0.00