SIMILAR PATTERNS OF AMINO ACIDS FOR 2OAX_C_SNLC3001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5i BH3822 PROTEIN

(Bacillus
halodurans) 		PF03099
(BPL_LplA_LipB) 		4 LEU A  63
LEU A  99
MET A 193
CYH A 150
 None
 1.31A 2oaxC-2p5iA:
0.0		 2oaxC-2p5iA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 LEU A 312
LEU A 286
MET A 159
CYH A 293
 None
 1.10A 2oaxC-2q4aA:
0.0		 2oaxC-2q4aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		4 LEU R 108
LEU R 126
MET R 147
CYH R 113
 A  N  78 ( 4.5A)
None
None
None
 1.23A 2oaxC-3jb9R:
0.0		 2oaxC-3jb9R:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyt ESTERASE A

(Paenarthrobacter
nitroguajacolicus) 		PF00144
(Beta-lactamase) 		4 LEU A 187
LEU A  67
MET A 157
CYH A  60
 None
 1.50A 2oaxC-3zytA:
0.0		 2oaxC-3zytA:
22.70