SIMILAR PATTERNS OF AMINO ACIDS FOR 2O1O_A_RISA400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dz3 STAGE 0 SPORULATION
PROTEIN A

(Geobacillus
stearothermophilus) 		PF00072
(Response_reg) 		5 LEU A  14
ASP A   9
ASP A  10
THR A  84
GLN A  88
 None
 1.36A 2o1oA-1dz3A:
undetectable		 2o1oA-1dz3A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ARG A 126
GLN A 185
LYS A 214
THR A 215
 None
 0.97A 2o1oA-1fpsA:
32.8		 2o1oA-1fpsA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ASP A 117
ARG A 126
GLN A 185
THR A 215
 None
 0.85A 2o1oA-1fpsA:
32.8		 2o1oA-1fpsA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ASP A 117
ASP A 121
ARG A 126
THR A 215
 None
 0.77A 2o1oA-1fpsA:
32.8		 2o1oA-1fpsA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ASP A 121
ARG A 126
LYS A 214
THR A 215
 None
 0.93A 2o1oA-1fpsA:
32.8		 2o1oA-1fpsA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		8 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
 0.40A 2o1oA-1rqjA:
25.8		 2o1oA-1rqjA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 LEU A  79
ASP A  82
ASP A  88
ARG A  93
GLN A 154
THR A 178
 None
 1.06A 2o1oA-1rtrA:
23.9		 2o1oA-1rtrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 LEU A  79
ASP A  88
ARG A  93
GLN A 154
LYS A 177
THR A 178
 None
 1.00A 2o1oA-1rtrA:
23.9		 2o1oA-1rtrA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
 None
 0.59A 2o1oA-1wy0A:
27.3		 2o1oA-1wy0A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
 None
 1.36A 2o1oA-2azkA:
23.8		 2o1oA-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
 None
 0.89A 2o1oA-2azkA:
23.8		 2o1oA-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 LEU A 220
ASP A 201
GLN A 197
THR A 156
ASN A 150
 None
 1.33A 2o1oA-2azkA:
23.8		 2o1oA-2azkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		8 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
 0.62A 2o1oA-2dh4A:
25.7		 2o1oA-2dh4A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.97A 2o1oA-2ftzA:
23.4		 2o1oA-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
 0.65A 2o1oA-2ftzA:
23.4		 2o1oA-2ftzA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
GLN A 185
 MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
GRG  A 500 (-3.2A)
 0.80A 2o1oA-2q80A:
24.3		 2o1oA-2q80A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
 0.51A 2o1oA-2q80A:
24.3		 2o1oA-2q80A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		6 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.57A 2o1oA-3aq0A:
23.7		 2o1oA-3aq0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		6 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.67A 2o1oA-3aqcB:
26.2		 2o1oA-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		6 LEU B  81
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.95A 2o1oA-3aqcB:
26.2		 2o1oA-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ARG A 105
GLN A 168
LYS A 192
THR A 193
 None
 1.13A 2o1oA-3lomA:
25.0		 2o1oA-3lomA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A  94
ASP A 100
GLN A 168
THR A 193
 None
 1.43A 2o1oA-3lomA:
25.0		 2o1oA-3lomA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A 100
ARG A 105
GLN A 168
THR A 193
 None
 0.97A 2o1oA-3lomA:
25.0		 2o1oA-3lomA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  81
ASP A  87
GLN A 153
LYS A 178
THR A 179
 None
 1.36A 2o1oA-3m0gA:
23.0		 2o1oA-3m0gA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  87
ARG A  92
GLN A 153
LYS A 178
THR A 179
 None
 0.90A 2o1oA-3m0gA:
23.0		 2o1oA-3m0gA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  86
ASP A  89
ARG A 100
GLN A 160
THR A 184
 GOL  A 310 ( 4.3A)
None
None
None
None
 1.14A 2o1oA-3m9uA:
24.1		 2o1oA-3m9uA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 LEU A  86
ASP A  89
ASP A  95
ARG A 100
LYS A 183
THR A 184
 GOL  A 310 ( 4.3A)
None
None
None
None
None
 0.96A 2o1oA-3m9uA:
24.1		 2o1oA-3m9uA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A  90
ASP A  93
ARG A 102
LYS A 179
THR A 180
 None
 0.76A 2o1oA-3mzvA:
24.7		 2o1oA-3mzvA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ASP A  78
GLN A 149
LYS A 172
THR A 173
 None
 1.34A 2o1oA-3npkA:
25.1		 2o1oA-3npkA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 LEU A  75
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 None
 0.85A 2o1oA-3npkA:
25.1		 2o1oA-3npkA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		7 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.47A 2o1oA-3p41A:
22.8		 2o1oA-3p41A:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ASP A  88
GLN A 153
LYS A 176
 None
 1.46A 2o1oA-3p8lA:
24.1		 2o1oA-3p8lA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ASP A  88
LYS A 176
THR A 177
 None
 1.36A 2o1oA-3p8lA:
24.1		 2o1oA-3p8lA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  88
ARG A  93
GLN A 153
LYS A 176
 None
 1.09A 2o1oA-3p8lA:
24.1		 2o1oA-3p8lA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  88
ARG A  93
LYS A 176
THR A 177
 None
 1.00A 2o1oA-3p8lA:
24.1		 2o1oA-3p8lA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.91A 2o1oA-3pkoA:
24.9		 2o1oA-3pkoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.79A 2o1oA-3pkoA:
24.9		 2o1oA-3pkoA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		8 LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
THR A 187
GLN A 225
 DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
 0.48A 2o1oA-3q1oA:
27.4		 2o1oA-3q1oA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
THR A 216
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 383 ( 4.0A)
 0.86A 2o1oA-3qqvA:
29.1		 2o1oA-3qqvA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		7 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
GLN A 254
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
 0.65A 2o1oA-3qqvA:
29.1		 2o1oA-3qqvA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A  74
ASP A  77
LYS A 162
THR A 163
GLN A 197
 None
 0.95A 2o1oA-3tc1A:
23.3		 2o1oA-3tc1A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
ASP A  88
ASP A  94
LYS A 185
THR A 186
 None
 1.12A 2o1oA-3ts7A:
23.9		 2o1oA-3ts7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
ASP A  94
ARG A  99
LYS A 185
THR A 186
 None
 0.68A 2o1oA-3ts7A:
23.9		 2o1oA-3ts7A:
23.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  97
ARG A 102
LYS A 187
THR A 188
 None
 1.23A 2o1oA-3ucaA:
24.6		 2o1oA-3ucaA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
 None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
 0.98A 2o1oA-3wjoA:
24.5		 2o1oA-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
 0.80A 2o1oA-3wjoA:
24.5		 2o1oA-3wjoA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.63A 2o1oA-3zouA:
22.3		 2o1oA-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
 0.49A 2o1oA-3zouA:
22.3		 2o1oA-3zouA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		8 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
 0.55A 2o1oA-4e1eA:
37.1		 2o1oA-4e1eA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
LYS A 178
THR A 179
 None
 0.85A 2o1oA-4f62A:
22.9		 2o1oA-4f62A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
GLN A 155
LYS A 178
THR A 179
 None
 1.04A 2o1oA-4f62A:
22.9		 2o1oA-4f62A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
LYS A 162
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
GER  A 301 ( 4.8A)
None
 1.16A 2o1oA-4fp4A:
20.1		 2o1oA-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 1.00A 2o1oA-4fp4A:
20.1		 2o1oA-4fp4A:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.81A 2o1oA-4gp1A:
26.5		 2o1oA-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.61A 2o1oA-4gp1A:
26.5		 2o1oA-4gp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 0.76A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
 0.53A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 LEU A  95
ASP A  98
ASP A 102
GLN A 167
THR A 163
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-3.5A)
476  A 402 (-4.8A)
 1.48A 2o1oA-4jzxA:
37.2		 2o1oA-4jzxA:
25.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
ASP A  97
ARG A 106
GLN A 165
LYS A 194
 None
 0.90A 2o1oA-4kk2A:
33.4		 2o1oA-4kk2A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
ASP A  97
ARG A 106
LYS A 194
THR A 195
 None
 0.93A 2o1oA-4kk2A:
33.4		 2o1oA-4kk2A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
ASP A  97
ASP A 101
ARG A 106
LYS A 194
 None
 1.25A 2o1oA-4kk2A:
33.4		 2o1oA-4kk2A:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
THR A 185
 None
 0.77A 2o1oA-4kkmA:
23.9		 2o1oA-4kkmA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  92
ARG A  97
LYS A 184
THR A 185
 None
 1.10A 2o1oA-4kkmA:
23.9		 2o1oA-4kkmA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		6 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
 IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
 0.85A 2o1oA-4lfeA:
24.8		 2o1oA-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		7 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.44A 2o1oA-4lfeA:
24.8		 2o1oA-4lfeA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.63A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		6 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.53A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  86
ARG A  91
THR A 179
GLN A 213
 None
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
 0.73A 2o1oA-4llsA:
24.8		 2o1oA-4llsA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		8 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
 0.40A 2o1oA-4p0vA:
36.3		 2o1oA-4p0vA:
29.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
 0.48A 2o1oA-4rxeA:
36.3		 2o1oA-4rxeA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
 0.58A 2o1oA-4rxeA:
36.3		 2o1oA-4rxeA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  80
ARG A  85
LYS A 163
THR A 164
 None
 1.12A 2o1oA-4wk5A:
22.5		 2o1oA-4wk5A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		5 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
 None
 0.77A 2o1oA-4wk5A:
22.5		 2o1oA-4wk5A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		8 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
 0.60A 2o1oA-5ahuB:
13.2		 2o1oA-5ahuB:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		7 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
LYS A 183
THR A 184
 None
 0.84A 2o1oA-5aypA:
22.6		 2o1oA-5aypA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  89
ASP A  92
ASP A  98
ARG A 103
THR A 193
 None
 1.05A 2o1oA-5e8hA:
22.8		 2o1oA-5e8hA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
 None
 1.03A 2o1oA-5e8lA:
22.8		 2o1oA-5e8lA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  97
ARG A 102
GLN A 166
LYS A 192
 None
 1.15A 2o1oA-5e8lA:
22.8		 2o1oA-5e8lA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 LEU A  79
ASP A  82
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
None
PO4  A 501 ( 4.9A)
None
None
 1.01A 2o1oA-5h9dA:
26.0		 2o1oA-5h9dA:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		7 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
THR A 244
GLN A 284
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
None
 0.70A 2o1oA-5hn7A:
36.8		 2o1oA-5hn7A:
32.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		5 ASP A  56
ASP A  60
GLN A 113
GLN A 166
ASN A 169
 MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
MG  A 503 (-2.9A)
 0.63A 2o1oA-5iysA:
5.7		 2o1oA-5iysA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 5 LEU A 141
ASP A 137
ARG A 140
LYS A 126
ASN A 277
 None
 1.46A 2o1oA-5x87A:
undetectable		 2o1oA-5x87A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 7 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
THR A 245
GLN A 284
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
C6M  A 401 (-3.7A)
 0.41A 2o1oA-6b07A:
36.1		 2o1oA-6b07A:
13.41