SIMILAR PATTERNS OF AMINO ACIDS FOR 2OA1_B_ADNB2005

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctm CYTOCHROME F

(Brassica rapa)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
4 GLY A 235
GLY A 234
VAL A  31
SER A  28
None
0.67A 2oa1B-1ctmA:
undetectable
2oa1B-1ctmA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3


(Reovirus sp.)
PF00979
(Reovirus_cap)
4 GLY A 319
GLY A 318
VAL A 302
LEU A   5
None
0.75A 2oa1B-1fn9A:
undetectable
2oa1B-1fn9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica)
PF00135
(COesterase)
4 GLY A 202
VAL A 323
SER A 228
LEU A 404
None
0.83A 2oa1B-1gqrA:
undetectable
2oa1B-1gqrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ism BONE MARROW STROMAL
CELL ANTIGEN 1


(Homo sapiens)
PF02267
(Rib_hydrolayse)
4 GLY A 200
GLY A 199
ASP A 230
VAL A 203
None
0.70A 2oa1B-1ismA:
undetectable
2oa1B-1ismA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE


(Acinetobacter
sp.)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 GLY A 218
GLY A 219
VAL A 316
LEU A 306
None
SO4  A 402 (-3.5A)
None
None
0.60A 2oa1B-1krhA:
3.7
2oa1B-1krhA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0n ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE


(Bacillus
subtilis)
PF01070
(FMN_dh)
4 GLY A 258
GLY A 259
VAL A 186
SER A 257
FMN  A 669 (-3.0A)
FMN  A 669 (-4.2A)
None
None
0.80A 2oa1B-1p0nA:
undetectable
2oa1B-1p0nA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 GLY A  87
GLY A  86
VAL A 165
LEU A  94
None
0.68A 2oa1B-1poxA:
2.3
2oa1B-1poxA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE


(Pseudomonas
putida)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
4 GLY A 156
GLY A 157
VAL A 214
LEU A 117
None
0.67A 2oa1B-1q1rA:
11.0
2oa1B-1q1rA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smk MALATE
DEHYDROGENASE,
GLYOXYSOMAL


(Citrullus
lanatus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A 218
GLY A 219
VAL A 302
LEU A 325
None
0.82A 2oa1B-1smkA:
undetectable
2oa1B-1smkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN


(Legionella
pneumophila)
PF01369
(Sec7)
4 GLY B 169
GLY B 168
VAL B 126
LEU B 135
None
0.77A 2oa1B-1xt0B:
undetectable
2oa1B-1xt0B:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE


(Rattus
norvegicus)
PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C)
4 GLY A 159
GLY A 160
VAL A  94
SER A 164
None
None
None
GOL  A 702 (-2.6A)
0.84A 2oa1B-1yjkA:
undetectable
2oa1B-1yjkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318


(Archaeoglobus
fulgidus)
PF02171
(Piwi)
4 GLY A 110
VAL A 100
SER A 136
LEU A 130
None
0.82A 2oa1B-1ytuA:
undetectable
2oa1B-1ytuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 GLY A 472
GLY A 471
SER A 166
LEU A 168
None
None
ANP  A 532 (-3.9A)
None
0.79A 2oa1B-2aj4A:
undetectable
2oa1B-2aj4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE


(Pseudomonas
putida)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
4 GLY A  98
GLY A  97
ASP A  88
LEU A 233
None
0.56A 2oa1B-2azqA:
undetectable
2oa1B-2azqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqw DIHYDROPTEROATE
SYNTHASE


(Thermus
thermophilus)
PF00809
(Pterin_bind)
4 GLY A 103
ASP A  21
VAL A 106
LEU A 100
None
0.74A 2oa1B-2dqwA:
undetectable
2oa1B-2dqwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE


(Thermus
thermophilus)
PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3)
4 GLY A  15
GLY A  12
VAL A  71
LEU A 298
None
0.72A 2oa1B-2ejwA:
4.1
2oa1B-2ejwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE


(Thermus
caldophilus)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
4 GLY A  19
GLY A  20
VAL A 246
LEU A  51
None
0.65A 2oa1B-2gqtA:
undetectable
2oa1B-2gqtA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE


(Trypanosoma
brucei)
PF00365
(PFK)
4 GLY A 106
GLY A 107
VAL A 103
SER A 172
None
0.69A 2oa1B-2higA:
undetectable
2oa1B-2higA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
4 GLY A 471
GLY A 264
VAL A 500
LEU A 494
XYQ  A1222 (-3.6A)
XYQ  A1222 (-3.4A)
None
None
0.77A 2oa1B-2hjhA:
2.5
2oa1B-2hjhA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE


(Thermus
caldophilus)
PF00162
(PGK)
4 GLY A 370
GLY A 371
VAL A 351
ARG A  34
None
0.79A 2oa1B-2ie8A:
undetectable
2oa1B-2ie8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE


(Homo sapiens)
PF00282
(Pyridoxal_deC)
4 GLY A 246
VAL A 280
SER A 245
LEU A 290
None
0.82A 2oa1B-2jisA:
undetectable
2oa1B-2jisA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis)
PF14597
(Lactamase_B_5)
4 GLY A 145
GLY A 144
VAL A 138
LEU A 195
None
0.80A 2oa1B-2p97A:
undetectable
2oa1B-2p97A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
4 GLY A 302
GLY A 301
VAL A 181
LEU A 444
HEM  A 500 (-3.5A)
HEM  A 500 ( 4.7A)
None
HEM  A 500 ( 4.7A)
0.78A 2oa1B-2pg6A:
undetectable
2oa1B-2pg6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN


(Homo sapiens)
PF01823
(MACPF)
4 GLY A 319
GLY A 318
ASP A 428
VAL A 235
None
0.78A 2oa1B-2qqhA:
undetectable
2oa1B-2qqhA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT


(Homo sapiens)
PF00089
(Trypsin)
4 GLY B 472
GLY B 639
VAL B 502
LEU B 544
None
0.79A 2oa1B-2qy0B:
undetectable
2oa1B-2qy0B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
4 GLY A 649
ASP A 608
VAL A 666
LEU A 658
None
0.84A 2oa1B-2vdcA:
undetectable
2oa1B-2vdcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51


(Fasciola
hepatica)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 GLY A 211
GLY A 212
VAL A 109
LEU A 165
None
0.83A 2oa1B-2wrtA:
undetectable
2oa1B-2wrtA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
4 GLY A 231
GLY A 230
VAL A 137
LEU A 345
HEM  A1400 (-3.2A)
PG4  A1399 ( 3.2A)
None
HEM  A1400 ( 4.7A)
0.70A 2oa1B-2xkrA:
undetectable
2oa1B-2xkrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE


(Oceanicola
granulosus)
PF07555
(NAGidase)
4 GLY A 239
GLY A 238
ASP A 220
VAL A 201
None
0.83A 2oa1B-2xsbA:
undetectable
2oa1B-2xsbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zec TRYPTASE BETA 2

(Homo sapiens)
PF00089
(Trypsin)
4 GLY A  46
GLY A 211
VAL A  73
LEU A 110
None
0.76A 2oa1B-2zecA:
undetectable
2oa1B-2zecA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT


(Corynebacterium
sp. U-96)
PF01266
(DAO)
4 GLY B  27
GLY B  28
VAL B 196
LEU B 232
FAD  B   1 (-3.3A)
FAD  B   1 ( 4.8A)
FAD  B   1 (-4.0A)
FAD  B   1 (-4.6A)
0.68A 2oa1B-3adaB:
13.9
2oa1B-3adaB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afo NADH KINASE POS5

(Saccharomyces
cerevisiae)
PF01513
(NAD_kinase)
4 GLY A 275
GLY A 274
VAL A 278
LEU A 286
None
0.69A 2oa1B-3afoA:
4.7
2oa1B-3afoA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c19 UNCHARACTERIZED
PROTEIN MK0293


(Methanopyrus
kandleri)
PF01969
(DUF111)
4 GLY A  63
GLY A  64
VAL A  74
ARG A  89
None
0.65A 2oa1B-3c19A:
5.2
2oa1B-3c19A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE


(Desulfovibrio
alaskensis)
no annotation 4 GLY A 319
GLY A 318
VAL A 354
LEU A 338
None
0.79A 2oa1B-3c8vA:
undetectable
2oa1B-3c8vA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbt PHOSPHATASE SC4828

(Streptomyces
coelicolor)
PF04167
(DUF402)
4 GLY A 144
GLY A 143
VAL A  61
LEU A  59
GLY  A 144 ( 0.0A)
GLY  A 143 ( 0.0A)
VAL  A  61 ( 0.6A)
LEU  A  59 ( 0.6A)
0.78A 2oa1B-3cbtA:
undetectable
2oa1B-3cbtA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN


(Bifidobacterium
longum)
PF02541
(Ppx-GppA)
4 GLY A 154
GLY A 155
VAL A 231
ARG A  29
SO4  A 345 (-3.4A)
SO4  A 345 ( 3.5A)
None
SO4  A 345 (-2.8A)
0.82A 2oa1B-3cerA:
undetectable
2oa1B-3cerA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE


(Leishmania
braziliensis)
PF01182
(Glucosamine_iso)
4 GLY A 122
GLY A 121
SER A 116
LEU A  78
None
0.75A 2oa1B-3ch7A:
undetectable
2oa1B-3ch7A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN


(Thermotoga
maritima)
PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5)
4 GLY A  10
ASP A 244
VAL A 182
LEU A 320
NAD  A 400 (-3.2A)
NAD  A 400 (-3.5A)
None
NAD  A 400 (-4.2A)
0.71A 2oa1B-3cinA:
undetectable
2oa1B-3cinA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE


(Thermoplasma
acidophilum)
PF07992
(Pyr_redox_2)
4 GLY A 162
GLY A 163
VAL A 213
LEU A 129
None
0.60A 2oa1B-3ctyA:
9.1
2oa1B-3ctyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE


(Bacillus
halodurans)
PF01266
(DAO)
PF16901
(DAO_C)
4 GLY A  25
GLY A  26
VAL A 193
LEU A 235
FAD  A 609 ( 4.0A)
None
FAD  A 609 ( 3.8A)
FAD  A 609 (-4.2A)
0.63A 2oa1B-3da1A:
9.2
2oa1B-3da1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus)
PF04820
(Trp_halogenase)
4 GLY A  14
GLY A  15
VAL A 134
SER A 168
FAD  A 600 (-3.2A)
FAD  A 600 ( 4.9A)
FAD  A 600 (-3.9A)
FAD  A 600 (-4.2A)
0.60A 2oa1B-3e1tA:
25.6
2oa1B-3e1tA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
4 GLY A 696
GLY A 697
ASP A 630
SER A 695
GOL  A 912 ( 3.1A)
GOL  A 912 ( 3.1A)
None
PCD  A 921 (-4.4A)
0.83A 2oa1B-3fahA:
undetectable
2oa1B-3fahA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609


(Methanocaldococcus
jannaschii)
PF13520
(AA_permease_2)
4 GLY C  31
VAL C 343
SER C  28
LEU C 103
None
0.82A 2oa1B-3gi8C:
undetectable
2oa1B-3gi8C:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA'


(Escherichia
coli)
PF09115
(DNApol3-delta_C)
PF13177
(DNA_pol3_delta2)
4 GLY E 108
GLY E 107
VAL E 111
LEU E  49
None
0.80A 2oa1B-3glgE:
undetectable
2oa1B-3glgE:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1


(Staphylococcus
aureus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 GLY A  18
GLY A  15
VAL A  79
LEU A 240
None
NAD  A 500 (-3.3A)
None
None
0.81A 2oa1B-3h3jA:
3.4
2oa1B-3h3jA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
4 GLY A  76
GLY A  75
VAL A 329
LEU A  41
None
0.80A 2oa1B-3hutA:
3.7
2oa1B-3hutA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
4 GLY A 181
GLY A 182
ASP A 161
VAL A 288
None
0.72A 2oa1B-3ne5A:
undetectable
2oa1B-3ne5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
4 GLY A  45
GLY A  46
VAL A  99
LEU A  41
None
0.82A 2oa1B-3pkoA:
undetectable
2oa1B-3pkoA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 GLY A 104
GLY A 105
VAL A 211
LEU A 201
None
FAD  A 773 (-3.3A)
None
None
0.72A 2oa1B-3redA:
8.9
2oa1B-3redA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN


(Bacillus virus
phi29)
PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3)
4 GLY A 464
GLY A 465
VAL A 436
ARG A 441
None
0.77A 2oa1B-3sucA:
undetectable
2oa1B-3sucA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3z MICROCEPHALIN

(Homo sapiens)
PF00533
(BRCT)
PF16589
(BRCT_2)
4 GLY A 798
VAL A 816
SER A 768
LEU A 775
None
0.62A 2oa1B-3u3zA:
undetectable
2oa1B-3u3zA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
4 GLY A  13
VAL A  47
SER A  10
LEU A  31
None
0.77A 2oa1B-3v2hA:
5.1
2oa1B-3v2hA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE


(Bifidobacterium
longum)
PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C)
4 GLY A 516
VAL A 529
SER A 546
LEU A 559
None
0.65A 2oa1B-3wfzA:
undetectable
2oa1B-3wfzA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA


(Staphylococcus
aureus)
PF02491
(SHS2_FTSA)
PF14450
(FtsA)
4 GLY A 201
GLY A 318
VAL A 223
LEU A 313
None
0.78A 2oa1B-3wquA:
undetectable
2oa1B-3wquA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
4 GLY A 234
GLY A 233
VAL A 140
LEU A 348
HEM  A1402 (-3.3A)
EDO  A1406 ( 3.4A)
None
HEM  A1402 ( 4.7A)
0.68A 2oa1B-3zbyA:
undetectable
2oa1B-3zbyA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL


(Homo sapiens)
PF07992
(Pyr_redox_2)
PF14721
(AIF_C)
4 GLY A 307
GLY A 308
VAL A 369
LEU A 267
None
0.62A 2oa1B-4bv6A:
10.2
2oa1B-4bv6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila)
PF01369
(Sec7)
4 GLY A 169
GLY A 168
VAL A 126
LEU A 135
None
0.65A 2oa1B-4c7pA:
2.8
2oa1B-4c7pA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis)
no annotation 4 GLY A  29
GLY A  28
VAL A  99
LEU A 232
None
0.78A 2oa1B-4gk9A:
undetectable
2oa1B-4gk9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpz DTALE2

(Xanthomonas)
PF03377
(TAL_effector)
4 GLY A 371
GLY A 370
VAL A 344
SER A 367
None
0.82A 2oa1B-4hpzA:
undetectable
2oa1B-4hpzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpz DTALE2

(Xanthomonas)
PF03377
(TAL_effector)
4 GLY A 507
GLY A 506
VAL A 480
SER A 503
None
0.80A 2oa1B-4hpzA:
undetectable
2oa1B-4hpzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1u DEPHOSPHO-COA KINASE

(Burkholderia
vietnamiensis)
PF01121
(CoaE)
4 GLY A   8
GLY A   9
VAL A  17
LEU A   6
None
0.82A 2oa1B-4i1uA:
2.9
2oa1B-4i1uA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2


(Saccharomyces
cerevisiae)
PF02146
(SIR2)
PF04574
(DUF592)
4 GLY A 471
GLY A 264
VAL A 500
LEU A 494
APR  A 602 (-3.7A)
APR  A 602 (-3.3A)
None
None
0.79A 2oa1B-4iaoA:
2.6
2oa1B-4iaoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA


(Vibrio
parahaemolyticus)
PF02080
(TrkA_C)
PF02254
(TrkA_N)
4 GLY A  12
GLY A   9
VAL A  70
LEU A 358
None
AGS  A 501 (-3.4A)
None
None
0.79A 2oa1B-4j9vA:
6.3
2oa1B-4j9vA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
PF17210
(SdrD_B)
4 GLY A 609
GLY A 608
ASP A 665
LEU A 611
None
None
CA  A 702 (-2.3A)
None
0.82A 2oa1B-4jdzA:
undetectable
2oa1B-4jdzA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3x HEMAGGLUTININ HA1

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 GLY A 249
GLY A 200
VAL A 130
LEU A 164
None
0.72A 2oa1B-4k3xA:
undetectable
2oa1B-4k3xA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Azospirillum
lipoferum)
PF13378
(MR_MLE_C)
4 GLY A 338
GLY A 337
VAL A 363
LEU A 328
None
0.74A 2oa1B-4kemA:
undetectable
2oa1B-4kemA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5o PUTATIVE GLUTATHIONE
TRANSFERASE


(Clonorchis
sinensis)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 GLY A 211
GLY A 212
VAL A 106
LEU A 165
None
0.76A 2oa1B-4l5oA:
undetectable
2oa1B-4l5oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9z MALYL-COA LYASE

(Rhodobacter
sphaeroides)
PF03328
(HpcH_HpaI)
4 GLY A 181
GLY A 182
ASP A 199
LEU A 164
None
0.80A 2oa1B-4l9zA:
undetectable
2oa1B-4l9zA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH


(Lechevalieria
aerocolonigenes)
PF04820
(Trp_halogenase)
5 GLY A  12
GLY A  13
ASP A  41
SER A 228
ARG A 231
None
0.80A 2oa1B-4lu6A:
62.2
2oa1B-4lu6A:
98.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH


(Lechevalieria
aerocolonigenes)
PF04820
(Trp_halogenase)
6 GLY A  12
GLY A  13
ASP A  41
VAL A 197
SER A 228
LEU A 233
None
0.52A 2oa1B-4lu6A:
62.2
2oa1B-4lu6A:
98.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc5 HEMAGGLUTININ

(Influenza A
virus)
PF00509
(Hemagglutinin)
4 GLY A 247
GLY A 198
VAL A 129
LEU A 162
None
0.81A 2oa1B-4mc5A:
undetectable
2oa1B-4mc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN


(Veillonella
parvula)
PF01497
(Peripla_BP_2)
4 GLY A  47
GLY A  46
SER A  43
LEU A  40
None
0.83A 2oa1B-4mo9A:
2.5
2oa1B-4mo9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN


(Sulfolobus
acidocaldarius)
PF01266
(DAO)
4 GLY A 234
GLY A 235
VAL A 269
ARG A 351
None
None
FDA  A 501 ( 4.7A)
None
0.76A 2oa1B-4opuA:
21.2
2oa1B-4opuA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyt UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(unidentified)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
4 GLY A  31
GLY A  32
VAL A 273
LEU A  70
None
0.82A 2oa1B-4pytA:
undetectable
2oa1B-4pytA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q80 SERINE PROTEASE 57

(Homo sapiens)
PF00089
(Trypsin)
4 GLY A  44
GLY A 197
VAL A  66
LEU A 106
None
0.81A 2oa1B-4q80A:
undetectable
2oa1B-4q80A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 GLY H  98
GLY H  99
ARG H  72
LEU H  79
None
0.68A 2oa1B-4utaH:
undetectable
2oa1B-4utaH:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 GLY A 304
GLY A 303
SER A 114
LEU A 116
None
None
MG  A 400 (-2.4A)
MG  A 400 ( 4.6A)
0.80A 2oa1B-4utgA:
undetectable
2oa1B-4utgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8i PROBABLE
SPHINGOSINE-1-PHOSPH
ATE LYASE


(Legionella
pneumophila)
PF00282
(Pyridoxal_deC)
4 GLY A 331
GLY A 330
ASP A 326
VAL A 370
None
0.83A 2oa1B-4w8iA:
undetectable
2oa1B-4w8iA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens)
PF00476
(DNA_pol_A)
4 GLY A2532
GLY A2531
VAL A2558
LEU A2327
None
0.59A 2oa1B-4x0qA:
2.5
2oa1B-4x0qA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE


(Mycoplasma
pneumoniae)
PF01266
(DAO)
4 GLY A  10
GLY A  11
VAL A 177
LEU A 216
FAD  A 401 (-3.2A)
FAD  A 401 ( 4.6A)
FAD  A 401 (-4.2A)
None
0.78A 2oa1B-4x9nA:
13.2
2oa1B-4x9nA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus)
PF01266
(DAO)
4 GLY A  11
GLY A  12
VAL A 180
SER A 208
FAD  A 401 (-3.3A)
FAD  A 401 ( 4.8A)
FAD  A 401 (-4.0A)
FAD  A 401 (-4.4A)
0.44A 2oa1B-4yshA:
13.7
2oa1B-4yshA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE


(Eimeria tenella)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 GLY A 214
VAL A 135
SER A 212
LEU A 152
None
0.79A 2oa1B-4ysjA:
undetectable
2oa1B-4ysjA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA


(Pseudomonas
fluorescens)
PF04820
(Trp_halogenase)
4 GLY A  12
GLY A  13
VAL A 187
SER A 218
FAD  A 601 (-3.2A)
FAD  A 601 (-3.3A)
FAD  A 601 (-3.8A)
FAD  A 601 (-4.9A)
0.29A 2oa1B-4z43A:
52.7
2oa1B-4z43A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA


(Pseudomonas
fluorescens)
PF04820
(Trp_halogenase)
4 GLY A  12
VAL A 187
SER A 218
LEU A 223
FAD  A 601 (-3.2A)
FAD  A 601 (-3.8A)
FAD  A 601 (-4.9A)
FAD  A 601 (-3.7A)
0.51A 2oa1B-4z43A:
52.7
2oa1B-4z43A:
53.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5q CYTOCHROME P450
HYDROXYLASE


(Streptomyces
atroolivaceus)
PF00067
(p450)
4 GLY A 241
GLY A 240
VAL A 152
LEU A 357
HEM  A 401 (-3.2A)
P33  A 407 ( 3.4A)
None
HEM  A 401 (-4.6A)
0.78A 2oa1B-4z5qA:
undetectable
2oa1B-4z5qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE


(Streptomyces
sp. CNQ-418)
PF04820
(Trp_halogenase)
4 GLY A  11
GLY A  12
VAL A 146
SER A 178
FAD  A 501 (-3.3A)
FAD  A 501 ( 4.9A)
FAD  A 501 (-4.0A)
FAD  A 501 (-4.6A)
0.59A 2oa1B-5bukA:
23.2
2oa1B-5bukA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 GLY A 464
GLY A 463
ASP A 487
LEU A 267
None
None
FAD  A 601 (-4.6A)
None
0.77A 2oa1B-5eb5A:
8.4
2oa1B-5eb5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5


(Homo sapiens)
PF00899
(ThiF)
4 GLY A  83
GLY A  82
VAL A 207
LEU A 254
None
0.79A 2oa1B-5iaaA:
6.6
2oa1B-5iaaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
4 GLY A1004
GLY A1003
VAL A1029
LEU A1012
None
0.76A 2oa1B-5ja1A:
2.2
2oa1B-5ja1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwb TYPE II
NADH:UBIQUINONE
OXIDOREDUCTASE


(Plasmodium
falciparum)
PF07992
(Pyr_redox_2)
4 GLY A 207
GLY A 208
VAL A 278
SER A 309
NAD  A 608 (-3.3A)
NAD  A 608 ( 4.8A)
NAD  A 608 (-4.2A)
NAD  A 608 (-4.7A)
0.48A 2oa1B-5jwbA:
9.8
2oa1B-5jwbA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2


(Staphylococcus
aureus)
no annotation 4 GLY D 149
GLY D 148
ASP D  75
LEU D 126
None
0.74A 2oa1B-5k59D:
undetectable
2oa1B-5k59D:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE


(Schistosoma
mansoni)
PF01048
(PNP_UDP_1)
4 GLY A 120
GLY A 121
ASP A 250
VAL A 262
CYT  A 301 (-3.3A)
None
None
None
0.77A 2oa1B-5ko5A:
undetectable
2oa1B-5ko5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC
SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 GLY A 301
ASP B 292
VAL A 296
LEU A 307
None
0.83A 2oa1B-5l3rA:
undetectable
2oa1B-5l3rA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC
SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00448
(SRP54)
PF02881
(SRP54_N)
4 GLY A 301
GLY B 296
ASP B 292
VAL A 296
None
0.82A 2oa1B-5l3rA:
undetectable
2oa1B-5l3rA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8


(Homo sapiens)
PF07686
(V-set)
4 GLY H  94
GLY H  95
ARG H  71
LEU H  78
None
EDO  H 202 ( 3.7A)
None
None
0.65A 2oa1B-5lbsH:
undetectable
2oa1B-5lbsH:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN


(Thermus
thermophilus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 GLY B 564
GLY B 563
VAL B 551
LEU A 602
None
0.80A 2oa1B-5mkkB:
undetectable
2oa1B-5mkkB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-)
no annotation 4 GLY A 116
GLY A 115
VAL A 444
SER A 476
None
0.64A 2oa1B-5ohsA:
undetectable
2oa1B-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII


(Homo sapiens)
no annotation 4 GLY B  44
GLY B 197
VAL B  66
LEU B 106
None
0.83A 2oa1B-6b74B:
undetectable
2oa1B-6b74B:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1


(Bos taurus)
no annotation 4 GLY A1425
GLY A1426
VAL A 420
SER A1380
None
0.76A 2oa1B-6bhuA:
undetectable
2oa1B-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila)
no annotation 4 GLY A 358
ASP A 304
VAL A 300
SER A 361
None
0.80A 2oa1B-6gebA:
undetectable
2oa1B-6gebA:
8.74