SIMILAR PATTERNS OF AMINO ACIDS FOR 2O4N_A_TPVA300_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5z L-LACTATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  41
ALA A  46
GLY A  25
ILE A  95
LEU A  66
 None
 1.36A 2o4nB-1a5zA:
undetectable		 2o4nB-1a5zA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 LEU A 510
ALA A  71
ILE A 211
GLY A  68
LEU A 514
 None
 0.96A 2o4nB-1aorA:
0.0		 2o4nB-1aorA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bl5 ISOCITRATE
DEHYDROGENASE

(Escherichia
coli) 		PF00180
(Iso_dh) 		4 ALA A 337
ILE A  37
GLY A 321
ILE A 322
 None
None
NAP  A   2 ( 3.9A)
None
 0.72A 2o4nB-1bl5A:
undetectable		 2o4nB-1bl5A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 5 ARG A 339
ALA A  69
GLY A  19
ILE A  17
LEU A 288
 None
 1.48A 2o4nB-1bwdA:
undetectable		 2o4nB-1bwdA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		4 LEU A 216
ALA A 166
GLY A 241
LEU A 174
 None
 0.59A 2o4nB-1cn3A:
0.0		 2o4nB-1cn3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cul TYPE II ADENYLYL
CYCLASE

(Rattus
norvegicus) 		PF00211
(Guanylate_cyc) 		5 LEU B 979
ILE B 918
GLY B 941
ILE B 940
LEU B 996
 None
None
None
103  B1082 (-4.9A)
None
 1.13A 2o4nB-1culB:
0.0		 2o4nB-1culB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		4 LEU E 165
GLY E 119
ILE E 120
LEU E   6
 None
 0.78A 2o4nB-1cziE:
6.8		 2o4nB-1cziE:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1n INITIATION FACTOR 2

(Geobacillus
stearothermophilus) 		PF03144
(GTP_EFTU_D2) 		5 LEU A 216
ALA A 151
GLY A 173
ILE A 148
LEU A 198
 None
 1.19A 2o4nB-1d1nA:
0.0		 2o4nB-1d1nA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 368
GLY A 199
ILE A 269
LEU A 362
 None
NAD  A1377 ( 3.7A)
NAD  A1377 (-4.0A)
None
 0.73A 2o4nB-1d1tA:
undetectable		 2o4nB-1d1tA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 ARG A 197
LEU A 139
ILE A 100
GLY A 168
ILE A 165
 CAA  A 300 ( 4.8A)
None
CAA  A 300 (-4.2A)
None
None
 1.21A 2o4nB-1dubA:
undetectable		 2o4nB-1dubA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
None
None
GOL  A 609 ( 3.9A)
 0.76A 2o4nB-1e1tA:
undetectable		 2o4nB-1e1tA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 242
ALA A 173
ILE A 108
GLY A 347
 None
 0.78A 2o4nB-1e5mA:
undetectable		 2o4nB-1e5mA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 LEU A1062
ALA A1331
ILE A1069
GLY A1028
ILE A1029
 None
 1.37A 2o4nB-1fdjA:
undetectable		 2o4nB-1fdjA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fu1 DNA REPAIR PROTEIN
XRCC4

(Homo sapiens) 		PF06632
(XRCC4) 		5 ARG A  71
LEU A  75
ILE A  34
GLY A 109
LEU A  28
 None
None
None
ACY  A 503 (-3.5A)
None
 1.47A 2o4nB-1fu1A:
undetectable		 2o4nB-1fu1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1goj KINESIN HEAVY CHAIN

(Neurospora
crassa) 		PF00225
(Kinesin) 		5 LEU A 172
ASP A 148
ALA A 151
ILE A 175
GLY A 190
 None
 1.35A 2o4nB-1gojA:
undetectable		 2o4nB-1gojA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyt CYTOSOL
AMINOPEPTIDASE

(Escherichia
coli) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ARG A 356
ALA A 321
GLY A 296
LEU A 454
 CO3  A 603 (-3.9A)
None
None
None
 0.74A 2o4nB-1gytA:
undetectable		 2o4nB-1gytA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II

(Bacteroides
fragilis) 		no annotation 4 LEU A  67
GLY A 102
ILE A  72
LEU A 111
 None
 0.74A 2o4nB-1hlkA:
undetectable		 2o4nB-1hlkA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ARG A   8
LEU A  23
ALA A  28
GLY A  49
ILE A  50
 A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
 0.80A 2o4nB-1hvcA:
14.0		 2o4nB-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  49
 A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
 0.57A 2o4nB-1hvcA:
14.0		 2o4nB-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  49
 A79  A 800 (-3.6A)
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
 0.55A 2o4nB-1hvcA:
14.0		 2o4nB-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
LEU A  23
ASP A  25
ALA A  28
ILE A  50
ILE A  84
 A79  A 800 (-3.4A)
A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 4.0A)
A79  A 800 (-3.8A)
 1.30A 2o4nB-1hvcA:
14.0		 2o4nB-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 ARG A   8
LEU A  23
ASP A  25
ALA A  28
ILE A  50
ILE A  84
 A79  A 800 (-3.6A)
A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.8A)
A79  A 800 (-3.6A)
 1.22A 2o4nB-1hvcA:
14.0		 2o4nB-1hvcA:
45.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		4 LEU A  23
ALA A  28
GLY A  49
ILE A  50
 A79  A 800 ( 4.0A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
 0.72A 2o4nB-1hvcA:
14.0		 2o4nB-1hvcA:
45.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iap GUANINE NUCLEOTIDE
EXCHANGE FACTOR
P115RHOGEF

(Homo sapiens) 		PF09128
(RGS-like) 		5 LEU A  62
ALA A  67
ILE A 222
GLY A  73
LEU A  59
 None
 1.40A 2o4nB-1iapA:
undetectable		 2o4nB-1iapA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 ARG A 209
LEU A 111
ASP A 113
ALA A 114
GLY A 196
 None
 1.45A 2o4nB-1k3vA:
undetectable		 2o4nB-1k3vA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 ARG A 298
ALA A 287
GLY A 244
ILE A 243
 None
 0.77A 2o4nB-1kczA:
undetectable		 2o4nB-1kczA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 LEU A 409
ILE A 438
GLY A 418
LEU A 428
 None
 0.77A 2o4nB-1kspA:
undetectable		 2o4nB-1kspA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 170
ALA A 277
GLY A 298
ILE A 232
LEU A 166
 None
 1.29A 2o4nB-1lamA:
undetectable		 2o4nB-1lamA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 179
ALA A 198
GLY A 204
ILE A 205
LEU A 224
 None
 1.16A 2o4nB-1m0uA:
undetectable		 2o4nB-1m0uA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6e CAPSID PROTEIN P40

(Human
gammaherpesvirus
4) 		PF00716
(Peptidase_S21) 		5 ARG A 214
LEU A 218
ASP A 221
ILE A 227
GLY A  11
 None
 1.11A 2o4nB-1o6eA:
undetectable		 2o4nB-1o6eA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		4 LEU A 146
GLY A 112
ILE A 111
LEU A 123
 None
 0.60A 2o4nB-1q0uA:
undetectable		 2o4nB-1q0uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A 287
ASP A 282
ALA A 697
GLY A 726
 None
 0.72A 2o4nB-1q8yA:
undetectable		 2o4nB-1q8yA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 173
ALA A 127
GLY A 420
ILE A 421
LEU A 169
 None
 0.90A 2o4nB-1qgdA:
undetectable		 2o4nB-1qgdA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ARG A 339
ALA A 326
GLY A 579
ILE A 578
LEU A 322
 None
 1.10A 2o4nB-1qhgA:
undetectable		 2o4nB-1qhgA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 ARG B 306
ILE B 256
GLY D 607
ILE D 608
 None
 0.69A 2o4nB-1qhhB:
undetectable		 2o4nB-1qhhB:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 LEU A  54
ILE A  43
GLY A 184
ILE A 232
 None
 0.75A 2o4nB-1qr7A:
undetectable		 2o4nB-1qr7A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs8 PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 LEU A 168
GLY A 122
ILE A 123
LEU A   8
 None
 0.76A 2o4nB-1qs8A:
6.0		 2o4nB-1qs8A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 ARG A  57
ASP A 255
GLY A  44
ILE A  45
 SO4  A 905 (-3.6A)
None
None
None
 0.73A 2o4nB-1r6aA:
undetectable		 2o4nB-1r6aA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 173
ALA A 127
GLY A 418
LEU A 169
 None
 0.66A 2o4nB-1r9jA:
undetectable		 2o4nB-1r9jA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkt PROTEIN YFIR

(Bacillus
subtilis) 		PF00440
(TetR_N) 		4 ALA A 202
ILE A  88
GLY A 145
ILE A 146
 None
 0.76A 2o4nB-1rktA:
undetectable		 2o4nB-1rktA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 LEU A 447
ILE A 321
GLY A 328
LEU A 451
 None
 0.67A 2o4nB-1ru3A:
undetectable		 2o4nB-1ru3A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2t PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Mytilus edulis) 		PF13714
(PEP_mutase) 		4 LEU A  71
ALA A  32
GLY A  42
ILE A  23
 None
 0.68A 2o4nB-1s2tA:
undetectable		 2o4nB-1s2tA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		6 ARG A   8
LEU A  23
ASP A  25
ALA A  28
ILE A  32
GLY A  49
 None
 0.70A 2o4nB-1sivA:
18.3		 2o4nB-1sivA:
49.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 LEU A 220
ASP A 219
ALA A  90
ILE A 186
GLY A  95
 None
 1.17A 2o4nB-1su7A:
undetectable		 2o4nB-1su7A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 LEU A 280
ALA A 271
ILE A 332
GLY A 252
LEU A 375
 None
 1.38A 2o4nB-1suvA:
undetectable		 2o4nB-1suvA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sva SIMIAN VIRUS 40

(Macaca mulatta
polyomavirus 1) 		PF00718
(Polyoma_coat) 		4 LEU 1 197
ALA 1 153
GLY 1 222
LEU 1 161
 None
 0.75A 2o4nB-1sva1:
undetectable		 2o4nB-1sva1:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1)
PF08542
(Rep_fac_C) 		5 ARG B 285
LEU B 286
ALA A 653
GLY A 561
ILE A 563
 None
 1.18A 2o4nB-1sxjB:
undetectable		 2o4nB-1sxjB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 175
ALA A 129
GLY A 427
ILE A 428
LEU A 171
 None
 0.91A 2o4nB-1tkcA:
undetectable		 2o4nB-1tkcA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tyg YJBS

(Bacillus
subtilis) 		PF02597
(ThiS) 		4 LEU B   2
ASP B  55
ILE B  41
LEU B   4
 None
 0.72A 2o4nB-1tygB:
undetectable		 2o4nB-1tygB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7w COENZYME A
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
COABC

(Escherichia
coli) 		PF04127
(DFP) 		5 ARG A 248
LEU A 233
ALA A 224
ILE A 272
GLY A 389
 None
 1.28A 2o4nB-1u7wA:
undetectable		 2o4nB-1u7wA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  90
ALA A  82
ILE A  65
ILE A  76
LEU A  59
 None
 1.16A 2o4nB-1uepA:
undetectable		 2o4nB-1uepA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 LEU A  85
ASP A  82
ILE A  34
GLY A  76
ILE A  71
 None
 1.33A 2o4nB-1uokA:
undetectable		 2o4nB-1uokA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v77 HYPOTHETICAL PROTEIN
PH1877

(Pyrococcus
horikoshii) 		PF01876
(RNase_P_p30) 		4 LEU A 145
ILE A 188
GLY A 128
ILE A 101
 None
 0.71A 2o4nB-1v77A:
undetectable		 2o4nB-1v77A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LEU A 243
GLY A 387
ILE A 350
LEU A 247
 None
 0.72A 2o4nB-1v8bA:
undetectable		 2o4nB-1v8bA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ILE A  69
GLY A 104
ILE A 103
LEU A  86
 None
 0.74A 2o4nB-1w5eA:
undetectable		 2o4nB-1w5eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 LEU A 314
ALA A 387
GLY A  59
ILE A  58
LEU A 303
 None
 1.47A 2o4nB-1w5tA:
undetectable		 2o4nB-1w5tA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wif RIKEN CDNA
4930408O21

(Mus musculus) 		PF00595
(PDZ) 		4 LEU A  40
GLY A  66
ILE A  67
LEU A  42
 None
 0.70A 2o4nB-1wifA:
undetectable		 2o4nB-1wifA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		4 LEU A 225
GLY A 216
ILE A 197
LEU A 464
 None
 0.77A 2o4nB-1wleA:
undetectable		 2o4nB-1wleA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		5 LEU A 270
ALA A 287
ILE A 285
GLY A 317
LEU A 280
 None
 1.44A 2o4nB-1wlsA:
undetectable		 2o4nB-1wlsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A  74
ALA A  79
GLY A 124
ILE A 126
 None
 0.73A 2o4nB-1wvgA:
undetectable		 2o4nB-1wvgA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00290
(Trp_syntA) 		5 LEU A 236
ILE A  62
GLY A  49
ILE A  48
LEU A 232
 None
IPL  A1001 ( 4.2A)
None
None
None
 1.16A 2o4nB-1wxjA:
undetectable		 2o4nB-1wxjA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 ASP A 225
ILE A 164
GLY A 340
ILE A 339
 None
 0.66A 2o4nB-1xfiA:
undetectable		 2o4nB-1xfiA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 LEU B 111
ILE B  44
GLY B  29
ILE B  28
 None
 0.71A 2o4nB-1y8qB:
undetectable		 2o4nB-1y8qB:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y97 THREE PRIME REPAIR
EXONUCLEASE 2

(Homo sapiens) 		no annotation 4 LEU A 131
ILE A 222
ILE A 112
LEU A 127
 None
 0.77A 2o4nB-1y97A:
undetectable		 2o4nB-1y97A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		4 LEU A 317
ILE A 323
GLY A 262
ILE A 255
 None
 0.76A 2o4nB-1ydxA:
undetectable		 2o4nB-1ydxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 LEU A 415
ASP A 447
ALA A 448
ILE A 485
ILE A 292
 None
 1.48A 2o4nB-1yfoA:
undetectable		 2o4nB-1yfoA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 LEU A  38
ILE A 106
ILE A  86
LEU A   7
 None
 0.76A 2o4nB-1yulA:
undetectable		 2o4nB-1yulA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 ALA B 337
ILE B 366
GLY B 392
ILE B 391
 None
 0.76A 2o4nB-1zunB:
undetectable		 2o4nB-1zunB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acv TRITERPENE
UDP-GLUCOSYL
TRANSFERASE UGT71G1

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 LEU A 223
ILE A 228
GLY A 178
ILE A 179
 None
 0.75A 2o4nB-2acvA:
undetectable		 2o4nB-2acvA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		4 ILE A 304
GLY A 248
ILE A 249
LEU A 257
 None
 0.77A 2o4nB-2b2iA:
undetectable		 2o4nB-2b2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		4 LEU A 257
ILE A 304
GLY A 248
ILE A 249
 None
 0.75A 2o4nB-2b2iA:
undetectable		 2o4nB-2b2iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  48
ALA A 178
ILE A 342
GLY A 172
ILE A 171
 None
None
None
None
FAD  A 601 (-4.0A)
 1.41A 2o4nB-2bc0A:
undetectable		 2o4nB-2bc0A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bju PLASMEPSIN II

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 LEU A 168
ALA A  20
GLY A 122
ILE A 123
LEU A   8
 None
None
IH4  A1330 ( 3.9A)
IH4  A1330 ( 4.4A)
None
 1.27A 2o4nB-2bjuA:
6.2		 2o4nB-2bjuA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 ALA A1285
ILE A1258
GLY A1172
ILE A1171
 None
 0.77A 2o4nB-2bruA:
undetectable		 2o4nB-2bruA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE

(Escherichia
coli) 		PF02734
(Dak2) 		5 ALA A  91
ILE A  89
GLY A  62
ILE A  64
LEU A  72
 None
 1.21A 2o4nB-2btdA:
undetectable		 2o4nB-2btdA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		5 LEU A 101
ALA A  75
GLY A   9
ILE A   6
LEU A  59
 None
NAD  A 401 (-3.7A)
None
None
None
 1.12A 2o4nB-2c20A:
undetectable		 2o4nB-2c20A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 436
ALA A 402
GLY A 341
ILE A 409
LEU A 439
 None
 1.48A 2o4nB-2cduA:
undetectable		 2o4nB-2cduA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddt SPHINGOMYELIN
PHOSPHODIESTERASE

(Bacillus cereus) 		PF03372
(Exo_endo_phos) 		5 LEU A  10
ALA A 301
ILE A 267
GLY A 193
ILE A  50
 None
 1.50A 2o4nB-2ddtA:
undetectable		 2o4nB-2ddtA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN

(Pyrococcus
horikoshii) 		PF00574
(CLP_protease) 		5 LEU A 150
ALA A 161
ILE A 165
GLY A 118
ILE A 117
 None
 1.46A 2o4nB-2deoA:
undetectable		 2o4nB-2deoA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg8 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ARG A  34
LEU A  21
ALA A  60
ILE A  14
ILE A  53
 None
 1.38A 2o4nB-2dg8A:
undetectable		 2o4nB-2dg8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		5 ARG A 266
LEU A 364
ASP A 361
ILE A  48
GLY A  63
 None
 1.18A 2o4nB-2drqA:
undetectable		 2o4nB-2drqA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 LEU A 148
ILE A 247
GLY A 235
ILE A 234
 None
None
None
NAP  A 476 (-3.8A)
 0.66A 2o4nB-2euhA:
undetectable		 2o4nB-2euhA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		5 LEU A 131
ALA A 185
GLY A 154
ILE A 153
LEU A 238
 None
 1.30A 2o4nB-2ewnA:
undetectable		 2o4nB-2ewnA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 ALA A 101
ILE A  70
GLY A 110
ILE A 109
 None
 0.68A 2o4nB-2f1kA:
undetectable		 2o4nB-2f1kA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 298
GLY A 210
ILE A 212
LEU A 304
 None
 0.68A 2o4nB-2f9gA:
undetectable		 2o4nB-2f9gA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhe GLUTATHIONE
S-TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 175
ILE A 182
ILE A  94
LEU A 158
 None
 0.77A 2o4nB-2fheA:
undetectable		 2o4nB-2fheA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		5 ARG A   8
LEU A  23
ASP A  25
ALA A  28
GLY A  55
 LP1  A 201 (-3.5A)
None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.4A)
 0.50A 2o4nB-2fmbA:
15.0		 2o4nB-2fmbA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		4 LEU A 499
GLY A 508
ILE A 507
LEU A 492
 None
 0.68A 2o4nB-2gj4A:
undetectable		 2o4nB-2gj4A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE

(Shewanella
oneidensis) 		PF00920
(ILVD_EDD) 		4 ALA A 313
ILE A 316
GLY A 279
ILE A 278
 None
 0.76A 2o4nB-2gp4A:
undetectable		 2o4nB-2gp4A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqt UDP-N-ACETYLENOLPYRU
VYLGLUCOSAMINE
REDUCTASE

(Thermus
caldophilus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 ALA A  79
ILE A 160
GLY A  45
LEU A 155
 FAD  A 601 ( 4.2A)
FAD  A 601 (-4.7A)
FAD  A 601 (-3.1A)
None
 0.66A 2o4nB-2gqtA:
undetectable		 2o4nB-2gqtA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A   9
ILE A 106
GLY A  40
ILE A  39
LEU A  72
 None
 1.46A 2o4nB-2hzgA:
undetectable		 2o4nB-2hzgA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		4 ILE A  88
GLY A  11
ILE A  20
LEU A  66
 None
 0.77A 2o4nB-2i5bA:
undetectable		 2o4nB-2i5bA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibp CITRATE SYNTHASE

(Pyrobaculum
aerophilum) 		PF00285
(Citrate_synt) 		5 ARG A 202
LEU A 206
ILE A 366
GLY A 350
ILE A 351
 None
 1.41A 2o4nB-2ibpA:
undetectable		 2o4nB-2ibpA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		5 LEU A  59
ASP A  88
ILE A  15
GLY A 113
ILE A 114
 None
 1.31A 2o4nB-2imhA:
undetectable		 2o4nB-2imhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqt FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS 1

(Porphyromonas
gingivalis) 		PF00274
(Glycolytic) 		5 ARG A  10
ILE A 174
GLY A  70
ILE A  69
LEU A 231
 None
 1.46A 2o4nB-2iqtA:
undetectable		 2o4nB-2iqtA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 ARG A 398
LEU A 672
ILE A 650
GLY A 444
LEU A 679
 None
 1.36A 2o4nB-2iutA:
undetectable		 2o4nB-2iutA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuu DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 ARG A 398
LEU A 672
ILE A 650
GLY A 444
LEU A 679
 None
 1.33A 2o4nB-2iuuA:
undetectable		 2o4nB-2iuuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00156
(Pribosyltran) 		5 LEU A  56
ILE A  92
GLY A  65
ILE A  64
LEU A  85
 None
None
None
None
CAS  A  82 ( 4.5A)
 1.15A 2o4nB-2jbhA:
undetectable		 2o4nB-2jbhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kep GENERAL SECRETION
PATHWAY PROTEIN G

(Pseudomonas
aeruginosa) 		PF08334
(T2SSG) 		5 LEU A 103
ASP A  53
ALA A  50
GLY A 144
LEU A 100
 None
 1.36A 2o4nB-2kepA:
undetectable		 2o4nB-2kepA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		4 LEU A  50
GLY A  78
ILE A  76
LEU A 107
 None
 0.75A 2o4nB-2l4cA:
undetectable		 2o4nB-2l4cA:
19.35